E. McDonald

发表

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis.

M. Webb, R. Dolle, T. Guo, 2004, Bioorganic & medicinal chemistry letters.

A convenient one-pot preparation and applications of high loading benzhydrylamine solid phase linkers

E. McDonald, J. Large, Jane E. Torr, 2007 .

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

L. Pearl, X. Barril, M. Drysdale, 2008, Cancer research.

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Paul Workman, Edward McDonald, Chrisostomos Prodromou, 2005, Bioorganic & medicinal chemistry letters.

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.

Xavier Barril, Paul Workman, Roderick E Hubbard, 2005, Journal of medicinal chemistry.

The identification of novel PLC-gamma inhibitors using virtual high throughput screening.

P. Workman, C. O'Neill, S. Eccles, 2009, Bioorganic & medicinal chemistry.

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Nathan Brown, Julian Blagg, Paul Workman, 2018, Molecular oncology.

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

P. Workman, F. Chan, R. T. te Poele, 2007, Molecular Cancer Therapeutics.

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.

S. Bevan, H. Gstach, Viral Patel, 2009, Bioorganic & medicinal chemistry letters.

Proof by synthesis that unrearranged hydroxymethylbilane is the product from deaminase and the substrate for cosynthetase in the biosynthesis of uro'gen-III

C. Fookes, A. Battersby, E. McDonald, 1979 .

Commentary Finding the needle in the haystack: why high-throughput screening is good for your health

P. Workman, G. Aherne, E. McDonald, 2002 .

Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.

P. Workman, A. Faisal, R. Bayliss, 2010, Journal of medicinal chemistry.

Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.

P. Workman, Chongbo Sun, J. Reynisson, 2007, Bioorganic & medicinal chemistry letters.

Thrombin inhibitors based on [5,5] trans-fused indane lactams.

N. Ramsden, H. Jhoti, H. Finch, 1999, Bioorganic & medicinal chemistry letters.

Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics.

D. Williams, A. Battersby, E. McDonald, 1981, The Biochemical journal.

Molecular profiling and combinatorial activity of CCT068127

M. Noble, P. Workman, S. Whittaker, 2017 .

Microwave-assisted synthesis of 4-amino-3,5-dihalopyridines

J. Blagg, E. McDonald, M. Pichowicz, 2010 .

Biosynthesis of type-III porphyrins: nature of the rearrangement process

A. Battersby, E. McDonald, E. Hunt, 1973 .

MMR201: A novel small molecule that selectively inhibits growth of MLH1 deficient tumor cells

Robert Brown, W. Aherne, V. O’Brien, 2006 .

Synthesis of resorcinylic macrocycles related to radicicol via ring-closing metathesis

P. Workman, E. McDonald, B. Atrash, 2006 .

Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol

P. Workman, E. McDonald, B. Atrash, 2006 .

A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition

J. Reynisson, K. Cheung, E. McDonald, 2010 .

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

J. Chiba, M. Yokoyama, J. Baldwin, 2006, Bioorganic & medicinal chemistry.

Biosynthesis of vitamin B12: experiments on loss of C-20 from the precursor macrocycle

N. Lewis, A. Battersby, E. McDonald, 1979 .

Biosynthesis of the natural porphyrins: experiments on the ring-closure steps and with the hydroxy-analogue of porphobilinogen

C. Fookes, A. Battersby, E. McDonald, 1979 .

Order of assembly of the four pyrrole rings during biosynthesis of the natural porphyrins

C. Fookes, A. Battersby, E. McDonald, 1979 .

Biosynthesis of vitamin B12: proof of A-B structure for sirohydrochlorin by its specific incorporation into cobyrinic acid

A. Battersby, E. McDonald, M. Thompson, 1978 .

Stereochemistry of biosynthesis of the vinyl groups of protoporphyrin-IX: a short synthesis of porphobilinogen

K. James, H. Wurziger, A. Battersby, 1975 .

Discovery and development of pyrazole-scaffold Hsp90 inhibitors.

