M. Doll

发表

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

P. Shah, K. Saurabh, M. Doll, 2020, BMC cancer.

UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

P. Shah, K. Saurabh, M. Doll, 2020, bioRxiv.

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, S. Bodduluri, 2017, Acta pharmaceutica Sinica. B.

Relationship between N-acetyltransferase 2 single-nucleotide polymorphisms and phenotype.

M. Doll, D. Hein, L. Millner, 2010, Carcinogenesis.

A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

N. Malats, M. Kogevinas, N. Rothman, 2010, Pharmacogenetics and genomics.

N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.

A. Folsom, W. Wen, M. Gross, 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

GSTM1 Null Genotype, Red Meat Consumption and Breast Cancer Risk (The Netherlands)

D. Grobbee, P. Peeters, M. Ocké, 2004, Cancer Causes & Control.

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

M. Doll, D. Hein, A. Fretland, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation.

J. States, M. Doll, D. Hein, 2004, Pharmacogenetics.

A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.

A. Deitz, M. Doll, D. Hein, 1997, Analytical biochemistry.

Identification of a novel allele at the human NAT1 acetyltransferase locus.

T. Rustan, A. Deitz, M. Doll, 1997, Biochemical and biophysical research communications.

Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat

M. Doll, D. Hein, J. Neale, 2008, Drug Metabolism and Disposition.

N-Acetyltransferase (Nat) 1 and 2 Expression in Nat2 Knockout Mice

E. Sim, M. Doll, D. Hein, 2006, Journal of Pharmacology and Experimental Therapeutics.

Tissue distribution of N‐acetyltransferase 1 and 2 catalyzing the N‐acetylation of 4‐aminobiphenyl and O‐acetylation of N‐hydroxy‐4‐aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster

M. Doll, D. Hein, A. Fretland, 2006, Molecular carcinogenesis.

NATb/NAT1*4 promotes greater arylamine N‐acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4‐aminobiphenyl

Jian Cai, J. States, M. Doll, 2012, Molecular carcinogenesis.

Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.

R. MacArthur, M. Doll, D. Hein, 2000, Pharmacogenetics.

Identification of N-Acetyltransferase 2 (NAT2) Transcription Start Sites and Quantitation of NAT2-Specific mRNA in Human Tissues

J. States, M. Doll, D. Hein, 2007, Drug Metabolism and Disposition.

Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration.

M. Doll, Leah J. Siskind, L. Beverly, 2019, American journal of physiology. Renal physiology.

Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease.

J. Megyesi, M. Doll, Leah J. Siskind, 2018, American journal of physiology. Renal physiology.

Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts

W. Pierce, J. States, M. Doll, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens

M. Doll, D. Hein, Mariam R. Habil, 2022, Frontiers in Pharmacology.

560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment

M. Doll, D. Hein, 2022, Frontiers in Pharmacology.

Metabolic activation of carcinogenic arylamines by rapid acetylator, slow acetylator, and chimeric recombinant Syrian hamster NAT2 allozymes.

M. Doll, D. Hein, R. J. Ferguson, 1995, Proceedings of the Western Pharmacology Society.

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.

T. Rustan, M. Doll, D. Hein, 1994, Human molecular genetics.

Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.

M. Doll, D. Hein, S. Roychowdhury, 2006, Toxicology and applied pharmacology.

Suramin protects from cisplatin-induced acute kidney injury

G. Arteel, J. Megyesi, R. Schnellmann, 2017 .

Comprehensive human NAT2 genotype method using single nucleotide polymorphism-specific polymerase chain reaction primers and fluorogenic probes.

M. Doll, D. Hein, 2001, Analytical biochemistry.

Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

M. Doll, D. Hein, Xiaoyan Zhang, 2018, Toxicology letters.

N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

M. Doll, D. Hein, Cecily Allen, 2017, Drug Metabolism and Disposition.

The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

M. Doll, R. Turesky, D. Hein, 2009, Chemical research in toxicology.

Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells.

M. Doll, R. Salazar-González, D. Hein, 2022, Toxicology and applied pharmacology.

Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

W. Pierce, M. Doll, N. Smith, 2009, Mutation research.

Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

W. Pierce, D. Grant, O. Sanchez, 2012, Cancer letters.

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

P. Shah, K. Saurabh, M. Doll, 2020, bioRxiv.

Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

J. States, M. Doll, D. Hein, 2012, Carcinogenesis.

Association of prostate cancer with rapid N‐acetyltransferase 1 (NAT1*10) in combination with slow N‐acetyltransferase 2 acetylator genotypes in a pilot case‐control study

M. Weinrich, N. Caporaso, M. Doll, 2002, Environmental and molecular mutagenesis.

Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.

