S. Ohkawa

发表

Synthesis of a novel series of benzocycloalkene derivatives as melatonin receptor agonists.

S. Hinuma, Koki Kato, M. Miyamoto, 2002, Journal of medicinal chemistry.

Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys

H. Nishikawa, M. Miyamoto, S. Ohkawa, 2004, Brain Research.

Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.

Y. Seyama, M. Minami, F. Takaku, 1987, The Journal of biological chemistry.

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Toshimasa Tanaka, Seiji Miwatashi, S. Asahi, 2005, Journal of medicinal chemistry.

Contractile activities of leukotrienes C4 and D4 on vascular strips from rabbits.

H. Okuda, G. Kito, S. Ohkawa, 1981, Life sciences.

Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats.

Y. Fujiwara, S. Ohkawa, A. Shino, 1991, Kidney international.

Coronary vasoconstriction and PGI2 release by leukotrienes in isolated guinea pig hearts

S. Ohkawa, H. Fukui, S. Terao, 1981 .

Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.

S. Ohkawa, S. Terao, Y. Shibouta, 1991, Journal of medicinal chemistry.

Ramelteon (TAK-375) Accelerates Reentrainment of Circadian Rhythm after a Phase Advance of the Light-Dark Cycle in Rats

H. Nishikawa, M. Miyamoto, K. Hirai, 2005, Journal of biological rhythms.

The sleep-promoting action of ramelteon (TAK-375) in freely moving cats.

H. Nishikawa, M. Miyamoto, K. Hirai, 2004, Sleep.

Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids.

S. Ohkawa, K Kato, K. Kato, 1985, Journal of medicinal chemistry.

Approach to the stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric hydrogenation

M. Adachi, K. Fukatsu, O. Uchikawa, 2006 .

Synthesis of TAK-218 using (R)-2-methylglycidyl tosylate as a chiral building block

K. Fukatsu, S. Ohkawa, N. Fujii, 1999 .

Kinetic Resolutions of Indan Derivatives Using Bacteria

K. Fukatsu, S. Ohkawa, K. Nakahama, 2002, Bioscience, biotechnology, and biochemistry.

Kinetic resolution of an indan derivative using Bacillus sp. SUI-12: synthesis of a key intermediate of the melatonin receptor agonist TAK-375.

O. Uchikawa, M. Kawada, S. Ohkawa, 2002, Journal of bioscience and bioengineering.

Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist

S. Hinuma, K. Nishiyama, Koki Kato, 2005, Neuropharmacology.

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.

S. Hinuma, H. Nishikawa, Koki Kato, 2002, Journal of medicinal chemistry.

Quinones. Part 2. General synthetic routes to quinone derivatives with modified polyprenyl side chains and the inhibitory effects of these quinones on the generation of the slow reacting substance of anaphylaxis (SRS-A)

S. Ohkawa, M. Shiraishi, Kaneyoshi Kato, 1983 .

Mechanism for the generation of active smooth muscle inhibitory factor (IF) from bovine retractor penis muscle (BRP).

T. Aoyama, C. Kawai, S. Ohkawa, 1989, Biochemical and biophysical research communications.

7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors.

D. L. Larson, P. Portoghese, A. Takemori, 1997, Journal of medicinal chemistry.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists.

Seiji Miwatashi, Y. Imai, S. Ohkawa, 2008, Chemical & pharmaceutical bulletin.

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils.

H. Eizawa, C. Kawai, K. Hiki, 1991, The Journal of biological chemistry.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors.

T. Kawamoto, Seiji Miwatashi, S. Ohkawa, 2005, Chemical & pharmaceutical bulletin.

7-Arylidenenaltrexones as Selective δ1 Opioid Receptor Antagonists

P. Portoghese, S. Ohkawa, 1998 .