M. Rodríguez-Franco

发表

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

E. Laurini, S. Pricl, C. Pérez, 2016, Future medicinal chemistry.

Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.

C. Pérez, B. Bartolomé, B. Hernández-Ledesma, 2006, Journal of medicinal chemistry.

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

P. Negredo, R. León, Manuela G. López, 2013, Neuropharmacology.

Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

E. Laurini, S. Pricl, C. Pérez, 2018, European journal of medicinal chemistry.

Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists

Maria M. M. Santos, Lídia M D Gonçalves, M. Rodríguez-Franco, 2017, ChemMedChem.

The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction.

R. León, Manuela G. López, M. Rodríguez-Franco, 2015, ACS chemical neuroscience.

Antinociceptive and modulatory effect of pathoplastic changes in spinal glia of a TLR4/CD14 blocking molecule in two models of pain in rat.

M. Rodríguez-Franco, C. Goicoechea, J. Uranga, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

I. Ferrer, E. Carro, D. Antequera, 2012, Neurobiology of Disease.

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.

A. Cuadrado, F. Gago, C. Pérez, 2020, European journal of medicinal chemistry.

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

J. Encinar, A. I. Rojo, A. Cuadrado, 2022, Redox biology.

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.

C. Pérez, Manuela G. López, M. Villarroya, 2014, European journal of medicinal chemistry.

Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.

C. Pérez, Manuela G. López, M. Villarroya, 2010, European journal of medicinal chemistry.

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21

F. Pavón, A. Serrano, A. Cippitelli, 2006, Neuropharmacology.

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

E. Laurini, S. Pricl, C. Pérez, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of New N‐(4‐Pyridyl)‐1‐aminopyrazoles and Their Muscarinic and Adrenergic Properties

C. Pérez, A. Badía, Ana Martínez, 2000, Archiv der Pharmazie.

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

C. Pérez, M. de la Fuente Revenga, M. Yáñez, 2015, ACS chemical neuroscience.

Synthesis, cytostatic and trichomonacide activities of 3,5-bis-(halomethyl)pyrazoles

J. Escario, L. Iturrino, M. Rodríguez-Franco, 1987 .

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

M. Loza, J. Brea, F. Feixas, 2022, Journal of medicinal chemistry.

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

A. Cuadrado, R. León, Manuela G. López, 2022, Medicinal research reviews.

Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2009, Journal of medicinal chemistry.

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

C. Pérez, N. Campillo, Manuela G. López, 2009, ChemMedChem.

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

A. Feilding, J. Riba, M. de la Fuente Revenga, 2017, Scientific Reports.

3‐Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

L. Santana, E. Uriarte, M. Rodríguez-Franco, 2015, ChemMedChem.

New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization.

D. Sugden, M. de la Fuente Revenga, M. Rodríguez-Franco, 2015, European journal of medicinal chemistry.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

F. J. Luque, V. Andrisano, M. Bartolini, 2012, Journal of medicinal chemistry.

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.

C. Pérez, M. Rodríguez-Franco, D. Viña, 2016, European journal of medicinal chemistry.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Stefano Alcaro, Katarina Nikolic, Francesco Ortuso, 2014, Journal of medicinal chemistry.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Jörg Rademann, C. Pérez, J. Rademann, 2012, Journal of medicinal chemistry.

Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.

S. Vilar, L. Santana, E. Uriarte, 2015, Bioorganic & medicinal chemistry letters.

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

C. Pérez, R. León, Manuela G. López, 2012, ACS chemical neuroscience.

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.

C. Pérez, R. León, Manuela G. López, 2011, European journal of medicinal chemistry.

Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease.

Ana Martínez, S. Conde, M. Rodríguez-Franco, 2002, Mini reviews in medicinal chemistry.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2009, Journal of medicinal chemistry.

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

M. de la Fuente Revenga, M. Rodríguez-Franco, D. Caignard, 2015, Journal of medicinal chemistry.

Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation

S. Conde, M. Rodríguez-Franco, C. Puig, 1998 .

Formation of mono- and di- nuclear complexes of Zn2+ from a 26 membered tetraester crown of 3,5-disubstituted pyrazole able to act as neutral and dianionic ligand

A. Samat, M. Rodríguez-Franco, P. Navarro, 1994 .

Regioselective lipase catalyzed synthesis of diester crowns. New asymmetric macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit

S. Conde, M. Rodríguez-Franco, M. Jimeno, 1997 .

Regioselective lipase-catalyzed synthesis of l-glutamic α-monoamide derivatives. Effect of the N-blocking group

Ana Martínez, S. Conde, M. Rodríguez-Franco, 1997 .

SELECTIVE DOPAMINE RECEPTORS : SYNTHESIS, COMPLEXING PROPERTIES, AND MOLECULAR MODELLING STUDIES OF NEW PODANDS DERIVED FROM 4-HYDROXY-1H-PYRAZOLE

Ana Martínez, M. Rodríguez-Franco, P. Navarro, 1999 .

Caesium-Assisted Cyclization of Large Polyether Hexa- and Octaester Pyrazolic Crowns

A. Samat, M. Rodríguez-Franco, P. Navarro, 1987 .

2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis.

M. Loza, J. Brea, J. Oyarzábal, 2020, Journal of medicinal chemistry.

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

C. Pérez, Irene Bolea, Abdelouahid Samadi, 2013, Current Alzheimer research.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

F. J. Luque, Vincenza Andrisano, Albert Badia, 2010, ChemMedChem.

Synthesis and in vitro study of nitro- and methoxy-2-phenylbenzofurans as human monoamine oxidase inhibitors.

G. Delogu, Amit Kumar, M. Rodríguez-Franco, 2021, Bioorganic chemistry (Print).

1-Benzyl-4-chloromethylpiperidine: A Building Block in the Synthesis of Compounds of Pharmacological Interest

M. I. Fernández-Bachiller, M. Rodríguez-Franco, 2002 .

Intermediates in the synthesis of dipyrazolic podands and ester crowns via regioselective lipase catalyzed hydrolysis of a tetraester

S. Conde, M. Rodríguez-Franco, I. Dorronsoro, 1997 .

Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

C. Pérez, R. León, Manuela G. López, 2022, Journal of medicinal chemistry.