N. Haddad

发表

Preparative Synthesis via Continuous Flow of 4,4,5,5-Tetramethyl-2-(3-trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane: A General Propargylation Reagent

Jinhua J. Song, C. Senanayake, J. T. Reeves, 2012 .

Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2013, The Journal of organic chemistry.

Olefin ring-closing metathesis as a powerful tool in drug discovery and development – potent macrocyclic inhibitors of the hepatitis C virus NS3 protease

M. Poirier, Y. Tsantrizos, Xudong Wei, 2006 .

Development of a Safe and Economical Synthesis of Methyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale

Jinhua J. Song, C. Senanayake, J. Mulder, 2013 .

Asymmetric Oxidation of a Dihydrothienopyrimidine

C. Senanayake, N. Grinberg, N. Haddad, 2017 .

Ambient temperature hydrophosphination of internal, unactivated alkynes and allenyl phosphineoxides with phosphine borane complexes.

C. Senanayake, Shengli Ma, Heewon Lee, 2009, Organic letters.

Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.

Jinhua J. Song, Bing-Shiou Yang, Jun Wang, 2016, Journal of the American Chemical Society.

Reengineered BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki–Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor

Jinhua J. Song, C. Senanayake, N. Yee, 2016 .

Rh-catalysed asymmetric conjugate addition of boronic acids to nitroalkenes employing a P-chiral P,π-hybrid ligand

C. Senanayake, N. Yee, K. Fandrick, 2016 .

Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts.

Jinhua J. Song, C. Senanayake, Xudong Wei, 2016, Organic letters.

Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

C. Senanayake, N. Yee, K. Fandrick, 2014 .

Palladium-catalyzed coupling of vinyl tosylates with arylsulfinate salts

C. Senanayake, Heewon Lee, N. Haddad, 2009 .

Simple N‐Heterocyclic Carbenes as Ligands in Ullmann‐Type Ether and Thioether Formations

Jiang-Ping Wu, C. Senanayake, Heewon Lee, 2016 .

Synthesis of P-Chiral Dihydrobenzooxaphospholes Through Negishi Cross-Coupling.

Jinhua J. Song, C. Senanayake, N. Yee, 2016, The Journal of organic chemistry.

Practical Synthesis of Di-tert-Butyl-Phosphinoferrocene

C. Senanayake, B. Qu, N. Haddad, 2014 .

Oxaphosphole-Based Monophosphorus Ligands for Palladium-Catalyzed Amination Reactions

C. Senanayake, Heewon Lee, B. Qu, 2011 .

A general and special catalyst for Suzuki-Miyaura coupling processes.

C. Senanayake, A. White, Xudong Wei, 2010, Angewandte Chemie.

Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene

Jinhua J. Song, C. Senanayake, Heewon Lee, 2021 .

Application of the palladium-catalyzed N-arylation of hydrazones to deactivated heteroaryl halides in the synthesis of pyrazoles

N. Haddad, Annette Salvagno, C. Busacca, 2004 .

Asymmetric methallylation of ketones catalyzed by a highly active organocatalyst 3,3'-F2-BINOL.

Jinhua J. Song, Jun Wang, C. Senanayake, 2013, Organic letters.

Sulfone Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and more - Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420.

B. Narayanan, C. Senanayake, Xudong Wei, 2020, The Journal of organic chemistry.

A highly convergent and efficient synthesis of a macrocyclic hepatitis C virus protease inhibitor BI 201302.

C. Senanayake, Xudong Wei, N. Yee, 2013, Organic letters.

Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution† †Electronic supplementary information (ESI) available. CCDC 1816601 and 1816602. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc00434j

Joyce C. Leung, Jinhua J. Song, C. Senanayake, 2018, Chemical science.

PAT Application in the Expedited Development of a Three-Step, One-Stage Synthesis of the Dipeptide Intermediate of HCV Protease Inhibitor Faldaprevir

C. Senanayake, Heewon Lee, B. Qu, 2015 .

Photochemistry of Compounds Containing CC Double Bonds

N. Haddad, 2009 .

Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2013, The Journal of organic chemistry.

Remarkable enhancement of enantioselectivity in the asymmetric conjugate addition of dimethylzinc to (Z)-nitroalkenes with a catalytic [(MeCN)₄Cu]PF₆-Hoveyda ligand complex.

Jinhua J. Song, C. Senanayake, J. Mulder, 2014, Angewandte Chemie.

Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions.

C. Senanayake, N. Yee, Heewon Lee, 2016, Angewandte Chemie.

Epimerization reaction of a substituted vinylcyclopropane catalyzed by ruthenium carbenes: mechanistic analysis.

