S. Saario

发表

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes.

A. Poso, J. Laitinen, T. Nevalainen, 2005, Chemistry & biology.

3‐Heterocycle‐Phenyl N‐Alkylcarbamates as FAAH Inhibitors: Design, Synthesis and 3D‐QSAR Studies

A. Poso, T. Nevalainen, S. Saario, 2010, ChemMedChem.

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

J. Laitinen, T. Järvinen, S. Saario, 2004, Biochemical pharmacology.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

J. Leppänen, A. Poso, T. Laitinen, 2013, Journal of medicinal chemistry.

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

J. Leppänen, A. Poso, T. Nevalainen, 2008, Journal of medicinal chemistry.

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.

T. Nevalainen, T. Järvinen, R. Juvonen, 2007, Journal of medicinal chemistry.

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide.

J. Laitinen, T. Nevalainen, T. Järvinen, 2006, Bioorganic & medicinal chemistry.

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

J. Laitinen, T. Järvinen, S. Saario, 2003, British journal of pharmacology.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

J. Laitinen, S. Saario, J. Savinainen, 2012, Acta physiologica.

Screening of Various Hormone‐Sensitive Lipase Inhibitors as Endocannabinoid‐Hydrolyzing Enzyme Inhibitors

Henri Xhaard, Antti Poso, Jukka Leppänen, 2009, ChemMedChem.

Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.

A. Poso, M. Lahtela-Kakkonen, S. Saario, 2009, European journal of medicinal chemistry.

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.

J. Laitinen, S. Saario, 2007, Basic & clinical pharmacology & toxicology.

Monoglyceride Lipase as an Enzyme Hydrolyzing 2‐Arachidonoylglycerol

J. Laitinen, S. Saario, 2007, Chemistry & biodiversity.

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

Erik A. A. Wallén, J. Gynther, M. Forsberg, 2002, Bioorganic & medicinal chemistry.

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors.

T. Nevalainen, S. Saario, Tapio Nevalainen, 2010, Current topics in medicinal chemistry.

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.

J. Leppänen, T. Nevalainen, C. Fowler, 2009, European journal of medicinal chemistry.

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling.

A. Poso, M. Lahtela-Kakkonen, T. Nevalainen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.

J. Laitinen, T. Nevalainen, S. Saario, 2006, Bioorganic & medicinal chemistry letters.

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.

Antti Poso, Tomi Järvinen, A. Poso, 2006, Journal of medicinal chemistry.

α‐Methylated Derivatives of 2‐Arachidonoyl Glycerol: Synthesis, CB1 Receptor Activity, and Enzymatic Stability.

J. Laitinen, T. Nevalainen, S. Saario, 2006 .

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

B. Cravatt, A. Speers, S. Saario, 2012, Chemical science.

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain.

J. Laitinen, T. Nevalainen, M. Lehtonen, 2006, Chemistry & biology.