C. Janko

发表

Sialylation of anti‐histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells

G. Schett, R. Bilyy, J. Rech, 2016, Clinical and experimental immunology.

Magnetic nanoparticles for cancer therapy

Philipp Tripal, Christoph Alexiou, Stephan Dürr, 2013 .

Magnetic nanoparticle-based drug delivery for cancer therapy.

Harald Unterweger, Christoph Alexiou, Stephan Dürr, 2015, Biochemical and biophysical research communications.

Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus

G. Schett, R. Bilyy, M. Herrmann, 2015, Lupus.

Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Enable a Stable Non-Spilling Loading of T Cells and Their Magnetic Accumulation

C. Alexiou, D. Dudziak, C. Janko, 2021, Cancers.

Inert Coats of Magnetic Nanoparticles Prevent Formation of Occlusive Intravascular Co-aggregates With Neutrophil Extracellular Traps

C. Alexiou, R. Bilyy, M. Herrmann, 2018, Front. Immunol..

Mitoxantrone-Loaded Nanoparticles for Magnetically Controlled Tumor Therapy–Induction of Tumor Cell Death, Release of Danger Signals and Activation of Immune Cells

C. Alexiou, A. Derer, B. Frey, 2020, Pharmaceutics.

Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy

C. Alexiou, R. Tietze, C. Janko, 2019, Front. Oncol..

Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility

Harald Unterweger, Christoph Alexiou, Geoffrey Lee, 2014, International journal of nanomedicine.

Superparamagnetic Iron Oxide Nanoparticles Carrying Chemotherapeutics Improve Drug Efficacy in Monolayer and Spheroid Cell Culture by Enabling Active Accumulation

C. Alexiou, R. Friedrich, C. Janko, 2020, Nanomaterials.

Functionalization of T lymphocytes for magnetically controlled immune therapy: Selection of suitable superparamagnetic iron oxide nanoparticles

C. Alexiou, R. Tietze, D. Dudziak, 2019, Journal of Magnetism and Magnetic Materials.

SPIONs functionalized with small peptides for binding of lipopolysaccharide, a pathophysiologically relevant microbial product.

C. Alexiou, W. Peukert, A. Boccaccini, 2019, Colloids and surfaces. B, Biointerfaces.

Multifunctional SPIONs for Theranostics in Cancer

L. Trahms, M. Uder, C. Alexiou, 2018 .

Strategies to optimize the biocompatibility of iron oxide nanoparticles – “SPIONs safe by design”

C. Alexiou, D. Eberbeck, R. Tietze, 2017 .

Nanomedical innovation: the SEON-concept for an improved cancer therapy with magnetic nanoparticles.

C. Alexiou, R. Tietze, R. Friedrich, 2015, Nanomedicine.

Imaging and quantification of SPIONs for cancer therapy with magnetic drug targeting

L. Trahms, M. Uder, C. Alexiou, 2015, International Workshop on Magnetic Particle Imaging.

Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy

C. Alexiou, A. Boccaccini, C. Maake, 2015, International journal of nanomedicine.

Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery

C. Alexiou, A. Boccaccini, D. Eberbeck, 2014, International journal of nanomedicine.

Journal watch: diagnostic nanoparticles.

C. Alexiou, R. Friedrich, I. Cicha, 2017, Nanomedicine.

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

J. M. Brauner, G. Schett, R. Bilyy, 2016, Proceedings of the National Academy of Sciences.

Autoimmunity and chronic inflammation - two clearance-related steps in the etiopathogenesis of SLE.

G. Schett, M. Herrmann, L. Munoz, 2010, Autoimmunity reviews.

Specific Removal of C-Reactive Protein by Apheresis in a Porcine Cardiac Infarction Model

W. Schrödl, R. Kunze, J. Schulz-Menger, 2010, Blood Purification.

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

C. Alexiou, R. Schneider-Stock, R. Tietze, 2022, International journal of nanomedicine.

Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro

K. Lauber, J. Rech, M. Herrmann, 2018, Front. Immunol..

Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus.

