H. Hiemstra

发表

Asymmetric organocatalytic Henry reaction.

J. V. van Maarseveen, T. Marcelli, Richard N S van der Haas, 2006, Angewandte Chemie.

Click chemistry as a route to cyclic tetrapeptide analogues: synthesis of cyclo-[Pro-Val-psi(triazole)-Pro-Tyr].

J. V. van Maarseveen, H. Hiemstra, Victoria D. Bock, 2006, Organic letters.

1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics.

D. Speijer, J. V. van Maarseveen, H. Hiemstra, 2007, Organic & biomolecular chemistry.

SULFOXIDE-STABILIZED GIANT PALLADIUM CLUSTERS IN CATALYZED OXIDATIONS

J. Geus, H. Hiemstra, P. V. Leeuwen, 1995 .

Chapter 4 N-Acyliminium Ions as Intermediates in Alkaloid Synthesis

H. Hiemstra, W. Speckamp, 1988 .

Intramolecular reactions of N-acyliminium intermediates

H. Hiemstra, W. Speckamp, 1985 .

Cupreines and cupreidines: an emerging class of bifunctional cinchona organocatalysts.

J. V. van Maarseveen, T. Marcelli, H. Hiemstra, 2006, Angewandte Chemie.

Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine, and (S)-Clarkeanidine via a Solvent-Directed Pictet–Spengler Reaction

J. V. van Maarseveen, S. I. Jørgensen, H. Hiemstra, 2018, The Journal of organic chemistry.

Palladium(II)-catalysed oxidation of allylic amines with molecular oxygen

H. Hiemstra, J. Michels, R. V. Benthem, 1994 .

"Clickphine": a novel and highly versatile P,N ligand class via click chemistry.

J. Reek, J. V. van Maarseveen, P. V. van Leeuwen, 2006, Organic letters.

PegPhos: a monodentate phosphoramidite ligand for enantioselective rhodium-catalysed hydrogenation in water.

B. Feringa, A. Minnaard, J. V. van Maarseveen, 2006, Organic & biomolecular chemistry.

Catalytic Asymmetric Pictet–Spengler Reactions via Sulfenyliminium Ions†

H. Hiemstra, J. Maarseveen, M. Wanner, 2007 .

Total Synthesis of Aquatolide.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2015, Organic Letters.

Crystal structure of (R)-5-isopropoxy-1-(toluene-4-sulfonyl)-1,5-dihydropyrrol-2-one, C14H17NO4S and of its cis-tetracarbonyliron complex, Fe(CO)4(C14H17NO4S), Zeitschrift fr Kristallographie

H. Schenk, K. Goubitz, H. Hiemstra, 1996 .

Enantioselective copper-catalysed propargylic substitution: synthetic scope study and application in formal total syntheses of (+)-anisomycin and (-)-cytoxazone.

J. V. van Maarseveen, H. Hiemstra, Z. Abiri, 2011, Chemistry.

Cinchona Alkaloid Catalyzed Sulfa-Michael Addition Reactions Leading to Enantiopure β-Functionalized Cysteines.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2015, The Journal of organic chemistry.

CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

H. Hiemstra, Victoria D. Bock, J. Maarseveen, 2005 .

Pd-Catalyzed cyclization reactions of acetylene-containing α-amino acids

H. Schoemaker, F. Rutjes, H. Hiemstra, 1998 .

Synthetic and Organocatalytic Studies of Quinidine Analogues with Ring-Size Modifications in the Quinuclidine Moiety.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2016, Chemistry.

Enamide-olefin ring-closing metathesis.

H. Schoemaker, F. Rutjes, J. V. van Maarseveen, 2001, Organic letters.

Cinchona Alkaloids in Asymmetric Organocatalysis

T. Marcelli, H. Hiemstra, 2010, Synthesis.

Palladium-Catalyzed Cyclization Reactions of Acetylene-Containing Amino Acids

H. Schoemaker, F. Rutjes, H. Hiemstra, 2002 .

Synthesis of Enantiopure Functionalized Pipecolic Acids via Amino Acid Derived N‐Acyliminium Ions

Wim J. N. Meester, H. Schoemaker, F. Rutjes, 1999 .

(S)-Pyroglutamic acid, (S)-malic acid and (S)-serine as useful starting materials in the synthesis of enantiopure hydroxyamidines.

F. Rutjes, H. Hiemstra, M. Ostendorf, 2000 .

Synthesis and reactivity of pyrrolidinone- and piperidinone-derived enol triflates

H. Hiemstra, W. Speckamp, T. Luker, 1996 .

4.5 – Additions to N-Acyliminium Ions

H. Hiemstra, W. Speckamp, 1991 .

Synthesis of the aspidosperma skeleton through allylsilane N-acyliminium cyclization

H. Hiemstra, W. Speckamp, J. Mittendorf, 1990 .

Synthetic studies towards gelsemine, I The importance of the antiperiplanar effect in the highly regioselective reduction of non-symmetrical cis-hexahydrophthalimides

H. Hiemstra, W. Speckamp, R. Vijn, 1987 .

Novel approach to trans-fused carbobicycles

H. Hiemstra, W. Speckamp, M. Moolenaar, 1985 .

Lewis acid induced reactions of propargyl trimethyl silane with ω-ethoxy lactams synthesis of γ-allenyl-GABA

H. Hiemstra, W. Speckamp, H. P. Fortgens, 1984 .

Palladium catalyzed cyclization reactions of acetylenic lactams

A. Spek, F. Rutjes, H. Hiemstra, 2001 .

Pd-Catalyzed Cyclization Reactions of Acetylene-Containing α-Amino Acids.

H. Schoemaker, F. Rutjes, H. Hiemstra, 1998 .

Fine-Tuning the Balance between Peptide Thioester Cyclization and Racemization

H. Hiemstra, J. Maarseveen, L. Wijsman, 2016 .

Intramolecular Staudinger ligation: a powerful ring-closure method to form medium-sized lactams.

