W. Duan

发表

Organocatalytic asymmetric Michael addition of 2,4-pentandione to nitroolefins.

Jian Wang, Weiqi Wang, Hao Li, 2005, Organic letters.

Shikonin derivatives: synthesis and inhibition of human telomerase.

Jian Ding, W. Duan, Qun Lu, 2002, Bioorganic & medicinal chemistry letters.

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Kaixian Chen, Hualiang Jiang, Jingwei Shao, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)

Jian Ding, Lin-jiang Tong, W. Duan, 2016 .

Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors.

Jian Ding, Lin-jiang Tong, Ting Peng, 2014, ACS medicinal chemistry letters.

Identification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin

Yi Chen, Jian Ding, Lin-jiang Tong, 2014, Acta Pharmacologica Sinica.

A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of alpha,alpha-disubstituted aldehydes to maleimides.

Lu-Yue Liu, Wei Wang, W. Duan, 2010, Chemistry.

8-Aminocyclazocine analogues: synthesis and structure-activity relationships.

J. Bidlack, M. Wentland, W. Duan, 2000, Bioorganic & medicinal chemistry letters.

DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice

Weiqi Wang, Jinpei Zhou, W. Duan, 2020, Diabetes.

Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, A gambogic acid derivative, in human leukemia HL-60 cells

Jin-jian Lu, Jian Ding, Li-ping Lin, 2007, Cancer biology & therapy.

Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain

Jian Ding, Z. Zuo, Linghua Meng, 2007, Molecular Cancer Therapeutics.

Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2020, ACS medicinal chemistry letters.

3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.

J. Bidlack, M. Wentland, W. Duan, 2001, Bioorganic & medicinal chemistry letters.

GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms

Jian Ding, Lin-jiang Tong, M. Geng, 2009, Acta Pharmacologica Sinica.

Design, synthesis and biological evaluation of acylhydrazone derivatives as PI3K inhibitors

Jian Ding, De-Sheng Mei, Linghua Meng, 2015 .

DW09849, a Selective Phosphatidylinositol 3-Kinase (PI3K) Inhibitor, Prevents PI3K Signaling and Preferentially Inhibits Proliferation of Cells Containing the Oncogenic Mutation p110α (H1047R)

Jian Ding, Lin-jiang Tong, Linghua Meng, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Catalytic enantioselective Henry reactions of isatins: application in the concise synthesis of (S)-(-)-spirobrassinin.

Lu-Yue Liu, W. Duan, Shilei Zhang, 2011, Chemistry.

An efficient method for demethylation of aryl methyl ethers

W. Duan, Wen Wang, L. Zuo, 2008 .

Design and Synthesis of Fluoroquinophenoxazines That Interact with Human Telomeric G-Quadruplexes and Their Biological Effects 1

O. Fedoroff, L. Hurley, S. Rha, 2001 .

Synthesis and antitumor activity of 10-arylcamptothecin derivatives.

M. Geng, Hongchun Liu, Yu Jiao, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase.

Qiu-feng Liu, H. Su, Yin-chun Ji, 2022, Journal of medicinal chemistry.

Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction

De-Sheng Mei, W. Duan, Wenjing Liu, 2013 .

Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.

L. Hurley, Mu-yong Kim, W. Duan, 2003, Journal of medicinal chemistry.

Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2020, European journal of medicinal chemistry.

Efficient synthesis of triarylmethanes via bisarylation of aryl aldehydes with arenes catalyzed by silica gel-supported sodium hydrogen sulfate

W. Duan, Fang Chen, Yixin Leng, 2010 .

Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.

Lu-Yue Liu, W. Duan, Shilei Zhang, 2010, The Journal of organic chemistry.

(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

Lirong Song, W. Duan, Shilei Zhang, 2008 .

Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: formation of two contiguous quaternary centered 3-substituted 3-hydroxyindol-2-ones.

Lu-Yue Liu, W. Duan, Shilei Zhang, 2009, Chemistry, an Asian journal.

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.

Xu Shen, Huibin Zhang, Jinpei Zhou, 2017, European journal of medicinal chemistry.

Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors.

C. Luo, M. Geng, Bin Zhao, 2016, ACS medicinal chemistry letters.

An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues.

Lirong Song, W. Duan, Shilei Zhang, 2008, Organic letters.

Selective debenzylation of benzyl esters by silica-supported sodium hydrogen sulphate

W. Duan, Y. Hu, L. Zuo, 2009 .

Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate

W. Duan, Linna Zhou, Wen Wang, 2008 .

Chiral cyclopropanes: Asymmetric synthesis of constanolactones A and B

J. Falck, J. Capdevila, N. Balu, 2002 .

Enatioselective organocatalytic synthesis of highly functionalized tetrahydrothiophenes by a Michael-aldol cascade reaction

W. Duan, Shilei Zhang, Wen Wang, 2009 .

Efficient, enantioselective organocatalytic synthesis of trichostatin A

W. Duan, Shilei Zhang, Wen Wang, 2006 .

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor.

Yechun Xu, M. Geng, Qiu-feng Liu, 2016, European journal of medicinal chemistry.

Simple cyclohexanediamine-derived primary amine thiourea catalyzed highly enantioselective conjugate addition of nitroalkanes to enones.

