C. Ducho

发表

Novel 5'-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analogues.

Anatol P. Spork, C. Ducho, 2010, Organic & biomolecular chemistry.

Efficient synthesis of the core structure of muraymycin and caprazamycin nucleoside antibiotics based on a stereochemically revised sulfur ylide reaction

R. Herbst‐Irmer, B. Dittrich, Anatol P. Spork, 2010 .

Lead structures for new antibacterials: stereocontrolled synthesis of a bioactive muraymycin analogue.

T. Bugg, Agnes Mihalyi, Anatol P. Spork, 2014, Chemistry.

Membrane-interacting properties of the functionalised fatty acid moiety of muraymycin antibiotics

C. Steinem, C. Ducho, O. Ries, 2015 .

The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model of the Gram-negative bacterial inner membrane.

M. Windbergs, C. Lehr, V. Rosilio, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Crotonase catalysis enables flexible production of functionalized prolines and carbapenams.

C. Schofield, J. Mecinović, T. Claridge, 2012, Journal of the American Chemical Society.

Concise synthesis of both diastereomers of 3-hydroxy-l-arginine

C. Ducho, Martin Büschleb, Anke Lemke, 2010 .

Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

C. Schofield, C. Ducho, J. Sorensen, 2009, Organic and biomolecular chemistry.

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.

D. Harding, C. Schofield, T. Claridge, 2011, Nature chemistry.

Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.

S. V. Van Lanen, K. Nonaka, T. Takatsu, 2013, Angewandte Chemie.

Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics.

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2018, The Journal of organic chemistry.

Pyridoxal-5′-Phosphate-Dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2020, Nature Chemical Biology.

The Biosynthesis of Capuramycin-type Antibiotics

J. Thorson, S. Garneau‐Tsodikova, A. Morris, 2015, The Journal of Biological Chemistry.

Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach

C. Ducho, Philine Kirsch, B. Schmidtgall, 2020, Chembiochem : a European journal of chemical biology.

Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media †

C. Ducho, B. Schmidtgall, Melissa Meng, 2018, Molecules.

Oligonucleotide analogues with cationic backbone linkages

C. Ducho, Melissa Meng, 2018, Beilstein journal of organic chemistry.

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction

T. Grossmann, C. Ducho, B. Schmidtgall, 2017, Chemistry.

Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.

Anatol P. Spork, C. Ducho, C. Höbartner, 2014, Chemical communications.

Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays.

R. Jahn, N. Gisch, Anatol P. Spork, 2016, Chemistry.

Enzymatically Cleavable siRNA Prodrugs: a New Paradigm for the Intracellular Delivery of RNA‐Based Therapeutics

C. Ducho, 2015, ChemMedChem.

Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order

J. Thorson, J. Rohr, Xiaodong Liu, 2018, Antimicrobial Agents and Chemotherapy.

Merging Natural Products: Muraymycin–Sansanmycin Hybrid Structures as Novel Scaffolds for Potential Antibacterial Agents

C. Ducho, G. Niro, S. Weck, 2020, Chemistry.

Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics

C. Ducho, Stefan Koppermann, Kristin Leyerer, 2020, Molbank.

Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit

C. Ducho, Stefan Koppermann, G. Niro, 2019, Molecules.

Solid Phase‐Supported Synthesis of Muraymycin Analogues

C. Ducho, Stefan Koppermann, Kristin Leyerer, 2019 .

Unified Synthesis of Densely Functionalized Amino Acid Building Blocks for the Preparation of Caprazamycin Nucleoside Antibiotics

C. Ducho, R. Linder, 2019, European Journal of Organic Chemistry.

Aminoribosylated Analogues of Muraymycin Nucleoside Antibiotics

C. Ducho, Stefan Koppermann, D. Wiegmann, 2018, Molecules.

Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures

Anatol P. Spork, C. Ducho, Stefan Koppermann, 2018, Molecules.