Wim J. N. Meester, H. Schoemaker, J. V. van Maarseveen, 2003, Angewandte Chemie.

A pincer auxiliary to force difficult lactamisations.

H. Schoemaker, J. V. van Maarseveen, H. Hiemstra, 2003, Organic & biomolecular chemistry.

Diastereoselective Synthesis of Medium-Sized Lactones by Cu(bpy)CI Catalyzed Cyclization of Trichloroacetates

H. Schoemaker, B. Kaptein, H. Hiemstra, 1993 .

Synthesis of medium-sized lactones by the copper(I)chloride/2,2'-bipyridine-catalyzed cyclization of di- and trichloroacetates

H. Schoemaker, B. Kaptein, H. Hiemstra, 1994 .

Synthesis of Enantiopure (S)-Indolylglycine by Organocatalyzed Friedel–Crafts Alkylation of Indole

H. Schoemaker, R. Gelder, H. Hiemstra, 2008 .

Alkaloid catalyzed asymmetric synthesis III the addition of mercaptans to 2-cyclohexene-1-one; determination of enantiomeric excess using 13C NMR.

H. Wynberg, H. Hiemstra, R. Helder, 1977 .

Determination of the enantiomeric purity of chiral ketones using 13C NMR spectroscopy of their diastereomeric cyclic ketals

H. Wynberg, H. Hiemstra, 1977 .

Ion pair effects in an intercalation process. An approach to the bicyclo[5.3.1]undecyl system of taxane

B. Trost, H. Hiemstra, 1982 .

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

S. Ingemann, H. Hiemstra, J. Maarseveen, 2013 .

Synthesis of vinyl fluorides by ring-closing metathesis

G. Haufe, H. Hiemstra, J. Maarseveen, 2004 .

Total synthesis of (±)-α-allokainic acid via two allylsilane N-acyliminium ion reactions

H. Mooiweer, H. Hiemstra, W. Speckamp, 1991 .

Organocatalytic enantioselective Pictet-Spengler reactions for the syntheses of 1-substituted 1,2,3,4-tetrahydroisoquinolines.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2014, The Journal of organic chemistry.

Cupreines and Cupreidines: An Emerging Class of Bifunctional Cinchona Organocatalysts

T. Marcelli, H. Hiemstra, J. Maarseveen, 2007 .

CuI‐Catalyzed Alkyne—Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

H. Hiemstra, Victoria D. Bock, J. Maarseveen, 2006 .

Enantioselective syntheses of corynanthe alkaloids by chiral Brønsted acid and palladium catalysis.

J. V. van Maarseveen, H. Hiemstra, M. Wanner, 2011, Chemistry.

Tin tetrachloride-induced π-cyclizations of glycine cation equivalents to substituted pipecolic acid derivatives

H. Hiemstra, W. Speckamp, P. Esch, 1991 .

Synthesis of isoquinolines and pyridines via palladium-catalysed iminoannulation of allenes

H. Hiemstra, Renatus W. Sinkeldam, K. Vrieze, 1999 .

Synthesis of cyclic α-hydrazino acid derivatives via N -acylhydrazonium ions

H. Hiemstra, W. N. Speckamp, F. Rutjes, 1993 .

Development and application of allyl, 2-sulfonylethyl and 2-thioethyl carbamate linkers for solid phase N-acyliminium ion chemistry.

Wim J. N. Meester, F. Rutjes, H. Hiemstra, 2001 .

Reductive cyclization of carbon-centered glycine radicals; a novel synthetic route to cyclic α-amino acids

H. Hiemstra, W. Speckamp, R. D. de Boer, 1992 .

Palladium-catalyzed aerobic oxidation of allylic amines via heterocyclic intermediates.

H. Hiemstra, R. V. Benthem, 2010 .

Palladium-catalyzed synthesis of amides and peptides

B. Kaptein, H. Hiemstra, W. Speckamp, 1991 .

Synthesis of Quinuclidines by Intramolecular Silver-Catalysed Amine Additions to Alkynes

S. Ingemann, H. Hiemstra, J. Maarseveen, 2014 .

Consecutive Pictet-Spengler Condensations toward Bioactive 8-Benzylprotoberberines: Highly Selective Total Syntheses of (+)-Javaberine A, (+)-Javaberine B, and (-)-Latifolian A

S. Ingemann, H. Hiemstra, J. Maarseveen, 2016 .

Organocatalytic enantioselective Pictet-Spengler approach to biologically relevant 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloids.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2015, The Journal of organic chemistry.

Addition of aromatic thiols to conjugated cycloalkenones, catalyzed by chiral .beta.-hydroxy amines. A mechanistic study of homogeneous catalytic asymmetric synthesis

H. Wynberg, H. Hiemstra, 1981 .

Synthesis of bicyclic guanidines from pyrrolidin-2-one

H. Hiemstra, A. Tuynman, Saskia Louwrier, 1996 .

Studies towards the synthesis of (+)-ptilomycalin A; Stereoselective N-acyliminium ion coupling reactions to enantiopure C-2 substituted lactams

A. Boom, H. Hiemstra, W. Speckamp, 1996 .

STUDIES TOWARDS THE SYNTHESIS OF GUANIDINE ALKALOIDS ; SYNTHESIS OF A TRICYCLIC GUANIDINE FROM SUCCINIMIDE

H. Hiemstra, A. Tuynman, M. Ostendorf, 1996 .

Formamide as a superior nitrogen nucleophile in palladium(II) mediated synthesis of imidazolidines

H. Hiemstra, R. V. Benthem, W. Speckamp, 1994 .

Stereoselective carbon-carbon bond formation via allylic N-sulfonyliminium ions

H. Hiemstra, W. Speckamp, J. Hopman, 1995 .

Completely regioselective α-acyliminium ion cyclizations with allyl and propargyl silanes

H. Hiemstra, W. Speckamp, 1983 .

Intermolecular reacitons of N-alkoxycarbonyliminium ions with propargyltrimethylsilane; oxazinone versus allene formation

H. Hiemstra, W. Speckamp, P. Esch, 1992 .

A Staudinger approach towards binol-derived MAP-type bidentate P,N ligands.

