Antonio G. García

发表

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

Chemical synthesis of galantamine, an acetylcholinesterase inhibitor for treatment of Alzheimer’s disease

J. Marco-Contelles, C. Rodríguez, Antonio G. García, 2005 .

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

P. Negredo, R. León, Manuela G. López, 2013, Neuropharmacology.

ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia.

J. Menéndez, R. León, Manuela G. López, 2017, ACS chemical neuroscience.

Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.

B. Bartolomé, Abdelouahid Samadi, E. Soriano, 2011, Bioorganic & medicinal chemistry.

Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease.

Antonio G. García, J. Arranz-Tagarro, J. Padín, 2012, ACS chemical neuroscience.

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway.

Manuela G. López, Laura Tabuenca del Barrio, Antonio G. García, 2010, Free radical biology & medicine.

Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices

R. León, Manuela G. López, Antonio G. García, 2017, Neuropharmacology.

Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties.

Manuela G. López, M. Villarroya, Antonio G. García, 2006, Cardiovascular drug reviews.

Small synthetic hyaluronan disaccharide BIS014 mitigates neuropathic pain in mice.

Manuela G. López, J. Entrena, Antonio G. García, 2022, The journal of pain.

New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10.

R. León, N. Cuenca, L. Fernández-Sánchez, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2009, Journal of medicinal chemistry.

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Manuela G. López, J. Roda, Abdelouahid Samadi, 2010, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.

F. J. Luque, M. Orozco, A. Morreale, 2004, Bioorganic & medicinal chemistry.

Synthesis of 6‐Amino‐1,4‐dihydropyridines that Prevent Calcium Overload and Neuronal Death.

R. León, Manuela G. López, J. Marco-Contelles, 2008 .

Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death.

R. León, Manuela G. López, J. Marco-Contelles, 2008, European journal of medicinal chemistry.

Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.

José Marco-Contelles, Antonio Guglietta, R. León, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals.

R. León, Manuela G. López, J. Marco-Contelles, 2006, European journal of medicinal chemistry.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.

F. J. Luque, X. Barril, R. León, 2008, Bioorganic & medicinal chemistry.

New multipotent tetracyclic tacrines with neuroprotective activity.

R. León, Manuela G. López, J. Marco-Contelles, 2006, Bioorganic & medicinal chemistry.

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.

R. León, Manuela G. López, Ignacio Moraleda, 2010, Journal of medicinal chemistry.

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

C. Pérez, R. León, Manuela G. López, 2012, ACS chemical neuroscience.

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.

C. Pérez, R. León, Manuela G. López, 2011, European journal of medicinal chemistry.

Antiproliferative effects of palladium(II) complexes of 5-nitrosopyrimidines and interactions with the proteolytic regulatory enzymes of the renin–angiotensin system in tumoral brain cells

Antonio G. García, Nuria A. Illán Cabeza, M. Carretero, 2013 .

oscillations ofcytosolic calcium and membranepotential inbovine chromaffin cells

Manuela G. López, Antonio G. García, A. R. Artalejo, 2011 .

Inhibition of voltage‐gated Ca2+ entry into GH3 and chromaffin cells by imidazole antimycotics and other cytochrome P450 blockers

J. García-Sancho, Manuela G. López, R. Fonteriz, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chondroitin Sulfate Protects SH-SY5Y Cells from Oxidative Stress by Inducing Heme Oxygenase-1 via Phosphatidylinositol 3-Kinase/Akt

Manuela G. López, M. Villarroya, Antonio G. García, 2007, Journal of Pharmacology and Experimental Therapeutics.

Neuroprotective Effect of the Novel Compound ITH33/IQM9.21 Against Oxidative Stress and Na+ and Ca2+ Overload in Motor Neuron-like NSC-34 Cells

Antonio G. García, Antonio G. García, C. de los Ríos, 2016, Neurotoxicity Research.

Aza‐CGP37157‐lipoic hybrids designed as novel Nrf2‐inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties

J. Menéndez, R. León, Giammarco Tenti, 2020, Drug development research.

Unequal Neuroprotection Afforded by the Acetylcholinesterase Inhibitors Galantamine, Donepezil, and Rivastigmine in SH-SY5Y Neuroblastoma Cells: Role of Nicotinic Receptors

Manuela G. López, E. Arias, M. Villarroya, 2005, Journal of Pharmacology and Experimental Therapeutics.

Synthesis of new derivatives of diltiazem blocking neuronal non-L-type calcium channel subtypes

Manuela G. López, M. Villarroya, Antonio G. García, 1998 .

Intracellular calcium and inflammatory markers, mediated by purinergic stimulation, are differentially regulated in monocytes of patients with major depressive disorder

Manuela G. López, Antonio G. García, P. López-García, 2021, Neuroscience Letters.

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH‐SY5Y neuroblastoma cells

Manuela G. López, Antonio G. García, J. Egea, 2010, Journal of pineal research.

Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation.

A. Nicke, Antonio G. García, J. Egea, 2021, Journal of medicinal chemistry.

PF9404C, a new slow NO donor with beta receptor blocking properties

A. Garcı́a, Manuela G. López, M. Villarroya, 1999, British journal of pharmacology.

On the antiatherogenity of calcium channel blockers: studies in proliferating vascular smooth muscle cells on age sensitivity, dose dependent inhibitory effect, and time of action.

M. Villarroya, Antonio G. García, A. Ruiz-Torres, 2002, Archives of gerontology and geriatrics.

Multi-target novel neuroprotective compound ITH33/IQM9.21 inhibits calcium entry, calcium signals and exocytosis.

A. Caricati‐Neto, M. Yáñez, S. Conde, 2011, Cell calcium.

Nicotinic receptor activation by epibatidine induces heme oxygenase‐1 and protects chromaffin cells against oxidative stress

A. Cuadrado, Manuela G. López, Antonio G. García, 2007, Journal of neurochemistry.

Melatonin–sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a ‘drug–prodrug’ mechanism of action

P. Rada, A. Cuadrado, R. León, 2015, British journal of pharmacology.

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

C. Pérez, N. Campillo, Manuela G. López, 2009, ChemMedChem.

Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans.

Manuela G. López, Antonio G. García, J. Egea, 2010, Osteoarthritis and cartilage.

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation

Antonio G. García, M. Martin-de-Saavedra, J. Egea, 2012, Neuropharmacology.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.