J. Empfield

发表

Synthetic strategies towards the total synthesis of phyllanthocin and breynolide. Application of stereochemically linear and convergent strategies

Amos B. Smith, J. Empfield, 1999 .

Reducing the Risk of Drug Attrition Associated with Physicochemical Properties

Paul D. Leeson, P. Leeson, J. Empfield, 2010 .

Real-Time in situ Raman Analysis of Microwave-Assisted Organic Reactions

J. Empfield, D. Pivonka, 2004, Applied spectroscopy.

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

Angela Hussainkhel, S. Decker, Matthew Waldbrook, 2021, bioRxiv.

ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.

J. Empfield, D. A. Trainor, K. Russell, 1995, The Journal of pharmacology and experimental therapeutics.

K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.

J. Empfield, D. A. Trainor, K. Russell, 1995, Pharmacology.

Zeneca ZD6169 and its analogs from a novel series of anilide tertiary carbinols: in vitro KATP channel opening activity in bladder detrusor.

A. Bonev, J. Empfield, D. A. Trainor, 1995, Pharmacology.

Total synthesis of (.+-.)-breynolide, an aglycon derivative of the orally active hypocholesterolemic agent breynin A

R. Rivero, Amos B. Smith, J. Duan, 1992 .

Total synthesis of (.+-.)-breynolide: an aglycon derivative of a potent, orally active hypocholesterolemic agent

R. Rivero, Amos B. Smith, J. Empfield, 1991 .

Coordination compounds with a biomimetic N2S2 ligand, resulting in long metal-thioether bonds. The crystal and molecular structure of [1,7-bis(5-methyl-4-imidazolyl)-2,6- dithiaheptane]bis(thiocyanato-N)cobalt(II)

E. Bouwman, J. Rijn, J. Reedijk, 1989 .

Chapter 9. Potassium Channel Openers

J. Empfield, K. Russell, 1995 .

Total Synthesis of (.+-.)-Breynolide: An Aglycon Derivative of a Potent, Orally Active Hypocholesterolemic Agent.

R. Rivero, Amos B. Smith, J. Empfield, 1991 .

Total Synthesis of (.+‐.)‐Breynolide, an Aglycon Derivative of the Orally Active Hypocholesterolemic Agent Breynin A.

R. Rivero, Amos B. Smith, J. Duan, 1993 .

Enantioselective synthesis of (+)-kjellmanianone

D. Boschelli, Amos B. Smith, J. Empfield, 1991 .

Phyllanthoside-phyllanthostatin synthetic studies. 7. Total synthesis of (+)-phyllanthocin and (+)-phyllanthocindiol

Amos B. Smith, J. Empfield, H. Vaccaro, 1991 .

Phyllanthoside-Phyllanthostatin synthetic studies. 6. An augmented spiroketalization tactic for the total synthesis of phyllanthocin

Amos B. Smith, J. Empfield, H. Vaccaro, 1989 .

Progress in Understanding and Treating SCN2A-Mediated Disorders

Stephan J Sanders, D. Malhotra, W. Chung, 2018, Trends in Neurosciences.

Syddansk Universitet Progress in Understanding and Treating SCN 2 A-Mediated Disorders

Stephan J Sanders, D. Malhotra, J. Hipp, 2018 .

Progress in understanding and treating SCN 2 A-mediated disorders 1 2

Stephan J Sanders, D. Malhotra, J. Hipp, 2018 .

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

R. DeVita, S. Decker, Matthew Waldbrook, 2019, Journal of medicinal chemistry.

Calcium dependent K-channels in guinea pig and human urinary bladder.

J. Empfield, D. A. Trainor, K. Russell, 1995, Biochemical and biophysical research communications.

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Angela Hussainkhel, J. Empfield, Jr., 2021, Bioorganic & medicinal chemistry letters.

N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.

K. Gibson, B. Masek, J. Empfield, 1996, Journal of medicinal chemistry.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

Wei Zhang, Angela Hussainkhel, Matthew Waldbrook, 2023, bioRxiv.

Molecular pharmacology of selective Nav1.6 and dual Nav1.6 and Nav1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

P. Ruben, Matthew Waldbrook, R. R. Parrish, 2023, bioRxiv.

Lessons learned from candidate drug attrition.

Paul D Leeson, P. Leeson, J. Empfield, 2010, IDrugs : the investigational drugs journal.

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.

R. Keith, Dean G. Brown, J. Empfield, 2003, Bioorganic & medicinal chemistry letters.

Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.

K. Bui, D. McCarthy, Yun Alelyunas, 2010, Bioorganic & medicinal chemistry letters.