H. Schenk, K. Goubitz, J. V. van Maarseveen, 2004, Angewandte Chemie.

Transition metal-catalysed chlorine transfer radical cyclizations of 2-(3-alken-1-oxy)-2-chloroacetates; formal total synthesis of avenaciolide and isoavenaciolide

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Enantioselective formal total synthesis of roseophilin.

H. Hiemstra, W. Speckamp, T. Luker, 2000, Organic letters.

A novel strategy for the synthesis of medium-sized lactams.

H. Schoemaker, J. V. van Maarseveen, H. Hiemstra, 2002, Organic letters.

N-Acyliminium ion chemistry and palladium catalysis: a useful combination to obtain bicyclic heterocycles.

F. Rutjes, H. Hiemstra, W. Karstens, 2001 .

Oxazaborolidine catalysed enantioselective reduction of cyclic meso-imides

R. Romagnoli, H. Hiemstra, W. Speckamp, 1997 .

Tributyl‐1,2‐propadien‐1‐yl‐stannane

H. Hiemstra, S. S. Kinderman, 2010 .

Synthesis of new N-heterocycles; intramolecular ring closure with imines

M. Pfeffer, H. Hiemstra, K. Vrieze, 1998 .

Conjugate addition of amines and thiols to (R)-1-acetyl-5-isopropoxy-3-pyrrolin-2-one; Preparation of enantiopure N-acyliminium ion precursors

H. Hiemstra, W. Speckamp, W. Koot, 1993 .

Studies toward the total synthesis of the oxindole alkaloid gelsedine: an efficient allene-terminated N-acyliminium ion cyclization

H. Hiemstra, W. R. B. V. Henegouwen, 1997 .

The total synthesis of (+)-gelsemine

N. Newcombe, H. Hiemstra, W. Speckamp, 1994 .

Dendritic phosphoramidite ligands in Rh-catalysed asymmetric hydrogenations

J. Reek, J. Back, H. Hiemstra, 2004 .

Transition metal-catalyzed chlorine transfer cyclizations of carbon-centered glycine radicals; A novel synthetic route to cyclic α-amino acids

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Radical-transfer catalysis versus Lewis acid catalysis by the copper(I) chloride/2,2′-bipyridine complex: an illustration of the synthetic significance of captodative radical stabilization

H. Hiemstra, W. Speckamp, J. H. Udding, 1992 .

Phosphine-catalyzed [3+2] annulation of cyanoallenes

Sape S. Kinderman, Jan H. van Maarseveen, Henk Hiemstra, 2011 .

Intramolecular [2+2] photocycloadditions as an approach towards the bicyclo[2.1.1]hexane substructure of solanoeclepin A

F. Rutjes, K. Goubitz, H. Hiemstra, 2000 .

Silicon directed N-acyliminium ion cyclizations. Highly selective syntheses of (.+-.)-isoretronecanol and (.+-.)-epilupinine

H. Hiemstra, W. Speckamp, R. Vijn, 1985 .

Synthesis of 2-substituted piperazines via direct α-lithiation

Jan H. van Maarseveen, Henk Hiemstra, H. Hiemstra, 2005 .

Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction.

Isabel P. Kerschgens, J. V. van Maarseveen, S. Ingemann, 2012, Chemical communications.

Diastereoselective alkylation of the dianion of 5-ethoxy-4(S)-hydroxy-1-isopropyl-2-pyrrolidinone; Synthesis of enantiomerically pure azabicycles

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1987 .

Total synthesis of (±)-anatoxin-a via N-acyliminium intermediates

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1986 .

Allenylmethylsilanes as nucleophiles in N-acyliminium ion chemistry.

J. V. van Maarseveen, H. Hiemstra, Gertjan Mentink, 2002, Organic letters.

A Kulinkovich Entry into Tertiary N-Acyliminium Ion Chemistry

F. Rutjes, H. Hiemstra, W. Speckamp, 1999 .

Palladium-Catalyzed Coupling/Cyclization Reactions of Allene-Substituted Lactams

F. Rutjes, H. Hiemstra, W. Karstens, 1997 .

ADDITION OF AROMATIC THIOLS TO CONJUGATED CYCLOALKENONES, CATALYZED BY CHIRAL β-HYDROXY AMINES. A MECHANISTIC STUDY OF HOMOGENEOUS CATALYTIC ASYMMETRIC SYNTHESIS

H. Wynberg, H. Hiemstra, 1981 .

Density Functional Theory Study of the Cinchona Thiourea‐ Catalyzed Henry Reaction: Mechanism and Enantioselectivity

F. Himo, T. Marcelli, H. Hiemstra, 2007 .

Construction of adjacent quaternary and tertiary stereocenters via an organocatalytic allylic alkylation of Morita-Baylis-Hillman carbonates

A. Spek, M. Lutz, T. Marcelli, 2007 .

Scope and limitations of the solution and solid phase synthesis of homoallylic amines via N-acyliminium ion reactions

Wim J. N. Meester, H. Schoemaker, F. Rutjes, 2004 .

Catalyzed Propargylic Substitution

H. Hiemstra, J. Maarseveen, R. Detz, 2009 .

Selective azetidine and tetrahydropyridine formation via Pd-catalyzed cyclizations of allene-substituted amines and amino acids.