D. Isenberg, M. Schiller, H. Lorenz, 2013, Glycobiology.

Autoantibodies against galectin-2 peptides as biomarkers for the antiphospholipid syndrome

D. Isenberg, M. Schiller, G. Schett, 2012, Lupus.

Peripheral Blood Stem Cells of Patients with Systemic Lupus Erythematosus Show Altered Differentiation into Macrophages

R. Voll, M. Herrmann, L. Munoz, 2010 .

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus.

R. Fietkau, G. Schett, R. Voll, 2009, Arthritis and rheumatism.

SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications

C. Alexiou, R. Friedrich, C. Janko, 2021, Physical Sciences Reviews.

Tuning the structure of aminoferrocene-based anticancer prodrugs to prevent their aggregation in aqueous solution.

C. Alexiou, A. Mokhir, C. Janko, 2018, Journal of inorganic biochemistry.

High hydrostatic pressure treatment generates inactivated mammalian tumor cells with immunogeneic features

R. Fietkau, E. Schlücker, M. Herrmann, 2010, Journal of immunotoxicology.

Nanomedicine for cardiovascular disorders.

C. Alexiou, R. Friedrich, I. Cicha, 2019, Nanomedicine.

Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.

C. Janko, J. Geyer, 2013, Journal of veterinary pharmacology and therapeutics.

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

C. Alexiou, L. Sellner, L. Kunz-Schughart, 2021, Cancers.

Nanomedicine for neuroprotection.

C. Alexiou, R. Friedrich, I. Cicha, 2019, Nanomedicine.

UVB-irradiated apoptotic cells induce accelerated growth of co-implanted viable tumor cells in immune competent mice

C. Berens, G. Schett, R. Bilyy, 2013, Autoimmunity.

Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications.

C. Alexiou, A. Boccaccini, C. Bogdan, 2022, Acta biomaterialia.

'Nano-lysing' the disease process: novel diagnostic and therapeutic nanoparticles.

C. Alexiou, R. Friedrich, I. Cicha, 2018, Nanomedicine.

Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture

C. Alexiou, R. Friedrich, C. Janko, 2022, Advanced Functional Materials.

Clearance of apo Nph induces an immunosuppressive response in pro-inflammatory type-1 and anti-inflammatory type-2 MΦ

M. Hoeve, I. Dransfield, S. Franz, 2009, Autoimmunity.

Navigation to the graveyard-induction of various pathways of necrosis and their classification by flow cytometry.

C. Berens, K. Lauber, M. Herrmann, 2013, Methods in molecular biology.

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

G. Schett, M. Herrmann, C. Janko, 2012, Front. Immun..

Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death

R. Fietkau, B. Frey, U. Gaipl, 2009, Autoimmunity.

Novel nanoparticulate drug delivery systems.

C. Alexiou, R. Friedrich, I. Cicha, 2016, Nanomedicine.

IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE

G. Schett, M. Herrmann, L. Munoz, 2010, Autoimmunity.

Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo.

A. Balakrishnan, M. Ott, C. Alexiou, 2017, Chemistry.

Nanomedicine for infectious diseases.

C. Alexiou, R. Tietze, R. Friedrich, 2020, Nanomedicine.

[1,10]Phenanthroline based cyanine dyes as fluorescent probes for ribonucleic acids in live cells

C. Alexiou, S. Yarmoluk, D. Kryvorotenko, 2017, Methods and applications in fluorescence.

Intranasal delivery of nanoparticles.

C. Alexiou, R. Tietze, R. Friedrich, 2022, Nanomedicine.

Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations

U. Schlötzer-Schrehardt, J. Kopitz, H. Gabius, 2012, Graefe's Archive for Clinical and Experimental Ophthalmology.

Nanoparticles for regenerative medicine.

