Yuya Oguro

发表

Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.

T. Kojima, M. Yabuki, Sei Yoshida, 2013, Journal of medicinal chemistry.

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.

Terufumi Takagi, H. Oki, Terufumi Takagi, 2013, Bioorganic & medicinal chemistry.

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

T. Miyazaki, Sei Yoshida, T. Ishikawa, 2017, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.

Terufumi Takagi, Naoki Miyamoto, Yuya Oguro, 2012, Bioorganic & medicinal chemistry.

Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent.

H. Sugimoto, K. Iwata, T. Miyazaki, 2020, Journal of medicinal chemistry.

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

S. Sasaki, T. Ohashi, H. Tojo, 2012, Bioorganic & medicinal chemistry.

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

M. Yabuki, Sei Yoshida, T. Ishikawa, 2013, Bioorganic & medicinal chemistry.

A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis

Yuya Oguro, S. Imamura, A. Hori, 2012, Cancer science.

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.

M. Tawada, Naoki Miyamoto, Yuya Oguro, 2013, Bioorganic & medicinal chemistry.

N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.

Terufumi Takagi, K. Okada, Naoki Miyamoto, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.

Terufumi Takagi, K. Okada, Naoki Miyamoto, 2010, Bioorganic & medicinal chemistry.

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety.

L. Qin, S. Gay, D. Dougan, 2021, Journal of medicinal chemistry.

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

K. Burke, Jie Yu, T. Miyazaki, 2019, Science Advances.

2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.

T. Miyazaki, Sei Yoshida, Misaki Homma, 2017, Bioorganic & medicinal chemistry.

Molecular mechanism and potential target indication of TAK-931 , a novel CDC 7-selective inhibitor

K. Burke, Jie Yu, T. Miyazaki, 2019 .

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

S. Sasaki, T. Ohashi, Yuta Tanaka, 2012, Bioorganic & medicinal chemistry.

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

S. Sasaki, T. Ohashi, Yuta Tanaka, 2012, Bioorganic & medicinal chemistry.

Abstract 2823: TAK-441, a novel investigational small molecule hedgehog pathway inhibitor for use in cancer therapy

M. Kawamura, S. Sasaki, H. Tojo, 2011 .