A. Trabocchi

发表

Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology

Andrea Trabocchi, A. Trabocchi, 2013 .

Computational-aided design of a library of lactams through a diversity-oriented synthesis strategy.

José L Medina-Franco, Elena Lenci, Andrea Trabocchi, 2020, Bioorganic & medicinal chemistry.

Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis.

J. Medina-Franco, A. Trabocchi, F. Saldívar-González, 2019, Organic & biomolecular chemistry.

A Glucose‐Derived α‐Hydroxy Aldehyde for the Petasis Reaction: Facile Access to Polyfunctional δ‐Amino Acids

A. Trabocchi, E. Lenci, Raffaele Bellini Puglielli, 2020, European Journal of Organic Chemistry.

Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds.

A. Trabocchi, E. Lenci, G. Menchi, 2017, Organic & biomolecular chemistry.

Synthetic Approaches towards Peptidomimetic Design

A. Trabocchi, A. Guarna, 2014 .

Two-step one-pot synthesis of dihydropyrazinones as Xaa-Ser dipeptide isosteres through morpholine acetal rearrangement.

A. Trabocchi, E. Lenci, G. Menchi, 2015, Organic & biomolecular chemistry.

Nanostars—decorated microfluidic sensors for surface enhanced Raman scattering targeting of biomolecules

F. Pavone, R. Cicchi, C. Credi, 2020, Journal of Physics: Photonics.

A Systems Biology Approach to Dissection of the Effects of Small Bicyclic Peptidomimetics on a Panel of Saccharomyces cerevisiae Mutants*

D. Cavalieri, A. Trabocchi, A. Guarna, 2010, The Journal of Biological Chemistry.

Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds.

F. Bianchini, A. Contini, A. Trabocchi, 2019, Bioorganic & medicinal chemistry.

Synthesis of diverse phenylglycine derivatives via transformation of Ugi four-component condensation primary adducts

A. Trabocchi, G. Menchi, S. Marcaccini, 2011 .

Use of click-chemistry in the development of peptidomimetic enzyme inhibitors.

A. Trabocchi, A. Guarna, G. Menchi, 2014, Current medicinal chemistry.

Carbohydrates in diversity-oriented synthesis: challenges and opportunities.

A. Trabocchi, E. Lenci, G. Menchi, 2016, Organic & biomolecular chemistry.

Solvent‐Dependent Conformational Behaviour of Model Tetrapeptides Containing a Bicyclic Proline Mimetic

D. Potenza, A. Trabocchi, A. Guarna, 2004 .

Design and Synthesis of Novel Raman Reporters for Bioorthogonal SERS Nanoprobes Engineering

F. Pavone, C. Credi, A. Trabocchi, 2022, International journal of molecular sciences.

Design, synthesis and evaluation of RGD peptidomimetic - Gold nanostar conjugates as M21 cell adhesion inhibitors.

F. Bianchini, F. Pavone, C. Credi, 2022, Bioorganic chemistry.

Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors.

A. Pupi, A. Trabocchi, E. Lenci, 2017, Bioorganic & medicinal chemistry.

Diversity‐Oriented Synthesis of Amino Acid–Derived Scaffolds and Peptidomimetics: A Perspective

A. Trabocchi, 2013 .

Insight to the binding mode of triazole RGD-peptidomimetics to integrin-rich cancer cells by NMR and molecular modeling.

F. Vasile, D. Potenza, A. Trabocchi, 2016, Bioorganic & medicinal chemistry.

Role of Side‐Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3 Integrin

A. Trabocchi, S. Raspanti, A. Guarna, 2014 .

Combination of click chemistry and sulfonamides to develop three-armed triazole compounds

F. Bianchini, A. Trabocchi, S. Raspanti, 2014 .

Case Study 2: Peptidomimetic Ligands for αvβ3 Integrin

A. Trabocchi, A. Guarna, 2014 .

Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity.

A. Pupi, A. Trabocchi, S. Raspanti, 2009, Bioorganic & medicinal chemistry.

Peptidomimetic Small-Molecule Inhibitors of 3CLPro Activity and Spike–ACE2 Interaction: Toward Dual-Action Molecules against Coronavirus Infections

A. Trabocchi, E. Lenci, Lorenzo Calugi, 2022, The Journal of organic chemistry.

Suzuki reaction of vinyl triflates from six- and seven-membered N-alkoxycarbonyl lactams with boronic acids and esters.

