Jihyae Ann

发表

Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a β-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.

Jiyoun Lee, D. Jo, H. Hong, 2018, Journal of medicinal chemistry.

Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

M. Kazanietz, P. Blumberg, M. Abba, 2019, Scientific Reports.

Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes

M. Kazanietz, P. Blumberg, R. Garg, 2018, Journal of Biological Chemistry.

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

D. Rossi, S. Collina, A. Pascale, 2015 .

α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands.

P. Blumberg, M. Peach, N. Lewin, 2018, Journal of medicinal chemistry.

Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).

P. Blumberg, D. H. Kim, N. Lewin, 2015, European journal of medicinal chemistry.

Discovery of a Simplified Deguelin Analog as an HSP90 C-terminal Inhibitor for HER2-positive Breast Cancer.

Hyun-Ju Park, Jihyae Ann, Jeewoo Lee, 2021, Bioorganic & medicinal chemistry letters.

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer

Ji Young Kim, Hyun-Ju Park, J. Seo, 2020, Molecular Cancer.

A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response

J. Seo, Jihyae Ann, Jeewoo Lee, 2022, Oncogene.

Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).

Ji Young Kim, Hyun-Ju Park, Raghaba Sahu, 2020, Bioorganic & medicinal chemistry letters.

Discovery of Novel Dual Adenosine A2A and A1 Receptor Antagonists with 1H-Pyrazolo[3,4-d]pyrimidin-6-amine Core Scaffold as Anti-Parkinson’s Disease Agents

Jihyae Ann, Jeewoo Lee, Juyoung Jung, 2022, Pharmaceuticals.

Design and Synthesis of an N-Benzyl 5-(4-Sulfamoylbenzylidene-2-thioxothiazolidin-4-one Scaffold as a Novel NLRP3 Inflammasome Inhibitor.

Jeewoo Lee, Jihyae Ann, Inhwa Hwang, 2022, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Jiyoun Lee, So young Lee, Jihyae Ann, 2018, European journal of medicinal chemistry.

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

J. Sacchettini, T. Igumenova, I. Krieger, 2022, Nature Communications.

2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, Jeewoo Lee, P. Blumberg, 2016, Bioorganic & medicinal chemistry.

Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.

Heejin Ha, Jihyae Ann, Young-Ho Kim, 2022, European journal of medicinal chemistry.

Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.

S. J. Y. Macalino, M. Cui, Sun Choi, 2019, Journal of medicinal chemistry.

Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.

M. Cui, Sun Choi, Jiyoun Lee, 2018, Bioorganic & medicinal chemistry.

Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level

P. Blumberg, L. Pearce, Jihyae Ann, 2019, Biomolecules & therapeutics.

Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.

Jiyoun Lee, Heejin Ha, Jihyae Ann, 2021, European journal of medicinal chemistry.

6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.

K. Schiene, Sun Choi, Jeewoo Lee, 2015, Bioorganic & medicinal chemistry letters.

Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.

Ji-Young Hwang, Larry V. Pearce, Peter M. Blumberg, 2019, European journal of medicinal chemistry.

Discovery of 1-(1H-Indazol-4-yl)-3-((1-Phenyl-1H-Pyrazol-5-yl)methyl) Ureas as Potent and Thermoneutral TRPV1 Antagonists.

G. Bahrenberg, P. Blumberg, Sun-Ok Kwon, 2020, Bioorganic & medicinal chemistry letters.

Discovery of indane propanamides as potent and selective TRPV1 antagonists.

G. Bahrenberg, P. Blumberg, Y. H. Kim, 2019, Bioorganic & medicinal chemistry letters.

Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists.

G. Bahrenberg, P. Blumberg, Changhoon Kim, 2018, Bioorganic & medicinal chemistry letters.

t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, G. Bahrenberg, P. Blumberg, 2017, Bioorganic & medicinal chemistry.

Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.

Sun Choi, P. Blumberg, Changhoon Kim, 2016, Bioorganic & medicinal chemistry letters.

Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.

M. Cui, Sun Choi, G. Bahrenberg, 2015, Bioorganic & medicinal chemistry.

α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.

M. Cui, Sun Choi, G. Bahrenberg, 2015, Bioorganic & medicinal chemistry letters.

Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

HyungChul Ryu, Suyoung Yoon, K. Schiene, 2015, European journal of medicinal chemistry.

Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist.

Jiyoun Lee, So young Lee, Jihyae Ann, 2016, Journal of medicinal chemistry.

