T. Appleton

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Alpha-turn mimetics: short peptide alpha-helices composed of cyclic metallopentapeptide modules.

James P Snyder, J. Snyder, D. Fairlie, 2004, Journal of the American Chemical Society.

Metal clips induce folding of a short unstructured peptide into an alpha-helix via turn conformations in water. Kinetic versus thermodynamic products.

D. Fairlie, Renée L. Beyer, H. Hoang, 2004, Journal of the American Chemical Society.

The Chemistry of Cisplatin in Aqueous Solution

S. Berners‐Price, T. Appleton, 2000 .

Reactions of platinum(II) aqua complexes. 1. Multinuclear (platinum-195, nitrogen-15, and phosphorus-31) NMR study of reactions between the cis-diamminediaquaplatinum(II) cation and the oxygen-donor ligands hydroxide, perchlorate, nitrate, sulfate, phosphate, and acetate

R. D. Berry, T. Appleton, John R. Hall, 1984 .

Aspects of the solution chemistry of trans-diammineplatinum(II) complexes

K. Barnham, T. Appleton, John R. Hall, 1992 .

S,O-versus S,N-chelation in the reactions of the cis-diamminediaquaplatinum(II) cation with methionine and S-methylcysteine

T. Appleton, J. Connor, John R. Hall, 1988 .

Reactions of cisplatin hydrolytes with methionine, cysteine, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniques.

L. Gahan, S. Berners‐Price, T. Appleton, 1999, Journal of inorganic biochemistry.

Reactions of cisplatin hydrolytes, cis-[Pt(15NH3)2(H2O) 2]2+, with N-acetyl-L-cysteine

T. Appleton, S. Hadi, 2010 .

Development of HPLC conditions for valid determination of hydrolysis products of cisplatin.

L. Gahan, T. Appleton, B. Charles, 1999, Journal of pharmaceutical sciences.

NMR study of acid-base equilibria and other reactions of ammineplatinum complexes with aqua and hydroxo ligands

S. Ralph, T. Appleton, J. R. Hall, 1989 .

Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA.

Y. Zou, N. Farrell, Y. Qu, 1995, Biochemistry.

N.M.R. study of acid−base equilibria of aminoalkylphosphonic acids, +NH3(CH2)nPO3H− (n=1,2,3): evidence for cyclization in solution

T. Appleton, H. A. Kimlin, J. R. Hall, 1984 .

Displacement of norbornadiene (NBD) from Pt(CF3)2(NBD) by weak donor ligands L, and reactions of cis-Pt(CF3)2L2 with water and acids

R. D. Berry, T. Appleton, J. R. Hall, 1989 .

[Pt2(.mu.-CH3CO2-O,O')4(H2O)2](ClO4)2, a platinum(III) dimeric cation with a very short, compressed, metal-metal bond

C. Kennard, T. Appleton, K. Byriel, 1992 .

Displacement of norbornadiene (NBD) from the mixed alkyl compound, Pt(CH3) (CF3)(NBD) by various ligands and the insertion of difluorocarbene into a PtCH3 bond promoted by the addition of iodide ion to Pt(CH3) (CF3)(NBD)

T. Appleton, J. R. Hall, Donald W. Neale, 1993 .

NMR Study of the reactions of the cis-diamminediaquaplatinum(II) cation with glutathione and amino acids containing a thiol group

P. Prenzler, T. Appleton, J. Connor, 1989 .

Formation of Pt(C3) (CF3) (diolefin) from Pt(CH3) 2(diolefin) and CF3I (diolefin = NBD, norbornadiene, or COD, 1,5-cyclooctadiene). The crystal structures of (η4-norbornadiene)(methyl)(trifluoromethyl)-platinum(II) and (η4-norbornadiene)bis(trifluoromethyl)platinum(II)

T. Mak, C. Kennard, T. Appleton, 1993 .

Oxidative addition to bis(trifluoromethyl)platinum(II) complexes with N-donor ligands

R. D. Berry, T. Appleton, J. R. Hall, 1988 .

Reactions of platinum(II) aqua complexes. 3. Multinuclear (nitrogen-15, platinum-195, carbon-13, and proton) NMR study of reactions of aqua and hydroxo complexes with glycine and (methylimino)diacetic acid