M. Drysdale, P. Workman, P. Brough, 2006, Current topics in medicinal chemistry.

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

P. Workman, Irina S. Chuckowree, P. Clarke, 2009, Molecular Cancer Therapeutics.

ClTi(OiPr)3-promoted reductive amination on the solid phase: combinatorial synthesis of a biaryl-based sulfonamide library.

E. McDonald, V. Bavetsias, Corey D. Gutierrez, 2008, Journal of combinatorial chemistry.

On the nucleophilic tele-substitution of dichloropyrazines by metallated dithianes

M. Hursthouse, E. McDonald, P. Horton, 2006 .

Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines

E. McDonald, C. Quevedo, V. Bavetsias, 2009 .

A note on the synthesis and biological activity of polyfluorobenzyl pyrethroid esters

E. McDonald, N. Punja, 1986 .

Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements.

P. Workman, P. Clarke, F. Raynaud, 2011, Bioorganic & medicinal chemistry.

Synthesis of unsymmetrical dibenzylketones: new procedures for the preparation and reduction of nitrostyrenes

E. McDonald, R. T. Martin, 1977 .

Syntheses and stereochemistry of 4-hydroxy tetrahydroisoquinolines in the 1-benzyl and 1-phenethyl series. Efficient routes to isopavines and homoisopavines

E. McDonald, P. Mckenna, R. Elliott, 1980 .

Tuning of hydrogen bond strength using substituents on phenol and aniline: A possible ligand design strategy

Jóhannes Reynisson, Edward McDonald, J. Reynisson, 2004, J. Comput. Aided Mol. Des..

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).

P. Workman, G. Aherne, M. Rowlands, 2009, Bioorganic & medicinal chemistry.

Cyclopenta[g]quinazolinone-based inhibitors of thymidylate synthase targeting α-folate receptor overexpressing tumours: synthetic approaches to 4-{N-[(6RS)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

E. McDonald, E. Henderson, V. Bavetsias, 2007 .

Facile generation of a library of 5-aryl-2-arylsulfonyl-1,3-thiazoles

E. McDonald, P. Sheldrake, M. Matteucci, 2006 .

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

G. Hardy, D. Belton, T. Skarzynski, 2001, Bioorganic & medicinal chemistry letters.

TiCl(OiPr)3 and NaBH(OAc)3: an efficient reagent combination for the reductive amination of aldehydes by electron-deficient amines

E. McDonald, V. Bavetsias, Corey D. Gutierrez, 2005 .

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

J. Chiba, M. Yokoyama, J. Baldwin, 2005, Bioorganic & medicinal chemistry letters.

Design of the substrate for oxidative phenol coupling. An efficient synthesis of the C-homoerythrinan skeleton

A. Suksamrarn, E. McDonald, 1978 .

Biosynthesis of porphyrins and related macrocycles. Part 25. Synthesis of analogues of coproporphyrinogen-III and studies of their interaction with coproporphyrinogen-III oxidase from Euglena gracilis

John A. Robinson, A. Battersby, E. McDonald, 1985 .

Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protoporphyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: synthesis of protoporphyrin XIII.

A. Hamilton, A. Battersby, E. McDonald, 1980, Journal of the Chemical Society. Perkin transactions 1.

Origin of the pigments of life: the type-III problem in porphyrin biosynthesis

A. Battersby, E. McDonald, 1979 .

Biosynthesis of type-III porphyrins: proof of intact ezymic conversion of the head-to-tail bilane into uro'gen-III by intramolecular rearrangement

M. Meegan, C. Fookes, A. Battersby, 1978 .

Diels–Alder reactivity of oxygenated dienes and furans. Synthesis of oxygenated biphenyls

A. Suksamrarn, E. McDonald, R. Wylie, 1979 .

Biosynthesis of the pigments of life: formation of the macrocycle

C. Fookes, A. Battersby, E. McDonald, 1980, Nature.

2-Pivalamido-3H-pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO3)3 in MeOH

E. McDonald, E. Henderson, V. Bavetsias, 2004 .

Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.

