Douglas S. Johnson

发表

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.

Marya Liimatta, L. Fitzgerald, B. Cravatt, 2007, Biochemistry.

J. Li, Douglas S. Johnson, 2007 .

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

K. Bales, Douglas S. Johnson, Yue-Ming Li, 2011, ACS chemical neuroscience.

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

Benjamin F. Cravatt, Paul Wren, Shobha N. Bhattachar, 2011, Journal of Pharmacology and Experimental Therapeutics.

Modern Drug Synthesis

J. Li, Douglas S. Johnson, Jie Jack Li, 1994 .

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

Timothy L. Foley, K. Fennell, J. Pandit, 2017, Journal of medicinal chemistry.

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

L. Chen, B. Cravatt, K. Zasadny, 2012, Nuclear medicine and biology.

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474.

B. Cravatt, A. Cognetta, J. Litchfield, 2019, ACS chemical biology.

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.

Xianzhong Wu, Heather E. Murrey, Christopher W. am Ende, 2016, ACS chemical neuroscience.

CC-1065 AND THE DUOCARMYCINS : UNDERSTANDING THEIR BIOLOGICAL FUNCTION THROUGH MECHANISTIC STUDIES

D. Boger, Douglas S. Johnson, 1996 .

Duocarmycin SA Shortened, Simplified, and Extended Agents: A Systematic Examination of the Role of the DNA Binding Subunit

D. Boger, Douglas S. Johnson, H. Cai, 1997 .

(+)- and ent-(-)-Duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA Alkylation Properties.Alkylation Site Models That Accommodate the Offset AT-Rich Adenine N3 Alkylation Selectivity of the Enantiomeric Agents

D. Boger, Douglas S. Johnson, W. Yun, 1994 .

SECOND DEFINITIVE TEST OF PROPOSED MODELS FOR THE ORIGIN OF THE CC-1065 AND DUOCARMYCIN DNA ALKYLATION SELECTIVITY

D. Boger, Douglas S. Johnson, 1995 .

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.

R. Everley, J. Telliez, Liang Xue, 2019, ACS chemical biology.

Bond with Me If You Can! Natural Product, Covalent Ligand, and Reactivity-Based Probe Compete for Cysteine in PP2A Complex.

Douglas S. Johnson, Jaimeen D Majmudar, Jaimeen D. Majmudar, 2017, Cell chemical biology.

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).

B. Cravatt, J. Dunbar, Yun-Song Song, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines

A. D. White, Douglas S. Johnson, M. Stier, 2007 .

Studies on the Stability and Stabilization of trans-Cyclooctenes through Radical Inhibition and Silver (I) Metal Complexation.

J. Judkins, Christopher W. am Ende, J. Fox, 2019, Tetrahedron.

Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes

O. Dmitrenko, Christopher W. am Ende, J. Fox, 2018, Chemical science.

O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.

B. Cravatt, M. Niphakis, Douglas S. Johnson, 2012, ACS chemical neuroscience.

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.

A. Narayanan, A. Gopalsamy, E. Hett, 2015, Molecular bioSystems.

Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology.

David J. Lapinsky, Douglas S. Johnson, D. J. Lapinsky, 2015, Future medicinal chemistry.

pH Dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI

D. Boger, Douglas S. Johnson, C. Boyce, 1997 .

Induction of endonucleolytic DNA fragmentation and apoptosis by the duocarmycins

D. Boger, Douglas S. Johnson, W. Wrasidlo, 1994 .

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Gregory W. Kauffman, David S. Ramirez, L. Pustilnik, 2017, MedChemComm.

Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

Gregory W. Kauffman, L. Pustilnik, A. Stepan, 2015, ACS medicinal chemistry letters.

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Timothy L. Foley, J. Pandit, J. Cianfrogna, 2018, Journal of medicinal chemistry.

Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain

Shobha N. Bhattachar, D. Nomura, B. Cravatt, 2011 .

Modern Drug Synthesis: Li/Modern

J. Li, Douglas S. Johnson, 2010 .

Target of γ‐secretase modulators, presenilin marks the spot

Douglas S. Johnson, Yue-Ming Li, Christina J. Crump, 2011, The EMBO journal.

Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012

Gregory W. Kauffman, A. Stepan, Martin Pettersson, 2013, Expert opinion on therapeutic patents.

Alkyne insertion reactions of metal-carbenes derived from enynyl-.alpha.-diazoketones [R'CN2COCR2CH2C.tplbond.C(CH2)n-2CH:CH2]

T. Hoye, Douglas S. Johnson, C. Dinsmore, 1990 .

Synthesis of fluorinated 1,8-naphthyridinone derivatives

A. D. White, Tingsheng Li, Douglas S. Johnson, 2007 .

Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit

D. Boger, Douglas S. Johnson, B. Bollinger, 1996 .

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.

Gregory W. Kauffman, L. Pustilnik, A. Stepan, 2015, Bioorganic & medicinal chemistry letters.

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

Raymond C Stevens, Marya Liimatta, R. Stevens, 2009, Chemistry & biology.

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

Raymond C Stevens, Marya Liimatta, R. Stevens, 2008, Proceedings of the National Academy of Sciences.

J. Lown,, L. McLaughlin, A. Begleiter, 1975 .

Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I

Douglas S. Johnson, Yiqing Zhou, P. Galatsis, 2014 .