S. Ralph, T. Appleton, John H. Hall, 1985 .

Reactions of platinum(II) aqua complexes. 3. Multinuclear (15N, 195Pt, 13C, and 1H) NMR study of reactions of aqua and hydroxo complexes with glycine and (methylimino)diacetic acid

S. Ralph, T. Appleton, J. R. Hall, 1985 .

Effect of chelate-ring size on spectroscopic and chemical properties of methylplatinum(II) complexes of the ditertiary phosphines Ph2P[CH2]nPPh2(n= 1,2, or 3)

T. Appleton, M. A. Bennett, I. Tomkins, 1976 .

Oxygen uptake by a cobalt(II) complex. An undergraduate experiment

T. Appleton, 1977 .

Metal clips that induce unstructured pentapeptides to be alpha-helical in water.

D. Fairlie, H. Hoang, T. Appleton, 2009, Journal of the American Chemical Society.

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance.

D. Fairlie, Jonathan Puddick, M. Prinsep, 2017, Inorganic chemistry.

Complexes with six-membered chelate rings. I. Preparation of platinum(II) and palladium(II) complexes of trimethylenediamine and some methyl-substituted derivatives

T. Appleton, J. R. Hall, 1970 .

Reaction of the cis-Diamminediaquaplatinum(II) Cation with N-Acetylglycine

P. Prenzler, T. Appleton, J. R. Hall, 1989 .

Complexes with six-membered chelate rings. V. Nuclear magnetic resonance and infrared spectra of some complexes of 1,3-diaminopropan-2-ol and 2-chloropropane-1,3-diamine with platinum and palladium

J. Hall, T. Appleton, 1972 .

Proton magnetic resonance of tris-ethylenediamine complexes

C. Hawkins, T. Appleton, J. R. Hall, 1970 .

Donor atom preferences in complexes of platinum and palladium with amino acids and related molecules

T. Appleton, 1997 .

Kinetics of site-exchange reactions in di- and tri-methylplatinum(IV) glycinate complexes, from N.M.R. lineshape analysis

T. Appleton, Mark A. Williams, J. R. Hall, 1983 .

Multinuclear NMR study of reactions of methylphosphonic acid, CH3PO3H2, and (aminoalkyl)phosphonic acids, NH2(CH2)nPO3H2 (n = 1-3), with the cis-diamminediaquaplatinum(II) cation and cis-diamminedihydroxoplatinum(II)

T. Appleton, J. R. Hall, I. Mcmahon, 1986 .

NMR spectra of platinum(III) complexes with sulfato- and phosphato-bridges

T. Appleton, J. R. Hall, Donald W. Neale, 1985 .

Trifluoromethylplatinum complexes and the nature of the platinum-trifluoromethyl bond

L. Manzer, M. Chisholm, T. Appleton, 1972 .

15N NMR study of the linkage isomerism of pentaammine(glycinato)rhodium(III)

T. Appleton, M. Cox, 1991 .

Formation of unsymmetrical cis-dialkyls of platinum(II) from platinum(II) hydroxo-complexes

T. Appleton, M. A. Bennett, 1973 .

15N and 195Pt NMR spectra of platinum ammine complexes: trans- and cis-influence series based on 195Pt-15N coupling constants and 15N chemical shifts

S. Ralph, T. Appleton, J. R. Hall, 1985 .

Oxidative addition, reductive elemination, and isomerization reactions of organoplatinum complexes

L. Manzer, T. Appleton, H. C. Clark, 1974 .

Synthesis of dimethylplatinum(IV) compounds, [{PtMe2X2}n], [{PtMe2XY}n], and, in solution, fac-[PtMe2X(H2O)3]+, where X and Y are anionic ligands

T. Appleton, Mark A. Williams, J. R. Hall, 1996 .

‘Platinum phosphate blues’. A comparison with ‘amide blues’

R. D. Berry, T. Appleton, J. R. Hall, 1982 .

Reactions of 3,3,3-trifluoropropyne with methylplatinum(II) complexes

R. Puddephatt, T. Appleton, H. C. Clark, 1972 .

Complexes with six-membered chelate rings. III. Factors influencing the values of the platinum-proton coupling constants 3JPt-N-C-H and 4JPt-N-C-CH3 in diamine complexes of platinum(II) and -(IV)

J. Hall, T. Appleton, 1971 .

Preparation and properties of hydroxo(methyl)-1,2-bis(diphenylphosphino)ethaneplatinum(II). A trans-influence series including .sigma. carbon donor ligands based on platinum-phosphorus coupling constants