H. Finch, E. McDonald, C. Mooney, 1999, Bioorganic & medicinal chemistry letters.

Biosynthesis of porphyrins and related macrocycles. IV. Synthesis of isomeric aminomethylpyrromethanes for biosynthetic study.

A. Battersby, E. McDonald, J. F. Beck, 1974, Journal of the Chemical Society. Perkin transactions 1.

Biosynthesis of porphyrins and related macrocycles. I. Synthesis of 14C-labelled pyrromethanes.

K. Gibson, A. Battersby, E. McDonald, 1973, Journal of the Chemical Society. Perkin transactions 1.

Radiation chemical studies with nitrofurazone as related to its mechanism of radiosensitization.

A. P. Reuvers, C. Greenstock, E. McDonald, 1973, Radiation research.

Nucleotide radical oxidation and addition reactions with cellular radiosensitizers.

C. Greenstock, J. Raleigh, E. McDonald, 1973, Biochemical and biophysical research communications.

Chemical screening tests for cellular radiosensitizers--nitrofurans.

C. Greenstock, J. Raleigh, E. McDonald, 1972, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Biosynthesis. Part 28.1,2 Colchicine: definition of intermediates between O-methylandrocymbine and colchicine and studies on speciosine

A. Battersby, E. McDonald, R. Woodhouse, 1998 .

Biosynthesis. Part 28. Colchicine: Definition of Intermediates Between O‐Methylandrocymbine and Colchicine and Studies on Speciosine.

A. Battersby, E. McDonald, R. Woodhouse, 2010 .

Enzymic formation of a tricarboxylic porphyrin and protoporphyrin-XIII from coprogen-IV

A. Battersby, E. McDonald, L. Mombelli, 1976 .

Intermediates in porphyrin biosynthesis: studies with 14C- and 13C-labelled pyrromethanes

K. Gibson, L. Mander, A. Battersby, 1973 .

Inhibitors of HSP90 and other chaperones for the treatment of cancer

M. Drysdale, P. Workman, B. Dymock, 2004 .

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.

A. Faisal, R. Bayliss, Chongbo Sun, 2010, Bioorganic & medicinal chemistry letters.

Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling

P. Workman, Stuart C. Wilson, G. Aherne, 2012, PloS one.

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.

Paul Workman, Peter M Fischer, Wayne Jackson, 2011, Bioorganic & medicinal chemistry.

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

P. Workman, D. Zheleva, D. Blake, 2020, PloS one.

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

Andrew J. Bannister, T. Kouzarides, P. Workman, 2005, Molecular Cancer Therapeutics.

Biosynthesis of vitamin B12: isolation and proof of structure of 3-episirohydrochlorin

A. Battersby, E. McDonald, R. Neier, 1979 .

The structures and chemistrty of isobacteriochlorins from

John A. Robinson, H. Morris, A. Battersby, 1977 .

Biosynthesis of vitamin B12: Structural studies on the corriphryins from and the link with sirohydrochlorin

H. Morris, D. Williams, N. Zaitseva, 1977 .

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.

T. Dale, P. Workman, K. Ewan, 2010, Cancer research.

Identification of Inhibitors of the Kinase Activity of Oncogenic V600EBRAF in an Enzyme Cascade High-Throughput Screen

C. Marshall, P. Workman, S. Whittaker, 2006, Journal of biomolecular screening.

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.

