J. Engel

发表

A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite

Matthew Bogyo, Zbynek Bozdech, J. Derisi, 2002, Science.

Host metabolism regulates intracellular growth of Trypanosoma cruzi.

Chih-Hao Lee, J. Engel, Kacey L Caradonna, 2013, Cell host & microbe.

A Primitive Enzyme for a Primitive Cell: The Protease Required for Excystation of Giardia

N. Rawlings, J. McKerrow, J. Engel, 1997, Cell.

Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene.

F. Gillin, A. Eakin, S. Reed, 1993, The Journal of clinical investigation.

Aryl ureas represent a new class of anti-trypanosomal agents.

F E Cohen, F. Cohen, J. McKerrow, 2000, Chemistry & biology.

Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi.

A. Mills, J. McKerrow, J. Engel, 1993, Molecular and biochemical parasitology.

Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection

J. McKerrow, J. Engel, P. Doyle, 1998, Journal of Experimental Medicine.

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

M. Arkin, K. Ang, J. McKerrow, 2011, PLoS neglected tropical diseases.

Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotes.

J. Cazzulo, J. Cannata, A. Stoppani, 1987, Molecular and biochemical parasitology.

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.

S. Castanys, F. Gamarro, B. Dallagiovanna, 1998, Gene.

Cysteine protease inhibitors as chemotherapy for parasitic infections.

J. McKerrow, C. Caffrey, J. Engel, 1999, Bioorganic & medicinal chemistry.

Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase

M. Correia, Poulomi Acharya, J. Engel, 2009, Molecular Pharmacology.

Trypanosoma cruzi: structure and transcription of kinetoplast DNA maxicircles of cloned stocks.

A. Frasch, D. Sánchez, A. Stoppani, 1986, The Journal of protozoology.

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.

K. Ang, J. McKerrow, L. Brinen, 2010, Journal of medicinal chemistry.

Drugs targeting parasite lysosomes.

Z. Mackey, J. Engel, S. Reed, 2008, Current pharmaceutical design.

Rapid identification of Trypanosoma cruzi isolates by ‘dot‐spot’ hybridization

A. Frasch, D. Sánchez, J. Engel, 1984, FEBS letters.

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.

Jeremy R. Duvall, S. Schreiber, Ana Rodriguez, 2014, ACS medicinal chemistry letters.

Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against Trypanosoma cruzi

Ana Rodriguez, J. Gut, B. Muñoz, 2013 .

Characterization of the mechanism of protein glycosylation and the structure of glycoconjugates in tissue culture trypomastigotes and intracellular amastigotes of Trypanosoma cruzi.

A. Parodi, L. de la Canal, J. Engel, 1986, Molecular and biochemical parasitology.

Trypanosoma cruzi cells undergo an alteration in protein N-glycosylation upon differentiation.

A. Parodi, J. Engel, 1985, The Journal of biological chemistry.

Glycoprotein assembly in Leishmaniamexicana

A. Parodi, J. Engel, J. Martin-Barrientos, 1984 .

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

J. McKerrow, W. Roush, J. Engel, 2001, Bioorganic & medicinal chemistry letters.

A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection

J. McKerrow, J. Engel, P. Doyle, 2007, Antimicrobial Agents and Chemotherapy.

A Cysteine Protease Inhibitor Cures Chagas’ Disease in an Immunodeﬁcient-Mouse Model of Infection (cid:1)

J. McKerrow, J. Engel, P. Doyle, 2007 .

Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes.

J. Dvorak, S. Beckmann, C. Grevelding, 2010, Molecular and biochemical parasitology.

Title Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

J. McKerrow, J. Engel, P. Doyle, 1998 .

Trypanosoma cruzi: quantification and analysis of the infectivity of cloned stocks.

J. Dvorak, J. Engel, P. Doyle, 1984, The Journal of protozoology.

Trypanosoma cruzi: of man, kissing-bugs, and frogs.

J. Engel, P. Doyle, I. Hsieh, 2000, Experimental parasitology.

End products and enzyme levels of aerobic glucose fermentation in trypanosomatids.

J. Cazzulo, J. Cannata, J. Engel, 1985, Molecular and biochemical parasitology.

Trypanosoma cruzi and Trypanosoma rangeli: Glutamate dehydrogenases and proteolytic activities

E. Segura, J. Cazzulo, A. Ruiz, 1981 .

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

J. McKerrow, W. Roush, J. Engel, 2001, Bioorganic & medicinal chemistry letters.

The crystal structure of cruzain: a therapeutic target for Chagas' disease.

R J Fletterick, R. Fletterick, C. Craik, 1995, Journal of molecular biology.

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Michelle R. Arkin, Joseph Mulvaney, Jiri Gut, 2012, PLoS neglected tropical diseases.

Cathepsin Cs Are Key for the Intracellular Survival of the Protozoan Parasite, Toxoplasma gondii*

S. Reed, J. Engel, S. Tomavo, 2007, Journal of Biological Chemistry.

Leishmania mexicana mexicana: quantitative analysis of the intracellular cycle

J. Dvorak, J. Engel, A. Gam, 1989, Parasitology.

A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Matthew P. Jacobson, M. Jacobson, Chiung-Kuang J. Chen, 2010, Antimicrobial Agents and Chemotherapy.

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

Michelle R. Arkin, Steven Chen, M. Arkin, 2010, Antimicrobial Agents and Chemotherapy.

The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.

M. Sajid, L. Brinen, J. H. Lee, 2009, Molecular and biochemical parasitology.

The Cathepsin B of Toxoplasma gondii,Toxopain-1, Is Critical for Parasite Invasion and Rhoptry Protein Processing*

K. Joiner, L. Brinen, M. Gray, 2002, The Journal of Biological Chemistry.

Two approaches to discovering and developing new drugs for Chagas disease.

