I. Bathurst

发表

Chemical genetics of Plasmodium falciparum

Anang A. Shelat, David S. Roos, John S. Lazo, 2010, Nature.

Structural and functional characterization of the abnormal Z α1‐antitrypsin isolated from human liver

P. M. George, R. Carrell, P. George, 1984, FEBS letters.

Human α1 ‐antitrypsin expression in Xenopus oocytes

R. Carrell, I. Bathurst, D. M. Errington, 1985 .

In vitro synthesis of M and Z forms of human α1‐antitrypsin

R. Carrell, E. Janus, I. Bathurst, 1982, FEBS Letters.

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: further studies using SERA 1 and MF75.2 adjuvant

P. Barr, I. Bathurst, J. Inselburg, 1993, Infection and immunity.

Soy (Glycine max)-derived phospholipids exhibit potent anti-apoptotic activity

J. D. Bradley, P. Barr, I. Bathurst, 1998 .

Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion

I. Bathurst, J. Shapiro, S. Umansky, 1997, Cell Death and Differentiation.

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes.

K. Liliom, G. Tigyi, M. Kiefer, 1996, Proceedings of the National Academy of Sciences of the United States of America.

In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species

D. Fidock, J. Lotharius, E. Ekland, 2011, Antimicrobial Agents and Chemotherapy.

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

David M. Shackleford, W. Guida, D. Kyle, 2014, Journal of medicinal chemistry.

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

David M. Shackleford, S. Charman, R. Brun, 2013, Drug design, development and therapy.

Antiapoptotic compound to enhance hypothermic liver preservation.

A. Columbano, C. Issel, I. Bathurst, 1997, Transplantation.

Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum

P. Barr, D. Kaslow, T. Ponnudurai, 1994, Infection and immunity.

Translation and processing of normal (PiMM) and abnormal (PiZZ) human α1‐antitrypsin

R. Carrell, I. Bathurst, D. M. Errington, 1983 .

Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils.

C. Winterbourn, S. Brennan, P. George, 1988, The Journal of clinical investigation.

α1‐Antitrypsin and serum albumin mRNA accumulation in normal, acute phase and ZZ human liver

R. Carrell, M. Edbrooke, R. Craig, 1985, FEBS letters.

The primary role of the P1 residue (ser359) of alpha-1-proteinase inhibitor.

J. Travis, N. Matheson, I. Bathurst, 1989, Biochemical and biophysical research communications.

Separation and characterization of low-molecular-weight nuclear RNA species that inhibit cell-free protein synthesis.

I. Bathurst, M. G. Smith, 1982, Biochimica et biophysica acta.

Human alpha 1-antitrypsin expression in Xenopus oocytes. Secretion of the normal (PiM) and abnormal (PiZ) forms.

R. Carrell, I. Bathurst, D. M. Errington, 1985, European journal of biochemistry.

Epitopes recognized by HIV-SF2 nef-specific CD4+ T-cell clones generated from HIV-1-uninfected donors.

K. Steimer, H. Erlich, P. Feucht, 1994, Vaccine.

New thymidine triphosphate analogue inhibitors of human immunodeficiency virus-1 reverse transcriptase.

G. L. Kenyon, P. Barr, I. Bathurst, 1992, Journal of medicinal chemistry.

Cellular and humoral immune responses to a recombinant P. falciparum CS protein in sporozoite-immunized rodents and human volunteers.

P. Barr, P. Romero, D. Herrington, 1990, Bulletin of the World Health Organization.

Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast.

C. Craik, P. Barr, D. Santi, 1990, Biochemical and biophysical research communications.

The observed inhibitory potency of 3'-azido-3'-deoxythymidine 5'-triphosphate for HIV-1 reverse transcriptase depends on the length of the poly(rA) region of the template.

G. L. Kenyon, P. Barr, I. Bathurst, 1992, Biochemistry.

Differential distribution of poly(A)-containing RNA sequences between the nucleus and post-nuclear supernatant of the lactating guinea-pig mammary gland.