W. Duan, Shilei Zhang, Xiaobei Chen, 2009, Organic letters.

A Novel Bifunctional Sulfonamide Primary Amine‐Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins

W. Duan, Shilei Zhang, F. Xue, 2008 .

An enantioselective synthesis of (+)-(S)-[n]-gingerols via the L-proline-catalyzed aldol reaction.

W. Duan, Shilei Zhang, Wen Wang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.

C. Luo, M. Geng, Fanwang Meng, 2016, Journal of medicinal chemistry.

Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones Catalyzed by Cinchona Alkaloid Derived Primary Amine.

De-Sheng Mei, W. Duan, Wen Wang, 2013 .

Organocatalytic enantioselective cross-aldol reactions of aldehydes with isatins: formation of two contiguous quaternary centered 3-substituted 3-hydroxyindol-2-ones.

Lu-Yue Liu, W. Duan, Shilei Zhang, 2009, Chemistry, an Asian journal.

Microwave assisted solvent-free CH amination by silica-supported manganese dioxide

W. Duan, Sufen Cao, 2016 .

Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice.

W. Duan, Yanyan Sun, Xu Shen, 2015, European journal of pharmacology.

SH‐7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor

Yi Chen, Hong Zhu, Jian Ding, 2006, International journal of cancer.

Asymmetric synthesis of 3(S),17-dihydroxytanshinone

W. Duan, Junchao Cai, Jiangang Zhang, 2004 .

Discovery of 1,3‐Diaryl‐pyridones as Potent VEGFR‐2 Inhibitors: Design, Synthesis, and Biological Evaluation

Jinpei Zhou, Jian Ding, Lin-jiang Tong, 2016, Chemical biology & drug design.

DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo

Jian Ding, Yin-chun Ji, W. Duan, 2020, Acta Pharmacologica Sinica.

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation

Jinpei Zhou, Wei Wang, W. Duan, 2020, Brain, Behavior, and Immunity.

Chemical Synthesis of Natural Products

W. Duan, 2011 .

Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity.

Yechun Xu, M. Geng, Qiu-feng Liu, 2014, ACS medicinal chemistry letters.

Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo

Hualiang Jiang, C. Mei, Li-li Fu, 2009, Investigational new drugs.

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

Cheng Luo, Hualiang Jiang, Kongkai Zhu, 2017, Journal of medicinal chemistry.

Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation.

M. Geng, Yin-chun Ji, W. Duan, 2021, European journal of medicinal chemistry.

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.

Kaixian Chen, Hualiang Jiang, J. Min, 2021, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors.

Jingwei Shao, M. Geng, Chen Wang, 2016, Bioorganic & medicinal chemistry letters.

Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α

Jingwei Shao, Jin Ding, Jifeng Feng, 2019, Theranostics.

Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives.

J. Bidlack, M. Wentland, W. Duan, 2000, Journal of Medicinal Chemistry.

Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.

Xufeng Sun, J. Bidlack, M. Wentland, 2003, Journal of medicinal chemistry.

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities

Jian Ding, M. Geng, Wei-ren Liu, 2016, Oncotarget.

Simple Cyclohexanediamine‐Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones.

Wei Wang, W. Duan, Shilei Zhang, 2009 .

O‐Linked Triazolotriazines: Potent and Selective c‐Met Inhibitors

Zhongjie Liang, C. Luo, M. Geng, 2012, ChemMedChem.

Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles.

W. Duan, Jing Ai, Xia Peng, 2018, Chemical research in toxicology.

Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity

Cheng Luo, Hua Zhang, Kongkai Zhu, 2019, Journal of Computer-Aided Molecular Design.

A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.

Cheng Luo, Jing Chen, Xu Shen, 2003, Acta pharmacologica Sinica.

Synthesis and biological activity of novel shikonin analogues.

Jian Ding, Li-ping Lin, W. Duan, 2009, Bioorganic & medicinal chemistry letters.

DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

Yi Chen, Jian Ding, Lin-jiang Tong, 2016, Acta Pharmacologica Sinica.

Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors

Jian Ding, Lin-jiang Tong, Ting Peng, 2015 .

Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors.

M. Geng, W. Duan, Jun Fan, 2018, Journal of medicinal chemistry.

Organocatalytic enantioselective conjugate addition to alkynones.

Hao Li, J. Wang, Wei Wang, 2004, Journal of the American Chemical Society.

Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors.

Huibin Zhang, Jinpei Zhou, Jian Ding, 2021, Bioorganic & medicinal chemistry.

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities

Jian Ding, M. Geng, Yin-chun Ji, 2016, Oncotarget.

Synthesis of triazolotriazine derivatives as c-Met inhibitors

Jian Ding, Yin-chun Ji, W. Duan, 2020, Molecular Diversity.

Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.

Weiliang Zhu, Joel L Sussman, Hualiang Jiang, 2005, The journal of physical chemistry. B.

Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma.

Huibin Zhang, Jinpei Zhou, W. Duan, 2023, European journal of medicinal chemistry.

Enantioselective Conjugate Addition of N-Heterocycles to α,β-Unsaturated Ketones Catalyzed by Chiral Primary Amines.

Wei Wang, W. Duan, Shilei Zhang, 2009 .

BB, a new EGFR inhibitor, exhibits prominent anti-angiogenesis and antitumor activities

Z. Miao, Jian Ding, Li-ping Lin, 2009, Cancer biology & therapy.