K. Fandrick

发表

A General Copper—BINAP Catalyzed Asymmetric Propargylation of Ketones with Propargyl Boronates.

C. Senanayake, J. T. Reeves, K. Fandrick, 2011 .

Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ and Empirically Derived Systematic Error Correction Terms: A Computational Small Molecule Structure Elucidation Method.

C. Tautermann, C. Senanayake, K. Fandrick, 2017, The Journal of organic chemistry.

Systematic investigation of DFT-GIAO 15N NMR chemical shift prediction using B3LYP/cc-pVDZ: application to studies of regioisomers, tautomers, protonation states and N-oxides.

K. Fandrick, Dongyue Xin, C. Sader, 2017, Organic & biomolecular chemistry.

Enantioselective Friedel-Crafts alkylations of alpha,beta-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes.

Davidr . Evans, K. Fandrick, Hyun-Ji Song, 2005, Journal of the American Chemical Society.

Enantioselective Nitrone Cycloadditions of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine−Cerium(IV) Triflate Complexes

Davidr . Evans, K. Fandrick, Hyun-Ji Song, 2006 .

Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.

Jinhua J. Song, Bing-Shiou Yang, Jun Wang, 2016, Journal of the American Chemical Society.

Reengineered BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki–Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor

Jinhua J. Song, C. Senanayake, N. Yee, 2016 .

Rh-catalysed asymmetric conjugate addition of boronic acids to nitroalkenes employing a P-chiral P,π-hybrid ligand

C. Senanayake, N. Yee, K. Fandrick, 2016 .

Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts.

Jinhua J. Song, C. Senanayake, Xudong Wei, 2016, Organic letters.

Tunable P-Chiral Bisdihydrobenzooxaphosphole Ligands for Enantioselective Hydroformylation.

C. Senanayake, Xumu Zhang, K. Fandrick, 2016, Organic letters.

Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

C. Senanayake, N. Yee, K. Fandrick, 2014 .

Assessing atropisomer axial chirality in drug discovery and development.

O. Hucke, S. LaPlante, P. Edwards, 2011, Journal of medicinal chemistry.

Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues.

Xiaodong Zhang, J. Macdougall, J. Cashman, 2003, Chemical research in toxicology.

A Computational Investigation of the Ligand-Controlled Cu-Catalyzed Site-Selective Propargylation and Allenylation of Carbonyl Compounds

C. Senanayake, M. Kozlowski, K. Fandrick, 2017, Organic letters.

Copper catalyzed asymmetric propargylation of aldehydes.

Jinhua J. Song, C. Senanayake, N. Yee, 2010, Journal of the American Chemical Society.

Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.

Jinhua J. Song, C. Senanayake, P. Mahaney, 2015, The Journal of organic chemistry.

Zinc catalyzed and mediated propargylations with propargyl boronates.

Jinhua J. Song, C. Senanayake, N. Yee, 2010, Organic letters.

Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2013, The Journal of organic chemistry.

Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor

Jinhua J. Song, Jun Wang, C. Senanayake, 2017 .

Remarkable enhancement of enantioselectivity in the asymmetric conjugate addition of dimethylzinc to (Z)-nitroalkenes with a catalytic [(MeCN)₄Cu]PF₆-Hoveyda ligand complex.

Jinhua J. Song, C. Senanayake, J. Mulder, 2014, Angewandte Chemie.

Zinc-catalyzed allenylations of aldehydes and ketones.

Jinhua J. Song, C. Senanayake, K. Fandrick, 2011, Organic letters.

Quantitative Analysis of Pectin in Drug Product by Size Exclusion Chromatography with Indirect Photometric Detection

C. Senanayake, K. Fandrick, Shengli Ma, 2015 .

Development of an Efficient Asymmetric Synthesis of the Chiral Quaternary 5-Lipoxygenase Activating Protein Inhibitor

Jinhua J. Song, C. Senanayake, J. Mulder, 2016 .

Challenges and Opportunities for Scaling the Ring‐Closing Metathesis Reaction in the Pharmaceutical Industry

Jinhua J. Song, C. Senanayake, N. Yee, 2014 .

A Mild Palladium‐Catalyzed Suzuki Coupling Reaction of Quinoline Carboxylates with Boronic Acids

C. Senanayake, K. Fandrick, Joe J. Gao, 2011 .

Copper-Catalyzed Asymmetric Propargylation of Cyclic Aldimines.

C. Senanayake, K. Fandrick, Daniel R Fandrick, 2016, Organic letters.

Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2018, Organic letters.

Addition of Non-Stabilized Carbon-Based Nucleophilic Reagents to ChiralN-Sulfinyl Imines

C. Senanayake, K. Fandrick, J. Sieber, 2019, Organic Reactions.

Enantioselective Friedel-Crafts alkylations catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes.

K. Scheidt, Davidr . Evans, K. Fandrick, 2003, Journal of the American Chemical Society.

Catalytic Enantioselective Pyrrole Alkylations of α,β-Unsaturated 2-Acyl Imidazoles

K. Fandrick, David A. Evans and, 2006 .

Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis.

C. Senanayake, K. Fandrick, Christian A. Malapit, 2015, Journal of the American Chemical Society.

A mild dihydrobenzooxaphosphole oxazoline/iridium catalytic system for asymmetric hydrogenation of unfunctionalized dialins.