L. Pearl, P. Workman, R. Marais, 2007, Cancer research.

Biosynthesis of porphyries and related macrocycles. Part 18. Proof by spectroscopy and synthesis that unrearranged hydroxymethylbilane is the product from deaminase and the substrate for cosynthetase in the biosynthesis of uroporphyrinogen-III

C. Fookes, A. Battersby, E. McDonald, 1982 .

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

P. Workman, M. Ashcroft, W. Aherne, 2005, Cancer research.

Biosynthesis of porphyrins and related macrocycles. Part 20. Purification of deaminase and studies on its mode of action

C. Fookes, A. Battersby, E. McDonald, 1983 .

Biosynthesis of porphyries and related macrocycles. Part 17. Chemical and enzymic transformation of isomeric aminomethylbilanes into uroporphyrinogens: proof that unrearranged bilane is the preferred enzymic substrate and detection of a transient intermediate

C. Fookes, A. Battersby, E. McDonald, 1982 .

Biosynthesis of porphyrins and related macrocycles. Part 16. Proof that the single intramolecular rearrangement leading to natural porphyrins (type-III) occurs at the tetrapyrrole level

M. Meegan, H. Wurziger, C. Fookes, 1981 .

Biosynthesis of porphyrins and related macrocycles. Part 12. Vitamin B12: studies with 1-methylbilanes

H. Wurziger, A. Battersby, E. McDonald, 1979 .

Biosynthesis of vitamin B12: structure of the trimethylisobacteriochlorin from Propionibacterium shermanii

H. Morris, A. Battersby, E. McDonald, 1979 .

Biosynthesis of vitamin B12: Isobacteriochlorins, the link between corrins and sulphite reductases

A. Battersby, E. McDonald, 1978 .

Biosynthesis of porphyrins and related macrocycles. Part 9. Biosynthesis of the corrin macrocycle of vitamin B12 including the sterochemistry of C-methylation in ring.

B. Golding, M. Ihara, A. Battersby, 1977, Journal of the Chemical Society. Perkin transactions 1.

Biosynthesis of porphyrins and related macrocycles. Part VI. Nature of the rearrangement process leading to the natural type III porphyrins.

A. Battersby, E. McDonald, E. Hunt, 1976, Journal of the Chemical Society. Perkin transactions 1.

Biosynthesis of vitamin B12: derivation of cobyrinic acid from uroporphyrinogen-III

D. Williams, M. Ihara, A. Battersby, 1975 .

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

P. Workman, K. Boxall, W. Aherne, 2007, Molecular Cancer Therapeutics.

Biosynthesis of porphyrins and related macrocycles. Part 14. Studies with [14C]isoporphobilinogen and four isomeric labelled pyrromethanes: specific conversion of the unrearranged pyrromethane NH3.AP.AP into haem and protoporphyrin-IX

K. Gibson, A. Battersby, E. McDonald, 1981 .

Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III. Studies with corresponding ring c methyl heptacarboxylic prophyrinogen, and proof of seven intact methyl transfers.

D. Williams, M. Ihara, A. Battersby, 1977, Journal of the Chemical Society. Perkin transactions 1.

Biosynthesis of porphyrins and related macrocycles. Part VII. Synthesis of specifically labelled (14 C1) uroporphyrin-III and of (10,14-13C2)-uroporphyrin-III. Conversion of the latter into (10,14-13C2)protoporphyrin-ix; Biosynthetic significance of its 13C nuclear magnetic resonance spectrum.

M. Ihara, A. Battersby, E. McDonald, 1976, Journal of the Chemical Society. Perkin transactions 1.

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors

M. Drysdale, P. Workman, Alan T. Henley, 2006, Molecular Cancer Therapeutics.

The contemporary drug development process: advances and challenges in preclinical and clinical development.

Paul Workman, Edward McDonald, Michelle D Garrett, 2003, Progress in cell cycle research.

Biosynthesis. Part 27.1,2 Colchicine: studies of the phenolic oxidative coupling and ring-expansion processes based on incorporation of multiply labelled 1-phenethylisoquinolines

E. W. Underhill, A. Battersby, E. McDonald, 1998 .

Total synthesis of compounds related to the homoerythrina alkaloids

A. Suksamrarn, E. McDonald, 1975 .

Biosynthesis of porphyrins and corrins.

