Hiroyuki Nakamura

发表

Prediction of an MMP-1 inhibitor activity cliff using the SAR matrix approach and its experimental validation

J. Bajorath, Yasunobu Asawa, A. Yoshimori, 2020, Scientific Reports.

Hiroyuki Nakamura, 2019, Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules.

Ligand-directed selective protein modification based on local single-electron-transfer catalysis.

Hiroyuki Nakamura, S. Sato, 2013, Angewandte Chemie.

Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy.

Minoru Suzuki, Y. Sakurai, Hiroyuki Nakamura, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Peptide Chain Elongation Using Unprotected Amino Acids in a Micro-flow Reactor.

Shinichiro Fuse, Hiroyuki Nakamura, Koshiro Masuda, 2019, Chemistry.

G-quadruplex-proximity protein labeling based on peroxidase activity.

H. Taguchi, Hiroyuki Nakamura, Shinichi Sato, 2020, Chemical communications.

Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy.

Y. Kaneda, K. Awazu, Hiroyuki Nakamura, 2015, Bioorganic & medicinal chemistry.

Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy

Y. Ozeki, Tomohiro Hayashi, Hanqin Liu, 2019, Applied Physics Express.

Elucidating the mode of action for thiophene-based organic D-π-A sensitizers for use in photodynamic therapy.

S. Okazaki, Shinichiro Fuse, Hiroyuki Nakamura, 2019, Bioorganic & medicinal chemistry.

The design, synthesis, and evaluation of organic dithienopyrrole-based D-π-A dyes for use as sensitizers in photodynamic therapy.

Shinichiro Fuse, Hiroyuki Nakamura, Shinichi Sato, 2018, Bioorganic & medicinal chemistry letters.

Thiophene‐Based Organic D–π–A Dyes as Potent Sensitizers for Photodynamic Therapy

S. Okazaki, Shinichiro Fuse, Hiroyuki Nakamura, 2017 .

Intracellular photocatalytic-proximity labeling for profiling protein-protein interactions in microenvironments.

H. Taguchi, Hiroyuki Nakamura, Shinichi Sato, 2022, Chemical communications.

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold

S. Kizaka-Kondoh, Hiroyuki Nakamura, Shinichi Sato, 2020, RSC advances.

Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity.

Shinichiro Fuse, Hiroyuki Nakamura, Shinichi Sato, 2020, Bioorganic & medicinal chemistry.

Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation.

Masaru Tanaka, Kazuki Kawai, S. Kume, 2021, Bioconjugate chemistry.

Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.

H. Wada, K. Ishihara, Hiroyuki Nakamura, 2017, Bioorganic & medicinal chemistry.

Water-Soluble closo-Docecaborate-Containing Pteroyl Derivatives Targeting Folate Receptor-Positive Tumors for Boron Neutron Capture Therapy

Hiroyuki Nakamura, T. Morita, H. Kawashima, 2020, Cells.

ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity.

Hiroyuki Nakamura, Shinichi Sato, Guangzhe Li, 2015, Bioorganic & medicinal chemistry letters.

Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer.

Hyun-soo Cho, Hiroyuki Nakamura, H. Ban, 2020, Biochemical and biophysical research communications.

Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity

Hiroyuki Nakamura, Guangzhe Li, Hidemitsu Minegishi, 2015 .

Design of Photoaffinity Probe Molecules for Identification and Modification of Target Proteins

Hiroyuki Nakamura, Shinichi Sato, H. Ban, 2014 .

Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN].

M. Pita, F. Teixidor, C. Viňas, 2018, Chemistry.

Protein Chemical Labeling Using Biomimetic Radical Chemistry

Hiroyuki Nakamura, Shinichi Sato, 2019, Molecules.

Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst.

Hiroyuki Nakamura, Shinichi Sato, K. Morita, 2015, Bioconjugate chemistry.

A laccase-catalysed tyrosine click reaction.

Hiroyuki Nakamura, Shinichi Sato, Keita Nakane, 2020, Organic & biomolecular chemistry.

Cyclic RGD-Functionalized closo-Dodecaborate Albumin Conjugates as Integrin Targeting Boron Carriers for Neutron Capture Therapy.

Minoru Suzuki, Kazuki Kawai, Hiroyuki Nakamura, 2020, Molecular pharmaceutics.

MRI-based Glucose Assay Using Magnetic Nanoparticle Sensors

I. Aoki, A. Sumiyoshi, Hiroyuki Nakamura, 2021, Analytical Sciences.

Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process

Rohmad Yudi Utomo, I. Aoki, A. Sumiyoshi, 2022, RSC advances.