T. Appleton, M. A. Bennett, 1978 .

Multinuclear NMR of cis-dicarbonylbis(dithiocarbamato)iron(II) complexes in chloroform solution

N. V. Duffy, T. Appleton, 1988 .

Amino acid complexes of platinum(IV). I. Trimethylplatinum(IV) complexes with glycinate, iminodiacetate, n-methyliminodiacetate, nitrilotriacetate, and ethylenediamine-tetraacetate

T. Appleton, J. R. Hall, L. Lambert, 1978 .

Reactions of fac-[PtMe2(OMe)(H2O)3]+ with halide ions: effect of halide trans effect on methoxide hydrolysis

G. Ayoko, T. Appleton, S. Hadi, 2003 .

Di- and trimethylplatinum(IV) complexes with aspartate: some subtle effects of chelate ring size

T. Appleton, J. R. Hall, T. G. Jones, 1995 .

Displacement of norbornadiene (NBD) from PtR2(NBD) (R = Me, CF3) by weak ligands

T. Appleton, Mark A. Williams, J. R. Hall, 1984 .

Amino acid complexes of platinum(IV). V. A dimethylplatinum(IV) complex containing deprotonated glycinate as an amido-bridging ligand, [PtMe2(OH)(μ-NHCH2CO2)]2−2

T. Appleton, J. R. Hall, N. H. Agnew, 1981 .

Amino acid complexes of platinum(IV). IV. Bis- and tris-(glycinate) complexes of cis-dimethylplatinum(IV): chelate ring closure and cleavage reactions☆

T. Appleton, J. R. Hall, N. H. Agnew, 1980 .

Reactions of the cis-diamminediaquaplatinum(II) cation with histidine and related molecules

T. Appleton, F. B. Ross, 1996 .

NMR Study of Properties in Solution of Platinum(II) Ammine-Aqua Complexes, Including Determination of Acid Dissociation Constants

S. Ralph, T. Appleton, J. R. Hall, 1988 .

15N and195Pt NMR Spectra of Platinum Ammine Complexes: trans- and cis-Influence Series Based on195Pt-15N Coupling Constants and15N Chemical Shifts

S. Ralph, T. Appleton, J. R. Hall, 1986 .

Reactions of di- and trimethylplatinum(IV) complexes with N-(phosphonomethyl)glycine (glyphosate) and iminobis(methylenephosphonic acid). Crystal structures of three dimethylplatinum(IV) complexes with N-(phosphonomethyl)glycine coordinated facially

C. Kennard, T. Appleton, D. Lynch, 1994 .

Reactions of platinum(II) aqua complexes. 2. Platinum-195 NMR study of reactions between the tetraaquaplatinum(II) cation and chloride, hydroxide, perchlorate, nitrate, sulfate, phosphate, and acetate

S. Ralph, T. Appleton, J. R. Hall, 1985 .

Oxidative addition and insertion reactions of cyclic alkyne-platinum(0) complexes

T. Appleton, T. Yoshida, M. A. Bennett, 1978 .

A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin

David P. Fairlie, D. Fairlie, M. Kelso, 2003 .

Preparation, Crystal Structures, and Properties of the Acetate-Bridged Platinum(III) Compounds [{(H2O)Pt(.mu.-CH3CO2)2}2]A2 (A- = ClO4-, CF3SO3-)

J. M. Garrett, C. Kennard, T. Appleton, 1995 .

Complexes with six-membered chelate rings. II. Proton magnetic resonance study of trimethylenediamine, some methyl-substituted derivatives, and their complexes with platinum(II) and palladium(II)

T. Appleton, J. R. Hall, 1970 .

Reactions of the cis-Diamminediaquaplatinum(II) Cation with Glycinamide, N-Glycylglycine, and N-(N-Glycylglycyl)glycine. Crystal Structure of a Complex with Two Diammineplatinum(II) Cations Bound to Glycylglycinate

T. Hambley, P. Prenzler, T. Appleton, 1990 .

Mechanism of the insertion of an acetylene into a methylplatinum(II) bond

M. Chisholm, T. Appleton, H. C. Clark, 1972 .

NMR spectra of iminobis(methylenephosphonic acid), HN(CH2PO3H2)2, and related ligands and of their complexes with platinum(II)

T. Appleton, J. R. Hall, I. Mcmahon, 1986 .

Complexes of Peptides and Related Molecules with Diammineplatinum (II) as Models for Platinum-Protein Interactions

P. Prenzler, T. Appleton, J. R. Hall, 1991 .

Platinum complexes with iminodiacetate and (methylimino)diacetate, including genuine meridional complexes

R. D. Berry, T. Appleton, J. R. Hall, 1985 .

Aspects of the Solution Chemistry of trans-Diammineplatinum(II) Complexes.

