P. Morgan

发表

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Paul Morgan, J. Arrowsmith, P. H. van der Graaf, 2012, Drug discovery today.

The use of preclinical pharmacokinetic and pharmacodynamic data to predict clinical doses: current and future perspectives

P. Morgan, 2001 .

Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2012, Journal of medicinal chemistry.

Impact of Physicochemical and Structural Properties on the Pharmacokinetics of a Series of α1L-Adrenoceptor Antagonists

K. Beaumont, I. Gardner, P. Morgan, 2007, Drug Metabolism and Disposition.

The sexually differentiated metabolism of [6,7-3H]17β-oestradiol in rats: Male-specific 15α- and male-selective 16α-hydroxylation and female-selective catechol formation

J. Maggs, P. Morgan, B. Pak, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Role of transport proteins in drug absorption, distribution and excretion

P. Morgan, A. Ayrton, Andrew Ayrton, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations.

K. Beaumont, S. Roffey, P. Morgan, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Role of transport proteins in drug discovery and development: a pharmaceutical perspective.

P. Morgan, A. Ayrton, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

CRTH2 is Critical to the Development of Colitis Induced by Dextran Sodium Sulfate (DSS)

H. Ma, E. Saiah, Z. Radi, 2012 .

Successful treatment of COVID-19 with remdesivir in the absence of humoral immunity

William L. Hamilton, N. Loman, J. Quick, 2020 .

Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.

D. Boschelli, A. Wissner, Xiaoke Yang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2014, Journal of medicinal chemistry.

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Wei Li, Xin Xu, Paul Morgan, 2009, Journal of medicinal chemistry.

Metabolism of the genotoxicant 2-nitropropane to a nitric oxide species.

A. Gescher, C. Kohl, P. Morgan, 1995, Chemico-biological interactions.

Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3

T. Walz, B. Coller, M. Filizola, 2022, J. Chem. Inf. Model..

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver.

M. Pirmohamed, D. Chadwick, B. K. Park, 2005, British journal of clinical pharmacology.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Yogesh Sabnis, J. Chrencik, G. Whitlock, 2017, Journal of medicinal chemistry.

Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.

C Roland Wolf, Paul Morgan, Clive J Ward, 2005, Biochemical pharmacology.

The metabolism of 2- and 4-fluoro-17 beta-oestradiol in the rat and its implications for oestrogen carcinogenesis.

B. K. Park, J. Maggs, P. Morgan, 1992, Biochemical pharmacology.

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

Hugh A Barton, Hannah M Jones, Maurice Dickins, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Role of transport proteins in drug discovery and development: a pharmaceutical perspective

P. Morgan, A. Ayrton, A. Ayrton, 2008 .

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.

R. Kurumbail, D. Hepworth, J. Guzova, 2017, European journal of medicinal chemistry.

Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.

T. Friedberg, P. Morgan, D. Yao, 2002, Biochemical pharmacology.

LC determination of carbamazepine in murine brain.

M. Pirmohamed, B. K. Park, A. Owen, 2001, Journal of pharmaceutical and biomedical analysis.

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements.

M. Pirmohamed, B. K. Park, C. Goldring, 2006, British journal of clinical pharmacology.

Multiple factors govern the association between pharmacology and toxicity in a class of drugs: toward a unification of class effect terminology.

Dennis A. Smith, P. Morgan, A. Harrison, 2011, Chemical research in toxicology.

Carbamazepine is not a substrate for P-glycoprotein.

M. Pirmohamed, D. Chadwick, B. K. Park, 2001, British journal of clinical pharmacology.

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades.

Susanne Winiwarter, Rhys D O Jones, Michael Davies, 2020, Trends in pharmacological sciences.

Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).

J. Bard, T. Mansour, E. Saiah, 2012, Bioorganic & medicinal chemistry letters.

Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4.

D. Boschelli, V. Rao, E. A. Murphy, 2014, Bioorganic & medicinal chemistry letters.

Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.

M. Andrews, Malcolm C. Mackenny, M. J. Pitcher, 2006, Bioorganic & medicinal chemistry letters.

The use of C(av) rather than AUC in safety assessment.

D A Smith, D K Walker, D. Smith, 2010, Regulatory toxicology and pharmacology : RTP.

In silico Study of 1,687 FDA Approved Drugs and 612 Natural Products Reveals Benzydamine’s Potential as a Direct Inhibitor of TNF-α

P. Morgan, Chih-Wen Lin, Meghan Mangal, 2018 .

Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.

Wei Li, Xin Xu, Paul Morgan, 2009, Journal of medicinal chemistry.

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

D. Joseph-McCarthy, A. Wissner, J. Ellingboe, 2008, Journal of medicinal chemistry.

Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.

M. Andrews, Malcolm C. Mackenny, D. Hepworth, 2008, Bioorganic & medicinal chemistry letters.