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, ChemMedChem.

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.

E. Papadopoulos, G. Wagner, C. Mitsiades, 2021, European journal of medicinal chemistry.

The enzymes of β-lactam biosynthesis.

Michael A McDonough, Christopher J Schofield, C. Schofield, 2013, Natural product reports.

Synthesis of Deuterium-Labelled 3-Hydroxy-L-arginine: Comparative Studies on Different Protecting-Group Strategies

C. Ducho, Anke Lemke, 2016 .

A Kaleidoscope of Contemporary Organic Chemistry: The 46th Bürgenstock Conference

C. Ducho, 2011 .

Second‐Generation cycloSal‐d4TMP Pronucleotides Bearing Esterase‐Cleavable Sites — The “Trapping” Concept

J. Balzarini, C. Ducho, C. Meier, 2006 .

Thieme Chemistry Journals Awardees – Where Are They Now? Ribosylation of an Acid-Labile Glycosyl Acceptor as a Potential Key Step for the Synthesis of Nucleoside Antibiotics

Anatol P. Spork, C. Ducho, D. Wiegmann, 2017 .

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

C. Ducho, Stefan Koppermann, D. Wiegmann, 2016, Beilstein journal of organic chemistry.

Stereocontrolled Synthesis of 5′- and 6′-Epimeric Analogues of Muraymycin Nucleoside Antibiotics

Anatol P. Spork, C. Ducho, 2013 .

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.

H. Arthanari, Chantal D. Bader, A. Kiemer, 2022, Journal of medicinal chemistry.

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors

R. Hartmann, A. Abadi, G. Piazza, 2018, Archiv der Pharmazie.

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks

C. Ducho, C. Höbartner, B. Schmidtgall, 2015, Beilstein journal of organic chemistry.

Aryl-Substituted and Benzo-Annulated CycloSal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity

E. De Clercq, L. Naesens, J. Balzarini, 2002, Antiviral chemistry & chemotherapy.

cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity.

J. Balzarini, C. Ducho, C. Meiera, 2002, Current topics in medicinal chemistry.

Esterase-cleavable cyclo Sal-pronucleotides – the trapping concept

J. Balzarini, C. Ducho, C. Meier, 2005 .

Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.

R. Esnouf, J. Balzarini, C. Ducho, 2004, Journal of medicinal chemistry.

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

T. Wichelhaus, E. Proschak, C. Ducho, 2021, RSC medicinal chemistry.

EPR Study into Cross-Termination and Fragmentation with the Phenylethyl–Phenylethyl Dithiobenzoate RAFT Model System

W. Meiser, C. Ducho, O. Ries, 2013 .

3,5-Di-(tert-Butyl)-6-fluoro-cycloSal-d4TMP − A Pronucleotide with a Considerably Improved Masking Group

J. Balzarini, C. Ducho, C. Meier, 2003 .

Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules

C. Ducho, Manuel Hawner, 2020, Molecules.

Non-inhibition of Acetylcholinesterase by cyclosal Nucleotides

J. Balzarini, C. Ducho, C. Meier, 2003, Nucleosides, nucleotides & nucleic acids.

BENZYL-FUNCTIONALIZED cycloSal-d4T MONOPHOSPHATES

E. De Clercq, J. Balzarini, C. Ducho, 2001, Nucleosides, nucleotides & nucleic acids.

Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.

S. Jessel, J. Balzarini, N. Gisch, 2007, Journal of medicinal chemistry.

Concise Synthesis and X-Ray Crystal Structure of N-Benzyl-2-(pyrimidin-4′-ylamino)-thiazole-4-carboxamide (Thiazovivin), a Small-Molecule Tool for Stem Cell Research

D. Stalke, C. Ducho, O. Ries, 2013 .

Synthesis of 2′‐Deoxyuridine Modified with a 3,5‐Difluoro‐4‐Methoxybenzylidene Imidazolinone Derivative for Incorporation into Oligonucleotide Probes for Detection of HER2 Breast Cancer Marker

B. Fischer, Noam Y. Steinman, C. Ducho, 2020, Current protocols in nucleic acid chemistry.

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

R. Hartmann, H. Brandstetter, Brigitta Elsässer, 2017, Journal of the American Chemical Society.

Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.