Horseradish‐Peroxidase‐Catalyzed Tyrosine Click Reaction

Hiroyuki Nakamura, Shinichi Sato, Kosuke Nakamura, 2017, Chembiochem : a European journal of chemical biology.

Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.

V. Huber, H. Kouji, H. Seimiya, 2020, Bioorganic & medicinal chemistry.

Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.

Yasunobu Asawa, Hiroyuki Nakamura, T. Matsumura, 2022, Journal of nutritional science and vitaminology.

Photodynamic Therapy by Glucose Transporter 1-Selective Light Inactivation

Hiroyuki Nakamura, Michihiko Tsushima, Kazuki Miura, 2022, ACS omega.

Target Protein Identification on Photocatalyst‐Functionalized Magnetic Affinity Beads

Hiroyuki Nakamura, Shinichi Sato, Michihiko Tsushima, 2020, Current protocols in protein science.

Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads.

Hiroyuki Nakamura, Shinichi Sato, Michihiko Tsushima, 2017, Chemical communications.

Single-Step, Rapid, and Mild Synthesis of β-Amino Acid N-Carboxy Anhydrides Using Micro-Flow Technology.

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2019, Chemistry, an Asian journal.

Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides: Basic-to-Acidic Flash Switching in a Microflow Reactor.

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2018, Angewandte Chemie.

Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides: Basic-to-Acidic Flash Switching in a Microflow Reactor.

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2018, Angewandte Chemie.

Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept

I. Sivaev, Hiroyuki Nakamura, Sergey A. Anufriev, 2020 .

Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen.

H. Taguchi, Hiroyuki Nakamura, M. Ishikawa, 2021, Journal of the American Chemical Society.

N'-acyl-N-methylphenylenediamine as a novel proximity labeling agent for signal amplification in immunohistochemistry.

M. Matsumura, Ken Hatano, Hiroyuki Nakamura, 2019, Bioorganic & medicinal chemistry.

1-Methyl-4-aryl-urazole (MAUra) labels tyrosine in proximity to ruthenium photocatalysts.

Ken Hatano, Hiroyuki Nakamura, Shinichi Sato, 2018, Chemical communications.

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors

N. Tanuma, F. Uchiumi, S. Tanuma, 2020, Molecules.

Carrier proteins-based boron delivery to tumor.

Hiroyuki Nakamura, Shinichi Sato, Shunsuke Kikuchi, 2019, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

closo-Dodecaborate-conjugated human serum albumins: preparation and in vivo selective boron delivery to tumor

Kazuki Kawai, Hiroyuki Nakamura, Shinichi Sato, 2018 .

Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake.

Hiroyuki Nakamura, Shinichi Sato, J. Kohno, 2019, Organic & biomolecular chemistry.

Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by trisubstituted carboranes for T-cell activation.

M. Oda, S. Ogawa, Yasunobu Asawa, 2022, Bioorganic & medicinal chemistry letters.

Raman cell imaging with boron cluster molecules conjugated with biomolecules

M. Mochizuki, Tomohiro Hayashi, Hiroyuki Nakamura, 2019, RSC advances.

Synthesis of 3-Hydroxy-4-Substituted Picolinonitriles from 4-Propargylaminoisoxazoles via Stepwise and One-Pot Isoxazolopyridine Formation/N–O Bond Cleavage Sequence

Shinichiro Fuse, Hiroyuki Nakamura, S. Yugandar, 2018, ACS Omega.

The Life of Pi Star: Exploring the Exciting and Forbidden Worlds of the Benzophenone Photophore.

G. Prestwich, G. Dormán, A. Pulsipher, 2016, Chemical reviews.

Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles.

Hiroyuki Nakamura, Guangzhe Li, 2016, Angewandte Chemie.

Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines.

Shinichiro Fuse, Hiroyuki Nakamura, T. Morita, 2020, Organic letters.

Rhodium(iii)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes.

Hiroyuki Nakamura, S. Yugandar, 2019, Chemical communications.

Gold(I)-Catalyzed Intramolecular SEAr Reaction: Efficient Synthesis of Isoxazole-Containing Fused Heterocycles.

Shinichiro Fuse, Hiroyuki Nakamura, T. Morita, 2018, Organic letters.

Step-by-Step Multifunctionalization of Isoxazoles Based On SEAr Reactions and C–H Direct Arylations

Shinichiro Fuse, Hiroyuki Nakamura, T. Morita, 2017, Synthesis.

Generation of an 4-Isoxazolyl Anion Species: Facile Access to Multifunctionalized Isoxazoles.

Shinichiro Fuse, Hiroyuki Nakamura, T. Morita, 2016, Angewandte Chemie.

Rapid and Mild One‐Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization

R. Krems, Hiroki Sugisawa, Shinichiro Fuse, 2021, Chemistry–Methods.

Integrated Micro‐Flow Synthesis Based on Photochemical Wolff Rearrangement

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2017 .

Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with diverse carbon pronucleophiles: facile access to functionalized tetrahydroquinolines.

Hiroyuki Nakamura, Kun Shao, Yueqing Li, 2020, Chemical communications.

Recent progresses in the synthesis of functionalized isoxazoles

Shinichiro Fuse, Hiroyuki Nakamura, S. Yugandar, 2018 .

Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity.

Shinichiro Fuse, Yasunobu Asawa, Hiroyuki Nakamura, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of 4-amino-5-allenylisoxazoles via gold(I)-catalysed propargyl aza-Claisen rearrangement.

M. Tsuda, Hiroyuki Nakamura, T. Morita, 2021, Organic & biomolecular chemistry.

Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

Shinichiro Fuse, Hiroyuki Nakamura, Hiroshi Tanaka, 2016, Nature Communications.

Design of MMP-1 inhibitors via SAR transfer and experimental validation

J. Bajorath, A. Yoshimori, Hiroyuki Nakamura, 2022, Scientific Reports.

Boron-Based Drug Design.

Hiroyuki Nakamura, H. Ban, 2015, Chemical record.

N‐Methylated Peptide Synthesis via Generation of an Acyl N‐Methylimidazolium Cation Accelerated by a Brønsted Acid

S. Kawauchi, Shinichiro Fuse, Hiroyuki Nakamura, 2020 .

N-Methylated Peptide Synthesis via Acyl N-Methylimidazolium Cation Generation Accelerated by a Brønsted Acid.

S. Kawauchi, Shinichiro Fuse, Hiroyuki Nakamura, 2020, Angewandte Chemie.

A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide.

Shinichiro Fuse, Hiroyuki Nakamura, Y. Mifune, 2016, Organic & biomolecular chemistry.

Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach.

Shinichiro Fuse, Hiroyuki Nakamura, N. Sugisawa, 2020, Chemical communications.

Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N-H/B-H Double Activation of 1,2-Azaborines.

Yasunobu Asawa, Hiroyuki Nakamura, Hiroki Murakami, 2021, Angewandte Chemie.

Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide)

A. A. Anisimov, I. Sivaev, Yasunobu Asawa, 2021, Molecules.

o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

Hiroyuki Nakamura, H. Ban, Jong-Dae Lee, 2018, Molecules.

Target-protein-selective inactivation and labelling using an oxidative catalyst.

Hiroyuki Nakamura, Shinichi Sato, Michihiko Tsushima, 2018, Organic & biomolecular chemistry.

Fluorescent boron carbide quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy

M. Kaur, Minoru Suzuki, J. Yun, 2021 .

Amphiphilic COSAN and I2-COSAN crossing synthetic lipid membranes: planar bilayers and liposomes.

A. Alcaraz, F. Teixidor, C. Viňas, 2014, Chemical communications.

Boron nitride (10BN) a prospective material for treatment of cancer by boron neutron capture therapy (BNCT)

M. Kaur, Minoru Suzuki, Manjeet Kumar, 2020 .

Catalyst-proximity protein chemical labelling on affinity beads targeting endogenous lectins.

H. Taguchi, Hiroyuki Nakamura, Shinichi Sato, 2019, Chemical Communications.

Tyrosine-Specific Chemical Modification with in Situ Hemin-Activated Luminol Derivatives.

Hiroyuki Nakamura, Shinichi Sato, Hiroyuki Nakamura, 2015, ACS chemical biology.

Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity.

S. Kizaka-Kondoh, Shinichiro Fuse, Hiroyuki Nakamura, 2019, Bioorganic & medicinal chemistry.

Comprehensive exploration of chemical space using trisubstituted carboranes

H. Kouji, Yasunobu Asawa, A. Yoshimori, 2021, Scientific Reports.

Design of Carborane-Based Hypoxia-Inducible Factor Inhibitors

Hiroyuki Nakamura, H. Ban, Guangzhe Li, 2018, Boron-Based Compounds.

Synthesis of protoporphyrin-lipids and biological evaluation of micelles and liposomes.

Hiroyuki Nakamura, Shoji Tachikawa, Shinichi Sato, 2014, Bioorganic & medicinal chemistry.

Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression

N. Nonoguchi, S. Miyatake, T. Kuroiwa, 2021, Scientific Reports.

Peptide Synthesis Utilizing Micro-flow Technology.

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2018, Chemistry, an Asian journal.

Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles

Hiroyuki Nakamura, Masato Tsuda, T. Morita, 2021, Tetrahedron Letters.

Discovery of bicyclo[3,3,1]non-2-ene as a novel skeleton for HIF-1 inhibitors.