Jinhua J. Song, C. Senanayake, K. McKellop, 2014, Angewandte Chemie.

Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands

Dajun Chen, C. Senanayake, K. Fandrick, 2013 .

Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2018, ACS catalysis.

General and rapid pyrimidine condensation by addressing the rate limiting aromatization.

Jinhua J. Song, C. Senanayake, K. Fandrick, 2014, Organic letters.

On the design of complex drug candidate syntheses in the pharmaceutical industry

Michael A. Schmidt, Martin D. Eastgate, Keith R. Fandrick, 2017 .

Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters.

C. Senanayake, Xudong Wei, K. Fandrick, 2015, Organic letters.

Hydrophosphination of propargylic alcohols and amines with phosphine boranes.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

A general copper-BINAP-catalyzed asymmetric propargylation of ketones with propargyl boronates.

C. Senanayake, K. Fandrick, Daniel R Fandrick, 2011, Journal of the American Chemical Society.

Copper-catalyst-controlled site-selective allenylation of ketones and aldehydes with propargyl boronates.

C. Senanayake, K. Fandrick, Daniel R Fandrick, 2013, Organic letters.

Highly diastereoselective zinc-catalyzed propargylation of tert-butanesulfinyl imines.

Jinhua J. Song, C. Senanayake, N. Yee, 2010, Organic letters.

Carbamoyl anion addition to N-sulfinyl imines: highly diastereoselective synthesis of α-amino amides.

C. Senanayake, K. Fandrick, Shengli Ma, 2013, Journal of the American Chemical Society.

Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design.

Jinhua J. Song, C. Senanayake, N. Yee, 2015, Angewandte Chemie.

Development of new P-chiral P,π-dihydrobenzooxaphosphole hybrid ligands for asymmetric catalysis.

Jinhua J. Song, C. Senanayake, K. Fandrick, 2014, Organic letters.

[2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides.

Jinhua J. Song, C. Senanayake, K. Fandrick, 2017, Organic letters.

Inspiring process innovation via an improved green manufacturing metric: iGAL

John D. Hayler, Ulrich Scholz, Stefan G. Koenig, 2018 .

Asymmetric synthesis of diverse α,α-diarylmethylamines via aryl Grignard additions to chiral N-2,4,6-triisopropylbenzenesulfinylimines

C. Senanayake, K. Fandrick, Z. Han, 2011 .

Mild and general zinc-alkoxide-catalyzed allylations of ketones with allyl pinacol boronates.

Jinhua J. Song, C. Senanayake, N. Yee, 2010, Organic letters.

An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3'-F2-BINOL.

Jiang-Ping Wu, Jun Wang, C. Senanayake, 2016, The Journal of organic chemistry.

Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.

Y. Tsantrizos, Jiang-Ping Wu, C. Senanayake, 2015, Angewandte Chemie.

Addressing the configuration stability of lithiated secondary benzylic carbamates for the development of a noncryogenic stereospecific boronate rearrangement.

Jinhua J. Song, C. Senanayake, J. Mulder, 2014, Organic letters.

Mechanistic studies on the chiral recognition of polysaccharide-based chiral stationary phases using liquid chromatography and vibrational circular dichroism: reversal of elution order of N-substituted alpha-methyl phenylalanine esters.

C. Senanayake, N. Yee, K. Fandrick, 2009, Journal of chromatography. A.

Insights into chromatographic enantiomeric separation of allenes on cellulose carbamate stationary phase.

E. Franses, C. Senanayake, N. Yee, 2014, Journal of chromatography. A.

Directly probing the racemization of imidazolines by vibrational circular dichroism: kinetics and mechanism.

C. Senanayake, N. Yee, K. Fandrick, 2010, Organic letters.

Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid

Jinhua J. Song, C. Senanayake, J. Mulder, 2016 .

Effective BI‐DIME Ligand for Suzuki–Miyaura Cross‐Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X

C. Senanayake, N. Yee, K. Fandrick, 2017 .

2,6‐Bis[(4S,5R)‐4,5‐dihydro‐4,5‐diphenyl‐2‐oxazolyl]pyridine

Davidr . Evans, K. Fandrick, 2009 .

Assay at low ppm level of dimethyl sulfate in starting materials for API synthesis using derivatization in ionic liquid media and LC-MS.

Andrei Medvedovici, Florin Albu, Keith R. Fandrick, 2013, Journal of pharmaceutical and biomedical analysis.

Heart-Cutting Two-Dimensional Ultrahigh-Pressure Liquid Chromatography for Process Development: Asymmetric Reaction Monitoring

Jinhua J. Song, C. Senanayake, Shaun Mendonsa, 2013 .

Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: identification of inhibitors of the human dopamine transporter.

A. Janowsky, J. Cashman, K. Fandrick, 2003, Bioorganic & medicinal chemistry.

Enantioselective Nitrone Cycloadditions of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Bis(oxazolinyl)pyridine—Cerium(IV) Triflate Complexes.

K. Fandrick, Hyun-Ji Song, D. A. Evans, 2006 .

Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form

Timothy J. N. Watson, A. Wells, A. Goswami, 2016 .