H. Habashita

发表

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

I D Kuntz, A G Skillman, T J Ewing, 1999, Journal of medicinal chemistry.

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach.

H. Ohno, M. Toda, Shingo Yamamoto, 2005, Bioorganic & medicinal chemistry.

Discovery of ONO-8590580: a novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders.

A. Beresford, H. Habashita, A. Macleod, 2020, Bioorganic & Medicinal Chemistry Letters.

Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.

H. Mitsuya, K. Maeda, M. Toda, 2006, Journal of medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.

H. Mitsuya, K. Maeda, M. Toda, 2007, Bioorganic & medicinal chemistry letters.

Efficacy and immunomodulatory actions of ONO‐4641, a novel selective agonist for sphingosine 1‐phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

M. Imai, S. Nakade, K. Sato, 2013, Clinical and experimental immunology.

Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models.

H. Ochiai, H. Habashita, Shiro Shibayama, 2013, European journal of pharmacology.

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry.

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

H. Mitsuya, K. Maeda, K. Hirai, 2010, Bioorganic & medicinal chemistry letters.

Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.

A. Otaka, H. Tamamura, N. Fujii, 2002, Bioorganic & medicinal chemistry.

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.

T. Kondo, S. Nakade, H. Habashita, 2017, Journal of medicinal chemistry.

Preventive and Therapeutic Efficacy of ONO-4641, a Selective Agonist for Sphingosine 1-Phosphate Receptor 1 and 5, in Preclinical Models of Type 1 Diabetes Mellitus.

S. Nakade, H. Habashita, Kenji Hiraizumi, 2021, Biological & pharmaceutical bulletin.

Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.

M. Minami, S. Nakade, H. Habashita, 2012, Bioorganic & medicinal chemistry letters.

Discovery of S1P agonists with a dihydronaphthalene scaffold.

M. Minami, S. Nakade, H. Habashita, 2011, Bioorganic & medicinal chemistry letters.

Syn-SN2′ Pathway in the Reaction of Certain γ-(Mesyloxy) α, β-Enoates with RCu(CN)MgX×BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity.

H. Tamamura, N. Fujii, T. Taga, 1993 .

“Higher order” zinc cuprates involving lithium chloride: Synthesis of (E)-alkene dipeptide isosteres free from reductive elimination products

N. Fujii, H. Yoshizawa, Yoshinori Yamamoto, 1992 .

A simple synthesis of Ω[(E)CHCH]gly dipeptide isosteres via reductive elimination of γ-oxygenated α,β-enoates with alkenylcopper reagents

A. Otaka, Yoshinori Yamamoto, H. Habashita, 1991 .

A highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediated reaction

A. Otaka, N. Fujii, Yoshinori Yamamoto, 1991 .

Unprecedented rearrangement reaction of 2-aziridinemethanols with “lower order” lithium methylcyanocuprate

F. Garrido, A. Mann, N. Fujii, 1993 .

Effects of structural modulation on biological activity of bombesin analogues with (E)-alkene bond.

M. Imamura, R. Hosotani, K. Fujimoto, 1996, Life sciences.

Effect of a New Bombesin Receptor Antagonist, (E)‐Alkene Bombesin Isostere, on Amylase Release from Rat Pancreatic Acini

M. Imamura, R. Hosotani, R. Doi, 1995, Pancreas.

Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an alpha,beta-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers.

