S. Tamano

T. Shirai, A. Hagiwara, M. Sano, 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model.

M. Hirose, T. Shirai, S. Tamano, 1998, Carcinogenesis.

Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay.

S. Fukushima, K. Imaida, A. Hagiwara, 1993, Teratogenesis, carcinogenesis, and mutagenesis.

Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats.

J. Ward, C. Weghorst, L. Keefer, 1996, Carcinogenesis.

Lack of Chemoprevention or Promotion Effects of Docosahexaenoic Acid on Small Intestine, Colon, Liver, Lung, Thyroid, Esophagus, Kidney, and Forestomach Carcinogenesis in a Rat Medium-Term Multi-Organ Carcinogenesis Model

K. Imaida, T. Shirai, T. Kakizoe, 2005 .

S. Imaoka, Y. Funae, T. Shirai, 1996, Cancer letters.

Immunohistochemical Detection of 8-Hydroxy-2'-deoxyguanosine in Paraffin-Embedded Sections of Rat Liver after Carbon Tetrachloride Treatment

M. Hirose, Satoru Takahashi, T. Shirai, 1998, Toxicologic pathology.

Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.

K. Imaida, T. Shirai, A. Hagiwara, 2001, Cancer letters.

Site‐specific Effects of Testosterone Propionate on the Prostate of Rat Pretreated with 3,2′‐Dimethyl‐4‐aminobiphenyl:Dose‐dependent Induction of Invasive Carcinomas

K. Imaida, M. Hirose, Satoru Takahashi, 1995, Japanese journal of cancer research : Gann.

Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.

K. Imaida, T. Shirai, A. Hagiwara, 1999, The Journal of toxicological sciences.

Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.

K. Imaida, T. Shirai, Y. Ikeda, 2001, Carcinogenesis.

Lack of Carcinogenicity of Quercetin in F344/DuCrj Rats

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Japanese journal of cancer research : Gann.

Lobe specific effects of testosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.

K. Imaida, T. Shirai, S. Tamano, 2000, Cancer letters.

Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats.

S. Fukushima, T. Shirai, M. Shibata, 1986, Cancer research.

Lack of tumor promoting effects of KCB-1, a recombinant human basic fibroblast growth factor, on two-stage skin carcinogenesis in female CD-1 (ICR) mice.

T. Nakamura, H. Sugimoto, A. Hagiwara, 1996, Cancer letters.

Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats

S. Fukushima, F. Furukawa, K. Nagano, 2015, Journal of Toxicologic Pathology.

Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.

S. Fukushima, F. Furukawa, K. Nagano, 2015, Journal of toxicologic pathology.

Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.

H. Tsuda, T. Sakata, N. Ito, 1983, Carcinogenesis.

Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis.

K. Imaida, T. Shirai, A. Hagiwara, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of enhancing effect of two Kampo medicines, Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on rat urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

T. Shirai, A. Hagiwara, N. Ito, 2002, Teratogenesis, carcinogenesis, and mutagenesis.

Experimental prostate carcinogenesis - rodent models.

K. Imaida, T. Shirai, M. Futakuchi, 2000, Mutation research.

Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.

Y. Kurata, H. Tsuda, N. Ito, 1985, Cancer letters.

Effects of Antioxidant 1‐O‐Hexyl‐2,3,5‐trimethylhydroquinone or Ascorbic Acid on Carcinogenesis Induced by Administration of Aminopyrine and Sodium Nitrite in a Rat Multi‐organ Carcinogenesis Model

M. Hirose, Satoru Takahashi, T. Shirai, 2002, Japanese journal of cancer research : Gann.

Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.

K. Imaida, M. Hirose, T. Shirai, 2005, The Journal of toxicological sciences.

Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats.

T. Shirai, Shugo Suzuki, S. Tamano, 2003, The Journal of toxicological sciences.

Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice

Y. Katsura, S. Tamano, N. Takada, 2004, Urological Research.

Beef Tallow, but Not Perilla or Corn Oil, Promotion of Rat Prostate and Intestinal Carcinogenesis by 3,2‐Dimethyl‐4‐aminobiphenyl

K. Imaida, Satoru Takahashi, T. Shirai, 2001, Japanese journal of cancer research : Gann.

No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.