D. G. Herries, R. Craig, I. Bathurst, 1980, European journal of biochemistry.

Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals

P. Barr, D. Kaslow, H. Gibson, 1991, The Journal of experimental medicine.

Recombinant SERA Protein of Plasmodium falciparum: Adjuvant Effects

P. Barr, I. Bathurst, J. Inselburg, 2003 .

protective immunity . falciparum : adjuvant effects on induction of by a recombinant SERA protein of Plasmodium Protective immunity induced in Aotus monkeys

P. Barr, I. Bathurst, G. Barchfeld, 2003 .

Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum

P. Barr, I. Bathurst, W. B. Li, 1991, Infection and immunity.

Post-transcriptional regulation of gene expression in guinea pig tissues

D. G. Herries, R. Craig, I. Bathurst, 1980, Nature.

Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers

Galen P. Miley, M. Mather, A. Vaidya, 2014, Journal of medicinal chemistry.

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

David M. Shackleford, Susan A Charman, Pradipsinh K Rathod, 2011, Journal of medicinal chemistry.

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

David M. Shackleford, Francisco-Javier Gamo, Xiaoyi Deng, 2011, Journal of medicinal chemistry.

Molecular physiology and pathology of α1‐antitrypsin

I. Bathurst, D. Boswell, 1985 .

Protein expression in yeast as an approach to production of recombinant malaria antigens.

I. Bathurst, 1994, The American journal of tropical medicine and hygiene.

Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).

E. De Clercq, P. Barr, J. Balzarini, 1992, The Journal of biological chemistry.

The predicted proteinase furin is not the hepatic proalbumin convertase.

S. Brennan, P. George, I. Bathurst, 1992, Biochimica et biophysica acta.

Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66.

G. L. Kenyon, P. Barr, I. Bathurst, 1990, Biochemical and biophysical research communications.

Specificity of yeast KEX2 protease for variant human proalbumins is identical to the in vivo specificity of the hepatic proalbumin convertase.

R. Peach, S. Brennan, I. Bathurst, 1990, The Journal of biological chemistry.

Yeast KEX2 protease has the properties of a human proalbumin converting enzyme.

A. Brake, R. Carrell, P. Barr, 1987, Science.

Structure and expression of the gene for Pv200, a major blood-stage surface antigen of Plasmodium vivax.

P. Barr, D. Kaslow, H. Gibson, 1992, Molecular and biochemical parasitology.

Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: adjuvant effects on induction of protective immunity

P. Barr, I. Bathurst, J. Inselburg, 1993, Infection and immunity.

Immunogenicity of recombinant Plasmodium falciparum SERA proteins in rodents.

P. Barr, H. Gibson, I. Bathurst, 1991, Molecular and biochemical parasitology.

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

P. Rosenthal, J. Regadera, D. Pompliano, 2008, PloS one.

Ubiquitin Fusion Approach to Heterologous Gene Expression in Yeast: High-Level Production of Amino-Terminal Authentic Proteins

K. Steimer, P. Barr, J. Shuster, 1991 .

Simian retrovirus-D serotype 1 (SRV-1) envelope glycoproteins gp70 and gp20: expression in yeast cells and identification of specific antibodies in sera from monkeys that recovered from SRV-1 infection

N. Pedersen, M. Power, P. Barr, 1988, Journal of virology.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

Relative distribution of post-nuclear poly(A)-containing RNA abundance groups within the nuclear and post-nuclear polyadenylated and non-polyadenylated RNA populations of the lactating guinea-pig mammary gland.

D. G. Herries, R. Craig, I. Bathurst, 1980, The Biochemical journal.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Christian Scheurer, Lukas Stingelin, David M. Shackleford, 2011, Proceedings of the National Academy of Sciences.

An experimental vaccine cocktail for Plasmodium falciparum malaria.

G. Hui, H. Gibson, I. Bathurst, 1993, Vaccine.

Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication

David M. Shackleford, R. Price, M. Mather, 2014 .

Medicines for Malaria Venture: sustaining antimalarial drug development.