T. Rustan, M. Doll, D. Hein, 1995, Cancer research.

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

N. Rothman, J. Lissowska, Robert C. G. Martin, 2004, BMC Genetics.

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

D. Grant, T. Rustan, M. Doll, 1993, Carcinogenesis.

Functional Genomics of C190T Single Nucleotide Polymorphism in Human N-Acetyltransferase 2

M. Doll, D. Hein, Yuanqi Zhu, 2002, Biological chemistry.

Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.

M. Doll, D. Hein, A. Fretland, 2001, Pharmacogenetics.

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

M. Doll, D. Hein, A. Fretland, 2001, Pharmacogenetics.

Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype*

M. Doll, D. Hein, A. Fretland, 1999, The Journal of Biological Chemistry.

Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.

T. Rustan, M. Doll, D. Hein, 1999, The Journal of pharmacology and experimental therapeutics.

Quinoxaline – Induced DNA Adduct Formation and Mutagenesis in DNA Repair – Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P 4501 A 1 and Rapid or Slow Acetylator N-Acetyltransferase 2

W. Pierce, J. States, M. Doll, 2007 .

2-Amino-3,8-Dimethylimidazo-[4,5-f]Quinoxaline–Induced DNA Adduct Formation and Mutagenesis in DNA Repair–Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P4501A1 and Rapid or Slow Acetylator N-Acetyltransferase 2

W. Pierce, J. States, M. Doll, 2007, Cancer Epidemiology Biomarkers & Prevention.

Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.

M. Doll, D. Hein, A. Fretland, 2002, Cancer detection and prevention.

Role of the N-acetylation polymorphism in solithromycin metabolism.

M. Doll, D. Hein, 2017, Pharmacogenomics.

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

J. Trent, M. Doll, R. Salazar-González, 2021, Archives of Toxicology.

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Manal M. Hassan, Douglas B. Evans, R. Wolff, 2006, Carcinogenesis.

4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat

G. Arteel, M. Doll, D. Hein, 2006, Journal of Pharmacology and Experimental Therapeutics.

Repeated administration of low-dose cisplatin in mice induces fibrosis.

G. Arteel, J. Megyesi, P. Shah, 2016, American journal of physiology. Renal physiology.

Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.

T. Rustan, A. Deitz, M. Doll, 1997, Mutation research.

Association between cigarette smoking and ovarian reserve among women seeking fertility care

K. Taylor, M. Doll, D. Hein, 2021, PloS one.

F4/80hi Resident Macrophages Contribute to Cisplatin-Induced Renal Fibrosis

P. Shah, M. Doll, Leah J. Siskind, 2022, Kidney360.

C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury.

J. Megyesi, M. Doll, Leah J. Siskind, 2020, American journal of physiology. Renal physiology.

Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

M. Doll, R. Salazar-González, D. Hein, 2019, Archives of Toxicology.

Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.

M. Doll, R. Valdes, D. Hein, 2006, Clinical chemistry.

Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells

M. Merchant, Daniel W. Wilkey, Jiong Cai, 2022, Data in Brief.

Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis

M. Merchant, Daniel W. Wilkey, Jiong Cai, 2022, Toxicology reports.

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

REVISION CARCIN-2008-00096 Interaction of the Cytochrome P4501A2, SULT1A1 and NAT Gene Polymorphisms with Smoking and Dietary Mutagen Intake in Modification of the Risk of Pancreatic Cancer

Jeffrey S. Morris, Manal M. Hassan, M. Hassan, 2007 .

Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.

M. Doll, D. Hein, Yi Feng, 2003, Pharmacogenetics.

Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1.

M. Doll, D. Hein, 2002, Analytical biochemistry.

Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol

T. Rustan, M. Doll, D. Hein, 2005, Archives of Toxicology.

Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

W. Pierce, W. Mcgregor, J. States, 2010, Mutation research.

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.

J. States, M. Doll, D. Hein, 2007, Carcinogenesis.

Effects of single nucleotide polymorphisms in human N‐acetyltransferase 2 on metabolic activation (O‐acetylation) of heterocyclic amine carcinogens

M. Doll, D. Hein, A. Fretland, 2006, International journal of cancer.

No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.