T. Shirai, M. Sano, S. Tamano, 1993, Journal of toxicology and environmental health.

L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3.

S. Fukushima, K. Imaida, T. Shirai, 1988, Cancer research.

Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters.

S. Fukushima, M. Shibata, Y. Kurata, 1986, Japanese journal of cancer research : Gann.

Arachidonate-enriched triglyceride oil does not promote tumor development in a rat medium-term multi-organ carcinogenesis model.

F. Furukawa, H. Kawashima, A. Hagiwara, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methylnitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet.

T. Shirai, S. Tamano, T. Masui, 1991, Carcinogenesis.

High Incidence and Histogenesis of Seminal Vesicle Adenocarcinoma and Lower Incidence of Prostate Carcinomas in the Lobund-Wistar Prostate Cancer Rat Model Using N-nitrosomethylurea and Testosterone

J. Ward, M. Waalkes, S. Rehm, 1996, Veterinary pathology.

Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat

T. Shirai, A. Hagiwara, M. Sano, 2006 .

Increased Susceptibility to N‐Nitrosomethylurea Gastric Carcinogenesis in Transforming Growth Factor α Transgenic Mice with Gastric Hyperplasia

J. Ward, G. Merlino, J. Jakubczak, 1995, Japanese journal of cancer research : Gann.

No enhancing effects of diacylglycerol oil on tumor development in a medium-term multi-organ carcinogenesis bioassay using male F344 rats.

O. Morita, A. Hagiwara, Y. Doi, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Marriage of a medium-term liver model to surrogate markers--a practical approach for risk and benefit assessment.

K. Imaida, T. Shirai, A. Hagiwara, 1999, Toxicologic pathology (Print).

13-Week Oral Toxicity and 4-week Recovery Study of Enzymatically Modified Isoquercitrin in F344/DuCrj Rats

K. Imaida, A. Hagiwara, M. Sano, 2002 .

Chemical-induced lung tumor in Tg-rasH2 mice: a novel mouse tumor model to assess immune checkpoint inhibitors combined with a chemotherapy drug

T. Numano, S. Tamano, Taiki Sugiyama, 2022, Journal of toxicologic pathology.

Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.

H. Tsuda, T. Sakata, N. Ito, 1983, Gan.

Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.

T. Shirai, N. Ito, S. Tamano, 1991, Cancer research.

Three‐Dimensional Observations By Scanning Electron Microscopy on the Blood Supply and Organization of Vasculature During Hepatocarcinogenesis in Rats

K. Imaida, H. Tsuda, N. Ito, 1984, Acta pathologica japonica.

Suppression of Lung Metastasis by Aspirin but Not Indomethacin in an in vivo Model of Chemically Induced Hepatocellular Carcinoma

F. Takeshita, T. Shirai, M. Futakuchi, 2002, Japanese journal of cancer research : Gann.

Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice.

S. Fukushima, M. Shibata, Y. Kurata, 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice.

S. Fukushima, M. Shibata, Y. Kurata, 1987, Journal of toxicology and environmental health.

HISTOPATHOLOGICAL EVALUATION OF SPONTANEOUS HEPATOCELLULAR TUMORS IN B6C3F1 HYBRID MICE

Satoru Takahashi, T. Shirai, A. Hagiwara, 1996 .

Carcinogenicity of Captafol in F344/DuCrj Rats

A. Hagiwara, Y. Kurata, N. Ito, 1990, Japanese journal of cancer research : Gann.

Medium-term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats.

S. Fukushima, F. Furukawa, K. Nagano, 2011, Toxicology.

Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.

T. Shirai, Shugo Suzuki, A. Hagiwara, 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.

C. Masuda, Y. Funae, T. Shirai, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Non-carcinogenicity of 2,2'--(4-aminophenyl)imino-bisethanol sulfate in a long-term feeding study in Fischer 344 rats.