A. Trabocchi, A. Guarna, E. Occhiato, 2001, The Journal of organic chemistry.

Synthesis and conformational analysis of small peptides containing 6-endo-BT(t)L scaffolds as reverse turn mimetics.

D. Potenza, A. Trabocchi, A. Guarna, 2002, The Journal of organic chemistry.

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

C. Supuran, A. Scozzafava, F. Carta, 2015, Journal of enzyme inhibition and medicinal chemistry.

Gold Nanostars Bioconjugation for Selective Targeting and SERS Detection of Biofluids

Martino Calamai, F. Pavone, C. Credi, 2021, Nanomaterials.

Novel small molecules for the treatment of infections caused by Candida albicans: a patent review (2002 – 2010)

A. Trabocchi, A. Guarna, C. Calugi, 2011, Expert opinion on therapeutic patents.

Synthesis of γ‐ and δ‐Amino Acids

A. Trabocchi, A. Guarna, G. Menchi, 2010 .

Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp3-Rich Morpholine Peptidomimetics

A. Trabocchi, E. Lenci, G. Menchi, 2018, Front. Chem..

Synthesis and Conformational Analysis of Constrained β‐Turn Mimetics Incorporating a Bicyclic Turn Inducer by Use of the Petasis Three‐Component Reaction on Solid Phase

A. Trabocchi, A. Guarna, G. Menchi, 2007 .

Sugar Amino Acids

A. Trabocchi, A. Guarna, 2014 .

The Basics of Peptidomimetics

A. Trabocchi, A. Guarna, 2014 .

A new family of cinchona-derived amino phosphine precatalysts: application to the highly enantio- and diastereoselective silver-catalyzed isocyanoacetate aldol reaction.

D. Dixon, A. Trabocchi, A. Guarna, 2011, Journal of the American Chemical Society.

Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5 alpha-reductase 1.

M. Serio, R. Mancina, A. Trabocchi, 2001, Bioorganic & medicinal chemistry.

Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds.

A. Trabocchi, A. Guarna, Filippo Sladojevich, 2008, Organic & biomolecular chemistry.

A new bicyclic proline-mimetic amino acid

A. Trabocchi, A. Guarna, N. Cini, 2003 .

Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

A. Trabocchi, E. Lenci, G. Menchi, 2020, Beilstein journal of organic chemistry.

Skeletal diversity by sequential one-pot and stepwise routes using morpholine ester scaffolds

A. Trabocchi, A. Guarna, Filippo Sladojevich, 2010 .

Recent advances in copper-catalyzed imine-based multicomponent reactions

A. Trabocchi, E. Lenci, Riccardo Innocenti, 2020 .

Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study

J. Medina-Franco, A. Trabocchi, F. Saldívar-González, 2019, RSC advances.

Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype.

P. Navarra, A. Cassone, F. De bernardis, 2012, Bioorganic & medicinal chemistry.

Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds.

A. Cassone, F. De bernardis, R. Cauda, 2010, Journal of medicinal chemistry.

One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation.

A. Trabocchi, A. Guarna, C. Lalli, 2012, Organic & biomolecular chemistry.

Diastereoselective Synthesis of Highly Constrained Spiro‐β‐Lactams by the Staudinger Reaction Using an Unsymmetrical Bicyclic Ketene

A. Trabocchi, A. Guarna, C. Lalli, 2007 .

Cyclic α‐Amino Acids as Proline Mimetics

A. Trabocchi, A. Guarna, 2014 .

Structural diversity of bicyclic amino acids

A. Trabocchi, A. Guarna, D. Scarpi, 2007, Amino Acids.

Solid‐Phase Synthesis and Combinatorial Approaches to Peptidomimetics

A. Trabocchi, A. Guarna, 2014 .

Synthesis of a new enantiopure bicyclic γ/δ-amino acid (BTKa) derived from tartaric acid and α-amino acetophenone

A. Trabocchi, A. Guarna, F. Machetti, 2002 .

Synthesis and conformational studies of a hybrid β-alanine–morpholine tetramer

A. Trabocchi, A. Guarna, G. Menchi, 2012 .

¹²⁵I-radiolabeled morpholine-containing arginine-glycine-aspartate (RGD) ligand of αvβ₃ integrin as a molecular imaging probe for angiogenesis.

Alberto Pupi, Andrea Trabocchi, Eleonora Vanzi, 2012, Journal of medicinal chemistry.