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2018, Scientific Reports.

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2022, Theranostics.

C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.

Ji Young Kim, J. Seo, Jihyae Ann, 2019, Cancer letters.

Discovery of Non-pungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.

S. Hwang, P. Blumberg, L. Pearce, 2019, Journal of medicinal chemistry.

Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).

Jiyoun Lee, Changhoon Kim, Woong Sub Byun, 2019, Bioorganic & medicinal chemistry.

Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Won Kyung Kim, Jiyoun Lee, Jihyae Ann, 2018, Bioorganic & medicinal chemistry.

Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Won Kyung Kim, Sunghoon Kim, Jiyoun Lee, 2016, Bioorganic & medicinal chemistry.

Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.

Do-Hee Kim, Y. Surh, H. Na, 2018, Cancer letters.

Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.

M. Cui, Sun Choi, Heejin Ha, 2018, Bioorganic & medicinal chemistry.

Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.

M. Cui, Sun Choi, Jiyoun Lee, 2017, Journal of medicinal chemistry.

Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template.

Jeewoo Lee, Hyundong Song, I. Mook‐Jung, 2013, Bioorganic & medicinal chemistry.

Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.

Ji Young Kim, Hyun-Ju Park, Kyu-Won Kim, 2019, Bioorganic & medicinal chemistry.

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.

Sun Choi, Yoonji Lee, P. Blumberg, 2021, Journal of medicinal chemistry.

In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523.

G. Bahrenberg, N. Damann, Jihyae Ann, 2020, European journal of pharmacology.

Discovery of 5-(N-Hydroxycarbamimidoyl) Benzofuran Derivatives as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.

Jihyae Ann, Jeewoo Lee, Juyoung Jung, 2021, Bioorganic & Medicinal Chemistry Letters.

The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.

Sun Choi, P. Blumberg, L. Pearce, 2013, European journal of medicinal chemistry.

Functional Group-Dependent Induction of Astrocytogenesis and Neurogenesis by Flavone Derivatives

Y. M. Kim, Hyun-Jung Kim, Jin-Mi Kang, 2019, Biomolecules.

Structural anatomy of C1 domain interactions with DAG and other agonists

J. Sacchettini, T. Igumenova, I. Krieger, 2021, bioRxiv.

Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

M. Kazanietz, P. Blumberg, M. Abba, 2019, Scientific Reports.

The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells

Ji Young Kim, J. Seo, Jihyae Ann, 2021, Cell death discovery.

Chiral 2-phenyl-3-hydroxypropyl esters as PKC-alpha modulators: HPLC enantioseparation, NMR absolute configuration assignment, and molecular docking studies.

F. Vasile, D. Potenza, D. Rossi, 2021, Chirality.

4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands.

Sun Choi, G. Bahrenberg, P. Blumberg, 2018, Bioorganic & medicinal chemistry.

Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.

Sun Choi, G. Bahrenberg, P. Blumberg, 2017, Bioorganic & medicinal chemistry letters.

2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.

M. Cui, Sun Choi, P. K. Sharma, 2014, Bioorganic & medicinal chemistry letters.

TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.

Sun Choi, HyungChul Ryu, Peter M. Blumberg, 2013, Bioorganic & medicinal chemistry.

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.

Dong Wook Kang, Sun Choi, HyungChul Ryu, 2013, European journal of medicinal chemistry.

An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells

Hyun-Jung Kim, S. Kong, Jihyae Ann, 2015, Biomolecules & therapeutics.

Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1).

P. Blumberg, L. Pearce, Jihyae Ann, 2017, Journal of medicinal chemistry.

Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones.

V. Marquez, Jihyae Ann, Jeewoo Lee, 2023, Biochemistry.

Syntheses and Antitumor Activities of Neorautenol and Shinpterocarpin Analogs

Jihyae Ann, Jeewoo Lee, Van-Hai Hoang, 2023, Bioorganic & Medicinal Chemistry Letters.

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2018, Scientific Reports.

The SAR analysis of TRPV1 agonists with the α-methylated B-region.

Vladimir A. Pavlyukovets, P. Blumberg, L. Pearce, 2012, Bioorganic & medicinal chemistry letters.

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

U. Laforenza, A. Tesei, D. Rossi, 2023, Pharmaceuticals.

The HSP90 inhibitor HVH-2930 exhibits potent efficacy against trastuzumab-resistant HER2-positive breast cancer

Jihyae Ann, Jeewoo Lee, Soeun Park, 2024, Theranostics.