R. Tynebor

发表

Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M4 Positive Allosteric Modulators

Scott T. Harrison, J. Uslaner, Sean M. Smith, 2019, ChemMedChem.

Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.

G. McGaughey, Youwei Yan, M. Lai, 2008, Journal of medicinal chemistry.

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.

G. McGaughey, Youwei Yan, M. Lai, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.

G. McGaughey, Youwei Yan, M. Lai, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1.

S. O'keefe, S. Natarajan, R. Tynebor, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.

S. O'keefe, S. Natarajan, R. Tynebor, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.

S. O'keefe, S. Natarajan, R. Tynebor, 2010, Bioorganic & medicinal chemistry letters.

Antiviral Activity of MK-4965, a Novel Nonnucleoside Reverse Transcriptase Inhibitor

D. Hazuda, Michael D. Miller, M. Lai, 2009, Antimicrobial Agents and Chemotherapy.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sarah L. Huszar, J. Uslaner, T. Tucker, 2014, Neuropharmacology.

Novel Method of Synthesizing Various Five Membered Heterocycles from an Aryl Tribromomethyl Group

R. Tynebor, Elizabeth J Millings, 2013 .

Synthesis of the 2H-quinolizin-2-one scaffold via a stepwise acylation—intramolecular annulation strategy

S. Natarajan, R. Tynebor, Bin Hu, 2006 .

Distinct Mutation Pathways of Non-Subtype B HIV-1 during In Vitro Resistance Selection with Nonnucleoside Reverse Transcriptase Inhibitors

D. Hazuda, G. McGaughey, Youwei Yan, 2010, Antimicrobial Agents and Chemotherapy.

Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with baccatins.

E. Pollina, X. Geng, I. Ojima, 2000, Chirality.