N. Rothman, W. Chow, J. Lissowska, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

M. Doll, D. Hein, A. Fretland, 2001, Journal of biochemical and molecular toxicology.

Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.

A. Deitz, M. Doll, D. Hein, 1995, Analytical biochemistry.

Association of the Histamine N‐Methyltransferase C314T (Thr105Ile) Polymorphism with Atopic Dermatitis in Caucasian Children

G. Kearns, M. Doll, J. Sullivan, 2008, Pharmacotherapy.

Acetylator Phenotype and Genotype in HIV‐Infected Patients with and without Sulfonamide Hypersensitivity

R. MacArthur, M. Doll, D. Hein, 2002, Journal of clinical pharmacology.

Acetyl CoA:arylamine N-acetyltransferase activity in rat hepatocytes cultured on different extracellular matrices.

W. Lindblad, M. Doll, D. Hein, 1997, Toxicology in vitro : an international journal published in association with BIBRA.

Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.

G. Arteel, E. Gäbele, R. Mason, 2003, Gastroenterology.

Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles

A. Deitz, M. Doll, D. Hein, 1997, Archives of Toxicology.

Role of Human N‐Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen‐Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay

W. Pierce, J. States, M. Doll, 2020, Environmental and molecular mutagenesis.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes

M. Doll, D. Hein, Mariam R. Habil, 2019, Pharmacogenetics and genomics.

Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells

M. Doll, D. Hein, Kennedy M. Walls, 2022, Journal of Cancer Research and Clinical Oncology.

Na/H Exchange Regulatory Factor 1 Deficient Mice Show Evidence of Oxidative Stress and Altered Cisplatin Pharmacokinetics

M. Brier, W. Watson, S. Khundmiri, 2021, Antioxidants.

Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Jian Cai, J. States, M. Doll, 2012, Drug Metabolism and Disposition.

Microsoft Word-84522533-file00

Jiong Cai, M. Doll, L. Millner, 2011 .

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.

T. Rustan, M. Doll, D. Hein, 1994, Drug metabolism and disposition: the biological fate of chemicals.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

J. States, M. Doll, D. Hein, 2020, Archives of Toxicology.

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

J. States, M. Doll, D. Hein, 2020, Archives of Toxicology.

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, D. Hein, 2020, Scientific Reports.

Acetylator Genotype-Dependent Metabolic Activation of N-Hydroxy-2-Aminofluorene in Syrian Hamster Lines Congenic at the NAT2 Locus

T. Rustan, M. Doll, D. Hein, 1994 .

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

M. Doll, D. Hein, 2017, Archives of Toxicology.

Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.

T. Rustan, M. Doll, D. Hein, 1993, Cancer research.

The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.

M. Doll, J. Peterson, S. Schaal, 2014, Investigative ophthalmology & visual science.

Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2

Samantha M. Carlisle, M. Doll, D. Hein, 2022, Frontiers in Pharmacology.

Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes.

S. Rai, S. Wise, J. States, 2019, Toxicology and applied pharmacology.

A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.

P. Woster, L. Lash, M. Doll, 2000, The Journal of investigative dermatology.

Acetyltransferases and susceptibility to chemicals.

T. Rustan, M. Doll, D. Hein, 1992, Toxicology letters.

Daily Rhythm in Plasma N-acetyltryptamine

C. Mason, P. Backlund, D. Klein, 2017, Journal of biological rhythms.

ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans

B. Schumacher, M. Doll, Najmeh Soltanmohammadi, 2019, Genetics.

Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2

G. Arteel, S. Barve, M. Doll, 2020, Toxicology reports.

Human N-acetylation of benzidine: role of NAT1 and NAT2.

T. Rustan, V. Lakshmi, A. Deitz, 1996, Cancer research.

Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements

J. States, M. Doll, D. Hein, 2007, Drug Metabolism And Disposition.

Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1

M. Doll, D. Hein, J. Neale, 2006, Pharmacogenetics and genomics.

Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells

C. McClain, Xiaohong Li, M. Doll, 2020, Hepatology.

Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

M. Brier, M. Rane, S. Khundmiri, 2019, The American journal of pathology.

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury

Y. Hannun, L. Obeid, J. Megyesi, 2022, Journal of lipid research.

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

A. Bielawska, Y. Hannun, L. Obeid, 2017, Journal of Lipid Research.

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Samantha M. Carlisle, M. Doll, D. Hein, 2020, Scientific Reports.

