Björn Over

Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.

Fabrizio Giordanetto, Jan Kihlberg, J. Kihlberg, 2014, Chemistry & biology.

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

Cell permeability beyond the rule of 5.

Bradley C Doak, Jan Kihlberg, Pär Matsson, 2016, Advanced drug delivery reviews.

Natural-product-derived fragments for fragment-based ligand discovery

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2012, Nature Chemistry.

Mining Natural Products for Macrocycles to Drug Difficult Targets

Vasanthanathan Poongavanam, J. Kihlberg, S. Geschwindner, 2020, Journal of medicinal chemistry.

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

Vasanthanathan Poongavanam, J. Kihlberg, G. Caron, 2018, Journal of medicinal chemistry.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

Fragment‐Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition

Gerhard Klebe, Katrin Silber, Hans-Dieter Gerber, 2010, ChemMedChem.

Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

H. Waldmann, K. Hübel, D. Rauh, 2011 .