K. Barnham, T. Appleton, J. R. Hall, 1992 .

T. Appleton, M. A. Bennett, M. Bennett, 1978 .

Amino acid complexes of palladium(II). 1. NMR study of the reactions of the diaqua(ethylenediamine)palladium(II) cation with ammonia, betaine, and the amino acids +NH3(CH2)nCO2 - (n = 1-3)

D. Bedgood, T. Appleton, J. R. Hall, 1994 .

Cisplatin as a synthon. Synthesis and characterization of triplatinum complexes containing three cis-(Pt(amine)2 units linked in a linear fashion

N. Farrell, Y. Qu, J. Hoeschele, 1993 .

Reactions of Nitroplatinum Complexes. 2. Reactions of K2[Pt(NO2)4] and Related Complexes with Aqueous Acids (CH3CO2H, HClO4, CF3SO3H, HNO3, and H2SO4): Pathways to Platinum(III) Complexes with Acetate Bridges. Crystal Structure of K2[{Pt(NO2)2(.mu.-CH3CO2)}2].cntdot.H2O

C. Kennard, K. Barnham, T. Appleton, 1995 .

Reactions of nitroplatinum complexes. 1. 15N and 195Pt NMR spectra of platinum(II) nitrite complexes

K. Barnham, T. Appleton, J. R. Hall, 1991 .

Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition

A. M. Pollard, A. D. Bain, Jimmy D Bell, 2010 .

Linkage isomerism in square-planar complexes of platinum and palladium with histidine and derivatives

S. Menzer, Trevor G. Appleton, Ferdinand J. Pesch, 1992 .

Reactions of the cis-diamminediaquaplatinum(II) cation with 2-aminomalonic acid and its homologs, aspartic and glutamic acids. Rearrangements of metastable complexes with carboxylate-bound ligands to N,O-chelates and formation of di- and trinuclear complexes

T. Appleton, J. R. Hall, Craig S. M. Thompson, 1990 .

Displacement of norbornadiene (NBD) from PtMe2(NBD) BY N-donors, dimethylsulfoxide, and cyanide, and reactions of cis-PtMe2L2 iodomethane

T. Appleton, Mark A. Williams, J. R. Hall, 1986 .

Linkage isomerism in the binding of pentapeptide Ac-His(Ala)3His-NH2 to (ethylenediamine)palladium(II): effect of the binding mode on peptide conformation.

D. Fairlie, M. Kelso, Renée L. Beyer, 2008, Inorganic chemistry.

NMR Study of Acid‐Base Equilibria and Other Reactions of Ammineplatinum Complexes with Aqua and Hydroxo Ligands.

S. Ralph, T. Appleton, J. R. Hall, 1989 .

REACTIONS OF TRANS-[PtX2(pic)2] (Pic = y-PICOLINE, X = Cl-, NO3-) WITH N-ACETYL-L-CYSTEINE AND GLUTATHIONE

T. Appleton, S. Hadi, 2012 .

STUDY OF REACTION OF TRANS-[Pt( 15 NH 3 ) 2 (H 2 O) 2 ] 2+ WITH N-ACETYL-L-CYSTEINE

T. Appleton, S. Hadi, 2010 .

Reactions of trans-[Pt(15NH3)2(H2O)2]2+ with Glutathione

T. Appleton, S. Hadi, 2008 .

Tris and tetrakis(1–methylcytosine) complexes of Pt(II): Syntheses and X–ray structures of [Pt(1–MeC–N3)3Cl]+ and [Pt(1–MeC–N3)4]2+ compounds

E. Freisinger, E. Zangrando, T. Appleton, 1998 .

15N N.M.R. Study of Some Palladium(II) Ammine Complexes

S. Ralph, T. Appleton, J. R. Hall, 1988 .

Metal clips that induce unstructured pentapeptides to be alpha-helical in water.

D. Fairlie, H. Hoang, T. Appleton, 2009, Journal of the American Chemical Society.