No Association Between Variant N-acetyltransferase Genes, Cigarette Smoking and Prostate Cancer Susceptibility Among Men of African Descent

D. Srivastava, G. Brock, V. Pihur, 2011, Biomarkers in cancer.

N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.

K. Baumgartner, M. Doll, Dongyan Yang, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

P. Shah, M. Doll, L. Beverly, 2022, Molecular carcinogenesis.

N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines

M. Doll, R. Salazar-González, D. Hein, 2019, Journal of oncology.

Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes.

M. Doll, D. Hein, 2012, Pharmacogenomics.

Codominant Expression of N-Acetylation and O-Acetylation Activities Catalyzed by N-Acetyltransferase 2 in Human Hepatocytes

T. Moeller, M. Doll, D. Hein, 2010, Journal of Pharmacology and Experimental Therapeutics.

Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes.

Robert C. G. Martin, M. Doll, D. Hein, 2009, DNA and cell biology.

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

M. Doll, D. Hein, A J Fretland, 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Hair dye use and risk of bladder cancer in the New England bladder cancer study

D. Silverman, N. Rothman, M. Karagas, 2011, International journal of cancer.

Meat Intake, Heterocyclic Amine Exposure, and Metabolizing Enzyme Polymorphisms in Relation to Colorectal Polyp Risk

Yu Shyr, Reid M. Ness, Jirong Long, 2008, Cancer Epidemiology Biomarkers & Prevention.

Molecular Genetics and Epidemiology of the NAT 1 and NAT 2 Acetylation Polymorphisms 1

M. Doll, D. Hein, Yi Feng, 2000 .

Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant

M. Doll, D. Hein, Mariam R. Habil, 2022, Frontiers in Pharmacology.

Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2

M. Doll, D. Hein, Y. Zang, 2007, Pharmacogenetics and genomics.

Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1).

J. States, M. Doll, D. Hein, 2004, Pharmacogenetics.

Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases

J. States, M. Doll, D. Hein, 2015, Biochemistry and biophysics reports.

Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Samantha M. Carlisle, J. States, M. Doll, 2018, Molecular carcinogenesis.

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

J. States, M. Doll, D. Hein, 2017, BMC Cancer.

Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.

Z. Deng, Chao Lei, M. Doll, 2022, Cell reports.

S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity.

C. McClain, W. Watson, M. Doll, 2014, Alcoholism, clinical and experimental research.

Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

Robert C. G. Martin, M. Doll, D. Hein, 2010, Cancer investigation.

Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma

N. Crawford, S. Galandiuk, R. Petras, 2007, BMC Medical Genetics.

Role of the renin‐angiotensin system in hepatic ischemia reperfusion injury in rats

G. Arteel, M. Doll, D. Hein, 2004, Hepatology.

No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).

N. Rothman, J. Lissowska, Robert C. G. Martin, 2005, The Journal of surgical research.

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Robert C. G. Martin, C. Ambrosone, Jiyoung Ahn, 2006, Breast Cancer Research.

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer

Jeffrey S. Morris, Manal M. Hassan, M. Hassan, 2008, Carcinogenesis.

N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer.

D. Noh, D. Kang, K. Yoo, 2003, Cancer letters.

NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women.

Diederick E Grobbee, D. Grobbee, P. Peeters, 2003, Pharmacogenetics.

Metabolic activation of aromatic and heterocyclicN-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases

T. Rustan, M. Doll, D. Hein, 2007, Archives of Toxicology.

UBQLN 4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors Graphical

Y. Shiloh, M. Fischer, D. Wieczorek, 2018 .

A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes

B. Schumacher, M. Doll, Matthias Rieckher, 2018, Journal of cellular physiology.

2‐amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine‐induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N‐acetyltransferase 2

W. Pierce, W. Mcgregor, J. States, 2007, Molecular carcinogenesis.

Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat

J. States, M. Doll, D. Hein, 2008, Drug Metabolism and Disposition.

Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.

M. Doll, D. Hein, J. Walraven, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Identification and Characterization of Functional Rat Arylamine N-Acetyltransferase 3: Comparisons with Rat Arylamine N-Acetyltransferases 1 and 2

M. Doll, D. Hein, J. Walraven, 2006, Journal of Pharmacology and Experimental Therapeutics.

Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.