H. Schoemaker, F. Rutjes, H. Hiemstra, 1999, Organic letters.

Intramolecular Butenolide Allene Photocycloadditions and Ensuing Retro‐Ene Reactions of Some Photoadducts

R. Peschar, K. Goubitz, H. Hiemstra, 2011 .

Synthesis of homoallylic amines via N-acyliminium ion reactions on solid support

Wim J. N. Meester, F. Rutjes, H. Hiemstra, 1999 .

A stereodivergent approach to substituted 4-hydroxypiperidines.

H. Schoemaker, F. Rutjes, J. Luten, 2002, The Journal of organic chemistry.

Amidopalladation of alkoxyallenes applied in the synthesis of an enantiopure 1-ethylquinolizidine frog alkaloid.

H. Schoemaker, F. Rutjes, J. V. van Maarseveen, 2004, Journal of the American Chemical Society.

A ring-closing metathesis-mediated route to novel enantiopure conformationally restricted cyclic amino acids †

H. Schoemaker, F. Rutjes, H. Hiemstra, 2000 .

Synthesis and X-ray crystal structure of (S)-9-hydroxymethyl-1,5-diazabicyclo[4.3.0]non-5-ene, an enantiopure DBN-analogue

K. Goubitz, H. Hiemstra, J. Dijkink, 1996 .

First total synthesis of ent-gelsedine via a novel iodide-promoted allene N-acyliminium ion cyclization.

F. Rutjes, H. Hiemstra, W. G. Beyersbergen van Henegouwen, 2000, The Journal of organic chemistry.

Radical transfer catalysis versus Lewis acid catalysis by the copper(I) chloride–2,2′-bipyridine complex: the effect of the structure of the ligand

H. Hiemstra, W. Speckamp, J. H. Udding, 1992 .

Synthesis of N-Boc-protected 1-amino-3-alken-2-ols from allylic carbamates via palladium(II)-catalyzed oxidative cyclization

H. Hiemstra, R. V. Benthem, W. Speckamp, 1992 .

Epimerization-free C-terminal peptide activation.

J. V. van Maarseveen, H. Hiemstra, A. Kluwer, 2013, Chemistry.

C-C Bond Formation via N-Phosphoryliminium Ions

H. Schoemaker, F. Rutjes, H. Hiemstra, 2004 .

Synthesis of Bridged Bicyclic Hydrazines Via Endocyclic N-Acylhydrazonium Intermediates - a Novel Route to the 1-Azatropane Skeleton

F. Rutjes, H. Hiemstra, W. Speckamp, 1993 .

Synthesis of 2-substituted chromenes via ring-closing metathesis and stable 1-benzopyrylium ions

F. Rutjes, H. Hiemstra, R. Doodeman, 2000 .

Ring-closing metathesis of allylic O,O- and N,O-acetals.

H. Schoemaker, F. Rutjes, H. Hiemstra, 2002 .

Studies Towards the Synthesis of Guanidine Alkaloids; Synthesis of a Tricyclic Guanidine from Succinimide.

H. Hiemstra, A. Tuynman, M. Ostendorf, 1996 .

New Applications of N‐Acyliminium Precursors: Tetracarbonyliron‐Mediated Stereoselective Alkylations of 5‐(R)‐Isopropoxy‐3‐pyrrolin‐2‐ones

H. Hiemstra, W. Speckamp, H. D. Koning, 1998 .

Studies Towards the Synthesis of (+)-Ptilomycalin A; Stereoselective N- Acyliminium Ion Coupling Reactions to Enantiopure C-2 Substituted Lactams.

A. Boom, H. Hiemstra, W. Speckamp, 1996 .

Synthesis of statine from (S)-malic acid; stereocontrol via radical cyclization

H. Hiemstra, W. Speckamp, M. Kranenburg, 1991 .

Oxazaborolidine catalyzed enantioselective reductions of cyclic meso-imides

H. Schoemaker, B. Kaptein, R. Romagnoli, 1994 .

Synthesis of 2,6-bridged piperazine-3-ones by N-acyliminium ion chemistry.

R. Bon, F. Rutjes, J. V. van Maarseveen, 2003, The Journal of organic chemistry.

A Novel Transition Metal-Catalyzed Route to Functionalized Dihydropyrans and Tetrahydrooxepines

H. Schoemaker, F. Rutjes, H. Hiemstra, 1998 .

Organocatalytic enantioselective total synthesis of (-)-arboricine.

J. V. van Maarseveen, H. Hiemstra, R. de Gelder, 2009, Organic letters.

Enantioselective BINOL-phosphoric acid catalyzed Pictet-Spengler reactions of N-benzyltryptamine.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2008, The Journal of organic chemistry.

Lewis-acid-induced reactions of α-methoxyglycinamide derivatives with silyl enol ethers. Formation of 3-amino-2-pyrrolidinones and 3-amino-2-pyrrolinones

H. Schoemaker, B. Kaptein, J. Kamphuis, 1992 .

Synthesis and use of water-soluble sulfonated dibenzofuran-based phosphine ligands

P. V. Leeuwen, H. Hiemstra, P. Kamer, 1999 .

Cinchonas and cupreidines

S. Ingemann, H. Hiemstra, 2013 .

Intramolecular reactions of acyclic N-acyliminium ions. III: Silicon assisted cyclocondensation of glyoxylic esters to proline and pipecolic acid derivatives

H. Mooiweer, H. Hiemstra, W. Speckamp, 1987 .

Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy

M. Lutz, J. V. van Maarseveen, H. Hiemstra, 2017, Nature Communications.

Synthesis of racemic .alpha.-amino carboxamides via Lewis acid-mediated reactions of .alpha.-methoxyglycinamide derivatives with allylsilanes: enzymic resolution to optically active .alpha.-amino acids

B. Kaptein, H. Mooiweer, J. Kamphuis, 1992 .

Synthesis of γ,δ-unsaturated α-amino acids from allylsilanes and glycidyl cation equivalents

