D. Spiegel

发表

An oligomer-based approach to skeletal diversity in small-molecule synthesis.

Jeremy R. Duvall, S. Schreiber, F. Schroeder, 2006, Journal of the American Chemical Society.

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

A. Krieger, J. Bavaria, R. Levy, 2020, bioRxiv.

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

A. Krieger, J. Bavaria, R. Levy, 2020, JACC. Basic to translational science.

Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease.

Christopher G. Parker, Andrew X. Zhang, P. McEnaney, 2012, ACS chemical biology.

Serendipitous discovery of two highly selective inhibitors of bacterial luciferase

D. Spiegel, Tae-Hee Kim, 2013 .

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.

G. Shulman, G. Cline, Dongyan Zhang, 2013, Cell metabolism.

Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties.

A. Krieger, R. Levy, H. Takano, 2021, Acta biomaterialia.

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

A. Krieger, R. Levy, H. Takano, 2020, bioRxiv.

Click-coated, heparinized, decellularized vascular grafts.

L. Niklason, R. Linhardt, C. Cai, 2015, Acta biomaterialia.

One‐Step Synthesis of 2,5‐Diaminoimidazoles and Total Synthesis of Methylglyoxal‐Derived Imidazolium Crosslink (MODIC)

D. Spiegel, Matthew D. Streeter, V. Sabbasani, 2019, Angewandte Chemie.

One‐Step Synthesis of 2,5‐Diaminoimidazoles and Total Synthesis of Methylglyoxal‐Derived Imidazolium Crosslink (MODIC)

D. Spiegel, Matthew D. Streeter, V. Sabbasani, 2019, Angewandte Chemie.

Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis

A. Cho, Rendy Kartika, D. Spiegel, 2016, Chemical science.

Encoded Silicon-Chip-Based Platform for Combinatorial Synthesis and Screening.

D. Spiegel, J. Vastl, Tina Wang, 2017, ACS combinatorial science.

A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules.

W. L. Jorgensen, J. Michel, J. Lubkowski, 2010, Journal of the American Chemical Society.

A "turn-on" fluorescent sensor for methylglyoxal.

D. Spiegel, K. Fitzgerald, Eugene Douglass, 2013, Journal of the American Chemical Society.

Combined Methylglyoxal Scavenger and Collagen Hydrogel Therapy Prevents Adverse Remodeling and Improves Cardiac Function Post‐Myocardial Infarction

E. Suuronen, Veronika Sedláková, E. Alarcon, 2021, Advanced Functional Materials.

The unique reactivity of N-phenacyl-derived thiazolium salts toward α-dicarbonyl compounds.

D. Spiegel, Taehan Kim, 2013, Rejuvenation research.

Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells.

P. Maher, A. Dafre, D. Spiegel, 2015, Free radical biology & medicine.

A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.

Paul J Thornalley, S. Rowan, N. Waheed, 2020, Free radical biology & medicine.

Exploring post-translational arginine modification using chemically synthesized methylglyoxal hydroimidazolones.

Rendy Kartika, D. Spiegel, Tina Wang, 2012, Journal of the American Chemical Society.

Toward the synthesis of phomoidride D.

Aaron A. Bedermann, Graham K. Murphy, Barry M. Twenter, 2013, The Journal of organic chemistry.

Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue.

Jason D. Ray, S. Rowan, Jonathan Clark, 2020, ACS chemical biology.

An Activity-Based Probe for Studying Crosslinking in Live Bacteria.

Sounok Sen, M. G. Pinho, S. Gautam, 2015, Angewandte Chemie.

Chemical probes reveal an extraseptal mode of cross-linking in Staphylococcus aureus.

S. Gautam, D. Spiegel, Taehan Kim, 2015, Journal of the American Chemical Society.

A dual role for CRTH2 in acute lung injury

G. Chupp, S. Gautam, D. Spiegel, 2022 .

A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules.

Alexander G Chamessian, B. Kazmierczak, P. McEnaney, 2010, ACS chemical biology.

An antibody-recruiting small molecule that targets HIV gp120.

Robert A. Domaoal, K. Anderson, Christopher G. Parker, 2009, Journal of the American Chemical Society.

Bifunctional small molecules that mediate the degradation of extracellular proteins

Jason D. Ray, E. Chirkin, Mengwen Zhang, 2020, Nature Chemical Biology.

Total Synthesis of (±)-Phomoidride D.

Aaron A. Bedermann, Joyce C. Leung, Graham K. Murphy, 2018, Angewandte Chemie.

Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides.

Aaron A. Bedermann, Graham K. Murphy, Barry M. Twenter, 2012, Organic letters.

CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C - H insertion

J. T. Njardarson, J. L. Wood, D. Spiegel, 2002 .

An expeditious approach toward the total synthesis of CP-263,114.

I. Mcdonald, J. T. Njardarson, J. L. Wood, 2001, Organic letters.

Deoxygenation of alcohols employing water as the hydrogen atom source.

J. L. Wood, D. Spiegel, M. R. Medeiros, 2005, Journal of the American Chemical Society.

Neutralization of Pathogenic Fungi with Small-Molecule Immunotherapeutics.

T. Roemer, E. Chirkin, P. Nantermet, 2017, Angewandte Chemie.

A comprehensive mathematical model for three-body binding equilibria.

Chad J. Miller, Eugene F Douglass, David A Spiegel, 2013, Journal of the American Chemical Society.

