K. Cheung

发表

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

L. Pearl, X. Barril, M. Drysdale, 2008, Cancer research.

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Paul Workman, Edward McDonald, Chrisostomos Prodromou, 2005, Bioorganic & medicinal chemistry letters.

Approaches to a cathodic route to polypyrrolylvinylenest

J. Utley, K. Cheung, F. R. Ahmed, 1995 .

5-Amino-6-hydroxy-3,4,5,6-tetrahydropyran-2-one (HAT) : a stable, cyclic form of glutamate 1-semialdehyde, the natural precursor for tetrapyrroles

M. Warren, P. Jordan, K. Cheung, 1993 .

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).

S. Robinson, R. V. van Montfort, M. Lamers, 2016, Journal of medicinal chemistry.

5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism.

J. Cooper, M. Sarwar, K. Cheung, 2001, Biochemical Society transactions.

A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition

J. Reynisson, K. Cheung, E. McDonald, 2010 .

Synthesis of 3-amino-3-vinylpropanoic acid and its conversion to 4-amino-5-hydroxy-4,5-dihydrofuran-2-one hydrochloride (HAD), a cyclic stabilised form of aspartate 1-semialdehyde hydrochloride

K. Cheung, P. Shoolingin‐Jordan, 1997 .

Synthesis of 4-(cyclic dialkylamino)-7-azaindoles by microwave heating of 4-halo-7-azaindoles and cyclic secondary amines

J. Caldwell, I. Collins, K. Cheung, 2007 .

Synthesis of 4‐(Cyclic dialkylamino)‐7‐azaindoles by Microwave Heating of 4‐Halo‐7‐azaindoles and Cyclic Secondary Amines.

J. Caldwell, I. Collins, K. Cheung, 2007 .

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)†

G. Aherne, M. Garrett, L. Hunter, 2010, Journal of medicinal chemistry.

Facile Chemical Syntheses of Porphobilinogen Analogues: A Four-Step Synthesis of iso-Porphobilinogen

K. Cheung, P. Shoolingin‐Jordan, 2001 .

The determination of the absolute configurations of diastereomers of (S)-camphanoyl 3-hydroxy-5-oxohexanoic acid derivatives by X-ray crystallography.

S. Coles, M. Hursthouse, K. Cheung, 2002, Angewandte Chemie.

Selective cleavage of Boc-acylamides. A novel approach to deacylation of carboxamides

U. Ragnarsson, J. Utley, K. Cheung, 1987 .

Indirect electrochemical reduction of meso- and d,l-1,2-dichloro-1,2-diphenylethane

J. Utley, T. Lund, S. Pedersen, 1987 .

4.04 – Biosynthesis of Heme

K. Cheung, Peter M. Shooling-Jordan, Kwai-Ming Cheung, 1999 .

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

L. Pearl, P. Workman, R. Marais, 2007, Cancer research.

Identification of inhibitors of checkpoint kinase 1 through template screening.

Ian Collins, Samantha Burns, David Williams, 2009, Journal of medicinal chemistry.

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Isaac M. Westwood, Julian Blagg, Florence I. Raynaud, 2013, Journal of medicinal chemistry.

A fluorescence polarization assay for inhibitors of Hsp90.

X. Barril, M. Drysdale, P. Workman, 2006, Analytical biochemistry.

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

L. Pearl, X. Barril, M. Drysdale, 2007, Molecular Cancer Therapeutics.

Characterization of a recombinant pea 5-aminolevulinic acid dehydratase and comparative inhibition studies with the Escherichia coli dehydratase.

M. Timko, K. Cheung, P. Spencer, 1997, Biochemistry.