H. Mooiweer, H. Hiemstra, W. Speckamp, 1989 .

Asymmetric induction in the base-catalysed Michael addition of nitromethane to chalcone

S. Colonna, H. Wynberg, H. Hiemstra, 1978 .

Application of an organozinc reagent derived from (S)-pyroglutamic acid: a formal synthesis of epibatidine

F. Rutjes, H. Hiemstra, W. Speckamp, 1999 .

Stereoselective Synthesis of Dihydropyrans via Vinylsilane-Terminated Cyclizations of Ester-Substituted Oxycarbenium Ion Intermediates

H. Hiemstra, W. Speckamp, R. Blaauw, 1997 .

Intramolecular reactions of 2-propynylsilanes with n-acyliminium ions

H. Hiemstra, W. Speckamp, M. Moolenaar, 1988 .

.omega.-Alkoxy lactams as dipolar synthons. Silicon-assisted synthesis of azabicycles and a .gamma.-amino acid

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1984 .

A novel synthetic route to 6‐azabicyclo[3.2.1]oct‐3‐enes via silicon directed N‐Acyliminium chemistry: Synthesis of (±)‐gabaculine

H. Hiemstra, W. Speckamp, Wim J. Klaver, 2010 .

π-Cyclizations of α-methoxycarbonyl oxycarbenium ions; synthesis of oxacyclic carboxylic esters

H. Hiemstra, W. Speckamp, L. L. M. Lolkema, 1994 .

Enantioselective synthesis of tunable chiral Clickphine P,N-ligands and their application in Ir-catalyzed asymmetric hydrogenation.

M. Lutz, J. Reek, J. V. van Maarseveen, 2015, The Journal of organic chemistry.

Formadide as a superior nitrogen nucleophile in palladium(II)mediated synthesis of imidazolidines

H. Hiemstra, W. Speckamp, G. R. Longarela, 1995 .

3‐Trimethylsilyl‐1‐propyne

H. Hiemstra, L. Miginiac, S. S. Kinderman, 2008 .

Novel Reductive Amination of Nitriles: An Efficient Route to 5-Hydroxypiperidone-Derived N,N-Acetals

H. Schoemaker, F. Rutjes, H. Hiemstra, 2003 .

Expedient pyrrolizidine synthesis by propargylsilane addition to N-acyliminium ions followed by gold-catalyzed alpha-allenyl amide cyclization.

J. V. van Maarseveen, H. Hiemstra, S. S. Kinderman, 2009, The Journal of organic chemistry.

Synthesis of the cyclobutanone core of solanoeclepin A intramolecular allene butenolide photocycloaddition.

H. Schenk, K. Goubitz, J. V. van Maarseveen, 2003, Organic & biomolecular chemistry.

Copper catalyzed chlorine transfer cyclizations of glycine and glycolic acid derivatives

H. Hiemstra, W. Speckamp, J. H. Udding, 1991 .

Intramolecular photochemical dioxenone-alkene [2 + 2] cycloadditions as an approach to the bicyclo[2.1.1]hexane moiety of solanoeclepin A.

H. Schenk, F. Rutjes, K. Goubitz, 2001, The Journal of organic chemistry.

Ring-closing metathesis of allylic O,O- and N,O-acetals.

H. Schoemaker, F. Rutjes, H. Hiemstra, 2002 .

Synthesis of Enantiomerically Pure Eight- and Nine-Membered Lactones by Copper(I) Chloride/2,2’-Bipyridine-Catalyzed Cyclization

H. Schoemaker, B. Kaptein, H. Hiemstra, 1995 .

Xanthate transfer cyclisation of glycolic acid-derived radicals; synthesis of 5-to 8-membered ring ethers.

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Synthesis of medium-sized lactones by copper(I) catalyzed atom transfer cyclization

H. Schoemaker, B. Kaptein, H. Hiemstra, 1992 .

Enantioselective copper-catalyzed propargylic amination.

J. V. van Maarseveen, H. Hiemstra, R. Detz, 2008, Angewandte Chemie.

Formation of medium-size bridged ring systems via ring-closing metathesis of 2,5-disubstituted-2,3-dihydro-1H-pyrroles

H. Schenk, K. Goubitz, H. Hiemstra, 2000 .

Intramolecular Staudinger ligation towards biaryl-containing lactams

H. Schoemaker, H. Hiemstra, G. Masson, 2006 .

Models of folate coenzymes—VII : Synthesis and carbon transfer reactions of N5,N10-methenyl and N5,N10-methylenetetrahydrofolate models

H. Hiemstra, U. Pandit, H. Bieräugel, 1983 .

Palladium-Catalyzed Reactions with N,N'-Diallyloxycarbonylhydrazines

F. Rutjes, H. Hiemstra, W. Speckamp, 1991 .

An N-acyliminium route to the 8-azabicyclo[3.2.1]octane (tropane) and the 9-azabicyclo[4.2.1]nonane ring system: synthesis of (±)-anatoxin-A

H. Hiemstra, W. Speckamp, P. Esch, 1987 .

Allenes in Novel Palladium-Catalyzed and Acid-Mediated Cyclization Processes

F. Rutjes, H. Hiemstra, M. Moolenaar, 1999 .

Palladium(II)-catalyzed intramolecular 1,2-oxidation of allenes involving nitrogen nucleophiles

J. Bäckvall, H. Hiemstra, W. Karstens, 2000 .

Palladium-catalyzed transprotection of allyloxycarbonyl-protected amines: efficient one pot formation of amides and dipeptides

B. Kaptein, H. Hiemstra, W. Speckamp, 1995 .

Allenylmethylsilanes as Nucleophiles in N‐Acyliminium Ion Chemistry.

H. Hiemstra, J. Maarseveen, Gertjan Mentink, 2003 .

An N-Acyliminium Route to the 8-Azabicyclo(3.2.1)octane (Tropane) and the 9-Azabicyclo(4.2.1)nonane Ring System. Synthesis of (.+-.)-Anatoxin-a.

