M. Verghese

发表

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

J. Veal, F. Schoenen, J. Stafford, 1995, Journal of medicinal chemistry.

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium*

S. Randell, G. Diamond, M. Verghese, 2000, The Journal of Biological Chemistry.

Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.

R. Snyderman, M. Verghese, 1987, Reviews of infectious diseases.

Reduced Three-Dimensional Motility in Dehydrated Airway Mucus Prevents Neutrophil Capture and Killing Bacteria on Airway Epithelial Surfaces1

S. Randell, R. Boucher, J. Sheehan, 2005, The Journal of Immunology.

Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.

R. Snyderman, M. Verghese, L. Charles, 1987, Journal of immunology.

Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis

R. Snyderman, B. Haribabu, D. Steeber, 2000, The Journal of experimental medicine.

Signal transduction in cells following binding of chemoattractants to membrane receptors

R. Snyderman, M. Verghese, S. Dillon, 1988, Virchows Archiv. B, Cell pathology including molecular pathology.

Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.

J. Murray, R. Snyderman, M. Verghese, 1987, The Journal of biological chemistry.

Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains.

R. Snyderman, M. Verghese, 1981, Journal of Immunology.

Function and regulation of chemoattractant receptors

A. Barr, R. Snyderman, D. Zhelev, 2000, Immunologic research.

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

R. Snyderman, L. Mcphail, M. Verghese, 1985, The Journal of biological chemistry.

Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants

R. Snyderman, C. Smith, M. Verghese, 1986, Journal of cellular biochemistry.

Effects of ion composition and tonicity on human neutrophil antibacterial activity.

R. Boucher, M. Verghese, M. W. Verghese, 1998, American journal of respiratory cell and molecular biology.

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

R. Snyderman, C. Smith, M. Verghese, 1985, The Journal of biological chemistry.

Biochemical changes in leukocytes in response to chemoattractants.

R. Snyderman, M. Verghese, 1988, Methods in enzymology.

Cytokine secretion by cystic fibrosis airway epithelial cells.

S. Randell, M. Verghese, M. Muhlebach, 2004, American journal of respiratory and critical care medicine.

A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction.

R. Snyderman, M. Verghese, R. J. Uhing, 1986, Biochemical and biophysical research communications.

Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.

R. Snyderman, M. Verghese, 1983, Journal of immunology.

Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.

R. Snyderman, M. Verghese, S. Dillon, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Airway Epithelial Surfaces Neutrophil Capture and Killing Bacteria on Dehydrated Airway Mucus Prevents Reduced Three-Dimensional Motility in

S. Randell, R. Boucher, J. Sheehan, 2005 .

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

R. Bast, B. Champion, F. Schoenen, 1994, Nature.

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.

R. Snyderman, C. Smith, M. Verghese, 1985, Biochemical and biophysical research communications.

Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice.

R. Snyderman, M. Verghese, 1982, Journal of immunology.

Phosphodiesterase type IV (PDE IV) inhibition. Synthesis and evaluation of a series of 1,3,4-trisubstituted pyrrolidines

J. Stafford, D. Cowan, P. Domanico, 1995 .

Airway epithelial cell tolerance to Pseudomonas aeruginosa

S. Randell, M. Verghese, Qi Wu, 2005, Respiratory research.

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

R. Snyderman, M. Verghese, Charles D. Smith, 1986, Journal of leukocyte biology.

P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells*

J. Boucheron, M. Verghese, T. Kneisler, 1996, The Journal of Biological Chemistry.

Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors.

D. Yarnall, J. Taylor, A. B. Strickland, 1995, The Journal of pharmacology and experimental therapeutics.

A canine model for determination of the therapeutic index of cytokine inhibitors.

R. Silverstein, M. Verghese, P. Baer, 1995, Laboratory animal science.