M. Jiménez-Díaz

发表

Chemical genetics of Plasmodium falciparum

Anang A. Shelat, David S. Roos, John S. Lazo, 2010, Nature.

A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides

F. Gamo, S. Alihodžić, Mirjana Bukvić, 2020, British journal of pharmacology.

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

Laura M Sanz, L. Ballell-Pages, J. Yli-Kauhaluoma, 2015, Journal of medicinal chemistry.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

P. Rathod, John White, M. Phillips, 2016, Journal of medicinal chemistry.

Anti-malarial Activity in the Mouse Model Dihydroorotate Dehydrogenase with Plasmodium falciparum Novel Inhibitors of Molecular Bases of Disease :

Margaret A. Phillips, Elizabeth J. Goldsmith, Dyann F. Wirth, 2010 .

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

A New In Vivo Screening Paradigm to Accelerate Antimalarial Drug Discovery

David M. Wilson, F. Gamo, J. Garcia-Bustos, 2013, PloS one.

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

David M. Shackleford, R. Price, P. Rathod, 2016, ACS infectious diseases.

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes

L. Shultz, M. Jiménez-Díaz, Iñigo Angulo-Barturen, 2009, Antimicrobial Agents and Chemotherapy.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

S. Croft, T. Bousema, F. Gamo, 2017, Nature Communications.

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.

E. Winzeler, S. Meister, K. Chibale, 2016, Journal of medicinal chemistry.

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

J. McCarthy, D. Leroy, P. O’Rourke, 2016, Antimicrobial Agents and Chemotherapy.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

E. Winzeler, S. Meister, K. Chibale, 2015, Journal of medicinal chemistry.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

Laura M Sanz, L. Ballell-Pages, M. Blackman, 2015, Journal of Medicinal Chemistry.

Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives.

F. Gamo, J. Vidal, Gonzalo Colmenarejo, 2014, ACS medicinal chemistry letters.

Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production.

M. Fresno, M. Muñoz-Fernández, M. Jiménez-Díaz, 2002, Cellular immunology.

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Richard D. Taylor, D. Goldberg, A. Cowman, 2022, Journal of medicinal chemistry.

Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.

K. Chibale, Dale Taylor, K. Wicht, 2018, Journal of medicinal chemistry.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

David M. Shackleford, Francisco-Javier Gamo, Xiaoyi Deng, 2011, Journal of medicinal chemistry.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

R. Price, K. Chibale, Dale Taylor, 2018, Antimicrobial Agents and Chemotherapy.

Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads

J. Burrows, S. T. Nguyen, M. Jiménez-Díaz, 2022, Molecular Pharmacology.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

P. Rosenthal, J. Regadera, D. Pompliano, 2008, PloS one.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Farah El Mazouni, T. Laird, P. Rathod, 2015, Science Translational Medicine.

Animal models of efficacy to accelerate drug discovery in malaria

M. Jiménez-Díaz, Iñigo Angulo-Barturen, Elena Fernández‐Álvaro, 2013, Parasitology.

Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

M. Llinás, P. Jansen, K. Dechering, 2019, Science Translational Medicine.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Hongshen Ma, Zheng Wang, Jeremy Horst, 2014, Proceedings of the National Academy of Sciences.

Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication

David M. Shackleford, R. Price, M. Mather, 2014 .

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

David M. Shackleford, G. Drewes, M. Bantscheff, 2017, Science Translational Medicine.

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Bradley I. Coleman, R. Barker, D. Wirth, 2011, Antimicrobial Agents and Chemotherapy.

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

D. Wirth, D. Fidock, Pavithra Viswanath, 2015, Nature Communications.

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

F. Gamo, E. Fang, Yen-Liang Chen, 2022, Journal of medicinal chemistry.

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

R. Price, P. Rosenthal, D. Fidock, 2021, Science Translational Medicine.

Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy.

P. Urban, M. Busquets, X. Fernàndez-Busquets, 2015, Journal of controlled release : official journal of the Controlled Release Society.

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.

D. Fidock, F. Gamo, A. Srivastava, 2014, Journal of medicinal chemistry.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

D. Wirth, F. Gamo, Pavithra Viswanath, 2014, Journal of medicinal chemistry.

Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

Jeremy N. Burrows, Benigno Crespo, Francisco-Javier Gamo, 2011, Antimicrobial Agents and Chemotherapy.

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.

R. Barker, B. Muñoz, J. Cortese, 2011, ACS medicinal chemistry letters.

Quantitative measurement of Plasmodium‐infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO‐16 fluorescence

M. Jiménez-Díaz, Iñigo Angulo-Barturen, D. Gargallo‐Viola, 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Erratum: Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum (Science Translational Medicine DOI: 10.1126/scitranslmed.aas9917)

M. Llinás, P. Jansen, K. Dechering, 2021 .

Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans

N. A. Malmquist, R. Sinden, F. Gamo, 2014, Antimicrobial Agents and Chemotherapy.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

P. Rosenthal, M. Llinás, D. Fidock, 2021, bioRxiv.

Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model

D. Leroy, M. Jiménez-Díaz, Iñigo Angulo-Barturen, 2023, Antimicrobial agents and chemotherapy.

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

P. Hewitt, D. Picard, S. Charman, 2017, ACS medicinal chemistry letters.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

R. Price, D. Fidock, R. Sinden, 2016, PLoS medicine.

Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS).

Simon J F Macdonald, F. Gamo, Laura M Sanz, 2011, ACS medicinal chemistry letters.

Feasibility of Flow Cytometry for Measurements of Plasmodium falciparum Parasite Burden in Studies in Areas of Malaria Endemicity by Use of Bidimensional Assessment of YOYO-1 and Autofluorescence

J. Sacarlal, J. Aponte, P. Alonso, 2011, Journal of Clinical Microbiology.

bidimensional assessment of YOYO-1 and autofluorescence

J. Sacarlal, J. Aponte, P. Alonso, 2011 .

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model*

Bradley I. Coleman, E. Goldsmith, R. Barker, 2010, The Journal of Biological Chemistry.

Improvement of detection specificity of Plasmodium‐infected murine erythrocytes by flow cytometry using autofluorescence and YOYO‐1

M. Jiménez-Díaz, Iñigo Angulo-Barturen, D. Gargallo‐Viola, 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.

Félix Calderón, Jeremy Burrows, F. Gamo, 2012, ACS medicinal chemistry letters.

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

F. Gamo, Virginia Franco, Benigno Crespo, 2015, Malaria Journal.

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria.

David M. Shackleford, P. Rathod, John White, 2020, Journal of medicinal chemistry.

Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E5455-E5462) 1 DOI: 10.1073/pnas.1414221111)

Anang A. Shelat, Zheng Wang, Jeremy A. Horst, 2015 .

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

A. Jirgensons, C. Withers-Martinez, F. Hackett, 2023, Journal of medicinal chemistry.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Farah El Mazouni, T. Laird, P. Rathod, 2015, Science Translational Medicine.

Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy.

P. Urban, M. Busquets, X. Fernàndez-Busquets, 2015, Journal of controlled release : official journal of the Controlled Release Society.