I. Bathurst, C. Hentschel, 2006, Trends in parasitology.

Life-spans of human T-cell responses to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax.

P. Barr, C. Khamboonruang, M. Good, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Bradley I. Coleman, R. Barker, D. Wirth, 2011, Antimicrobial Agents and Chemotherapy.

Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant Pfs25.

B. Moss, P. Barr, D. Kaslow, 1992, Memorias do Instituto Oswaldo Cruz.

Cellular proliferative responses in squirrel monkeys immunized with recombinant and synthetic Plasmodium vivax circumsporozoite peptides.

A. Hightower, T. Ruebush, I. Bathurst, 1991, The American journal of tropical medicine and hygiene.

A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat.

I. Bathurst, M. Funk-Archuleta, M. W. Foehr, 1997, Nutrition and cancer.

Antiapoptotic activity of the Bowman-Birk inhibitor can be attributed to copurified phospholipids.

P. Pemberton, I. Bathurst, J. Goddard, 1999, Nutrition and cancer.

Pyridoxal-5′-Phosphate Inhibits the Polymerase Activity of a Recombinant RNase H-Deficient Mutant of HIV-1 Reverse Transcriptase

P. Barr, I. Bathurst, L. Moen, 1992 .

Plasmodium vivax sporozoite antibodies in individuals exposed during a single malaria outbreak in a non-endemic area.

A. Krettli, I. Bathurst, C. Fontes, 1991, The American journal of tropical medicine and hygiene.

N myristylation of the human immunodeficiency virus type 1 gag polyprotein precursor in Saccharomyces cerevisiae

K. Steimer, P. Barr, H. Gibson, 1989, Journal of virology.

Fine epitope specificity of antibodies to region II of the Plasmodium vivax circumsporozoite protein correlates with ability to bind recombinant protein and sporozoites.

P. Barr, M. Good, K. Baumgart, 1997, Acta tropica.

Ex Vivo Activity of Endoperoxide Antimalarials, Including Artemisone and Arterolane, against Multidrug-Resistant Plasmodium falciparum Isolates from Cambodia

S. Tyner, Xavier C Ding, D. Saunders, 2014, Antimicrobial Agents and Chemotherapy.

CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives

S. Nwaka, K. Chibale, H. Vial, 2010, Malaria Journal.

Inhibition of cell-free protein synthesis by low-molecular-weight nuclear polyadenylate-containing ribonucleic acid species isolated from the lactating guinea pig.

R. Craig, I. Bathurst, P. Campbell, 1980, The Biochemical journal.

Inhibitory activity against sporozoites induced by antibodies directed against nonrepetitive regions of the circumsporozoite protein of Plasmodium vivax

R. Wirtz, C. Chizzolini, J. Broderson, 1992, European journal of immunology.

Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum.

L. Gerena, D. Caridha, P. Wipf, 2011, Journal of medicinal chemistry.

Malaria transmission-blocking vaccines.

P. Barr, D. Kaslow, I. Bathurst, 1992, Trends in biotechnology.

Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat.

P. Pemberton, I. Bathurst, M. Funk-Archuleta, 1999, Nutrition and cancer.

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

David M. Shackleford, S. Norval, K. Read, 2011, Malaria Journal.

Safety and immunogenicity of a recombinant sporozoite malaria vaccine against Plasmodium vivax.

M. Levine, P. Barr, R. Edelman, 1991, The American journal of tropical medicine and hygiene.

Immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax.

J. F. Young, T. Ruebush, W. Ballou, 1989, The American journal of tropical medicine and hygiene.

Synthetic peroxides: a viable alternative to artemisinins.

I. Bathurst, 2008 .

Human Z α1‐antitrypsin accumulates intracellularly and stimulates lysosomal activity when synthesised in the Xenopus oocyte

R. Carrell, I. Bathurst, R. Foreman, 1985, FEBS letters.

Characterization of a recombinant Onchocerca volvulus antigen (Ov33) produced in yeast.

G. Lando, T. Asonganyi, I. Bathurst, 1997, American Journal of Tropical Medicine and Hygiene.