C. Alexiou, R. Friedrich, I. Cicha, 2019, Nanomedicine.

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).

M. Herrmann, L. Munoz, B. Frey, 2008, Autoimmunity reviews.

Imaging modalities using magnetic nanoparticles – overview of the developments in recent years

Philipp Tripal, Christoph Alexiou, Arnd Dörfler, 2013 .

Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids

C. Alexiou, S. Odenbach, R. Friedrich, 2015, Molecules.

Flow cytometry for intracellular SPION quantification: specificity and sensitivity in comparison with spectroscopic methods

Lutz Trahms, Philipp Tripal, Christoph Alexiou, 2015, International journal of nanomedicine.

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

T. Harrer, M. Lell, R. Holmdahl, 2014, Nature Medicine.

Targeting of drug‐loaded nanoparticles to tumor sites increases cell death and release of danger signals

C. Alexiou, R. Friedrich, B. Frey, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones

J. Geyer, C. Janko, 2012, Current pharmaceutical biotechnology.

Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications

Wei Li, C. Alexiou, A. Boccaccini, 2016, Scientific Reports.

Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: evaluation of size-dependent imaging properties, storage stability and safety

C. Alexiou, A. Boccaccini, T. Fey, 2018, International journal of nanomedicine.

Phospholipids: Key Players in Apoptosis and Immune Regulation

M. Herrmann, L. Munoz, B. Frey, 2009, Molecules.

Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake

L. Trahms, C. Alexiou, D. Eberbeck, 2017, International journal of nanomedicine.

Magnetic Drug Targeting Reduces the Chemotherapeutic Burden on Circulating Leukocytes

Christoph Alexiou, Stephan Dürr, Luis E. Munoz, 2013, International journal of molecular sciences.

Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles*

K. Lauber, M. Schiller, G. Schett, 2011, The Journal of Biological Chemistry.

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

G. Schett, M. Herrmann, L. Munoz, 2012, Front. Immun..

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

K. Lauber, G. Schett, R. Voll, 2010, The Journal of Biological Chemistry.

The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations

G. Schett, M. Herrmann, L. Munoz, 2010, Autoimmunity.

Analysis of Hypericin-Mediated Effects and Implications for Targeted Photodynamic Therapy

C. Alexiou, R. Friedrich, C. Janko, 2017, International journal of molecular sciences.

The involvement of E6, p53, p16, MDM2 and Gal-3 in the clinical outcome of patients with cervical cancer

C. Alexiou, U. Jeschke, C. Kuhn, 2017, Oncology letters.

Functionalization Of T Lymphocytes With Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles For Magnetically Controlled Immune Therapy

C. Alexiou, R. Tietze, R. Friedrich, 2019, International journal of nanomedicine.

ROS-Responsive N-Alkylaminoferrocenes for Cancer-Cell-Specific Targeting of Mitochondria

C. Alexiou, A. Mokhir, R. Bilyy, 2018, Angewandte Chemie.

ROS-Responsive N-Alkylaminoferrocenes for Cancer-Cell-Specific Targeting of Mitochondria.

C. Alexiou, A. Mokhir, R. Bilyy, 2018, Angewandte Chemie.

Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during therapy

R. Bilyy, M. Herrmann, J. Knopf, 2017, Clinical and experimental immunology.

An Endoplasmic Reticulum Specific Pro‐amplifier of Reactive Oxygen Species in Cancer Cells

C. Alexiou, L. Sellner, A. Mokhir, 2021, Angewandte Chemie.

Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use

C. Alexiou, E. Tombácz, I. Zupkó, 2015 .

Cooperative binding of Annexin A5 to phosphatidylserine on apoptotic cell membranes

M. Herrmann, L. Munoz, M. Biermann, 2013, Physical biology.

Immunohistochemical Evaluation of E6/E7 HPV Oncoproteins Staining in Cervical Cancer.

