G. Ward

发表

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.

G. Chessari, P. Williams, E. J. Lewis, 2015, Journal of medicinal chemistry.

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

P. Johnston, D. Longley, G. Chessari, 2013, Cell Death and Disease.

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

G. Chessari, P. Williams, E. Chiarparin, 2017, Journal of medicinal chemistry.

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

M. Salto‐Tellez, D. Longley, G. Chessari, 2016, Oncotarget.

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

G. McKenzie, L. Young, J. Lamb, 2003, The Journal of clinical investigation.

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism

G. McKenzie, L. Young, J. Lamb, 2003 .

Antagonism of inhibitors of apoptosis proteins reveals a novel, immune-based therapeutic approach for T-cell lymphoma

H. Saini, R. Ferraldeschi, H. Keer, 2021 .

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one

G. Chessari, P. Williams, G. Saxty, 2018, Journal of medicinal chemistry.

Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.

B. Moss, T. Fuerst, C. K. Stover, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

C. Murray, J. Vialard, D. Newell, 2017, Molecular Cancer Therapeutics.

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

J. Bertin, J. Choudhary, Lu Yu, 2021, Nature Communications.

Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production

G. McKenzie, E. Briend, B. Champion, 2006, The Journal of Immunology.

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

G. Chessari, J. Lyons, N. Thompson, 2018, Molecular Cancer Therapeutics.

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

G. McKenzie, E. Briend, B. Champion, 2006, BMC Cell Biology.

Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

C. Murray, V. Berdini, D. Newell, 2011, Molecular Cancer Therapeutics.

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

M. Boerries, S. Fulda, M. Vogler, 2019, Cell Death & Differentiation.

Nuclear Ca2+ and CaM kinase IV specify hormonal‐ and Notch‐responsiveness

G. McKenzie, H. Bading, G. Hardingham, 2005, Journal of neurochemistry.

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

M. Boerries, S. Fulda, M. Vogler, 2019, Cell Death and Differentiation.

Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma

H. Saini, J. Lyons, R. Ferraldeschi, 2021, Blood advances.

Abstract 1738: JNJ-42756493 is an inhibitor of FGFR-1, 2, 3and4 with nanomolar affinity for targeted therapy

C. Murray, J. Vialard, D. Newell, 2014 .

Role of interferon-gamma in T-cell responses to Semliki Forest virus-infected murine brain cells.

G. Ward, P. Tomkins, A. Morris, 1988, Immunology.

Interaction of v-Ki-ras oncogene and interferon-gamma in the control of histocompatibility antigen expression in mouse fibroblasts.

G. Ward, A. Morris, W. Bateman, 1989, Cellular immunology.