H. Hiemstra, W. Speckamp, P. Esch, 1987 .

Formal Synthesis of Solanoeclepin A: Enantioselective Allene Diboration and Intramolecular [2+2] Photocycloaddition for the Construction of the Tricyclic Core.

J. V. van Maarseveen, H. Hiemstra, J. Smits, 2016, Chemistry.

Oxazinone versus allene formation in the reaction of N-alkoxycarbonyliminium ions with propargyltrimethylsilane

H. Hiemstra, W. Speckamp, P. Esch, 1988 .

Total Synthesis of Desoxoprosophylline: Application of a Lactam-Derived Enol Triflate to Natural Product Synthesis

H. Hiemstra, W. Speckamp, T. Luker, 1997 .

Synthesis of the tricyclic core of solanoeclepin a through intramolecular [2+2] photocycloaddition of an allene butenolide

J. V. van Maarseveen, H. Hiemstra, B. Hue, 2005 .

Synthesis of oxacyclic carboxylic esters by way of methoxycarbonyloxonium ions; Evidence for a cationic oxa-cope rearrangement

H. Mooiweer, H. Hiemstra, W. Speckamp, 1988 .

Synthesis and Absolute Configuration of the Aristotelia Alkaloid Peduncularine.

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1989 .

Completely regioselective α-acyliminium ion cyclizations with allyl and propargyl silanes

H. Hiemstra, W. Speckamp, 1983 .

Intramolecular reactions of acyclic N-acyliminium ions I propargyl silanes as nucleophiles

H. Hiemstra, W. Speckamp, S. Stegenga, 1985 .

Stereoselective Carbon‐Carbon Bond Formation via Allylic N‐ Sulfonyliminium Ions.

H. Hiemstra, W. Speckamp, J. Hopman, 1995 .

Intermolecular Reactions of N‐Alkoxycarbonyliminium Ions with Propargyltrimethylsilane; Oxazinone versus Allene Formation.

H. Hiemstra, W. Speckamp, P. Esch, 1992 .

Determination of the Absolute Configuration of 3-Pyrrolin-2-ones

A. Spek, B. Feringa, J. Gawroński, 1999 .

Stereoselective synthesis of enantiopure 4,5-disubstituted pyrrolidin-2-ones by consecutive cuprate addition and N-acyliminium coupling

H. Hiemstra, W. Speckamp, W. Koot, 1992 .

Synthesis of cyclic α-amino acids through ring closure of glycine derived free radicals

H. Hiemstra, W. Speckamp, P. Esch, 1990 .

Studies towards the total synthesis of solanoeclepin A: synthesis of the 7-oxabicyclo[2.2.1]heptane moiety and attempted seven-membered ring formation

F. Rutjes, H. Hiemstra, J. Maarseveen, 2002 .

Synthesis of enantiopure aza-analogues of cocaine

H. Hiemstra, W. Speckamp, N. Teerhuis, 1997 .

Enantioselective high-performance liquid chromatographic separation of N-methyloxycarbonyl unsaturated amino acids on macrocyclic glycopeptide stationary phases.

H. Schoemaker, H. Hiemstra, A. Duchateau, 2006, Journal of chromatography. A.

A Short Covalent Synthesis of an All-Carbon-Ring [2]Rotaxane

J. V. van Maarseveen, H. Hiemstra, A. Ehlers, 2017, Organic letters.

Attempted [2]Catenane Synthesis via a Quasi[1]catenane by a Templated Backfolding Strategy

H. Hiemstra, J. Maarseveen, M. Wanner, 2018 .

Resolution and some properties of (1,1)')-bi(dibenzofuranyl)2,2'-diol(BIFOL)

H. Schenk, K. Goubitz, H. Hiemstra, 1997 .

Reconstructing the Discontinuous and Conformational β1/β3‐Loop Binding Site on hFSH/hCG by Using Highly Constrained Multicyclic Peptides

J. Benschop, J. V. van Maarseveen, H. Hiemstra, 2015, Chembiochem : a European journal of chemical biology.

Enantioselective Synthesis of Hydroxy‐Substituted DBN‐Type Amidines as Potential Chiral Catalysts

F. Rutjes, H. Hiemstra, M. Ostendorf, 2000 .

Enantioselective Synthesis of Hydroxy-Substituted DBN-Type Amidines as Potential Chiral Catalysts.

F. Rutjes, H. Hiemstra, M. Ostendorf, 2000 .

Asymmetric Synthesis ‒ The Essentials. Edited by Mathias Christmann and Stefan Bräse

H. Hiemstra, 2007 .

Xanthate transfer addition of a glycine radical equivalent to alkenes; a novel route to a-amino acid derivates.

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Synthesis of the Dibenzofuran‐Based Diphosphine Ligand BIFAP and Its Water‐Soluble Derivative BIFAPS and Their Use in Ruthenium‐Catalyzed Asymmetric Hydrogenation.[≠]

A. Spek, H. Hiemstra, H. Kooijman, 1999 .

Unequivocal determination of complex molecular structures using anisotropic NMR measurements

Josep Saurí, R Thomas Williamson, Gary E Martin, 2017, Science.

