E. Ryan

发表

Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products

A. Maguire, N. O'Brien, E. Ryan, 2005, British Journal of Nutrition.

Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts

A. Maguire, N. O'Brien, E. Ryan, 2006, International journal of food sciences and nutrition.

Detailed Structural Characterization of Sphingolipids via 193 nm Ultraviolet Photodissociation and Ultra High Resolution Tandem Mass Spectrometry

G. Reid, E. Ryan, Catherine Quynh Nhu Nguyen, 2017, Journal of The American Society for Mass Spectrometry.

Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases

Spencer J. Williams, G. Davies, D. Ascher, 2018, ACS central science.

An in vitro toolbox to accelerate anti-malarial drug discovery and development

David M. Shackleford, Dennis A. Smith, S. Charman, 2020, Malaria Journal.

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

J. Baell, V. Avery, S. Charman, 2013, European journal of medicinal chemistry.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

P. Rathod, John White, M. Phillips, 2016, Journal of medicinal chemistry.

Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

David M. Shackleford, M. J. Abbott, Paul W. Alexander, 2013, Journal of medicinal chemistry.

Phytosterol Oxidation Products: Their Formation, Occurrence, and Biological Effects

A. Maguire, N. O'Brien, E. Ryan, 2009 .

Bioactivity of ellagic acid-, lutein- or sesamol-enriched meat patties assessed using an in vitro digestion and Caco-2 cell model system

J. Kerry, P. Allen, N. O'Brien, 2010 .

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

R. Prankerd, S. Charman, W. Charman, 2009, Antimicrobial Agents and Chemotherapy.

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties.

David M. Shackleford, S. Charman, Marie Lopez, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.

K. Chibale, M. Witty, S. Charman, 2012, Journal of medicinal chemistry.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

David M. Shackleford, J. Chollet, S. Charman, 2017, Journal of medicinal chemistry.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

David M. Shackleford, Brice Campo, M. Belén, 2018, Bioorganic & medicinal chemistry.

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

K. Chibale, Dale Taylor, M. Witty, 2014, Journal of medicinal chemistry.

Lipidomic Analysis Reveals Differences in Bacteroides Species Driven Largely by Plasmalogens, Glycerophosphoinositols and Certain Sphingolipids

L. Gethings, D. Clarke, S. Joyce, 2022, bioRxiv.

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

David C. S. Huang, J. Chambers, J. White, 2014, ChemMedChem.

Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives.

J. Kerry, A. Maguire, S. Hogan, 2005, Organic & biomolecular chemistry.

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.

David M. Shackleford, Paul W. Alexander, E. Chatelain, 2013, Bioorganic & medicinal chemistry.

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

M. J. Abbott, Paul W. Alexander, E. Chatelain, 2012, Journal of medicinal chemistry.

Bioactivity of herb-enriched beef patties.

J. Kerry, N. O'Brien, M. O’Grady, 2009, Journal of medicinal food.

Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes

A. Maguire, N. O'Brien, E. Ryan, 2007, Plant foods for human nutrition.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

J. Chollet, S. Charman, E. Ryan, 2013, Journal of medicinal chemistry.

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

Galen P. Miley, M. Mather, A. Vaidya, 2014, Journal of medicinal chemistry.

3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity.

J. Baell, V. Avery, E. Ryan, 2010, Bioorganic & medicinal chemistry letters.

Novel orally active antimalarial thiazoles.

K. Chibale, M. Witty, S. Charman, 2011, Journal of medicinal chemistry.

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

Christel A. S. Bergström, J. Baell, V. Avery, 2014, Journal of medicinal chemistry.

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.

Ana Rodriguez, K. Read, J. Baell, 2016, Journal of medicinal chemistry.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.

S. Charman, E. Ryan, L. Dias, 2017, European journal of medicinal chemistry.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication

David M. Shackleford, R. Price, M. Mather, 2014 .

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

M. J. Abbott, Paul W. Alexander, S. Cornwall, 2013, Future medicinal chemistry.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Julie Clark, George Papadatos, Jeremy N. Burrows, 2016, ACS central science.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J. Baell, V. Avery, S. Charman, 2015, Journal of medicinal chemistry.

Chemical Derivatization and Ultrahigh Resolution and Accurate Mass Spectrometry Strategies for "Shotgun" Lipidome Analysis.

E. Ryan, G. E. Reid, 2016, Accounts of chemical research.

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes.

S. Charman, J. Pinson, E. Ryan, 2015, Chemical research in toxicology.

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

David M. Shackleford, J. Keiser, S. Charman, 2020, Journal of medicinal chemistry.

Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives.

J. Kerry, A. Maguire, S. Hogan, 2005, Organic and biomolecular chemistry.