K. Nakai

发表

A small molecule that binds Hedgehog and blocks its signaling in human cells

Stuart L. Schreiber, S. Schreiber, Sam W. Lee, 2009, Nature chemical biology.

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

K. Nakai, Ayako Moritomo, Takayuki Inoue, 2018, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of C-Aromataxane Derivatives as P-Glycoprotein-Mediated Multi Drug Resistance Reversal Agents

T. Ishikawa, H. Nakagawa, T. Doi, 2015 .

Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.

A. Tanaka, K. Nakai, Ayako Moritomo, 2015, Bioorganic & medicinal chemistry.

Syn-SN2′ Pathway in the Reaction of Certain γ-(Mesyloxy) α, β-Enoates with RCu(CN)MgX×BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity.

H. Tamamura, N. Fujii, T. Taga, 1993 .

Value-added olefin-based materials originating from FI catalysis: Production of vinyl- and Al-terminated PEs, end-functionalized PEs, and PE/polyethylene glycol hybrid materials

H. Terao, K. Nakai, K. Matoishi, 2011 .

Preparation and Characteristics of Well-defined Polyethylene/Poly(ethylene glycol) Hybrid Materials of Different Molecular Architectures

K. Nakai, K. Matoishi, T. Fujita, 2010 .

Unprecedented rearrangement reaction of 2-aziridinemethanols with “lower order” lithium methylcyanocuprate

F. Garrido, A. Mann, N. Fujii, 1993 .

A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-Vinylaziridines over Their 2,3-Trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosteres

Y. Miwa, H. Tamamura, N. Fujii, 1997 .

Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an alpha,beta-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers.

Y. Miwa, H. Tamamura, N. Fujii, 1997, The Journal of organic chemistry.

A thermodynamic preference of chiral cis-γ,δ-epimino-(E)-α,β-unsaturated esters over other stereoisomers: Synthetically useful Pd(0)-catalyzed equilibrated reactions of aziridines bearing an α,β-unsaturated ester group

H. Tamamura, N. Fujii, Yoshinori Yamamoto, 1996 .

Synthesis of optically pure 2-aziridinemethanols: versatile synthetic building blocks

A. Otaka, H. Tamamura, N. Fujii, 1994 .

A Novel Route to Diastereomerically Pure (E)-Alkene Dipeptide Isosteres from β-Aziridinyl-α,β-enoates by Treatment with Organocopper Reagents†‡

Y. Miwa, N. Fujii, T. Taga, 1994 .

AZA-PAYNE REARRANGEMENT OF ACTIVATED 2-AZIRIDINEMETHANOLS AND 2,3-EPOXY AMINES UNDER BASIC CONDITIONS

A. Otaka, Y. Miwa, H. Tamamura, 1995 .

SN2′ Ring opening of aziridines bearing an α,β-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres

A. Otaka, Y. Miwa, H. Tamamura, 1995 .

A formal total synthesis of taxol aided by an automated synthesizer.

T. Doi, Takashi Takahashi, Shinichiro Fuse, 2006, Chemistry, an Asian journal.

An aza-Payne rearrangement-epoxide ring opening reaction of 2-aziridinemethanols in a one-pot manner: A regio- and stereoselective synthetic route to diastereomerically pure N-protected 1,2-amino alcohols

H. Tamamura, N. Fujii, Yoshinori Yamamoto, 1996 .

A one-pot aza-Payne rearrangement-epoxide ring opening reaction of 2-aziridinemethanols: A regio- and stereoselective synthetic route to diastereomerically pure 1,2-amino alcohols

A. Otaka, H. Tamamura, N. Fujii, 1995 .

Remarkable difference in reactivity of ordinary vinylcopper reagents and vinylzinc halide containing a copper salt towards γ-mesyloxy-α, β-enoates. Synthesis of homochiral 1,4-dienes

N. Fujii, Yoshinori Yamamoto, K. Nakai, 1993 .

Simple one-pot transformations of toluene-p-sulfonates of 2,3-epoxy alcohols into allylic alcohols

H. Tamamura, N. Fujii, M. Fujiwara, 1996 .

SN2′ selective alkylation of allylic chlorides and mesylates with RZnX reagents generated from Grignard reagents, zinc chloride, lithium chloride, and Cu(II)-salts

F. Garrido, A. Mann, N. Fujii, 1993 .

Syn‐SN2′ Pathway in the Reaction of Certain γ‐(Mesyloxy) α, β‐Enoates with RCu(CN)MgX×BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity.

H. Tamamura, N. Fujii, T. Taga, 1993 .

An unusual thermodynamic preference of chiral N-arylsulfonyl cis-3-alkyl-2-vinylaziridines over their trans-isomers: palladium(0)-catalysed equilibration reactions

Y. Miwa, H. Tamamura, N. Fujii, 1996 .

[Controlling signal transduction with synthetic ligands].

K. Nakai, Kazuo Nakai, 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer.

T. Ishikawa, H. Nakagawa, T. Doi, 2005, Bioorganic & medicinal chemistry letters.

Ukraine: Dilemma and Difficulties of Building a Nation-State

K. Nakai, 1997 .

Involvement of cholinergic processes in cholecystokinin (CCK) release by luminal oleic acid

K. Nakai, S. Kanai, A. Funakoshi, 1997 .

Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel

T. Doi, Takashi Takahashi, K. Nakai, 2001 .

ChemInform Abstract: Stereo- and Regio-selective Ti-Mediated Radical Cyclization of Epoxy-Alkenes: Synthesis of the A and C Ring Synthons of Paclitaxel.

T. Doi, Takashi Takahashi, K. Nakai, 2002 .

The synthesis of the CD ring of paclitaxel

T. Doi, Takashi Takahashi, K. Nakai, 2001 .