A. Alanine

发表

Neighborhood-preserving visualization of adaptive structure-activity landscapes: application to drug discovery.

Wolfgang Guba, Petra Schneider, Gisbert Schneider, 2011, Angewandte Chemie.

Lead generation--enhancing the success of drug discovery by investing in the hit to lead process.

Alexander Alanine, A. Alanine, M. Nettekoven, 2003, Combinatorial chemistry & high throughput screening.

Biosynthesis of vitamin B12: the multi-enzyme synthesis of precorrin-4 and factor IV.

J. Crouzet, A. Battersby, A. Alanine, 1997, Chemistry & biology.

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.

T. Woltering, G. Adam, V. Mutel, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of Annulated Pyridines by Intramolecular Inverse‐Electron‐Demand Hetero‐Diels–Alder Reaction under Superheated Continuous Flow Conditions

Falk Morawitz, Rainer E. Martin, Alexander Alanine, 2012 .

Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.

Alexander Alanine, Markus Bender, Edilio Borroni, 2010, Journal of medicinal chemistry.

Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.

Remo Hochstrasser, Rainer E. Martin, Horst Vogel, 2014, Angewandte Chemie.

Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

K. Bleicher, Yves Wuethrich, A. Alanine, 2002 .

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.

J. Peters, F. Blasco, S. Kolczewski, 2008, Bioorganic & medicinal chemistry letters.

4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

A guide to drug discovery: Hit and lead generation: beyond high-throughput screening

Hans-Joachim Böhm, Klaus Müller, Konrad H. Bleicher, 2003, Nature Reviews Drug Discovery.

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

J. Kemp, L. Lovat, T. Hoffmann, 2002, Nature.

Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model.

S. Woodhead, M. Webber, A. White, 2013, Organic & biomolecular chemistry.

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

Facile preparation of 2-imino tetrahydrofurans, pyrans and oxepans

C. Fishwick, A. Alanine, C. Szántay, 1989 .

Pharmacological Characterization of Ro 63-1908 (1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a Novel Subtype-SelectiveN-Methyl-d-Aspartate Antagonist

J. Kemp, J. Kew, E. Pinard, 2002, Journal of Pharmacology and Experimental Therapeutics.

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Christine J. Martin, Lesley S. Sheehan, M. Gregory, 2017, Nature Communications.

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

J. Peters, F. Blasco, S. Kolczewski, 2008, Bioorganic & medicinal chemistry letters.

Development of a virtual screening method for identification of "frequent hitters" in compound libraries.

Wolfgang Guba, Petra Schneider, Gisbert Schneider, 2002, Journal of medicinal chemistry.

A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Gisbert Schneider, Olivier Roche, Gerhard Trube, 2002, Chembiochem : a European journal of chemical biology.

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, G. Trube, A. Bourson, 2002, Bioorganic & medicinal chemistry letters.

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

E. Pinard, V. Mutel, G. Trube, 2004 .

Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.

E. Pinard, V. Mutel, G. Trube, 2001, Bioorganic & medicinal chemistry letters.

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Markiyan Samborskyy, Mohammad Nur-E-Alam, Alexander Alanine, 2017, Nature Communications.

An Ireland-ClaisenRearrangement/Lactonisation Cascade as a Key Step in StudiesTowards the Synthesis of (-)-Euonyminol:

Andrew J. P. White, M. Webber, A. Alanine, 2011 .

Generation and cycloadditions of tetrahydrofuryl, pyranyl, and oxepanyl-2-imminium methylides

C. Fishwick, A. Alanine, C. Szántay, 1989 .

Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups (13C18O2H) is enzymatically converted into cobyrinic acid

R. Vishwakarma, F. Leeper, A. Battersby, 1993 .

Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists

A. Alanine, L. Anselm, L. Steward, 2004 .