Resolution of methyl cis-3-chloromethyl-2-tetrahydrofurancarboxylate via enzymatic hydrolysis

H. Schoemaker, B. Kaptein, K. Goubitz, 1993 .

Synthesis of bicyclic 3-pyrazolidinones via p-cyclization reactions of exocyclic N-acylhydrazonium ions

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Backbone amide linker strategy for the synthesis of 1,4-triazole-containing cyclic tetra- and pentapeptides

J. Geenevasen, Sandrine Calvet-Vitale, H. Hiemstra, 2008 .

Synthesis of bridged bicyclic hydrazines via cyclic N-acylhydrazonium intermediates

F. Rutjes, H. Hiemstra, W. Speckamp, 1991 .

Synthesis of enantiopure (nor-)azatropanes viaN-acylhydrazonium ion intermediates

H. Hiemstra, W. Speckamp, N. Teerhuis, 1997 .

Cyclic 1,2-Dinitrogen Compounds through N,N'-Di(Methoxycarbonyl)Hydrazinium Intermediates

F. Rutjes, H. Mooiweer, H. Hiemstra, 1988 .

Studies on the role of the 2-oxonia Cope rearrangement in pi-cyclizations of alpha-methoxycarbonyl oxycarbenium ions

H. Hiemstra, W. Speckamp, C. Semeijn, 1994 .

Toward Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving

J. McAlpine, Shao-Nong Chen, G. Pauli, 2016, The Journal of organic chemistry.

Preparation of γ oxo-α-amino acids from silyl enol ethers and glycine cation equivalents; a facile synthesis of (±)-5-hydroxy.4.Oxonorvaline (HON)

H. Mooiweer, H. Hiemstra, W. Speckamp, 1990 .

Preparation of Cyclic Alpha-Hydrazino Acids through N-Acylhydrazonium Intermediates

F. Rutjes, H. Hiemstra, W. Speckamp, 1992 .

Synthesis of Enantiopure (Nor-)Azatropanes via N-Acylhydrazonium Ion Intermediates.

H. Hiemstra, W. Speckamp, N. Teerhuis, 1997 .

Cyclic 1,2-Dinitrogen Compounds Through N,N′-Di(methoxycarbonyl)hydrazinium Intermediates.

F. Rutjes, H. Mooiweer, H. Hiemstra, 1989 .

Xanthate Transfer Cyclisation of Glycine Radicals; Synthesis of 5- and 6-Membered Ring Nitrogen Heterocycles

H. Hiemstra, W. Speckamp, J. H. Udding, 2010 .

Synthesis of a Naturally Occurring Diene‐Containing Amino Acid and Its Glutamyl Dipeptide via N‐Acyliminium Ion Chemistry

H. Schoemaker, T. Sonke, H. Hiemstra, 2008 .

Copper-catalyzed N-acyliminium ion cyclization to 3-azabicyclo(3.3.1) nonanes; synthesis of 2,4-distributed 1-aza-adamantanes

H. Hiemstra, W. Speckamp, J. H. Udding, 1994 .

Models of folate coenzymes—VIII : An approach to yohimbane alkaloids via carbon-fragment transfer from N5, N10-methylenetetrahydrofolate models

H. Hiemstra, U. Pandit, M. Wijnberg, 1983 .

Carbon Transfer via N5, N1 0-Methylenetetrahydrofolate Models

H. Hiemstra, U. Pandit, H. Bieräugel, 1979 .

Regioselective synthesis of (±)-gabaculine

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1986 .

Transfer of functionalized carbon fragments via substituted 5, 10-methylentetetrahydrofolate models.

H. Hiemstra, U. Pandit, H. Bieräugel, 1982 .

A Two Synthon Approach to D15,17,19-Yohimbane Skeleton via a N5,N10-Methylenetetrahydrofolate Model. A Facile Route to b-Carboline Alkaloids

H. Hiemstra, U. Pandit, H. Bieräugel, 1981 .

A NOVEL ACID STABLE/BASE LABILE CARBAMATE LINKER FOR N-ACYLIMINIUM ION REACTIONS ON SOLID SUPPORT

F. Rutjes, H. Hiemstra, J. Maarseveen, 1999 .

Synthesis of γ,δ-unsaturated α-methyl-α-amino acids via coupling of allylsilanes with an α-methylglycine cation equivalent

H. Schoemaker, B. Kaptein, J. Kamphuis, 1992 .

Synthesis of the cyclobutanone core of solanoeclepin . A via intramolecular allene butenolide photocycloaddition

H. Schenk, K. Goubitz, H. Hiemstra, 2004 .

Synthetic studies toward gelsemine. 2. Preparation of the tetracyclic skeletal part by way of a highly stereospecific intramolecular reaction of a silyl enol ether with an N-acyliminium ion

H. Hiemstra, W. Speckamp, R. Vijn, 1988 .

Allyldimethylsilyl triflate: a self catalyzed silyl nucleophile

M. Brook, H. Hiemstra, G. R. Crowe, 1994 .

Synthesis of .alpha.-substituted .alpha.-amino acids via cationic intermediates

H. Schoemaker, B. Kaptein, M. Brook, 1993 .

Formation of bicyclic pyrroles and furans through an enone allene photocycloaddition and fragmentation sequence

J. V. van Maarseveen, R. Gelder, H. Hiemstra, 2008 .

Chirality preservation in pyrrolinone iron tetracarbonyl complexes – a route to enantiopure 5-substituted pyrrolinones

H. Hiemstra, W. Speckamp, J. Hopman, 1995 .

Palladium(0)-catalyzed coupling reactions of an N-tosylpyrrolidinone-derived enamine triflate

F. Rutjes, H. Hiemstra, W. Speckamp, 1996 .

Enantioselective synthesis of the tetracyclic left-hand substructure of solanoeclepin A

F. Rutjes, K. Goubitz, H. Hiemstra, 2000 .

Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation.

J. V. van Maarseveen, H. Hiemstra, P. Timmerman, 2012, Organic letters.

Tomato-produced 7-epizingiberene and R-curcumene act as repellents to whiteflies.

S. Schütz, M. Haring, M. Sabelis, 2011, Phytochemistry.

Synthesis of D‐(+)‐Biotin through Selective Ring Closure of N‐Acyliminium Silyl Enol Ethers

H. Hiemstra, W. Speckamp, E. Poetsch, 1995 .

Ring‐Closing Metathesis on Solid Support: Elaboration of a Cyclization/Cleavage Strategy Towards Unsaturated α‐Ester‐Substituted N‐Heterocycles

G. M. Visser, H. Schoemaker, F. Rutjes, 1998 .

Enantioselective synthesis of a key tricyclic intermediateen route to (+)-gelsemine

J. Cintrat, H. Hiemstra, W. Speckamp, 1999 .

Tin Tetrachloride‐Induced π‐Cyclizations of Glycine Cation Equivalents to Substituted Pipecolic Acid Derivatives.

