Jonathan W. Wojtkowiak

发表

Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302

Shingo Matsumoto, Katarzyna A Rejniak, James B. Mitchell, 2015, Cancer & metabolism.

Acidity generated by the tumor microenvironment drives local invasion.

Robert J Gillies, Robert A Gatenby, Yoganand Balagurunathan, 2013, Cancer research.

Imaging pH and metastasis

Robert J Gillies, R. Gillies, G. Martinez, 2011, NMR in biomedicine.

pH sensing and regulation in cancer

Robert J. Gillies, Mehdi Damaghi, R. Gillies, 2013, Front. Physiol..

Application of Evolutionary Principles to Cancer Therapy.

Robert A Gatenby, R. Gatenby, P. Enriquez-Navas, 2015, Cancer research.

A physical sciences network characterization of non-tumorigenic and metastatic cells

Christopher S. Poultney, Casey M. Kraning-Rush, Shannon M. Mumenthaler, 2013, Scientific Reports.

Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Robert J. Gillies, Shingo Matsumoto, Masayuki Matsuo, 2014, PloS one.

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

R. Gillies, R. Gatenby, M. Bui, 2022, Cell reports.

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

R. Gibbs, J. Reiners, R. Mattingly, 2010, Journal of Pharmacology and Experimental Therapeutics.

Induction of Apoptosis in Neurofibromatosis Type 1 Malignant Peripheral Nerve Sheath Tumor Cell Lines by a Combination of Novel Farnesyl Transferase Inhibitors and Lovastatin

R. Gibbs, J. Reiners, R. Mattingly, 2008, Journal of Pharmacology and Experimental Therapeutics.

Working together: Farnesyl transferase inhibitors and statins block protein prenylation.

R. Gibbs, R. Mattingly, Jonathan W. Wojtkowiak, 2009, Molecular and cellular pharmacology.

Proton export upregulates aerobic glycolysis

R. Gillies, M. Bui, Daniel Verduzco, 2022, BMC Biology.

Suppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033

M. Tainsky, R. Mattingly, P. Mathieu, 2008, Cancer biology & therapy.

Drug resistance and cellular adaptation to tumor acidic pH microenvironment.

R. Gillies, Daniel Verduzco, Jonathan W. Wojtkowiak, 2011, Molecular pharmaceutics.

Targeting the metabolic microenvironment of tumors.

R. Gillies, Jonathan W. Wojtkowiak, K. Bailey, 2012, Advances in pharmacology.

Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1.

R. Gibbs, M. Tainsky, J. Kraniak, 2006, Biochemical pharmacology.

Aborted Autophagy and Nonapoptotic Death Induced by Farnesyl Transferase Inhibitor and Lovastatin

Bonnie F. Sloane, J. Reiners, R. Mattingly, 2011, Journal of Pharmacology and Experimental Therapeutics.

Synthesis, biochemical, and cellular evaluation of farnesyl monophosphate prodrugs as farnesyltransferase inhibitors.

Sarah A. Scott, R. Gibbs, J. Reiners, 2007, Journal of medicinal chemistry.

The Damaging Effect of Passenger Mutations on Cancer Progression.

Jacob G. Scott, Jacob G Scott, Christopher D. McFarland, 2017, Cancer research.

Passenger DNA alterations reduce cancer fitness in cell culture and mouse models

Jacob G. Scott, Christopher D. McFarland, L. Mirny, 2015, bioRxiv.

Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.

Bonnie F. Sloane, R. Gillies, M. Bogyo, 2013, Neoplasia.

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.

R. Gillies, J. Mulé, Mehdi Damaghi, 2016, Cancer research.

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

R. Gillies, R. Gatenby, M. Bui, 2015, Nature Communications.

Metabolic Profiling of healthy and cancerous tissues in 2D and 3D

R. Gillies, Andy Neilson, Jonathan W. Wojtkowiak, 2017, Scientific Reports.

Proton export drives the Warburg Effect

R. Gillies, M. Bui, Daniel Verduzco, 2021, bioRxiv.

Mechanisms of buffer therapy resistance.

R. Gillies, Y. Balagurunathan, Jonathan W. Wojtkowiak, 2014, Neoplasia.

Evaluation of the “Steal” Phenomenon on the Efficacy of Hypoxia Activated Prodrug TH-302 in Pancreatic Cancer

R. Gillies, A. Baker, G. Martinez, 2014, PloS one.

Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.

Robert J Gillies, Marilyn M Bui, Robert A Gatenby, 2017, Cancer research.

Cell-surface markers for colon adenoma and adenocarcinoma

D. Coppola, D. Shibata, S. Enkemann, 2016, Oncotarget.

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

Bonnie F. Sloane, R. Gillies, E. Haller, 2012, Cancer research.

Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model.

Robert J Gillies, Robert A Gatenby, R. Gillies, 2011, Journal of cancer science & therapy.

Microsoft Word-92117691-file00

R. Gibbs, J. Reiners, R. Mattingly, 2010 .

MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts

R. Gillies, A. Baker, G. Martinez, 2016, PloS one.

Autophagy on acid

R. Gillies, Jonathan W. Wojtkowiak, 2012, Autophagy.

Gastrointestinal Stromal Tumor Patients with Molecular Testing Exhibit Superior Survival Compared to Patients without Testing: Results from the Life Raft Group (LRG) Registry

J. Trent, Jonathan W. Wojtkowiak, Norman J. Scherzer, 2023, Cancer investigation.

Predicting the Response of Breast Cancer to Neoadjuvant Therapy Using a Mechanically Coupled Reaction-Diffusion Model.

Thomas E Yankeelov, Michael I Miga, Jared A Weis, 2015, Cancer research.

Application of Evolutionary Principles to Cancer Therapy.

R. Gatenby, P. Enriquez-Navas, Jonathan W. Wojtkowiak, 2015, Cancer research.