C. Senanayake, Xudong Wei, N. Yee, 2006, The Journal of organic chemistry.

Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ

Jinhua J. Song, S. Venkatraman, C. Senanayake, 2022, Organic Process Research & Development.

Chromatographic and spectroscopic studies on the chiral recognition of sulfated beta-cyclodextrin as chiral mobile phase additive enantiomeric separation of a chiral amine.

C. Senanayake, N. Yee, Shengli Ma, 2009, Journal of chromatography. A.

The P-Chiral Phosphane Ligand (MeO-BIBOP) for Efficient and Practical Large-Scale Rh-Catalyzed Asymmetric Hydrogenation of N-Acetyl Enamides with High TONs

Jun Wang, C. Senanayake, N. Yee, 2013 .

Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.

C. Senanayake, Xudong Wei, N. Yee, 2010, Organic letters.

Experimental evidence for the “twisted” approach in intramolecular 2+2 photocycloadditions

N. Haddad, D. Becker, Natalya Morlender, 1995 .

Steric effects in intramolecular [2+2] photocycloaddition of CC double bonds to cyclohexenones.

N. Haddad, D. Becker, 1993 .

Diradical intermediates in intramolecular [2+2] photocycloaddition

N. Haddad, D. Becker, C. Denekamp, 1992 .

Mechanistic Studies on the [2 + 2] Photocycloaddition of Deuterium-Labeled Olefins

N. Haddad, D. Becker, 1989 .

Topological and Steric Effects in Mechanism of Intramolecular [2+2] Photocycloadditions

N. Haddad, D. Becker, Y. Sahali, 1989 .

STUDIES TOWARDS TOTAL SYNTHESIS OF BORRELIDIN, STEREOSELECTIVE SYNTHESIS OF THE POLYSUBSTITUTED MACROLIDIC PART

A. Brik, N. Haddad, M. Grishko, 1997 .

Studies towards total synthesis of borrelidin, regioselective methylation of bis-epoxides and structure determination

A. Brik, N. Haddad, M. Grishko, 1997 .

Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl3

C. Senanayake, Shengli Ma, Heewon Lee, 2012 .

Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor

Jinhua J. Song, Bing-Shiou Yang, Jun Wang, 2021, Organic Process Research & Development.

Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2018, Organic letters.

Recent Advances in Non-Precious Metal Catalysis

B. Qu, N. Haddad, F. Buono, 2022, Organic Process Research & Development.

Enantioselective Synthesis of Spiro Ethers and Spiro Ketals via Photoaddition of Dihydro-4-pyrones to Chiral 1,3-Dioxin-4-ones†

N. Haddad, and Igor Rukhman, Z. Abramovich, 1997 .

Convergent synthesis of the quinolone substructure of BILN 2061 via carbonylative Sonogashira coupling/cyclization.

N. Haddad, V. Farina, Jonathan Tan, 2006, The Journal of organic chemistry.

Palladium catalyzed alkoxy- and aminocarbonylation of vinyl tosylates.

C. Senanayake, Heewon Lee, N. Haddad, 2011, Organic letters.

Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene

C. Senanayake, Heewon Lee, N. Grinberg, 2009 .

A mild dihydrobenzooxaphosphole oxazoline/iridium catalytic system for asymmetric hydrogenation of unfunctionalized dialins.

Jinhua J. Song, C. Senanayake, K. McKellop, 2014, Angewandte Chemie.

Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes.

Jinhua J. Song, C. Senanayake, Xudong Wei, 2014, The Journal of organic chemistry.

Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands

Dajun Chen, C. Senanayake, K. Fandrick, 2013 .

Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation.

C. Senanayake, A. White, Xudong Wei, 2010, Organic letters.

A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc05612a

Joyce C. Leung, Jinhua J. Song, C. Senanayake, 2019, Chemical science.

Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2018, ACS catalysis.

Application of a Preformed Pd-BIDIME Precatalyst to Suzuki-Miyaura Cross-Coupling Reaction in Flow.

Jinhua J. Song, C. Senanayake, N. Yee, 2019, The Journal of organic chemistry.

Tandem Pd(II)-Catalyzed Vinyl Ether Exchange−Claisen Rearrangement as a Facile Approach to γ,δ-Unsaturated Aldehydes

C. Senanayake, Xudong Wei, N. Haddad, 2007 .

Hydrophosphination of propargylic alcohols and amines with phosphine boranes.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

Application of the Palladium-Catalyzed N-Arylation of Hydrazones to Deactivated Heteroaryl Halides in the Synthesis of Pyrazoles.