M. Hirose, M. Shibata, S. Tamano, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

SPONTANEOUS THYROID, PARATHYROID, AND PANCREATIC ISLET TUMORS IN F344 RATS AND B6C3F1 MICE

A. Hagiwara, M. Shibata, Y. Kurata, 1989 .

Correlation between medium-term liver bioassay system data and results of long-term testing in rats.

M. Tatematsu, N. Ito, R. Hasegawa, 1990, Carcinogenesis.

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

N Ito, T. Sugimura, K. Imaida, 1997, Cancer research.

A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats.

T. Shirai, A. Hagiwara, Y. Doi, 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.

T. Shirai, A. Hagiwara, Y. Doi, 2006, The Journal of toxicological sciences.

Two Different Constituents of Madder Colors Lack Tumor Promoting or Carcinogenic Potential in a Medium-term Multi-organ Carcinogenesis Bioassay in Rats

K. Imaida, A. Hagiwara, M. Sano, 1997 .

Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, K. Imaida, A. Hagiwara, 1994, The Journal of toxicological sciences.

Lack of promotion of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in mice by rat cancer promoters.

S. Fukushima, S. Tamano, T. Masui, 1993, Teratogenesis, carcinogenesis, and mutagenesis.

Modification by α-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine

S. Fukushima, M. Hirose, T. Shirai, 1987 .

Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats.

S. Fukushima, Y. Kurata, N. Ito, 1985, Japanese journal of cancer research : Gann.

Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol.

T. Shirai, Y. Kurata, H. Tsuda, 1984, Cancer letters.

[Modifying effects of beraprost sodium (TRK-100) on N-methyl-N-nitrosourea (MNU) carcinogenesis in F344 rats].

S. Fukushima, A. Hagiwara, M. Shibata, 1989, The Journal of toxicological sciences.

Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin

T. Shirai, N. Ito, S. Tamano, 1992 .

Ectopic Intestinal Glands in the Forestomach of a F344 Rat

A. Hagiwara, Y. Kurata, S. Tamano, 1990, Veterinary pathology.

Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder.

S. Fukushima, M. Hirose, M. Shibata, 1988, Carcinogenesis.

Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentration and pH.

S. Fukushima, K. Imaida, T. Shirai, 1987, Cancer research.

Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.

S. Fukushima, H. Tsuda, K. Hosoda, 1983, Cancer letters.

Four-week Feeding Study of Kusagi Color, a Natural Blue Food Colorant, in F344 Rats

K. Imaida, T. Shirai, A. Hagiwara, 2002 .

Medium-term bioassays as alternative carcinogenicity test.

N Ito, K. Imaida, T. Shirai, 1998, The Journal of toxicological sciences.

Lung Tumor Induction by 26-week Dermal Application of 1,2-Dichloroethane in CB6F1-Tg rasH2 Mice

T. Numano, Y. Doi, S. Tamano, 2017, Toxicologic pathology.

Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.

J. Ward, G. Merlino, S. Tamano, 1994, Carcinogenesis.

Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice.

S. Fukushima, G. Merlino, R. Puatanachokchai, 2006, Asian Pacific journal of cancer prevention : APJCP.

Medium-term Rat Liver Bioassay for Rapid Detection of Hepatocarcinogenic Substances

K. Imaida, M. Hirose, T. Shirai, 1997 .

[Effect of diuretic, azosemide (SK-110), in combination with antibiotic, cephaloridine, on kidney].

N. Asaeda, Y. Tagawa, S. Tamano, 1984, The Journal of toxicological sciences.

A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats.

Y. Tsushima, T. Shirai, K. Uchida, 2008, Food and Chemical Toxicology.

Lack of carcinogenicity of magnesium chloride in a long-term feeding study in B6C3F1 mice.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats.

A. Hagiwara, T. Numano, S. Tamano, 2010, The Journal of toxicological sciences.

Suppression of metastasis by nuclear factor kB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma

T. Shirai, M. Futakuchi, S. Tamano, 2004, Cancer science.

Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.

S. Fukushima, A. Hagiwara, N. Ito, 1982, Journal of the National Cancer Institute.

Dose-dependence of 2-amino-1-methy1–6-phenylimidazo[4, 5-b]-pyridine (PhIP) carcinogenicity in rats

N Ito, T. Sugimura, K. Imaida, 1993 .

Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.

H. Wanibuchi, S. Imaoka, Y. Funae, 1998, Carcinogenesis.

Decrease of Prostaglandin E2 and 5–Bromo–2′–deoxyuridine Labeling but Not Prostate Tumor Development by Indomethacin Treatment of Rats Given 3,2′–Dimethyl‐4‐aminobiphenyl and Testosterone Propionate

T. Shirai, M. Shibata, N. Ito, 1997, Japanese journal of cancer research : Gann.

Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.

K. Imaida, T. Shirai, H. Aoki, 2002, The Journal of toxicological sciences.

White, but not Red, Ginseng Inhibits Progression of Intestinal Carcinogenesis in Rats.

M. Kaneko, S. Fukushima, H. Wanibuchi, 2002, Asian Pacific journal of cancer prevention : APJCP.

Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice.

T. Shirai, A. Hagiwara, N. Ito, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

S. Fukushima, H. Wanibuchi, M. Wei, 2012, Journal of toxicologic pathology.

Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate.

K. Imaida, T. Shirai, M. Futakuchi, 2001, Carcinogenesis.

Organ‐dependent Modifying Effects of Caffeine, and Two Naturally Occurring Antioxidants α‐Tocopherol and n‐Tritriacontane‐16,18‐dione, on 2‐Amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine (PhIP)‐induced Mammary and Colonic Carcinogenesis in Female F344 Rats

M. Hirose, T. Shirai, A. Hagiwara, 1999, Japanese journal of cancer research : Gann.

A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats.

T. Shirai, A. Hagiwara, Y. Toda, 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of Tumor Promoting Effects of Carrageenan on 1,2-Dimethylhydrazine-induced Colorectal Carcinogenesis in Male F344 Rats

K. Imaida, T. Shirai, A. Hagiwara, 2001 .

F 344 / DuCri Rats

T. Shirai, A. Hagiwara, M. Sano, 2014 .

13-Week Oral Toxicity of Guarana Extract in F344/DuCrj Rats

T. Shirai, A. Hagiwara, M. Sano, 2005 .

Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats.

S. Fukushima, M. Hirose, A. Hagiwara, 1986, Journal of the National Cancer Institute.

13-Week oral toxicity study of captafol in F344/DuCrj rats.

M. Shibata, Y. Kurata, N. Ito, 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Modification of an in vivo Lung Metastasis Model of Hepatocellular Carcinoma by Low Dose N-nitrosomorpholine and Diethylnitrosamine

F. Takeshita, T. Shirai, M. Futakuchi, 2005, Clinical & Experimental Metastasis.

Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats.

T. Shirai, H. Aoki, A. Hagiwara, 2003, The Journal of toxicological sciences.

Low Susceptibility of Nude Mice to Induction of Invasive Urinary Bladder Cancers by N-Ethyl-N-(4-hydroxybutyl)nitrosamine

S. Fukushima, T. Shirai, S. Tamano, 1992, Toxicologic pathology.

Time‐ and Dose‐dependent Induction of Invasive Urinary Bladder Cancers by N‐Ethyl‐N‐(4‐hydroxybutyl)nitrosamine in B6C3F1 Mice

S. Fukushima, T. Shirai, A. Hagiwara, 1991, Japanese journal of cancer research : Gann.

Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats

F. Furukawa, T. Shirai, Masanori Otsuka, 2011, Journal of toxicologic pathology.

Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model.

M. Hirose, T. Shirai, M. Futakuchi, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Correlation between Medium‐term Multi‐organ Carcinogenesis Bioassay Data and Long‐term Observation Results in Rats

S. Fukushima, K. Imaida, A. Hagiwara, 1993, Japanese journal of cancer research : Gann.

Subchronic toxicity study of sodium o-phenylphenate in mice.

S. Fukushima, A. Hagiwara, M. Shibata, 1985, Toxicology letters.

Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative.

Satoru Takahashi, T. Shirai, C. Toda, 2006, Reproductive toxicology.