C. Alexiou, U. Jeschke, C. Kuhn, 2016, Anticancer research.

Effect of BSA-coated Superparamagnetic Iron Oxide Nanoparticles on Granulosa Cells.

C. Alexiou, U. Jeschke, S. Dürr, 2016, Anticancer research.

The Progression of Cell Death Affects the Rejection of Allogeneic Tumors in Immune-Competent Mice – Implications for Cancer Therapy

T. Harrer, C. Berens, M. Niederweis, 2014, Front. Immunol..

Surface code—biophysical signals for apoptotic cell clearance

J. M. Brauner, M. Herrmann, C. Maueröder, 2013, Physical biology.

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

T. Winkler, G. Schett, R. Voll, 2010, Apoptosis.

Colourful death: Six-parameter classification of cell death by flow cytometry—Dead cells tell tales

C. Berens, M. Herrmann, C. Maueröder, 2013, Autoimmunity.

Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes

C. Alexiou, B. Frey, C. Janko, 2022, Nanomaterials.

Magnetic Tissue Engineering of the Vocal Fold Using Superparamagnetic Iron Oxide Nanoparticles.

C. Alexiou, O. Friedrich, Anna Fliedner, 2019, Tissue engineering. Part A.

Non-immunogenic dextran-coated superparamagnetic iron oxide nanoparticles: a biocompatible, size-tunable contrast agent for magnetic resonance imaging

Harald Unterweger, Aldo R Boccaccini, Tobias Bäuerle, 2017, International journal of nanomedicine.

Different Storage Conditions Influence Biocompatibility and Physicochemical Properties of Iron Oxide Nanoparticles

Rohit Agarwal, Christoph Alexiou, Geoffrey Lee, 2015, International journal of molecular sciences.

Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells.

R. Sauer, R. Fietkau, B. Frey, 2010, Biochemical and biophysical research communications.

The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

G. Schett, A. Tincani, L. Andreoli, 2015, Journal of immunology research.

Orally administered nanoparticles for gastrointestinal applications.

C. Alexiou, R. Tietze, I. Cicha, 2023, Nanomedicine.

Sodium and potassium urate crystals differ in their inflammatory potential

G. Schett, M. Herrmann, L. Munoz, 2009, Autoimmunity.

CRP and SAP from different species have different membrane ligand specificities

W. Schrödl, R. Schindler, C. Janko, 2013, Autoimmunity.

Redox modulation of HMGB1-related signaling.

G. Schett, I. Ivanović‐Burmazović, M. Herrmann, 2014, Antioxidants & redox signaling.

Non-magnetic chromatographic separation of colloidally metastable superparamagnetic iron oxide nanoparticles and suspension cells.

C. Alexiou, R. Tietze, D. Dudziak, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety

C. Alexiou, J. Szebeni, B. Coolen, 2023, International journal of nanomedicine.

Real-time cell analysis of human cancer cell lines after chemotherapy with functionalized magnetic nanoparticles.

Christoph Alexiou, Stephan Dürr, Rainer Tietze, 2012, Anticancer research.

Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs.

C. Alexiou, L. Sellner, A. Mokhir, 2017, Angewandte Chemie.

Graphene-Induced Hyperthermia (GIHT) Combined With Radiotherapy Fosters Immunogenic Cell Death

R. Boukherroub, S. Szunerits, M. Podolska, 2021, Frontiers in Oncology.

CRP/anti-CRP Antibodies Assembly on the Surfaces of Cell Remnants Switches Their Phagocytic Clearance Toward Inflammation

K. Lauber, G. Schett, M. Herrmann, 2011, Front. Immun..

Magnetic nanoparticles for medical applications.