N. Haddad, Annette Salvagno, C. Busacca, 2004 .

Novel application of the palladium-catalyzed N-arylation of hydrazones to a versatile new synthesis of pyrazoles

N. Haddad, James A. Baron, 2002 .

Ligand-Accelerated Stereoretentive Suzuki-Miyaura Coupling of Unprotected 3,3'-Dibromo-BINOL.

C. Senanayake, N. Yee, Shengli Ma, 2016, The Journal of organic chemistry.

Reduction of tertiary phosphine oxides with DIBAL-H.

C. Senanayake, Heewon Lee, N. Grinberg, 2008, The Journal of organic chemistry.

A superior method for the reduction of secondary phosphine oxides.

Paul S. Sabila, C. Senanayake, Xudong Wei, 2005, Organic letters.

[2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

Asymmetric hydrogenation of unsaturated ureas with the BIPI ligands.

C. Senanayake, Heewon Lee, N. Grinberg, 2008, Organic letters.

Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2018, The Journal of organic chemistry.

Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts.

C. Senanayake, M. Kozlowski, Mac G. Schumer, 2020, Synlett : accounts and rapid communications in synthetic organic chemistry.

Recent Advances in Nonprecious Metal Catalysis

B. Qu, N. Haddad, F. Buono, 2021, Organic Process Research & Development.

Enantioselective Nickel-Catalyzed Mizoroki-Heck Cyclizations To Generate Quaternary Stereocenters.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2017, Organic letters.

Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor.

Jinhua J. Song, M. Ostermeier, J. Mack, 2014, Organic letters.

Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.

Y. Tsantrizos, Jiang-Ping Wu, C. Senanayake, 2015, Angewandte Chemie.

Development of the BIPI ligands for asymmetric hydrogenation

C. Senanayake, Sreedhar Cheekoori, Heewon Lee, 2012 .

The effect of chromophore transposition on the stereochemical outcome of the intramolecular dioxenone photocycloaddition reaction

J. Winkler, P. Williard, N. Haddad, 1989 .

About the stereochemistry of intramolecular [2+2] photocycloadditions

N. Haddad, D. Becker, 1986 .

Regiochemistry and stereochemistry of intramolecular [2+2] photocycloaddition of carbon-carbon double bonds to cyclohexenones

N. Haddad, D. Becker, Y. Sahali, 1991 .

An Approach to the Synthesis of the Manzamine Alkaloids Via the Vinylogous Amide PHotocycloAddition/Retro‐Mannich Fragmentation/Mannich Closure Cascade (pharM)

M. Siegel, J. Winkler, J. Axten, 1997 .

Rhodium‐Catalyzed Asymmetric Allenylation of Sulfonylimines and Application to the Stereospecific Allylic Allenylation

Jinhua J. Song, C. Senanayake, N. Yee, 2016 .

Enantioselective Synthesis of 4-Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene Derivatives.

C. Senanayake, M. Kozlowski, Xumu Zhang, 2019, The Journal of organic chemistry.

Catalytic asymmetric hydrogenation of heterocyclic ketone-derived hydrazones, pronounced solvent effect on the inversion of configuration

C. Senanayake, Shengli Ma, Heewon Lee, 2011 .

The order of first bond formation in the intramolecular photocycloaddition of 2-(4′-pentenyl)-cyclohex-2-enones

N. Haddad, N. Galili, 1997 .

The chemistry of Ru cyclopropylmethylidene complexes: Mechanistic studies and synthetic implications for the ring-closing metathesis reaction

C. Senanayake, Xudong Wei, N. Yee, 2009 .

Efficient large-scale synthesis of BILN 2061, a potent HCV protease inhibitor, by a convergent approach based on ring-closing metathesis.

Xudong Wei, Jinghua Xu, Fabrice Gallou, 2006, The Journal of organic chemistry.

Directly probing the racemization of imidazolines by vibrational circular dichroism: kinetics and mechanism.

C. Senanayake, N. Yee, K. Fandrick, 2010, Organic letters.

Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone

Joyce C. Leung, Hao Wu, Heewon Lee, 2022, Organic Process Research & Development.

