R. Niemi

发表

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes.

A. Poso, J. Laitinen, T. Nevalainen, 2005, Chemistry & biology.

Synthesis, in vitro evaluation, and intraocular pressure effects of water-soluble prodrugs of endocannabinoid noladin ether.

T. Järvinen, J. Vepsäläinen, R. Niemi, 2003, Journal of medicinal chemistry.

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

J. Laitinen, T. Järvinen, S. Saario, 2004, Biochemical pharmacology.

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide.

J. Laitinen, T. Nevalainen, T. Järvinen, 2006, Bioorganic & medicinal chemistry.

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

J. Laitinen, T. Järvinen, S. Saario, 2003, British journal of pharmacology.

Controlled release of saccharides from matrix tablets.

J. Ketolainen, O. Korhonen, M. Lehtonen, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Prodrug approaches to ophthalmic drug delivery

T. Järvinen, R. Niemi, T. Järvinen, 2007 .

Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition.

P. Bummer, B. D. Anderson, R. Niemi, 2003, Journal of pharmaceutical sciences.

Bisphosphonate prodrugs: unusual dimerisation of clodronic acid trimethyl ester to a cyclic bis(bisphosphonate)

J. Vepsäläinen, R. Niemi, M. Ahlgrén, 2000 .

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid.

J. Vepsäläinen, R. Niemi, T. Järvinen, 1999, Journal of medicinal chemistry.

Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells.

J. Mönkkönen, J. Vepsäläinen, R. Niemi, 2001, International journal of pharmaceutics.

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate.

J. Vepsäläinen, R. Niemi, H. Taipale, 1999, Journal of medicinal chemistry.

In‐vitro corneal permeation of cannabinoids and their water‐soluble phosphate ester prodrugs

R. Niemi, J. Juntunen, T. Järvinen, 2005, The Journal of pharmacy and pharmacology.

Anandamide prodrugs. 1. Water-soluble phosphate esters of arachidonylethanolamide and R-methanandamide.

T. Nevalainen, J. Huuskonen, R. Niemi, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

First synthesis of etidronate partial amides starting from PCl3.

M. Peräkylä, J. Vepsäläinen, R. Niemi, 2003, Organic & biomolecular chemistry.

Bisphosphonate prodrugs: synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate.

J. Vepsäläinen, R. Niemi, P. Turhanen, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel partial amides of clodronic acid

J. Vepsäläinen, R. Niemi, H. Taipale, 1998 .

Simultaneous determination of clodronate and its partial ester derivatives by ion-pair reversed-phase high-performance liquid chromatography coupled with evaporative light-scattering detection.

J. Vepsäläinen, R. Niemi, H. Taipale, 1997, Journal of chromatography. B, Biomedical sciences and applications.

The Eurasian Union – much potential, little results

Riku Niemi, R. Niemi, 2016 .

Synthesis, hydrolysis, and intraocular pressure lowering effects of fadolmidine prodrugs.

J. Huuskonen, R. Niemi, K. Laine, 2005, International journal of pharmaceutics.

Fadolmidine‐induced ocular hypotension in normotensive rabbits

J. Huuskonen, J. Savolainen, R. Niemi, 2005, The Journal of pharmacy and pharmacology.

Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects.

J. Mönkkönen, S. Auriola, J. Vepsäläinen, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.