M. Doll, D. Hein, A. Fretland, 1997, Toxicology and applied pharmacology.

Metabolic Activation of yV-Hydroxy-2-aminofluorene and 7V-Hydroxy-2-acetylaminofluorene by Monomorphic W-Acetyltransferase (NATI) and Polymorphic W-Acetyltransferase (NAT2) in Colon Cytosols of Syrian Hamsters Congenie at the NAT2 Locus1

Timothy, M. Doll, D. Hein, 2006 .

High N-Acetyltransferase 1 Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 5α-androstane-3β, 17β-Diol, or Dihydrotestosterone in Breast Cancer Cells

Samantha M. Carlisle, C. Klinge, Robert C. G. Martin, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Haplotype of N-Acetyltransferase 1 and 2 and Risk of Pancreatic Cancer

Manal M. Hassan, J. Hixson, M. Hassan, 2007, Cancer Epidemiology Biomarkers & Prevention.

Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress

M. Doll, R. Salazar-González, D. Hein, 2023, Archives of Toxicology.

Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells*

C. Klinge, Y. Teng, R. Prough, 2015, The Journal of Biological Chemistry.

N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

Pharmacologic inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury.

P. Shah, M. Doll, Leah J. Siskind, 2022, American journal of physiology. Renal physiology.

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

J. States, M. Sanders, M. Doll, 2017, BMC Cancer.

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status

M. Doll, R. Salazar-González, D. Hein, 2022, Frontiers in Pharmacology.

Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Samantha M. Carlisle, C. Klinge, M. Doll, 2018, Molecular carcinogenesis.

Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats.

M. Doll, D. Hein, 1995, Pharmacogenetics.

TaqMan Real Time–Polymerase Chain Reaction Methods for Determination of Nucleotide Polymorphisms in Human N‐Acetyltransferase‐1 (NAT1) and ‐2 (NAT2)

M. Doll, D. Hein, 2004, Current protocols in toxicology.

Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.

E. Bowman, C. Harris, Robert C. G. Martin, 2008, DNA and cell biology.

Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1

Samantha M. Carlisle, Xinmin Yin, J. States, 2016, Metabolomics.

Simultaneous Determination of 7 N-Acetyltransferase-2 Sequence Variations by Allele-Specific Primer Extension Assay

M. Doll, R. Valdes, D. Hein, 2006 .

Cloning, expression, and functional characterization of rapid and slow acetylator polymorphic N-acetyl-transferase encoding genes of the Syrian hamster.

T. Rustan, M. Doll, D. Hein, 1996, Pharmacogenetics.

Syrian hamster monomorphic N-acetyltransferase (NAT1) alleles: amplification, cloning, sequencing, and expression in E. coli.

T. Rustan, M. Doll, D. Hein, 1994, Pharmacogenetics.

Polymorphic arylamine N-acetyltransferase encoding gene (NAT2) from homozygous rapid and slow acetylator congenic Syrian hamsters.

M. Doll, D. Hein, R. J. Ferguson, 1994, Gene.

Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.

T. Rustan, M. Doll, D. Hein, 1994, Toxicology and applied pharmacology.

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

M. Doll, D. Hein, 2017, Archives of Toxicology.

Chemoprevention of Arylamine-Induced Colorectal Aberrant Crypts

M. Doll, D. Hein, Yi Feng, 2008, Experimental biology and medicine.

Correction: Acetylator phenotype and genoype in patients infected with HIV: Discordance between methods for phenotype determination and genotype (Pharmacogenetics (2000) 10 (171-182))

R. MacArthur, M. Doll, D. Hein, 2000 .

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

M. Doll, D. Hein, 2017, Archives of Toxicology.

Suramin Protects From Cisplatin‐Induced Acute Kidney Injury

G. Arteel, J. Megyesi, R. Schnellmann, 2016, American journal of physiology. Renal physiology.

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

N. Rothman, J. Lissowska, Robert C. G. Martin, 2004, BMC Genetics.

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Manal M. Hassan, Douglas B. Evans, R. Wolff, 2006, Carcinogenesis.

Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Jian Cai, J. States, M. Doll, 2012, Drug Metabolism and Disposition.

N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

M. Doll, D. Hein, C. Allen, 2017, Drug Metabolism and Disposition.

Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat

J. States, M. Doll, Elizabeth H. Ristagno, 2008, Drug Metabolism and Disposition.