D. McComsey

发表

Asymmetric induction in an enammonium-iminium rearrangement. Mechanistic insight via NMR, deuterium labeling, and reaction rate studies. Application to the stereoselective synthesis of pyrroloisoquinoline antidepressants

K. Sorgi, C. Maryanoff, D. McComsey, 1990 .

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

C. Derian, A. Pandey, D. McComsey, 2001, Journal of medicinal chemistry.

Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.

C. Derian, D. McComsey, B. Maryanoff, 2001, Bioorganic & medicinal chemistry letters.

Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.

A. Gibbs, M. Connelly, D. McComsey, 2012, Bioorganic & medicinal chemistry letters.

Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships [Erratum to document cited in CA107(17):154217r]

R. Shank, S. Nortey, D. McComsey, 1988 .

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

C. Derian, D. McComsey, B. Maryanoff, 2003, Bioorganic & medicinal chemistry letters.

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.

M. D'Andrea, C. Derian, D. McComsey, 2001, The Journal of pharmacology and experimental therapeutics.

Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.

R. Shank, A. Klinger, D. McComsey, 2006, Journal of medicinal chemistry.

Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).

D. McComsey, B. Maryanoff, D. Oksenberg, 1999, Bioorganic & medicinal chemistry letters.

Examination of Two Independent Kinetic Assays for Determining the Inhibition of Carbonic Anhydrases I and II: Structure–Activity Comparison of Sulfamates and Sulfamides

R. Shank, D. McComsey, B. Maryanoff, 2006, Chemical biology & drug design.

Exploration of Potential Prodrugs of RWJ‐445167, an Oxyguanidine‐based Dual Inhibitor of Thrombin and Factor Xa

Tianbao Lu, M. Player, D. McComsey, 2006, Chemical biology & drug design.

Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions

G. Bemis, H. Almond, D. McComsey, 1986 .

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.

C. Derian, D. McComsey, B. Maryanoff, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.

Robert H. Chen, D. McComsey, B. Maryanoff, 2007, Bioorganic & medicinal chemistry letters.

N‐Vinylpyrrolidin‐2‐One as a 3‐Aminopropyl Carbanion Equivalent in the Synthesis of Substituted 1‐Pyrrolines: 2‐Phenyl‐1‐Pyrroline

K. Sorgi, C. Maryanoff, D. McComsey, 2003 .

Synthesis and stereochemistry of 7-phenyl-2-propionanilidobenzo[a]quinolizidine derivatives. Structural probes of fentanyl analgesics.

D. McComsey, B. Maryanoff, J. F. Gardocki, 1981, Journal of medicinal chemistry.

Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.

E. Opas, Z. Sui, Dana L. Johnson, 2014, Bioorganic & medicinal chemistry letters.

Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.

R. Shank, S. Nortey, D. McComsey, 1990, Journal of medicinal chemistry.

Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state

S. L. Mayo, D. McComsey, B. Maryanoff, 1989 .

Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.

R. Shank, S. Nortey, D. McComsey, 1987, Journal of medicinal chemistry.

Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.

R. Shank, D. McComsey, B. Maryanoff, 1984, Journal of medicinal chemistry.

Additions and Corrections - Stereochemistry of Intramolecular Amidoalkylation Reactions in the Synthesis of Polycyclic Isoquinoline Derivatives.

D. McComsey, B. Maryanoff, B. Duhl-Emswiler, 1983 .

Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators

R. Shank, D. McComsey, B. Maryanoff, 1996 .

Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles.

J J McNally, R. Shank, S. Nortey, 1999, Bioorganic & medicinal chemistry letters.

Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308.

J A Mitchell, D. McComsey, B. Maryanoff, 1999, Journal of medicinal chemistry.

Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors.

R. Shank, S. Nortey, A. Reitz, 1995, Journal of medicinal chemistry.

7-fluoroindazoles as potent and selective inhibitors of factor Xa.

Mark R Player, D. Parks, Yu-Kai Lee, 2008, Journal of medicinal chemistry.

Bis(trifluoroacetoxy)borane

D. McComsey, B. Maryanoff, 2001 .

(1,3‐Dioxolan‐2‐ylmethyl)triphenylphosphonium Bromide

D. McComsey, B. Maryanoff, M. Reid, 2006 .

Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies.