STEREOSELECTIVE SYNTHESIS OF SPIROETHERS AND SPIROKETALS VIA PHOTOADDITIONOF DIHYDRO-4-PYRONES TO 1,3-DIOXIN-4-ONES

N. Haddad, I. Ruhman, Z. Abramovich, 1996 .

TOTAL SYNTHESIS OF (+)-LIGUDENTATOL VIA PHOTOADDITION-FRAGMENTATION-AROMATIC ANNULATION SEQUENCE

N. Haddad, Husein Salman, 1997 .

Synthesis of substituted phenols Via photoaddition-fragmentation-aromatic annelation sequence☆

N. Haddad, Irina Kuzmenkov, 1996 .

Total Synthesis of (+)-Ligudentatol via Photoaddition-Fragmentation- Aromatic Annulation Sequence.

N. Haddad, Husein Salman, 1997 .

Studies on the intramolecular [2+2] photocycloaddition of dihydro-4-pyrones

N. Haddad, Irina Kusmenkov, 1993 .

Synthesis of Substituted Phenols via Photoaddition-Fragmentation- Aromatic Annelation Sequence.

N. Haddad, Irina Kuzmenkov, 1996 .

Highly efficient trapping of short-lived 1,4-diradicals, the order of first bond formation in the intramolecular photocycloaddition of 3-(4′-pentenyl)-cyclohex-2-enones

N. Haddad, D. Becker, N. Galili, 1996 .

Trapping of 1,4-diradical intermediate in intramolecular[2+2] photocycloaddition

N. Haddad, D. Becker, Y. Sahali, 1989 .

Stereoselective Synthesis of Spiroethers and Spiroketals via Photoaddition of Dihydro-4-pyrones to 1,3-Dioxin-4-ones.

N. Haddad, I. Ruhman, Z. Abramovich, 1996 .

Intramolecular Photoaddition of Alkenes to Chiral 1,3-Dioxin-4-ones: Evidence for Effect of Pyramidalization on the Facial Selectivity

N. Haddad, Z. Abramovich, 1995 .

Practical Large‐Scale Synthesis of the Hepatitis C Virus Protease Inhibitor BI 201335

C. Senanayake, Xudong Wei, J. Smoliga, 2012 .

Does the Threshold Enantiomerization Route of Crowded Tetraarylethenes Involve Double Bond Rotation

Katsuhiro Maeda, Z. Rappoport, N. Haddad, 1995 .

Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling

Jinhua J. Song, C. Senanayake, B. Qu, 2022, Organic Process Research & Development.

Start selective and rigidify: The discovery path towards a next generation of EGFR tyrosine kinase inhibitors.

Julian E. Fuchs, P. Ettmayer, A. Baum, 2019, Journal of medicinal chemistry.

Inside-outside stereoisomerism. 4. An unusual rearrangement of the trans-bicyclo[5.3.1]undecan-11-yl radical

J. Winkler, N. Haddad, V. Sridar, 1989 .

Effective BI‐DIME Ligand for Suzuki–Miyaura Cross‐Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X

C. Senanayake, N. Yee, K. Fandrick, 2017 .

Nickel-catalyzed C-3 direct arylation of pyridinium ions for the synthesis of 1-azafluorenes

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2016, Chemical science.

Bromo-directed N-2 alkylation of NH-1,2,3-triazoles: efficient synthesis of poly-substituted 1,2,3-triazoles.

C. Senanayake, N. Haddad, Xiaojun Wang, 2009, Organic letters.

Highly regioselective N-2 arylation of 4,5-dibromo-1,2,3-triazole: efficient synthesis of 2-aryltriazoles.

C. Senanayake, Heewon Lee, N. Haddad, 2009, Organic letters.

Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides.

C. Senanayake, N. Yee, B. Qu, 2020, The Journal of organic chemistry.

Large-scale asymmetric synthesis of a cathepsin S inhibitor.

C. Senanayake, Xudong Wei, Heewon Lee, 2010, The Journal of organic chemistry.

Modular Dihydrobenzoazaphosphole Ligands for Suzuki–Miyaura Cross-Coupling

Jinhua J. Song, C. Senanayake, N. Yee, 2018, Synthesis.

BABIPhos Family of Biaryl Dihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation.

Jinhua J. Song, C. Senanayake, N. Yee, 2018, Organic letters.

Oxaphosphole‐Based Monophosphorus Ligands for Palladium‐Catalyzed Amination Reactions.

C. Senanayake, Heewon Lee, B. Qu, 2011 .

Heart-Cutting Two-Dimensional Ultrahigh-Pressure Liquid Chromatography for Process Development: Asymmetric Reaction Monitoring

Jinhua J. Song, C. Senanayake, Shaun Mendonsa, 2013 .

Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution

Joyce C. Leung, Jinhua J. Song, C. Senanayake, 2018, Chemical science.