A. Yoshimori, Hiroyuki Nakamura, H. Ueda, 2018, Bioorganic & medicinal chemistry.

Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction.

H. Ueda, M. Matsumura, T. Ueno, 2020, Bioconjugate chemistry.

2-Dimensional Nanomaterials with Imaging and Diagnostic Functions for Nanomedicine; A Review

J. Choy, Hiroyuki Nakamura, Goeun Choi, 2020 .

Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.

H. Osada, M. Kawatani, Y. Futamura, 2015, Journal of medicinal chemistry.

Development of a Peptide Sensor Derived from Human ACE2 for Fluorescence Polarization Assays of the SARS-CoV-2 Receptor Binding Domain.

H. Ueda, Hiroyuki Nakamura, S. Okada, 2023, Analytical chemistry.

Recent advances in the integrated micro-flow synthesis containing photochemical reactions

Shinichiro Fuse, Hiroyuki Nakamura, Yuma Otake, 2018 .

Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells.

Hiroyuki Nakamura, H. Ban, M. Park, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Development of Albumin‐closo‐Dodecaborate Conjugates as Boron Carriers for Neutron‐Capture Therapy by Ru(bpy)3‐Photocatalyzed Modification of Tyrosine

Hiroyuki Nakamura, Shinichi Sato, Satomu Ishii, 2017 .

Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release

Y. Shimoyama, Y. Kitamoto, Hiroyuki Nakamura, 2023, Ultrasonics sonochemistry.

Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors.

Hiroyuki Nakamura, Shinichi Sato, D. Kanoh, 2014, Dalton transactions.

Recent Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous Catalysts

Shinichiro Fuse, Hiroyuki Nakamura, N. Sugisawa, 2020, Catalysts.

Asymmetric Synthesis of Bicyclic Isoxazolines via Dearomative Cycloaddition of 4-Nitroisoxazoles with Zwitterionic π-Allyl Palladium Species.

Hiroyuki Nakamura, T. Morita, Non Ito, 2023, Organic letters.

Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy

Hiroyuki Nakamura, Satomu Ishii, 2018, Journal of Organometallic Chemistry.

BODIPY Catalyzes Proximity‐Dependent Histidine Labelling

H. Taguchi, Hiroyuki Nakamura, Tatsuya Niwa, 2022, ChemCatChem.

Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model.

Rohmad Yudi Utomo, Hiroyuki Nakamura, S. Okada, 2022, Chemical communications.

Design, synthesis, and evaluation of azo D-π-A dyes as photothermal agents.

S. Kawauchi, Shinichiro Fuse, Hiroyuki Nakamura, 2019, Organic & biomolecular chemistry.

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Shinichiro Fuse, Hiroyuki Nakamura, Shinichi Sato, 2018, Synthesis.

Ligand-directed selective protein modification based on local single-electron-transfer catalysis.

Hiroyuki Nakamura, S. Sato, 2013, Angewandte Chemie.

Amphiphilic COSAN and I2-COSAN crossing synthetic lipid membranes: planar bilayers and liposomes.

A. Alcaraz, F. Teixidor, C. Viňas, 2014, Chemical communications.

Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy.

Jingdong Zhang, Xu Wang, Hiroyuki Nakamura, 2021, Bioorganic & medicinal chemistry letters.

Synthesis of protoporphyrin-lipids and biological evaluation of micelles and liposomes.

Hiroyuki Nakamura, Shinichi Sato, S. Tachikawa, 2014, Bioorganic & medicinal chemistry.

1-Methyl-4-aryl-urazole (MAUra) labels tyrosine in proximity to ruthenium photocatalysts.

Ken Hatano, Hiroyuki Nakamura, Shinichi Sato, 2018, Chemical communications.

Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90-Heat Shock Factor 1 Interaction.

Yasunobu Asawa, Hiroyuki Nakamura, T. Morita, 2024, ACS medicinal chemistry letters.

Discovery of three-dimensional bicyclo[3.3.1]nonanols as novel heat shock protein 90 inhibitors.

Hiroyuki Nakamura, T. Morita, Kazuki Miura, 2023, Bioorganic & medicinal chemistry.

Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads.

Hiroyuki Nakamura, Shinichi Sato, Michihiko Tsushima, 2017, Chemical communications.

Methylene Insertion into Nitrogen‐Heteroatom Single Bonds of 1,2‐Azoles via a Zinc Carbenoid: An Alternative Tool for Skeletal Editing

J. Takaya, Hiroyuki Nakamura, T. Morita, 2023, Advanced science.

Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity.

Shinichiro Fuse, Yasunobu Asawa, Hiroyuki Nakamura, 2016, Bioorganic & medicinal chemistry letters.