A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2‐Positive Breast Cancer Cells

R. Tao, Brian R. McNaughton, D. Spiegel, 2016, Chembiochem : a European journal of chemical biology.

Sirtuin 2 Regulates Protein LactoylLys Modifications

Jason D. Ray, J. Galligan, E. Chapman, 2021, Chembiochem : a European journal of chemical biology.

Pentosinane, a Post-Translational Modification of Human Proteins with Underappreciated Stability.

D. Spiegel, Matthew D. Streeter, Yannan Liu, 2022, Journal of the American Chemical Society.

Fluorescent stem peptide mimics: In situ probes for peptidoglycan crosslinking.

S. Gautam, D. Spiegel, Taehan Kim, 2020, Methods in enzymology.

Expanding the scope of trialkylborane/water-mediated radical reactions.

J. L. Wood, D. Spiegel, M. R. Medeiros, 2007, Organic letters.

The art of innovation in organic chemistry: synthetic efforts toward the phomoidrides.

I. Mcdonald, J. T. Njardarson, J. L. Wood, 2003, Chemical reviews.

Vibrational assignments and a potential function for 3,3-difluorocyclopropene-d0, -d1, and -d2

N. Craig, D. Spiegel, R. A. MacPhail, 1978 .

Exterior design: strategies for redecorating the bacterial surface with small molecules.

S. Gautam, T. Gniadek, D. Spiegel, 2013, Trends in biotechnology.

Glyoxalase Goes Green: The Expanding Roles of Glyoxalase in Plants

S. Sankaranarayanan, M. Samuel, D. Spiegel, 2017, International journal of molecular sciences.

Concise total synthesis of glucosepane

C. Drăghici, D. Spiegel, Tina Wang, 2015, Science.

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

N. Smargiasso, D. Baiwir, P. Delvenne, 2016, eLife.

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

H. Zischka, T. Misgeld, T. Korn, 2020, Nature Immunology.

Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus.

S. Gautam, D. Spiegel, E. Lester, 2016, ACS chemical biology.

Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules.

Markus K. Dahlgren, Robert A. Domaoal, W. L. Jorgensen, 2014, Chemical science.

Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor.

Min Liu, C. Yuan, Mingdong Huang, 2016, Angewandte Chemie.

Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies

Weifang Shan, A. Balog, Andrew X. Zhang, 2014, Journal of the American Chemical Society.

A chemically induced vaccine strategy for prostate cancer.

P. Schultz, A. Dubrovska, C. Cho, 2011, ACS chemical biology.

Chemical control over immune recognition: a class of antibody-recruiting small molecules that target prostate cancer.

W. L. Jorgensen, J. Michel, Andrew X. Zhang, 2009, Journal of the American Chemical Society.

Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators.

Christopher G. Parker, R. Tao, M. Kolesnikova, 2013, ACS chemical biology.

Reprogramming urokinase into an antibody-recruiting anticancer agent.

Andrew X. Zhang, P. McEnaney, D. Spiegel, 2012, ACS chemical biology.

A synthetic rhamnose glycopolymer cell surface receptor for endogenous antibody recruitment.

S. van Calenbergh, L. Albertazzi, B. D. De Geest, 2019, Biomacromolecules.

Classically activated mouse macrophages produce methylglyoxal that induces a TLR4‐ and RAGE‐independent proinflammatory response

K. D. Collins, S. Vogel, D. Spiegel, 2020, Journal of leukocyte biology.

Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

J. Bellier, V. Castronovo, J. Cochrane, 2017, Scientific Reports.

Chapter 4 Pushing the Bacterial Envelope Strategies for Re-Engineering Bacterial Surfaces with Heterologous Proteins and Sugars

Samir Gautam, David Spiegel, S. Gautam, 2014, Micro- and Nanoengineering of the Cell Surface.

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

Kristie L. Rose, L. Marnett, J. Galligan, 2018, Proceedings of the National Academy of Sciences.

Generation and characterization of antibodies against arginine-derived advanced glycation endproducts.

D. Spiegel, Matthew D. Streeter, Tina Wang, 2015, Bioorganic & medicinal chemistry letters.

Biocatalytic Reversal of Advanced Glycation End Product Modification

J. Crawford, D. Spiegel, S. Sohn, 2019, Chembiochem : a European journal of chemical biology.

A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate In Vivo efficacy in Three Distinct Animal Models

Matthew E. Welsch, D. Spiegel, Christian M. Vidal, 2019, Blood.

Comment on a suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands

D. Spiegel, Eugene Douglass, 2021, The Journal of biological chemistry.

Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.

James R. Roede, J. Galligan, M. Johannsen, 2019, Cell chemical biology.

Grand challenge commentary: Synthetic immunology to engineer human immunity.

David A Spiegel, D. Spiegel, 2010, Nature chemical biology.

Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro‐ and Nanopatterned Surfaces

David J Mooney, Eric Stern, Tadeusz Malinski, 2009, Advanced functional materials.

M. Stammers, A. Segonds-Pichon, I. Niewczas, 2020, The Journal of Biological Chemistry.

A call to ARMs: the promise of immunomodulatory small molecules

D. Spiegel, 2013, Expert review of clinical pharmacology.

RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm

J. Bavaria, R. Assoian, H. Takayama, 2021 .

A Slick Solution to a Sticky Problem.

Lokesh Sharma, Charles S Dela Cruz, Samir Gautam, 2018, Biochemistry.