Y. Miwa, H. Tamamura, N. Fujii, 1997, The Journal of organic chemistry.

A thermodynamic preference of chiral cis-γ,δ-epimino-(E)-α,β-unsaturated esters over other stereoisomers: Synthetically useful Pd(0)-catalyzed equilibrated reactions of aziridines bearing an α,β-unsaturated ester group

H. Tamamura, N. Fujii, Yoshinori Yamamoto, 1996 .

Synthesis of optically pure 2-aziridinemethanols: versatile synthetic building blocks

A. Otaka, H. Tamamura, N. Fujii, 1994 .

A Novel Route to Diastereomerically Pure (E)-Alkene Dipeptide Isosteres from β-Aziridinyl-α,β-enoates by Treatment with Organocopper Reagents†‡

Y. Miwa, N. Fujii, T. Taga, 1994 .

AZA-PAYNE REARRANGEMENT OF ACTIVATED 2-AZIRIDINEMETHANOLS AND 2,3-EPOXY AMINES UNDER BASIC CONDITIONS

A. Otaka, Y. Miwa, H. Tamamura, 1995 .

Determination of absolute configuration of the alkyl group at the α-position in the acyclic α-alkyl-(E)-β,γ-enoates by circular dichroism

N. Fujii, Yoshinori Yamamoto, H. Habashita, 1990 .

Remarkable difference in reactivity of ordinary vinylcopper reagents and vinylzinc halide containing a copper salt towards γ-mesyloxy-α, β-enoates. Synthesis of homochiral 1,4-dienes

N. Fujii, Yoshinori Yamamoto, K. Nakai, 1993 .

One-pot transformation of p-toluenesulfonates of 2,3-epoxy alcohols into allyic alcohols

H. Tamamura, N. Fujii, T. Kimachi, 1997 .

Simple one-pot transformations of toluene-p-sulfonates of 2,3-epoxy alcohols into allylic alcohols

H. Tamamura, N. Fujii, M. Fujiwara, 1996 .

SN2′ selective alkylation of allylic chlorides and mesylates with RZnX reagents generated from Grignard reagents, zinc chloride, lithium chloride, and Cu(II)-salts

F. Garrido, A. Mann, N. Fujii, 1993 .

(E)-stereoselective synthesis of vinylglycines from (R)-serine via organocopper–BF3 and related reagents

A. Otaka, Y. Miwa, H. Tamamura, 1994 .

Syn‐SN2′ Pathway in the Reaction of Certain γ‐(Mesyloxy) α, β‐Enoates with RCu(CN)MgX×BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity.

H. Tamamura, N. Fujii, T. Taga, 1993 .

A Simple Synthesis of ψ((E)CH=CH)Gly Dipeptide Isosteres via Reductive Elimination of γ‐Oxygenated α,β‐Enoates with Alkenylcopper Reagents.

A. Otaka, H. Habashita, T. Ibuka, 2010 .

Highly Selective Synthesis of (E)‐Alkene Isosteric Dipeptides With High Optical Purity via RCu(CN)Li·BF3 Mediated Reaction

N. Fujii, Yoshinori Yamamoto, H. Habashita, 1990 .

A Highly Stereoselective Synthesis of E-Alkene Dipeptide Isosters via Organocyanocopper - Lewis Acid-Mediated Reaction.

A. Otaka, H. Habashita, T. Ibuka, 1991 .

Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5*

Hiroaki Mitsuya, Kazuhisa Yoshimura, H. Mitsuya, 2001, The Journal of Biological Chemistry.

Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead.

H. Kohno, S. Nakade, H. Habashita, 2016, ACS medicinal chemistry letters.

Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.

M. Minami, S. Nakade, H. Habashita, 2011, Bioorganic & medicinal chemistry letters.

Novel and potent anti-malarial agents.

Kristin M. Brinner, I. Gluzman, D. Goldberg, 2002, Bioorganic & medicinal chemistry.

Efficacy and immunomodulatory actions of ONO‐4641, a novel selective agonist for sphingosine 1‐phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

S. Nakade, K. Sato, H. Habashita, 2013, Clinical and experimental immunology.

Abstract WP286: ONO-8610539, an Injectable Small-Molecule Inhibitor of Blood Coagulation Factor XIa, Improves Cerebral Ischemic Injuries Associated with Photothrombotic Occlusion of Rabbit Middle Cerebral Artery

Yasushi Hirota, H. Habashita, A. Imagawa, 2017 .