Jin Zhu

发表

Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo.

Jian Li, Xin Chen, Xi Yang, 2020, European journal of medicinal chemistry.

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

S. Peltz, X. Tong, Z. Gu, 2013, Antimicrobial Agents and Chemotherapy.

Repurposing of antitumor drug candidate Quisinostat lead to novel spirocyclic antimalarial agents

Jian Li, Ruoxi Li, Lubing Jiang, 2020 .

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

Hualiang Jiang, Honglin Li, Weiqiang Lu, 2009, Molecules.

Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism

Hualiang Jiang, Weihua Li, Jian Li, 2015, ChemMedChem.

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.

Hualiang Jiang, Xu Shen, Honglin Li, 2012, Bioorganic & medicinal chemistry letters.

Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

Weiqiang Lu, Jin Huang, Q. Xiao, 2016, Scientific Reports.

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

Jian Li, Ruoxi Li, Keting Bao, 2021, Cell Death & Disease.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Z. Gu, C. Espiritu, H. Ren, 2013, Bioorganic & Medicinal Chemistry Letters.

Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.

Hualiang Jiang, Yun Tang, Jin Huang, 2017, Bioorganic & medicinal chemistry.

A strategy enabling enantioselective direct conjugate addition of inert aryl methane nucleophiles to enals with a chiral amine catalyst under mild conditions.

Weiqi Wang, J. Li, Hao Li, 2013, Chemistry.

Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions

Hao Li, Wei Wang, Hexin Xie, 2011, Nature Communications.

Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice

Jian Li, A. Moskalev, Keting Bao, 2021, Oxidative medicine and cellular longevity.

Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.

Hai-bin Luo, Jian Li, Yi-You Huang, 2018, Bioorganic & medicinal chemistry.

Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.

Q. Xiao, Feifei Chen, L. Lan, 2016, Journal of medicinal chemistry.

A highly efficient approach to unnatural amino-acids containing 3-hydroxyoxindole skeleton via a one-pot, three-component procedure

Hualiang Jiang, Fei Mao, Jin Zhu, 2015 .

Curcumin-based polarity fluorescent probes: Design strategy and biological applications

Fei Mao, Jin Zhu, Yuan Guo, 2020, Dyes and Pigments.

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway

Jian Li, Keting Bao, Xiaofan Xu, 2022, Acta pharmaceutica Sinica. B.

1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator.

Hualiang Jiang, Ting Shi, Xu Shen, 2012, Biochemical and biophysical research communications.

Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.

Wei Wang, Wangsheng Li, Jian Li, 2022, European journal of medicinal chemistry.

Direct oxidative conversion of 3-aryl propionaldehydes to 3-aryl acroleins promoted by SOMO catalysis

Wenchao Lu, Jin Zhu, Jing Deng, 2012 .

Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions

Hualiang Jiang, Xu Shen, J. Li, 2010, Molecules.

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Molecules.

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Weiliang Zhu, Jian Li, Honglin Li, 2011, Journal of medicinal chemistry.

Synthesis of 3-substituted 1,5-aldehyde esters via an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals.

Hualiang Jiang, Fei Wang, Wei Wang, 2012, Chemical communications.

A Direct Amine‐Palladium Acetate Cocatalyzed Saegusa Oxidation Reaction of Unmodified Aldehydes to α,β‐Unsaturated Aldehydes

Hualiang Jiang, Jie Liu, Hexin Xie, 2009 .

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Ying Yu, Zhenting Gao, Wenzhong Yan, 2012, Journal of medicinal chemistry.

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

Weiqiang Lu, Jin Huang, Jian Li, 2015 .

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Honglin Li, Jin Huang, Jin Zhu, 2009, Journal of medicinal chemistry.

Synthesis of gamma-Oxo-alpha,beta-dehydro-alpha-amino Acids from N-tert-Butyloxycarbonyl-alpha-Imino Esters and Carbonylmethyl 2-Pyridinylsulfones via an Mannich-Elimination Cascade

Deyan Wu, C. Sheng, Jin Zhu, 2014 .

Direct oxidation of beta-aryl substituted aldehydes to alpha,beta-unsaturated aldehydes promoted by an o-anisidine-Pd(OAc)2 co-catalyst.

Hualiang Jiang, J. Li, Jie Liu, 2009, Chemistry, an Asian journal.

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

L. Lan, Jian Li, Fei Mao, 2020, Medicinal research reviews.

Organocatalytic Enantioselective Friedel- Crafts Reaction of 1-Naphthols with Isatins and an Unexpected Spontaneous Dehydration Process

Deyan Wu, Jin Zhu, Jian Li, 2014 .

Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis.

Jian Li, C. Sheng, Fei Mao, 2018, Bioorganic & medicinal chemistry.

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Yanliang Ren, Jian Wan, Jian Li, 2020, European journal of medicinal chemistry.

Pd-catalyzed cascade Heck-Saegusa: direct synthesis of enals from aryl iodides and allyl alcohol.

Hualiang Jiang, Jie Liu, Wei Wang, 2010, Chemical communications.

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

Jian Li, Fei Mao, Jin Zhu, 2014, Molecules.

Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Ramesh Kakarla, Guangming Chen, Song Huang, 2014, Journal of medicinal chemistry.

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Min Huang, C. Luo, M. Geng, 2017, Journal of medicinal chemistry.

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Bioorganic & medicinal chemistry letters.

Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping.

Zhili Zuo, Weiliang Zhu, Oi Wah Liew, 2012, Journal of medicinal chemistry.

Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.

Luhua Lai, Jianfeng Pei, Jin Huang, 2009, Journal of medicinal chemistry.

Efficient preparation of trans-α,β-unsaturated aldehydes from saturated aldehydes by oxidative enamine catalysis

Deyan Wu, Xinhong Yu, A. Song, 2011 .

Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice

Xu Shen, J. Chen, Jin Ren, 2019, Acta Pharmacologica Sinica.

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

Jian Li, Fei Mao, Jin Zhu, 2017, Journal of medicinal chemistry.

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

Jian Li, Lei Fan, Fei Mao, 2019, Acta pharmaceutica Sinica. B.

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

L. Cui, Jian Li, Jie Cui, 2020, Cell discovery.

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

Yan Ding, L. Cui, J. Li, 2020, Cell Discovery.

Synthesis, Structure–Activity Relationship, and Pharmacophore Modeling Studies of Pyrazole‐3‐Carbohydrazone Derivatives as Dipeptidyl Peptidase IV Inhibitors

Hualiang Jiang, Guixia Liu, Yun Tang, 2012, Chemical biology & drug design.

Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.

Jian Li, Xiaofan Xu, R. Jia, 2023, European journal of medicinal chemistry.

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.

Feifei Chen, L. Lan, Jian Li, 2018, ACS medicinal chemistry letters.

Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections.

Feifei Chen, L. Lan, Jian Li, 2018, European journal of medicinal chemistry.

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.

Feifei Chen, L. Lan, Jian Li, 2017, Journal of medicinal chemistry.

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN).

Q. Xiao, Feifei Chen, L. Lan, 2016, Journal of medicinal chemistry.

HL005—A new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7

Xu Shen, Honglin Li, Hualiang Jiang, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Refinement and 3D‐QSAR Studies of Inhibitors of Cyclophilin A Containing Amide Linker

Hualiang Jiang, Yun Tang, Jian Li, 2008, QSAR & combinatorial science.

Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation

Hualiang Jiang, Yun Tang, Jin Huang, 2017, Chinese Chemical Letters.

Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation.

Jian Li, Haiyan Zhang, Wei Wang, 2017, ACS chemical neuroscience.

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.

Jian Li, Zhengyu Lu, Naixia Zhang, 2016, Journal of medicinal chemistry.

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents.

Jian Zhang, Jian Li, Haiyan Zhang, 2018, ACS chemical neuroscience.

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Yun Tang, Jian Li, Hai-Yan Zhang, 2018, European journal of medicinal chemistry.

The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel.

Hualiang Jiang, Jian Li, Zhaobing Gao, 2013, Toxicology letters.

Development of Second‐Generation Small‐Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy

Hualiang Jiang, Gang Chen, Jian Li, 2015, ChemMedChem.

Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety.

Yan Ding, Fei Mao, Jin Zhu, 2022, Journal of medicinal chemistry.

2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies

Hualiang Jiang, Honglin Li, Weiqiang Lu, 2009, Molecules.

Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.

Jian Zhang, Jian Li, Wei Wang, 2018, Bioorganic & medicinal chemistry.

Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.

Q. Cao, L. Lan, Jian Li, 2022, European journal of medicinal chemistry.

Design and synthesis of novel hydroxamic acid derivatives based on quisinostat as promising antimalarial agents with improved safety

Jin Zhu, Zhenghui Huang, Jian Li, 2022, Acta Materia Medica.

Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer.

Jian Li, Fei Mao, Jin Zhu, 2020, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of N2,N4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first examples of small-molecular FGFR-1 activator

J. Li, Wenchao Lu, Baoli Li, 2014 .

Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

Yu Zhang, Kunqian Yu, Jin Zhu, 2008, Molecules.

Discovery of synergistic activity of fluoroquinolones in combination with antimicrobial peptides against clinical polymyxin-resistant Pseudomonas aeruginosa DK2

Q. Cao, L. Lan, Fei Mao, 2020 .

The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.

Haiyan Zhang, Fei Mao, Yixiang Xu, 2021, European journal of medicinal chemistry.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Hualiang Jiang, Xu Shen, Honglin Li, 2009, Journal of medicinal chemistry.

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors

Yun Tang, Weiqiang Lu, Jin Huang, 2016, Journal of enzyme inhibition and medicinal chemistry.

Discovery of Benzylidene Derivatives as Potent Syk Inhibitors: Synthesis, SAR Analysis, and Biological Evaluation

Hualiang Jiang, Jian Li, L. Miao, 2015, Archiv der Pharmazie.

Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat.

Jian Li, Yan Ding, Ruoxi Li, 2021, Journal of medicinal chemistry.

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity

Jian Li, Fei Mao, Jin Zhu, 2014, Molecules.

Feifei Chen, Jian Li, Fei Mao, 2017, Journal of medicinal chemistry.