Diversity-oriented synthesis of morpholine-containing molecular scaffolds.

A. Trabocchi, A. Guarna, C. Lalli, 2009, Chemistry.

β‐Turn Peptidomimetics

A. Trabocchi, A. Guarna, 2014 .

Synthesis of a bicyclic δ-amino acid as a constrained Gly-Asn dipeptide isostere

A. Trabocchi, A. Guarna, G. Menchi, 2008, Amino Acids.

3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter.

A. Pupi, A. Trabocchi, S. Raspanti, 2006, Bioorganic & medicinal chemistry.

3-Aza-8,10-dioxa-bicyclo[5.2.1]decane (9-exo BTKa) carboxylic acid as a new reverse turn inducer: synthesis and conformational analysis of a model peptide

A. Trabocchi, A. Guarna, D. Stranges, 2006 .

Synthesis of a constrained tricyclic scaffold based on trans-4-hydroxy-l-proline

A. Trabocchi, A. Guarna, G. Menchi, 2005 .

Synthesis of Glycidol‐ and Sugar‐Derived Bicyclic β‐ and γ/δ‐Amino Acids for Peptidomimetic Design

A. Trabocchi, A. Guarna, G. Menchi, 2005 .

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

R. Leatherbarrow, A. Trabocchi, A. Guarna, 2001, Bioorganic & medicinal chemistry.

Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids: A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid

A. Trabocchi, A. Guarna, F. Machetti, 1999 .

Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae

Duccio Cavalieri, Matteo Brilli, Andrea Trabocchi, 2017, Front. Pharmacol..

Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

P. Navarra, A. Cassone, F. De bernardis, 2014, The Journal of pharmacy and pharmacology.

A solid-phase approach towards the development of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds

A. Trabocchi, A. Guarna, G. Menchi, 2004, Molecular Diversity.

Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs

A. Trabocchi, A. Guarna, 2014 .

Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds.

D. Cavalieri, A. Trabocchi, A. Guarna, 2010, Organic & biomolecular chemistry.

Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in beta-turn peptides.

A. Trabocchi, A. Guarna, Filippo Sladojevich, 2010, Organic & biomolecular chemistry.

Configurationally driven folding of model tetrapeptides containing L- or D-morpholine-3-carboxylic acids as beta-turn nucleators.

A. Trabocchi, A. Guarna, Filippo Sladojevich, 2009, Chirality.

Convenient route to enantiopure fmoc-protected morpholine-3-carboxylic acid.

A. Trabocchi, A. Guarna, Filippo Sladojevich, 2007, The Journal of organic chemistry.

Skeletal diversity from carbohydrates: use of mannose for the diversity-oriented synthesis of polyhydroxylated compounds.

Elena Lenci, Andrea Trabocchi, A. Trabocchi, 2015, The Journal of organic chemistry.

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

F. Bianchini, A. Trabocchi, E. Lenci, 2016, Molecules.

Enantiospecific synthesis of 3-aza-6,8-dioxa-bicyclo[3.2.1]octane carboxylic acids from erythrose

A. Trabocchi, A. Guarna, F. Machetti, 2003 .

Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand.

F. Bianchini, A. Trabocchi, A. Guarna, 2014, Chemistry.

Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective αvβ5 integrin ligand

A. Pupi, D. Potenza, A. Trabocchi, 2009, Amino Acids.

γ- and δ-Amino Acids: Synthetic Strategies and Relevant Applications

A. Trabocchi, A. Guarna, F. Guarna, 2005 .

Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold

A. Trabocchi, A. Guarna, 2014 .

Case Study 1: Peptidomimetic HIV Protease Inhibitors

A. Trabocchi, A. Guarna, 2014 .

Peptidomimetic toolbox for drug discovery.

Elena Lenci, Andrea Trabocchi, A. Trabocchi, 2020, Chemical Society reviews.

γ‐ and δ‐Amino Acids: Synthetic Strategies and Relevant Applications

A. Trabocchi, A. Guarna, F. Guarna, 2006 .

Synthetic approaches toward small molecule libraries

Andrea Trabocchi, Elena Lenci, A. Trabocchi, 2020 .

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle

S. Heath, M. Gut, I. Gut, 2018, Scientific Reports.

Diversity-Oriented Synthesis as a Tool for Chemical Genetics

A. Trabocchi, E. Lenci, A. Guarna, 2014, Molecules.

Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors.