C. Schubert, G. Leo, R. Hansen, 2008, The Journal of organic chemistry.

Correction. Properties of Bis(trifluoroacetoxy)borane as a Reducing Agent of Organic Compounds

S. Nortey, D. McComsey, B. Maryanoff, 1981 .

Borane complexes in trifluoroacetic acid. Reduction of indoles to indolines and generation of bis(trifluoroacetoxy)borane

D. McComsey, B. Maryanoff, 1978 .

Structural studies on McN-5652-X, a high-affinity ligand for the serotonin transporter in mammalian brain.

Xiaolin Cao, L. Nafie, R. Dukor, 2003, Bioorganic & medicinal chemistry.

Resolution and absolute configuration of 1,2,3,5,6,10bβ‐hexahydro‐6α‐phenylpyrrolo[2,1‐α]isoquinoline (McN‐4612‐Z). A problem of determination of the enantiomeric purity for a tertiary amine

D. McComsey, B. Maryanoff, 1985 .

THE REACTION OF AMINES WITH METHYLENE CHLORIDE. A BRIEF REVIEW

C. Maryanoff, D. McComsey, J. Mills, 1984 .

Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.

R. Shank, D. McComsey, B. Maryanoff, 2005, Journal of medicinal chemistry.

Iminium ion cyclizations. Highly stereoselective synthesis of substituted tetrahydroisoquinoline derivatives

D. McComsey, B. Maryanoff, 1980 .

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

K. Wilcox, H. White, D. Brenneman, 2013, Journal of medicinal chemistry.

Reaction of amines with methylene chloride. Evidence for rapid aminal formation from N-methylenepyrrolidinium chloride and pyrrolidine

C. Maryanoff, D. McComsey, J. Mills, 1987 .

The Reaction of Amines with Methylene Chloride. Evidence for Rapid Aminal Formation from N-Methylenepyrrolidinium Chloride and Pyrrolidine.

C. Maryanoff, D. McComsey, J. Mills, 1987 .

Carbonic anhydrase-II inhibition. what are the true enzyme-inhibitory properties of the sulfamide cognate of topiramate?

D. McComsey, B. Maryanoff, M. Todd, 2008, Journal of medicinal chemistry.

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

S. Emanuel, H. Ye, C. Derian, 2003, Bioorganic & medicinal chemistry letters.

Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.

R. Shank, D. McComsey, B. Maryanoff, 1998, Bioorganic & medicinal chemistry letters.

Preclinical evaluation of McN-5707 as a potential antidepressant.

R. Shank, D. McComsey, B. Maryanoff, 1987, The Journal of pharmacology and experimental therapeutics.

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif.

D. McComsey, B. Maryanoff, R. Scarborough, 1998, Bioorganic & medicinal chemistry letters.

Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042

B. D. Harris, D. McComsey, B. Maryanoff, 1996 .

Protease-activated receptor-2 (PAR-2): structure-function study of receptor activation by diverse peptides related to tethered-ligand epitopes.

D. McComsey, B. Maryanoff, C. E. Smith, 2001, Archives of biochemistry and biophysics.

Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies.

G. Leo, D. McComsey, B. Maryanoff, 1999, Bioorganic & medicinal chemistry.

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN.

D. McComsey, B. Maryanoff, L. R. Hecker, 1999, Bioorganic & medicinal chemistry letters.

McN-5652: a highly potent inhibitor of serotonin uptake.

R. Shank, D. McComsey, B. Maryanoff, 1988, The Journal of pharmacology and experimental therapeutics.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

L. Leclercq, R. Iannucci, H. White, 2009, Journal of medicinal chemistry.

DEALKYLATION OF A TERTIARY AMINE GROUP BY AN INTRAMOLECULAR CARBAMYL CHLORIDE FUNCTIONALITY

C. Maryanoff, D. McComsey, B. Maryanoff, 1983 .

The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2.

T. Kirchner, Z. Sui, Dana L. Johnson, 2014, Bioorganic & medicinal chemistry letters.

Deoxygenation of Acetylenic Carbinols. Reduction of Cobalt Carbonyl Adducts with Borane-Methyl Sulfide and Trifluoroacetic Acid

A. Reitz, C. Maryanoff, D. McComsey, 1986 .

Substituted pyrrolines useful as kinase inhibitors.

D. McComsey, B. Maryanoff, B. Conway, 2003 .

Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.

A. Gibbs, D. McComsey, B. Maryanoff, 2011, ACS medicinal chemistry letters.