A. Battersby, E. McDonald, 1976, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Oxidative coupling of phenols and phenolic ethers. Part 4. Synthesis of dibenz[d,f]azonines and a dibenz[d,f]azacine, via direct coupling

E. McDonald, R. Wylie, 1980 .

Synthesis of C-homoerysodienone and its conversion into B-homoerysodienone via a dibenz[d,f]azecine; potential precursors of the homoerythrina alkaloids

A. Suksamrarn, E. McDonald, 1978 .

Design of the substrate for oxidative phenol coupling: An efficient dienone synthesis

A. Suksamrarn, E. McDonald, 1975 .

Biosynthesis of schelhammeridine: Mode of specific incorporation of [2-14C]tyrosine

J. Milner, A. Battersby, E. McDonald, 1975 .

Alkaloid biosynthesis. Part XVIII. Biosynthesis of colchicine from the 1-phenethylisoquinoline system

A. Battersby, E. McDonald, J. H. Clements, 1972 .

A fluorescence polarization assay for inhibitors of Hsp90.

X. Barril, M. Drysdale, P. Workman, 2006, Analytical biochemistry.

Biosynthesis of vitamin B12: the macrocycle and studies on the geminal methyl groups of ring c

B. Golding, M. Ihara, A. Battersby, 1973 .

Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer.

Paul Workman, Edward McDonald, P. Workman, 2006, Current topics in medicinal chemistry.

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

L. Pearl, X. Barril, M. Drysdale, 2007, Molecular Cancer Therapeutics.

Abstract #3863: Derivatives of seliciclib with improved potency both in vitro and in vivo as novel cyclin dependent kinase (CDK) inhibitors

P. Workman, D. Zheleva, D. Maccallum, 2009 .

Electrocyclic reactions of protonated chalcones: synthesis of 3-arylindan-1-ones

E. McDonald, Paul A. Smith, 1980 .

Combinatorial Library of Biaryl-Based Sulfonamides

E. McDonald, V. Bavetsias, Corey D. Gutierrez, 2008 .

Chemical and enzymic studies on biosynthesis of the natural porphyrin macrocycle: Formation and role of unrearranged hydroxymethylbilane and order of assembly of the pyrrole rings

C. Fookes, A. Battersby, E. McDonald, 1979 .

Finding the needle in the haystack: why high-throughput screening is good for your health

P. Workman, G. Aherne, E. McDonald, 2002, Breast Cancer Research.

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Ian Collins, Paul Workman, Edward McDonald, 2006, Bioorganic & medicinal chemistry.

Homoaporphine systems and related dienones: isolation, structure, and synthesis

M. Munro, A. Battersby, E. McDonald, 1967 .

322 Novel isoquinoline-5-sulfonamides as biochemical and cellular inhibitors of PKB/AKt

P. Workman, M. Garrett, L. Hunter, 2004 .

Vitamins and cofactors: highlights of ESBOC 2009.

Edward McDonald, E. McDonald, 2009, Nature chemical biology.

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.

T. Dale, P. Workman, K. Ewan, 2010, Cancer research.

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

P. Workman, Irina S. Chuckowree, P. Clarke, 2009, Molecular Cancer Therapeutics.

Facile Generation of a Library of 5-Aryl-2-arylsulfonyl-1,3-thiazoles.

E. McDonald, P. Sheldrake, M. Matteucci, 2006 .

Biosynthesis of porphyrins and related macrocycles. Part II. Synthesis of δ-amino[5-13C]laevulinic acid and [11-13C] porphobilinogen: incorporation of the latter into protoporphyrin-IX

A. Battersby, E. McDonald, E. Hunt, 1973 .

P. Workman, M. Ashcroft, W. Aherne, 2005, Cancer research.

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).

P. Workman, G. Aherne, M. Rowlands, 2009, Bioorganic & medicinal chemistry.