A. M. V. D. van den Nieuwendijk

发表

Pyrazole derivatives as partial agonists for the nicotinic acid receptor.

A. IJzerman, J. Brussee, T. van Herk, 2003, Journal of medicinal chemistry.

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

H. Overkleeft, G. A. van der Marel, T. Wennekes, 2014, Journal of medicinal chemistry.

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.

H. Overkleeft, G. A. van der Marel, B. Kessler, 2007, Bioorganic & medicinal chemistry letters.

Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors.

H. Overkleeft, G. A. van der Marel, B. Florea, 2007, Organic & biomolecular chemistry.

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.

D. Filippov, H. Overkleeft, G. A. van der Marel, 2006, Chemistry & biology.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

G. A. van der Marel, H. Ovaa, G. Davies, 2017, Journal of the American Chemical Society.

Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate.

M. Ubbink, M. Prudêncio, A. M. V. D. van den Nieuwendijk, 2007, Chemistry.

Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors.

H. Overkleeft, A. W. Tuin, G. V. van Westen, 2019, Bioorganic & medicinal chemistry.

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.

H. Overkleeft, G. A. van der Marel, B. Florea, 2010, Journal of medicinal chemistry.

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00029d

T. van der Wel, M. van der Stelt, H. Overkleeft, 2017, MedChemComm.

Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.

A. IJzerman, L. Heitman, A. Göblyös, 2004, Journal of medicinal chemistry.

Synthesis of Glycosylated 1-Deoxynojirimycins Starting from Natural and Synthetic Disaccharides

H. Overkleeft, A. M. V. D. van den Nieuwendijk, J. Aerts, 2018, European Journal of Organic Chemistry.

Inhibition of nucleoside transport by new analogues of nitrobenzylthioinosine.

A. IJzerman, A. Borghini, A. M. V. D. van den Nieuwendijk, 2003, Bioorganic & medicinal chemistry.

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

H. Overkleeft, G. A. van der Marel, A. M. V. D. van den Nieuwendijk, 2015, The Journal of organic chemistry.

Synthesis of reduced collagen crosslinks.

J. Brussee, R. Bank, A. M. V. D. van den Nieuwendijk, 1999, Bioorganic & medicinal chemistry letters.

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

H. Overkleeft, B. Cravatt, T. van der Wel, 2017, Journal of medicinal chemistry.

Ultrasensitive in situ visualization of active glucocerebrosidase molecules.

G. A. van der Marel, C. Hollak, M. Witte, 2010, Nature chemical biology.

Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.

H. Overkleeft, G. A. van der Marel, J. Brussee, 2010, Organic letters.

Direct Stereoselective Aziridination of Cyclohexenols with 3‐Amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors

H. Overkleeft, G. A. van der Marel, M. Artola, 2019, European journal of organic chemistry.

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.

R. Maehr, H. Overkleeft, G. A. van der Marel, 2004, Bioorganic & medicinal chemistry letters.

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

H. Overkleeft, Juan Zhou, B. Cravatt, 2015, Proceedings of the National Academy of Sciences.

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.

H. Overkleeft, B. Florea, E. D. Mock, 2016, Chemical communications.

Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6.

H. Overkleeft, M. van der Stelt, A. M. V. D. van den Nieuwendijk, 2018, Chemistry, an Asian journal.

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds.

H. Overkleeft, M. van Buchem, A. Windhorst, 2016, Bioorganic & medicinal chemistry.

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.

Benedikt M Kessler, Hidde L Ploegh, H. Overkleeft, 2003, Angewandte Chemie.

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes.

H. Overkleeft, G. A. van der Marel, A. W. Tuin, 2016, Molecular bioSystems.

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

H. Overkleeft, B. Cravatt, T. van der Wel, 2017, Journal of Medicinal Chemistry.

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.

H. Overkleeft, B. Florea, E. D. Mock, 2016, Chemical communications.

Ultrasensitive in situ visualization of active glucocerebrosidase molecules.

G. A. van der Marel, C. Hollak, M. Witte, 2010, Nature chemical biology.