I D Kerr, C. Craik, R. S. Ferreira, 2009, Memorias do Instituto Oswaldo Cruz.

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

M. Bogyo, P. Selzer, J. McKerrow, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Protease Trafficking in Two Primitive Eukaryotes Is Mediated by a Prodomain Protein Motif*

J. Mottram, J. McKerrow, L. Brinen, 1999, The Journal of Biological Chemistry.

Temporal Analysis of the Honey Bee Microbiome Reveals Four Novel Viruses and Seasonal Prevalence of Known Viruses, Nosema, and Crithidia

J. Derisi, R. Andino, J. Ruby, 2011, PloS one.

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.

David S Hartsough, D. Hartsough, C. Craik, 2005, Bioorganic & medicinal chemistry.

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

M. Correia, Poulomi Acharya, M. Liao, 2010, The Journal of Biological Chemistry.

Secretory and Endocytic Pathways Converge in a Dynamic Endosomal System in a Primitive Protozoan

E. Ghedin, A. Debrabant, J. Engel, 2001, Traffic.

Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

J. Palmer, J. McKerrow, D. Bainton, 1998, Journal of cell science.

A Contiguous Compartment Functions as Endoplasmic Reticulum and Endosome/Lysosome in Giardia lamblia

R. Fetter, A. Hehl, M. Sajid, 2009, Eukaryotic Cell.

Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain

Paul M. Selzer, William R. Roush, P. Selzer, 2000 .

Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

M. Correia, Poulomi Acharya, J. Engel, 2010, The Journal of Biological Chemistry.

Contribution to New Therapies for Chagas Disease

J. Engel, P. Doyle, 2013 .

Leishmania donovani: long-term culture of axenic amastigotes at 37 degrees C.

J. Engel, P. Pimenta, D. Dwyer, 1991, Experimental parasitology.

Trypanosoma cruzi: biological characterization of clones derived from chronic chagasic patients. II. Quantitative analysis of the intracellular cycle.

J. Dvorak, J. Engel, P. Doyle, 1985, The Journal of protozoology.

Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.

J. McKerrow, J. Engel, J C Engel, 2000, Journal of cell science.

KetoneCruzain Inhibitors as PromisingNewLeads for Chagas Disease Chemotherapy

K. Ang, J. McKerrow, L. Brinen, 2010 .

Trypanosoma cruzi: biological characterization of 19 clones derived from two chronic chagasic patients. I. Growth kinetics in liquid medium.

E. Segura, J. Dvorak, J. Engel, 1982, The Journal of protozoology.

The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion

J. McKerrow, D. Greenbaum, J. Engel, 2011, PLoS pathogens.

Trypanosoma cruzi: cell biological behavior of epimastigote and amastigote forms in axenic culture.

J. Dvorak, J. Engel, 1988, The Journal of protozoology.

Trypanosoma cruzi: flow cytometric analysis. I. Analysis of total DNA/organism by means of mithramycin-induced fluorescence.

J. Dvorak, J. Engel, M. S. Crane, 1982, The Journal of protozoology.

Isolate-dependent differences in the oxidative metabolism of Trypanosoma cruzi epimastigotes.

J. Dvorak, J. Engel, P. Doyle, 1990, Molecular and biochemical parasitology.

Trypanosoma cruzi: elemental composition heterogeneity of cloned stocks.

R. Leapman, J. Dvorak, J. Engel, 1988, Molecular and biochemical parasitology.

Strains and clones of Trypanosoma cruzi differ in their expression of a surface antigen identified by a monoclonal antibody.

A. Sher, J. Dvorak, J. Engel, 1984, Molecular and biochemical parasitology.

Leishmania donovani: long-term culture of axenic amastigotes at 37 degrees C.

J. Engel, P. Pimenta, D. Dwyer, 1991, Experimental parasitology.

Cellular and molecular biological analyses of nifurtimox resistance in Trypanosoma cruzi.

T. Nozaki, J. Dvorak, J. Engel, 1996, The American journal of tropical medicine and hygiene.

[Variation in the infective capacity of cultured forms of Trypanosoma cruzi].

E. Subías, E. Segura, J. Engel, 1980, Medicina.

The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design.

M. Mcgrath, J. McKerrow, J. Engel, 1995, Parasitology today.

Giardia lamblia cysteine proteases

M. Sajid, J. McKerrow, M. Abodeely, 2006, Parasitology Research.

Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.

P. Focia, S. Craig, A. Eakin, 2000, Chemistry & biology.

Analysis of 6-(2,2-Dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.

S. Craig, J. Engel, F. Medrano, 2003, Journal of medicinal chemistry.

LdARF1 in Trafficking and Structural Maintenance of the trans‐Golgi Cisternal Network in the Protozoan Pathogen Leishmania donovani

E. Ghedin, J. Engel, D. Dwyer, 2004, Traffic.

Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids.

S. Nadler, J. Engel, V. Chan, 1997, Experimental parasitology.

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

Michelle R. Arkin, Anjan Debnath, Philip J. Rosenthal, 2011, PLoS neglected tropical diseases.

Polymorphisms within minicircle sequence classes in the kinetoplast DNA of Trypanosoma cruzi clones.

A. Frasch, D. Sánchez, R. Macina, 1985, Molecular and biochemical parasitology.

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

M. Arkin, K. Ang, J. McKerrow, 2010, Antimicrobial Agents and Chemotherapy.

Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection

J. McKerrow, J. Engel, P. Doyle, 1998, The Journal of experimental medicine.

M. Correia, Poulomi Acharya, J. Engel, 2009, Molecular Pharmacology.