C. Alexiou, R. Friedrich, I. Cicha, 2017, Nanomedicine.

Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models

C. Alexiou, F. Ludwig, D. Eberbeck, 2018, International journal of nanomedicine.

Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids

C. Pilarsky, C. Alexiou, R. Friedrich, 2023, Materials.

In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions

C. Alexiou, C. Janko, S. Lyer, 2022, Cancers.

Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

C. Alexiou, R. Boukherroub, S. Szunerits, 2020, Cells.

CRP discriminates primary from secondary necrosis

M. Rauh, G. Schett, M. Herrmann, 2011 .

Loading of nuclear autoantigens prototypically recognized by systemic lupus erythematosus sera into late apoptotic vesicles requires intact microtubules and myosin light chain kinase activity

G. Schett, R. Voll, M. Herrmann, 2015, Clinical and experimental immunology.

Impact of Superparamagnetic Iron Oxide Nanoparticles on Vocal Fold Fibroblasts: Cell Behavior and Cellular Iron Kinetics

C. Bohr, M. Döllinger, C. Alexiou, 2017, Nanoscale Research Letters.

Treatment with DNAse I fosters binding to nec PBMC of CRP

G. Schett, C. Janko, A. Sheriff, 2009, Autoimmunity.

Toxicity of Mitoxantrone-loaded Superparamagnetic Iron Oxide Nanoparticles in a HT-29 Tumour Spheroid Model.

C. Alexiou, R. Friedrich, I. Cicha, 2016, Anticancer research.

Loading of Primary Human T Lymphocytes with Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Does Not Impair Their Activation after Polyclonal Stimulation

C. Alexiou, D. Dudziak, Geoffrey Lee, 2020, Cells.

Cells under pressure - treatment of eukaryotic cells with high hydrostatic pressure, from physiologic aspects to pressure induced cell death.

R. Fietkau, E. Schlücker, M. Herrmann, 2008, Current medicinal chemistry.

Genotoxicity of Superparamagnetic Iron Oxide Nanoparticles in Granulosa Cells

C. Alexiou, U. Jeschke, C. Janko, 2015, International journal of molecular sciences.

Recent nanomedicine articles of outstanding interest: nanoparticle functionalization for disease diagnostics and therapy.

C. Alexiou, R. Friedrich, I. Cicha, 2015, Nanomedicine.

Magnetic microgels for drug targeting applications: Physical–chemical properties and cytotoxicity evaluation

C. Alexiou, L. Vékás, R. Tietze, 2015 .

Immunohistochemical Evaluation of the Role of p53 Mutation in Cervical Cancer: Ser-20 p53-Mutant Correlates with Better Prognosis.

C. Alexiou, U. Jeschke, C. Kuhn, 2016, Anticancer research.

N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells

C. Alexiou, A. Mokhir, C. Janko, 2020, Molecules.

Nanomaterial-based ophthalmic therapies.

C. Alexiou, R. Tietze, I. Cicha, 2023, Nanomedicine.

Highlights from the latest articles in nanoparticles, nanomaterials and nanotoxicity testing.

C. Alexiou, R. Friedrich, I. Cicha, 2015, Nanomedicine.

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

T. Harrer, M. Lell, R. Holmdahl, 2014, Nature Medicine.

Tuning the structure of aminoferrocene-based anticancer prodrugs to prevent their aggregation in aqueous solution.

C. Alexiou, A. Mokhir, C. Janko, 2018, Journal of inorganic biochemistry.

Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality

C. Alexiou, H. Hackstein, Markéta Kubánková, 2023, Frontiers in immunology.

Specific Removal of C-Reactive Protein by Apheresis in a Porcine Cardiac Infarction Model

W. Schrödl, R. Kunze, J. Schulz-Menger, 2010, Blood Purification.

Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs

C. Alexiou, R. Tietze, S. Krappmann, 2023, International journal of nanomedicine.

Immune complex formation after exposure of autoantigens on the surface of secondary necrotic cells (SNEC) promotes inflammation in SLE

G. Schett, M. Herrmann, L. Munoz, 2012 .

Magnetic Tissue Engineering for Voice Rehabilitation - First Steps in a Promising Field.

C. Bohr, M. Döllinger, C. Alexiou, 2016, Anticancer Research.