A. Trabocchi, A. Guarna, C. Calugi, 2014, European journal of medicinal chemistry.

Occurrence of Morpholine in Central Nervous System Drug Discovery

A. Trabocchi, E. Lenci, Lorenzo Calugi, 2021, ACS chemical neuroscience.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells

A. Pupi, F. Bianchini, B. Mazzanti, 2016, Molecular and Cellular Biochemistry.

Occurrence of the d-Proline Chemotype in Enzyme Inhibitors

Andrea Trabocchi, Elena Lenci, A. Trabocchi, 2019, Symmetry.

Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis.

A. Pupi, F. Bianchini, A. Trabocchi, 2010, Journal of medicinal chemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands.

F. Bianchini, A. Trabocchi, Lorenzo Sernissi, 2016, Bioorganic & medicinal chemistry.

Principles and applications of small molecule peptidomimetics

A. Trabocchi, 2020 .

Novel matrix metalloproteinase inhibitors: an updated patent review (2014 - 2020)

A. Trabocchi, E. Lenci, Lucrezia Cosottini, 2021, Expert opinion on therapeutic patents.

Smart Design of Small‐Molecule Libraries: When Organic Synthesis Meets Cheminformatics

Elena Lenci, Andrea Trabocchi, A. Trabocchi, 2019, Chembiochem : a European journal of chemical biology.

Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries.

A. Trabocchi, E. Lenci, Lorenzo Baldini, 2021, Bioorganic & medicinal chemistry.

Copper-Catalyzed A3 -Coupling for the Diversity-Oriented Synthesis of Proline-Derived Alkynyl-Substituted Peptidomimetic Scaffolds

A. Trabocchi, E. Lenci, G. Menchi, 2019, European Journal of Organic Chemistry.

Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis.

A. Pupi, A. Passeri, F. Bianchini, 2015, Bioorganic & medicinal chemistry.

Chemical genetics approach to drug discovery by diversity-oriented synthesis (DOS) of peptidomimetics

D. Cavalieri, A. Trabocchi, A. Guarna, 2011 .

Identification of a short ACE2-derived stapled peptide targeting the SARS-CoV-2 spike protein

A. Contini, A. Trabocchi, E. Lenci, 2023, European Journal of Medicinal Chemistry.

A study of a D-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

F. Bianchini, Jessica Ruzzolini, A. Trabocchi, 2015 .

Synthesis of morpholine derivatives using the Castagnoli-Cushman reaction as BACE1 inhibitors: Unexpected binding activity of cyclic thioamides.

A. Trabocchi, E. Lenci, Lorenzo Calugi, 2020, Bioorganic & medicinal chemistry letters.

Heterocyclic HIV-protease inhibitors.

A. Trabocchi, A. Guarna, C. Calugi, 2013, Current medicinal chemistry.

3D printing of multifunctional optofluidic systems for high-sensitive detection of pathological biomarkers in liquid biopsies

Riccardo Cicchi, Francesco S. Pavone, Caterina Credi, 2020, Photonics Europe.

Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.

C. Supuran, A. Angeli, F. Carta, 2021, European journal of medicinal chemistry.

Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors

A. Trabocchi, A. Guarna, C. Calugi, 2013, Journal of enzyme inhibition and medicinal chemistry.

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle

S. Heath, M. Gut, I. Gut, 2018, Scientific Reports.

D-proline-based peptidomimetic inhibitors of anthrax lethal factor.

A. Trabocchi, A. Guarna, C. Lalli, 2012, European journal of medicinal chemistry.

Multilayered nanoparticles as optical sensors for amyloid ß-peptide (1-42) targeting in liquid samples

B. Nacmias, S. Bagnoli, F. Pavone, 2023, BiOS.

Discovery of a d-Pro-Lys peptidomimetic inhibitor of MMP9: addressing the gelatinase selectivity beyond S1' subsite.

A. Contini, A. Trabocchi, E. Lenci, 2020, Bioorganic & medicinal chemistry letters.

Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles

L. Marinelli, F. S. Di Leva, M. Baiula, 2023, Journal of chemical information and modeling.

Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis

F. Bianchini, A. Trabocchi, E. Lenci, 2022, Molecules.

Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2.

M. Assfalg, M. D'Onofrio, V. Calderone, 2024, ACS medicinal chemistry letters.