T. Nomanbhoy

发表

Functional interrogation of the kinome using nucleotide acyl phosphates.

Helge Weissig, Stephen Tanner, H. Weissig, 2007, Biochemistry.

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.

Marya Liimatta, L. Fitzgerald, B. Cravatt, 2007, Biochemistry.

Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis.

P. Schimmel, T. Nomanbhoy, P Schimmel, 1999, Molecular cell.

ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.

J. Kozarich, J. Rosenblum, T. Nomanbhoy, 2015, Biochemistry.

ERK5 kinase activity is dispensable for cellular immune response and proliferation

Y. Hu, H. Weissig, J. Kozarich, 2016, Proceedings of the National Academy of Sciences.

Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe.

J. Kozarich, J. Rosenblum, M. Patricelli, 2014, Journal of the American Chemical Society.

Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors.

Y. Hu, J. Kozarich, J. Rosenblum, 2005, Bioorganic & medicinal chemistry letters.

Active site of an aminoacyl-tRNA synthetase dissected by energy-transfer-dependent fluorescence.

P. Schimmel, T. Nomanbhoy, 2001, Bioorganic & medicinal chemistry letters.

Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs

V. Serra, M. Palafox, E. Okerberg, 2019, Molecular Cancer Therapeutics.

Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer.

J. Erickson, R. Cerione, T. Nomanbhoy, 1999, Biochemistry.

Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

J. Kozarich, J. Rosenblum, M. Patricelli, 2017, PloS one.

Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

J. Kozarich, J. Rosenblum, M. Patricelli, 2016, PloS one.

Profiling Native Kinases by Immuno‐Assisted Activity‐Based Profiling

E. Okerberg, T. Nomanbhoy, A. Aban, 2013, Current protocols in chemical biology.

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).

B. Cravatt, J. Dunbar, Yun-Song Song, 2009, Bioorganic & medicinal chemistry letters.

Fluorescence assays of Cdc42 interactions with target/effector proteins.

R. Cerione, T. Nomanbhoy, 1999, Biochemistry.

Reinvestigating the role of ERK5: kinase activity is not required for cellular immune response or proliferation

Y. Hu, H. Weissig, J. Kozarich, 2016, bioRxiv.

Use of fluorescence spectroscopy to study the regulation of small G proteins.

R. Cerione, T. Nomanbhoy, 1998, Methods in molecular biology.

Abstract 225: Chemoproteomic evaluation of target engagement in clinical samples

T. Nomanbhoy, 2017 .

Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2

N. Gray, Qingsong Liu, Xianming Deng, 2011, Nature chemical biology.

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.

J. Kozarich, J. Rosenblum, Qiang Li, 2011, Bioorganic & medicinal chemistry letters.

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein*

Robert Kay, R. Cerione, T. Nomanbhoy, 1996, The Journal of Biological Chemistry.

Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain

Shobha N. Bhattachar, D. Nomura, B. Cravatt, 2011 .

Synthesis of AX7593, a quinazoline-derived photoaffinity probe for EGFR.

P. S. Leventhal, T. Nomanbhoy, K. Shreder, 2004, Organic letters.

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

Benjamin F. Cravatt, Paul Wren, Shobha N. Bhattachar, 2011, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

R. Young, J. Bradner, N. Gray, 2017, Nature chemical biology.

Pharmacological perturbation of CDK 9 using selective CDK 9 inhibition or degradation

Green, R. Young, J. Bradner, 2018 .

PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells

M. DePamphilis, A. Chakraborty, T. Nomanbhoy, 2023, Autophagy.

Discovery of potent and selective covalent inhibitors of JNK.

Taebo Sim, Mario Niepel, Scott B Ficarro, 2012, Chemistry & biology.

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Shobha N. Bhattachar, B. Cravatt, D. T. Dudley, 2011, ACS medicinal chemistry letters.

In situ kinase profiling reveals functionally relevant properties of native kinases.

N. Gray, H. Weissig, Jiing-Dwan Lee, 2011, Chemistry & biology.

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

M. Rosen, R. Cerione, D. Manor, 1997, Nature.

Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence.

R. Cerione, D. Manor, T. Nomanbhoy, 1996, Biochemistry.

Functional interrogation of kinases and other nucleotide‐binding proteins

J. Kozarich, J. Rosenblum, T. Nomanbhoy, 2013, FEBS letters.

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.

J. Kozarich, J. Rosenblum, G. Sharma, 2016, Biochemistry.

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

P. Cohen, N. Gray, K. Westover, 2014, Journal of medicinal chemistry.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

D. Rice, N. Richards, S. Sedelnikova, 2019, Communications biology.

Molecular basis of human asparagine synthetase inhibitor specificity

D. Rice, N. Richards, S. Sedelnikova, 2018 .

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.

R. Tibshirani, I. Lossos, Y. Natkunam, 2016, Blood.

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.

Y. Hu, H. Weissig, J. Kozarich, 2013, Bioorganic & medicinal chemistry letters.

Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes.

J. Rosenblum, J. Burbaum, T. Nomanbhoy, 2003, Assay and drug development technologies.

Characterization of the Interaction between RhoGDI and Cdc42Hs Using Fluorescence Spectroscopy (*)

Richard A. Cerione, R. Cerione, T. Nomanbhoy, 1996, The Journal of Biological Chemistry.

Mutational separation of two pathways for editing by a class I tRNA synthetase.

Paul Schimmel, Shigeyuki Yokoyama, Osamu Nureki, 2002, Molecular cell.

Simultaneous binding of two proteins to opposite sides of a single transfer RNA

P. Schimmel, R. Giegé, T. Nomanbhoy, 2001, Nature Structural Biology.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

D. Rice, N. Richards, S. Sedelnikova, 2019, Communications Biology.

IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

L. Cascione, S. Napoli, F. Bertoni, 2023, Cancer research communications.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity

D. Rice, N. Richards, S. Sedelnikova, 2019, Communications Biology.

Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase

P. Schimmel, A. Bishop, T. Nomanbhoy, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Errors from selective disruption of the editing center in a tRNA synthetase.

P. Schimmel, T. Nomanbhoy, T. Hendrickson, 2000, Biochemistry.

Functional interrogation of kinases and other nucleotide‐binding proteins

J. Kozarich, J. Rosenblum, T. Nomanbhoy, 2013, FEBS letters.

Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase.

P. Schimmel, T. Nomanbhoy, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

J. Hardy, S. Savinov, J. Kozarich, 2019, Biochemistry.