B. Le Bourdonnec

发表

Comprehensive survey of combinatorial library synthesis: 2005.

J. Salvino, R. Dolle, B. Le Bourdonnec, 2006, Journal of combinatorial chemistry.

Discovery of a series of aminopiperidines as novel iNOS inhibitors.

R. Dolle, L. Leister, J. Cassel, 2008, Bioorganic & medicinal chemistry letters.

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.

Daniel F Tardiff, K. Rhodes, J. Piotrowski, 2018, Cell reports.

The selective mu‐opioid receptor antagonist adl5510 reduces levodopa‐induced dyskinesia without affecting antiparkinsonian action in mptp‐lesioned macaque model of Parkinson's disease

J. Brotchie, S. Fox, T. H. Johnston, 2011, Movement disorders : official journal of the Movement Disorder Society.

Discovery of Acyl Ureas as Highly Selective Small Molecule CSF1R Kinase Inhibitors.

Stacie L. Bulfer, Michael D. Kaufman, B. Le Bourdonnec, 2022, Bioorganic & medicinal chemistry letters.

Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).

Stacie L. Bulfer, Michael D. Kaufman, B. Le Bourdonnec, 2022, Bioorganic & medicinal chemistry letters.

Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.

Michael Koblish, R. Dolle, L. Leister, 2010, Bioorganic & medicinal chemistry letters.

CB2 selective sulfamoyl benzamides: optimization of the amide functionality.

Michael Koblish, R. Dolle, Markku A. Savolainen, 2009, Bioorganic & medicinal chemistry letters.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008.

Wei Zhang, Guillermo A Morales, Roland E Dolle, 2009, Journal of combinatorial chemistry.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

Wei Zhang, Guillermo A Morales, Roland E Dolle, 2008, Journal of combinatorial chemistry.

Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).

T. Graczyk, Michael Koblish, R. Dolle, 2009, Journal of medicinal chemistry.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2006.

Wei Zhang, J. Salvino, R. Dolle, 2007, Journal of combinatorial chemistry.

Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties.

P. Law, P. Portoghese, T. Metzger, 2002, Journal of medicinal chemistry.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

Roland E. Dolle, Wei Zhang, Wei Zhang, 2008, Journal of combinatorial chemistry.

o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.

P. Portoghese, C. McCurdy, B. Le Bourdonnec, 2007, Journal of medicinal chemistry.

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

J. Goossens, S. Yous, R. Houssin, 2002, Journal of Medicinal Chemistry.

Pyrazolidine-3,5-dione angiotensin-II receptor antagonists.

B. Norberg, F. Durant, J. Hénichart, 2001, Acta crystallographica. Section C, Crystal structure communications.

Affinity labels as tools for the identification of opioid receptor recognition sites.

H. Loh, P. Law, P. Portoghese, 2001, Farmaco.

Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors

R. Dolle, L. Leister, J. Cassel, 2009, The open medicinal chemistry journal.

δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization

Roland E Dolle, C. Gaveriaux-Ruff, B. Kieffer, 2012, Journal of Pharmacology and Experimental Therapeutics.

Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson’s Disease

Daniel F Tardiff, K. Rhodes, M. Lucas, 2022, Molecular Neurobiology.

Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors.

H. Loh, P. Law, P. Portoghese, 2000, Journal of medicinal chemistry.

Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

T. Graczyk, Michael Koblish, R. Dolle, 2008, Journal of medicinal chemistry.

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

R. Dolle, J. Cassel, B. Le Bourdonnec, 2008, Bioorganic & medicinal chemistry letters.

Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).

D. Ferguson, G. Poda, H. Loh, 2001, Journal of Medicinal Chemistry.

Medicinal chemistry strategies to reduce CYP2D6 inhibitory activity of lead candidates.

L. Leister, B. Le Bourdonnec, Bertrand Le Bourdonnec, 2009, Current medicinal chemistry.

Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.

T. Graczyk, R. Dolle, B. Le Bourdonnec, 2006, Bioorganic & medicinal chemistry letters.

trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists.

R. Dolle, J. Cassel, B. Le Bourdonnec, 2003, Bioorganic & medicinal chemistry letters.

Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.

T. Graczyk, T. Herbertz, R. Dolle, 2006, Journal of medicinal chemistry.