Jian‐Qiang Fan

发表

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

Jian‐Qiang Fan, Jian-Qiang Fan, 2008, Biological chemistry.

Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin.

S. Ishii, K. Yasuda, Jian‐Qiang Fan, 2007, The Biochemical journal.

Hydrophilic iminosugar active‐site‐specific chaperones increase residual glucocerebrosidase activity in fibroblasts from Gaucher patients

S. Ishii, Y. Ichikawa, Jian‐Qiang Fan, 2006, The FEBS journal.

Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes.

S. Yokoyama, S. Ishii, Makoto Watanabe, 2008, Biochimica et biophysica acta.

SYNTHESIS AND CHARACTERIZATION OF PECTIN-DEHYDROGENATION POLYMER COMPLEX BY ISOTOPIC LABELING METHOD

Jian‐Qiang Fan, Yimin Xie, Peng Wang, 2013 .

A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity.

Jian‐Qiang Fan, 2003, Trends in pharmacological sciences.

Active‐site‐specific chaperone therapy for Fabry disease

S. Ishii, Jian‐Qiang Fan, 2007, The FEBS journal.

Rational Design and Synthesis of Highly Potent -Glucocerebrosidase Inhibitors

XiaoXiang Zhu, Shihong Li, Jian‐Qiang Fan, 2005 .

Transfer of Man9GlcNAc tol-fucose by endo-β-N-acetylglucosaminidase fromArthrobacter protophormiae

K. Takegawa, B. Reinhold, V. Reinhold, 1996, Glycoconjugate Journal.

Preclinical Efficacy and Safety of 1-Deoxygalactonojirimycin in Mice for Fabry Disease

T. Shimada, S. Ishii, H. Yoshioka, 2009, Journal of Pharmacology and Experimental Therapeutics.

Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease.

A. Kulkarni, S. Ishii, H. Yoshioka, 2004, Biochimica et biophysica acta.

Alternative splicing in the alpha-galactosidase A gene: increased exon inclusion results in the Fabry cardiac phenotype.

R. Desnick, S. Ishii, Jian‐Qiang Fan, 2002, American journal of human genetics.

COMBINED CHEMICAL AND ENZYMATIC SYNTHESIS OF A C-GLYCOPEPTIDE AND ITS INHIBITORY ACTIVITY TOWARD GLYCOAMIDASES

Lai-Xi Wang, K. Kitajima, S. Inoue, 1997 .

Iminosugars as Active‐Site‐Specific Chaperones for the Treatment of Lysosomal Storage Disorders

Jian‐Qiang Fan, 2008 .

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

Satoshi Ishii, Yoshiyuki Suzuki, S. Ishii, 1999, Nature Medicine.

Enzymatic synthesis of neoglycoconjugates by transglycosylation with endo-beta-N-acetylglucosaminidase A.

K. Takegawa, Jian‐Qiang Fan, 2003, Methods in enzymology.

Efficient and rapid purification of recombinant human alpha-galactosidase A by affinity column chromatography.

S. Ishii, K. Yasuda, Jian‐Qiang Fan, 2004, Protein expression and purification.

Introduction: Pharmacological chaperone therapy for lysosomal storage disorders – leveraging aspects of the folding pathway to maximize activity of misfolded mutant proteins

Jian‐Qiang Fan, 2007, The FEBS journal.

In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives.

S. Ishii, K. Yasuda, Jian‐Qiang Fan, 2000, European journal of biochemistry.

Preclinical Efficacy and Safety of 1-Deoxygalactonojirimycin in Mice for Fabry Disease

T. Shimada, S. Ishii, H. Yoshioka, 2009, Journal of Pharmacology and Experimental Therapeutics.

Rescue of mutant alpha-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes.

S. Yokoyama, S. Ishii, Makoto Watanabe, 2008, Biochimica et biophysica acta.