J. Rohr, Pallab Pahari, S. V. Van Lanen, 2012, Journal of the American Chemical Society.

Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY.

T. Bugg, B. Gust, R. Goss, 2014, Chemical communications.

Stereoselective synthesis of uridine-derived nucleosyl amino acids.

D. Stalke, Anatol P. Spork, C. Ducho, 2011, The Journal of organic chemistry.

Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471.

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, Journal of natural products.

Enzymatic Cβ-H Functionalization of l-Arg and l-Leu in Nonribosomally Derived Peptidyl Natural Products: A Tale of Two Oxidoreductases.

J. Thorson, S. V. Van Lanen, C. Ducho, 2021, Journal of the American Chemical Society.

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.

C. Schofield, J. Mecinović, T. Claridge, 2010, Chemical communications.

Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.

B. Kessler, C. Schofield, T. Claridge, 2008, Angewandte Chemie.

A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine

D. Stalke, C. Ducho, Martin Büschleb, 2012, Amino Acids.

Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY.

C. Ducho, Stefan Koppermann, 2016, Angewandte Chemie.

Specific, sensitive, and quantitative detection of HER-2 mRNA breast cancer marker by fluorescent light-up hybridization probes.

Y. Shav-Tal, N. Kinor, Eli Varon, 2020, Bioconjugate chemistry.

An oligonucleotide probe incorporating the chromophore of green fluorescent protein is useful for the detection of HER-2 mRNA breast cancer marker.

Y. Shav-Tal, Eli Varon, B. Fischer, 2019, European journal of medicinal chemistry.

Amino acid motifs in natural products: synthesis of O-acylated derivatives of (2S,3S)-3-hydroxyleucine

D. Stalke, C. Ducho, Martin Büschleb, 2014, Beilstein journal of organic chemistry.

Muraymycin Nucleoside‐Peptide Antibiotics: Uridine‐Derived Natural Products as Lead Structures for the Development of Novel Antibacterial Agents

C. Ducho, Stefan Koppermann, D. Wiegmann, 2016 .

Improved Convergent Synthesisof 5′-epi-Analogues of Muraymycin NucleosideAntibiotics

Anatol P. Spork, C. Ducho, Stefan Koppermann, 2009 .

Pyridoxal-5′-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase

Xiaodong Liu, Zhao-yong Yang, S. V. Van Lanen, 2018, Proceedings of the National Academy of Sciences.

Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents.

R. Hartmann, H. Brandstetter, R. Müller, 2021, ChemMedChem.

Targeting the binding pocket of the fluorophore 8‐anilinonaphthalene‐1‐sulfonic acid in the bacterial enzyme MurA

M. Engel, C. Ducho, Reem K Fathalla, 2023, Archiv der Pharmazie.

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

R. J. Doerksen, M. Jackson, Sudeshna Roy, 2022, bioRxiv.

The Biosynthesis of Capuramycin-type Antibiotics

J. Thorson, S. Garneau‐Tsodikova, A. Morris, 2015, The Journal of Biological Chemistry.

The Biosynthesis of Capuramycin-type Antibiotics: Identification of the A-102395 Biosynthetic Gene Cluster, Mechanism of Self-Resistence, and Formation of Uridine-5'-Carboxamide

S. Garneau‐Tsodikova, Manjula Sunkara, Masanori Funabashi, 2019 .

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

C. Beisswenger, C. Lehr, B. Loretz, 2023, ACS central science.

Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.

J. Rohr, Pallab Pahari, S. V. Van Lanen, 2012, Journal of the American Chemical Society.