H. Hiemstra, W. Speckamp, P. Esch, 1991 .

Synthesis of strained cyclic peptides via an aza-Michael-acyl-transfer reaction cascade.

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2012, Chemical Communications.

Synthesis of Strained Cyclic Peptides via an Aza‐Michael—Acyl‐Transfer Reaction Cascade.

S. Ingemann, H. Hiemstra, J. Maarseveen, 2012 .

Improved Auxiliary for the Synthesis of Medium-Sized Bis(lactams)

S. Ingemann, H. Hiemstra, T. P. Jansen, 2008 .

Carbosilane dendrimeric carbodiimides: site isolation as a lactamization tool.

J. Reek, J. V. van Esch, J. V. van Maarseveen, 2006, The Journal of organic chemistry.

Studies Toward the Total Synthesis of the Oxindole Alkaloid Gelsedine: An Efficient Allene‐Terminated N‐Acyliminium Ion Cyclization.

H. Hiemstra, W. R. B. V. Henegouwen, 1998 .

Enantioselective Approach to the Right‐Hand Substructure of Solanoeclepin A

R. Gelder, H. Hiemstra, J. Smits, 2016 .

Studies towards the total synthesis of solanoeclepin A: synthesis and potato cyst nematode hatching activity of analogues containing the tetracyclic left-hand substructureElectronic supplementary information (ESI) available: further experimental details. See http://www.rsc.org/suppdata/p1/b2/b202020

F. Rutjes, S. Wallner, H. Hiemstra, 2002 .

Synthesis of the right-hand substructure of solanoeclepin A

H. Hiemstra, R. Blaauw, J. Benningshof, 2001 .

Highly diastereoselective synthesis of β-amino alcohols

Wim J. N. Meester, F. Rutjes, H. Hiemstra, 2001 .

Synthetic studies toward taxanes. A sulfur based approach to the benzilic acid rearrangement

B. Trost, H. Hiemstra, 1986 .

(R)‐1‐Acetyl‐5‐isopropoxy‐3‐pyrrolin‐2‐one: A Versatile Chiral Dienophile from (S)‐Malic Acid.

H. Hiemstra, W. Speckamp, W. Koot, 1992 .

(R)-1-Acetyl-5-isopropoxy-3-pyrrolin-2-one: a versatile chiral dienophile from (S)-malic acid

H. Hiemstra, W. Speckamp, W. Koot, 1992 .

General and Facile Route to Isomerically Pure Tricyclic Peptides Based on Templated Tandem CLIPS/CuAAC Cyclizations.

J. V. van Maarseveen, H. Hiemstra, P. Timmerman, 2018, Angewandte Chemie.

Synthesis and resolution of BICOL, a carbazole analogue of BINOL

H. Schenk, K. Goubitz, H. Hiemstra, 2002 .

Synthesis and Resolution of BICOL, a Carbazole Analogue of BINOL.

K. Goubitz, H. Hiemstra, J. Fraanje, 2002 .

Synthesis of Racemic α-Amino Carboxamides via Lewis Acid- Mediated Reactions of α-Methoxyglycinamide Derivatives with Allylsilanes: Enzymatic Resolution to Optically Active α-Amino Acids.

B. Kaptein, H. Mooiweer, J. Kamphuis, 1993 .

Catalytic asymmetric Pictet-Spengler reactions via sulfenyliminium ions.

J. V. van Maarseveen, Richard N S van der Haas, H. Hiemstra, 2007, Angewandte Chemie.

Selective enrichment of azide-containing peptides from complex mixtures.

C. D. de Koster, C. Bertozzi, L. de Jong, 2009, Journal of proteome research.

Enantioselective Organocatalytic Thiol Addition to α,β-Unsaturated α-Amino Acid Derivatives

J. V. van Maarseveen, S. Ingemann, H. Hiemstra, 2012, Synlett.

Silicon-assisted synthesis of bridged azabicyclic systems via N-acyliminium intermediates

H. Hiemstra, W. Speckamp, Wim J. Klaver, 1988 .

Diastereoselective Synthesis of Medium‐Sized Lactones by Cu(bpy)Cl Catalyzed Cyclization of Trichloroacetates.

H. Hiemstra, W. N. Speckamp, F. Pirrung, 1994 .

Glyoxylates as Versatile Building Blocks for the Synthesis of α-Amino Acid and α-Alkoxy Acid Derivatives via Cationic Intermediates

Wim J. N. Meester, H. Schoemaker, F. Rutjes, 2003 .

Highly Enantioselective Synthesis of a 2,3-Dihydroindole Mediated by N-Methylephedrine

H. Hiemstra, W. Speckamp, R. Vijn, 1984 .

Palladium-Catalyzed Reactions with TVjA^-diallyloxycarbonylhydrazines

H. Hiemstra, W. Speckamp, M. Paz, 2019 .

Enantioselective syntheses of corynanthe alkaloids by chiral Brønsted acid and palladium catalysis.

J. V. van Maarseveen, H. Hiemstra, M. Wanner, 2011, Chemistry.

Total synthesis of (+)-yohimbine via an enantioselective organocatalytic Pictet-Spengler reaction.

Jan H van Maarseveen, Bart Herlé, Martin J Wanner, 2011, The Journal of organic chemistry.

Total Synthesis of (+)-Gelsedine.

F. Rutjes, H. Hiemstra, Winfred G. Beyersbergen van Henegouwen, 1999, Angewandte Chemie.