A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats.

T. Shirai, H. Aoki, A. Hagiwara, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Lack of effects of 1439 MHz electromagnetic near field exposure on the blood–brain barrier in immature and young rats

Osamu Fujiwara, Jianqing Wang, Tadashi Ogiso, 2005, Bioelectromagnetics.

A medium‐term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals

Tomoyuki Shirai, T. Shirai, Seiko Tamano, 2003, Cancer science.

Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate.

T. Shirai, N. Ito, S. Tamano, 1984, Journal of the National Cancer Institute.

Epoprostenol sodium, a prostaglandin I2, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats.

H. Tokado, A. Hagiwara, M. Sano, 2001, Cancer letters.

Immunohistochemically Detected O 6-and N 7-Methyldeoxyguanosine in Organs of Rats Administrated N-Methyl-N-Nitrosourea

Akihiro, S. Fukushima, S. Tamano, 2008 .

Immunohistochemically Detected O6-and N7-Methyldeoxyguanosine in Organs of Rats Administrated N-Methyl-N-Nitrosourea

S. Fukushima, A. Hagiwara, S. Tamano, 1997 .

Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay.

T. Sugimura, M. Nagao, T. Shirai, 1994, Carcinogenesis.

Forestomach Neoplasm Induction in F344/DuCrj Rats and B6C3F1 Mice Exposed to Sesamol

M. Hirose, N. Ito, S. Tamano, 1992, Japanese journal of cancer research : Gann.

Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine.

T. Shirai, S. Tamano, S. Fukushima, 1991, Carcinogenesis.

Sequential changes of the forestomach of F344 rats, Syrian golden hamsters, and B6C3F1 mice treated with butylated hydroxyanisole.

S. Fukushima, K. Imaida, M. Hirose, 1986, Japanese journal of cancer research : Gann.

Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C), in male F344 rats.

T. Sugimura, M. Nagao, A. Hagiwara, 1994, Carcinogenesis.

A Medium-Term, Rapid Rat Bioassay Model for the Detection of Carcinogenic Potential of Chemicals

M. Tatematsu, S. Fukushima, K. Imaida, 2010, Toxicologic pathology.

Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C.

S. Fukushima, M. Shibata, Y. Kurata, 1990, Cancer letters.

Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl.

S. Fukushima, M. Shibata, S. Tamano, 1989, Cancer letters.

Lack of a modifying effect by the diuretic drug furosemide on the development of neoplastic lesions in rat two-stage urinary bladder carcinogenesis.

S. Fukushima, A. Hagiwara, M. Shibata, 1989, Journal of toxicology and environmental health.

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.

N Ito, T. Shirai, N. Ito, 1995, Princess Takamatsu symposia.

Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats.

A. Hagiwara, Y. Doi, T. Omoto, 2010, The Journal of toxicological sciences.

Comparative Effects of Carcinogens on the Induction of Placental Glutathione S-Transferase-positive Liver Nodules in a Short-term Assay and of Hepatocellular Carcinomas in a Long-term Assay

M. Tatematsu, H. Tsuda, N. Ito, 1985, Toxicologic pathology.

Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats

T. Numano, Y. Doi, S. Tamano, 2019, Journal of toxicologic pathology.

Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.

K. Imaida, T. Shirai, M. Futakuchi, 2000, Cancer letters.

Dose-dependent Induction of Glandular Stomach Preneoplastic and Neoplastic Lesions in Male F344 Rats Treated with Catechol Chronically

M. Hirose, T. Shirai, A. Hagiwara, 2001, Toxicologic pathology.

Subchronic oral toxicity study of captafol in B6C3F1 mice.

N. Ito, M. Sano, S. Tamano, 1993, Journal of toxicology and environmental health.

Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.

K. Imaida, M. Hirose, T. Shirai, 1995, Toxicology letters.

Lack of modifying effects of p-phenylenediamine on induction of gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.

M. Shibata, H. Tsuda, S. Tamano, 1990, Toxicology letters.

Lack of modifying effects of 2,2'-[(4-aminophenyl) imino] bisethanol sulfate on induction of preneoplastic gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.

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