C. Milligan

发表

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

J. Clemente, R. DesJarlais, Robyn Miller, 2011, Protein science : a publication of the Protein Society.

Identification and biological evaluation of thiazole-based inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2018, Bioorganic & medicinal chemistry letters.

Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.

Christopher F Stratton, R. DesJarlais, J. Spurlino, 2022, Journal of medicinal chemistry.

6-Substituted quinolines as RORγt inverse agonists.

J. Edwards, J. Spurlino, M. Cummings, 2017, Bioorganic & medicinal chemistry letters.

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2020, Bioorganic & medicinal chemistry letters.

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.

J. Spurlino, C. Page, V. Boswell-Smith, 2008, Bioorganic & medicinal chemistry letters.

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.

J. Edwards, J. Spurlino, M. Cummings, 2017, Bioorganic & medicinal chemistry letters.

Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.

R. DesJarlais, B. Grasberger, C. Schubert, 2006, Archives of biochemistry and biophysics.

Hit-to-Lead Optimization and Discovery of a Potent, and Orally Bioavailable G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor.

R. DesJarlais, J. Spurlino, Zhijie Liu, 2020, Bioorganic & medicinal chemistry letters.

The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.

P. Connolly, Shu-chen Lin, M. McDonnell, 2020, Bioorganic & medicinal chemistry letters.

The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).

P. Connolly, Sui-Po Zhang, C. M. Flores, 2020, Bioorganic & medicinal chemistry letters.

Structural determination of estrogen-related receptor γ in the presence of phenol derivative compounds

J. Spurlino, H. Askari, A. Klinger, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

K. Rhodes, J. Spurlino, L. Kuo, 2017, The Journal of Biological Chemistry.

Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

John J. M. Wiener, Jennifer D. Venable, Jianmei Wei, 2022, Journal of medicinal chemistry.

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.

J. Spurlino, C. Page, B. Tounge, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

K. Rhodes, J. Spurlino, L. Kuo, 2017, The Journal of Biological Chemistry.