Duocarmycin SA Shortened, Simplified, and Extended Agents: A Systematic Examination of the Role of the DNA Binding Subunit.

D. Boger, Douglas S. Johnson, Donald L. Hertzog, 1997 .

Reversed and Sandwiched Analogs of Duocarmycin SA: Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into the Source of Catalysis

D. Boger, Douglas S. Johnson, P. Mésini, 1997 .

CC‐1065 and the Duocarmycins: Understanding Their Biological Function Through Mechanistic Studies

D. Boger, Douglas S. Johnson, 1996 .

Catalytic Enantioselective Amination of Enolsilanes Using C2‐Symmetric Copper(II) Complexes as Chiral Lewis Acids.

Davidr . Evans, Douglas S. Johnson, 1999 .

Chemical Proteomic Technologies for Drug Target Identification

K. Geoghegan, Douglas S. Johnson, 2010 .

Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease

P. Greengard, Bin Zhang, E. Masliah, 2020, Nature.

Contemporary Drug Synthesis: Li/Drug Synthesis

B. Roth, J. Li, Douglas S. Johnson, 2004 .

Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment.

N. Brandon, P. Verhoest, C. J. Schmidt, 2014, ACS chemical biology.

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin*

K. Bales, Christopher W. am Ende, Martin Pettersson, 2013, The Journal of Biological Chemistry.

An Isotopically Tagged Azobenzene‐Based Cleavable Linker for Quantitative Proteomics

E. Weerapana, N. Pace, T Eric Ballard, 2013, Chembiochem : a European journal of chemical biology.

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

B. Cravatt, Douglas S. Johnson, Kay Ahn, 2009, Expert opinion on drug discovery.

Recent advances in medicinal chemistry.

B. Blagg, Douglas S. Johnson, R. Garbaccio, 2011, Bioorganic & medicinal chemistry letters.

Development and mechanism of γ-secretase modulators for Alzheimer's disease.

Douglas S. Johnson, Yue-Ming Li, Christina J. Crump, 2013, Biochemistry.

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.

B. Cravatt, E. Weerapana, Douglas S. Johnson, 2010, Future medicinal chemistry.

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Shobha N. Bhattachar, B. Cravatt, D. T. Dudley, 2011, ACS medicinal chemistry letters.

Structural and Chemical Biology of Presenilin Complexes.

P. S. St George-Hyslop, Martin Pettersson, Douglas S. Johnson, 2017, Cold Spring Harbor perspectives in medicine.

Utility of chemical probes for mass spectrometry based chemical proteomics

Jeffrey G Martin, Douglas S. Johnson, Bekim Bajrami, 2022, Advances in Chemical Proteomics.

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Graham M. West, Sherry L. Niessen, Claude Ambroise, 2016, Nature Communications.

Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes.

K. Geoghegan, Christopher W. am Ende, Douglas S. Johnson, 2017, Cell chemical biology.

γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease

Martin Pettersson, Douglas S. Johnson, 2017 .

Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.

P. Verhoest, C. Steppan, Travis T Wager, 2020, Cell chemical biology.

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

Jennifer A. Ward, K. Guckian, Jeffrey G Martin, 2021, Chembiochem : a European journal of chemical biology.

Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB

Alan A. Wilson, S. Houle, S. Kish, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Development of clickable active site-directed photoaffinity probes for γ-secretase.

K. Bales, Christopher W. am Ende, Douglas S. Johnson, 2012, Bioorganic & medicinal chemistry letters.

Protein tyrosine kinase inhibitors

B. Roth, J. Li, Douglas S. Johnson, 2004, Reactions weekly.

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.

Douglas S. Johnson, Yue-Ming Li, N. Gertsik, 2014, MedChemComm.

BMS-708,163 targets presenilin and lacks notch-sparing activity.

Feng Wang, K. Bales, S. Sisodia, 2012, Biochemistry.

Novel γ-secretase modulators: a review of patents from 2008 to 2010

Gregory W. Kauffman, Martin Pettersson, Christopher W. am Ende, 2011, Expert opinion on therapeutic patents.

Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes

K. Geoghegan, Douglas S. Johnson, T. E. Ballard, 2014 .

Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.

Gregory W. Kauffman, L. Pustilnik, S. Sakya, 2014, Journal of medicinal chemistry.

Pharmacological Assessment of γ-Secretase Activity from Rodent and Human Brain

K. Bales, K. Atchison, Martin Pettersson, 2012 .

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Gregory W. Kauffman, L. Pustilnik, S. Sakya, 2012, Bioorganic & medicinal chemistry letters.

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging

J. Judkins, Christopher W. am Ende, L. Di, 2015, Journal of the American Chemical Society.

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

R. Stevens, J. Long, B. Cravatt, 2009, Chemistry & biology.

Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist.

Maura E. Charlton, Cheryl Li, Douglas S. Johnson, 2008, Bioorganic & medicinal chemistry letters.

Fluorophosphonate‐Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics

Douglas S. Johnson, Hua Xu, Jason K. Dutra, 2020, Chembiochem : a European journal of chemical biology.

Blocking of Fatty Acid Amide Hydrolase Activity with PF-04457845 in Human Brain: A Positron Emission Tomography Study with the Novel Radioligand [11C]CURB

Alan A. Wilson, S. Houle, S. Kish, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.