Zhonghui Lu

发表

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Chen Lihua, Zelda R. Wasserman, Karl D. Hardman, 2002 .

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

R. Magolda, J. Trzăskos, M. Covington, 2003, Bioorganic & medicinal chemistry letters.

Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.

M. Covington, C. Decicco, J. Duan, 2005, Bioorganic & medicinal chemistry letters.

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

D. Shuster, J. Macor, J. Yanchunas, 2020, Journal of medicinal chemistry.

Discovery of highly potent, selective, covalent inhibitors of JAK3.

S. Spergel, G. Schieven, J. Barrish, 2017, Bioorganic & medicinal chemistry letters.

Reliability and validity of the repetitive behavior scale-revised for young Chinese children with autism spectrum disorder in Jiangxi Province

Zhonghui Lu, Liyun Huang, Shipu Zou, 2022, Frontiers in Pediatrics.

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.

David S. Nirschl, David S Nirschl, Sidney Pitt, 2014, Bioorganic & medicinal chemistry letters.

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

Michael A. Galella, D. Shuster, D. Shen, 2019, ACS medicinal chemistry letters.

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Soong-Hoon Kim, W. Pitts, M. Covington, 2007, Bioorganic & medicinal chemistry letters.

α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

David D. Christ, K. Vaddi, M. Covington, 2008 .

Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.

Zelda R Wasserman, J. Trzăskos, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.

J. Trzăskos, K. Vaddi, M. Covington, 2008, Bioorganic & medicinal chemistry letters.

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

J. Trzăskos, K. Vaddi, M. Covington, 2008, Bioorganic & medicinal chemistry letters.

Four bioactive new steroids from the soft coral Lobophytum pauciflorum collected in South China Sea

Zhonghui Lu, Xu-li Tang, Pinglin Li, 2022, Beilstein journal of organic chemistry.

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Bioorganic & medicinal chemistry letters.

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.

Zhuyin Li, C. Weigelt, B. Fink, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Zhiling Yu, Zhonghui Lu, Y. Pang, 2023, Molecules.

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Michael A. Galella, D. Shen, J. Barrish, 2018, Bioorganic & medicinal chemistry letters.

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019 .

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019, Bioorganic & medicinal chemistry letters.

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists.

C. Weigelt, B. Fink, T. Huynh, 2020, Bioorganic & medicinal chemistry letters.