H. Nagase

Ko Suzuki, H. Nagase, J. Gorski, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin).

K. Suzuki, J. Enghild, G. Salvesen, 1991, Biomedica biochimica acta.

Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT1080 Fibrosarcoma Cells*

V. Dolo, H. Nagase, P. Mignatti, 1997, The Journal of Biological Chemistry.

Production of matrix metalloproteinases 2 and 3 (stromelysin) by stromal cells of giant cell tumor of bone.

K. Suzuki, Y. Sasaguri, M. Morimatsu, 1992, The American journal of pathology.

Effects of H2-receptor antagonists on matrix metalloproteinases in rat gastric tissues with acetic acid-induced ulcer.

S. Murakami, H. Nagase, H. Yamada, 1991, Journal of pharmacobio-dynamics.

Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3.

K. Suzuki, J. Enghild, G. Salvesen, 1992, Matrix (Stuttgart, Germany). Supplement.

Zymography of Metalloproteinases

H. Nagase, L. Troeberg, 2003, Current protocols in protein science.

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.

H. Nagase, L. Troeberg, 2003, Methods in molecular biology.

CHARACTERIZATION OF AN IMMUNOSUPPRESSIVE COLON CANCER CELLS' FACTOR DERIVED FROM

F. Robertson, E. Ebert, A. Roberts, 1987 .

Reactive Site Mutations in Tissue Inhibitor of Metalloproteinase-3 Disrupt Inhibition of Matrix Metalloproteinases but Not Tumor Necrosis Factor-α-converting Enzyme*

K. Brew, M. Kashiwagi, Zhihong Xie, 2005, Journal of Biological Chemistry.

Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15

Lindsay S. Cooley, A. Krüger, D. Edwards, 2015, International journal of cancer.

Elucidating the Function of Non catalytic Domains of Collagenases and Aggrecanases

H. Nagase, K. Fushimi, 2008, Connective tissue research.

Screening of potential ADAMTS-4 inhibitors utilizing a collagen- model FRET substrate

T. Spicer, G. Fields, P. Hodder, 2008 .

Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints.

Y. Okada, E. D. Harris, H. Nagase, 1987, The Journal of rheumatology.

Substrate specificities and activation mechanisms of matrix metalloproteinases.

K. Suzuki, J. Enghild, G. Salvesen, 1991, Biochemical Society transactions.

LRP‐1‐mediated endocytosis regulates extracellular activity of ADAMTS‐5 in articular cartilage

C. L. Murphy, D. Strickland, S. D. Scilabra, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A personal journey with matrix metalloproteinases

H. Nagase, 2016, Biological chemistry.

Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface*

Y. Itoh, K. Iwata, K. Tanzawa, 1998, The Journal of Biological Chemistry.

Folding and characterization of the amino‐terminal domain of human tissue inhibitor of metalloproteinases‐1 (TIMP‐1) expressed at high yield in E. coli

K. Brew, S. V. Van Doren, Ko Suzuki, 1996, FEBS letters.

Modulation of production of matrix metalloproteinases from ovine endometrial cells by ovine trophoblast interferon.

H. Nagase, L. Salamonsen, A. Hampton, 1994, Journal of reproduction and fertility.

Localization of collagenase at the basal plasma membrane of a human pancreatic carcinoma cell line.

K. Suzuki, U. Moll, S. Zucker, 1990, Cancer research.

Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts.

L. Liotta, S. Zucker, J. Wieman, 1988, Journal of the National Cancer Institute.

Complete primary structure of human matrix metalloproteinase-3

Y. Otani, J. Saus, E. D. Harris, 1988 .

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

J. Enghild, C. Scavenius, George Bou-Gharios, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases.

K. Suzuki, H. Nagase, J. Fowlkes, 1995, Progress in growth factor research.

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Timp-1 is Mediated via Effects on Mmp Inhibition: Implications for Reversibility of Liver Fibrosis

J. Iredale, P. Soloway, Xiaoying Zhou, 2002 .

Amino acid sequence of hen ovomacroglobulin (ovostatin) deduced from cloned cDNA.

K. Nielsen, L. Sottrup-jensen, H. Nagase, 1994, DNA sequence : the journal of DNA sequencing and mapping.

Rabbit procollagenase synthesized and secreted by a high-yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation.

R. Palmiter, K. Suzuki, C. Brinckerhoff, 1990, The Journal of biological chemistry.

Importance of matrix metalloproteinases in human trophoblast invasion.

A. Campana, P. Bischof, Y. Itoh, 1995, Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.

Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP-3) by rheumatoid synovial cells in vitro and in vivo

D. Woolley, L. Tetlow, H. Nagase, 2004, Rheumatology International.

Identification of the 183RWTNNFREY191Region as a Critical Segment of Matrix Metalloproteinase 1 for the Expression of Collagenolytic Activity*

D. Dinakarpandian, G. Fields, K. Shimokawa, 2000, The Journal of Biological Chemistry.

Involvement of tissue inhibitors of metalloproteinases (TIMPS) during matrix metalloproteinase activation.

K. Suzuki, K. Brew, M. Gehring, 1996, Advances in experimental medicine and biology.

[27] Human stromelysins 1 and 2

H. Nagase, 1995 .

Progesterone increases the production of tissue inhibitor of metalloproteinases‐2 in rabbit uterine cervical fibroblasts

Y. Itoh, H. Nagase, Y. Mori, 1994, FEBS letters.

Matrix Metalloproteinases: A Role in Implantation?

D. Woolley, H. Nagase, L. Salamonsen, 1994 .

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) is induced in rabbit articular chondrocytes by cotreatment with interleukin 1 beta and a protein kinase C activator.

H. Nagase, E. Arner, Y. Ogata, 1992, Experimental cell research.

Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3.

J. Woessner, H. Nagase, Z. Gunja-Smith, 1989, The Biochemical journal.

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate.

Y. Okada, E. D. Harris, H. Nagase, 1988, The Biochemical journal.

A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function.

L. Yan, M. Sarras, H. Nagase, 1995, Development.

Immunolocalization of the matrix metalloproteinases gelatinase B and stromelysin 1 in human endometrium throughout the menstrual cycle.

D. Woolley, H. Nagase, M. Jeziorska, 1996, Journal of reproduction and fertility.

Matrix metalloproteinases and their tissue inhibitors at the ovine trophoblast-uterine interface.

D. Woolley, H. Nagase, L. Salamonsen, 2019, Journal of reproduction and fertility. Supplement.

Digestion of C1q collagen‐like domain with MMPs‐1, ‐2, ‐3, and ‐9 further defines the sequence involved in the stimulation of neutrophil superoxide production

A. Henschen-Edman, H. Nagase, A. Tenner, 1999, Journal of leukocyte biology.

Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)

K. Brew, M. Gehring, Ko Suzuki, 1998, Biological chemistry.

Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation

S. Nagata, H. Fukuyama, M. Tanaka, 2003, Cell Death and Differentiation.

Activation mechanisms of matrix metalloproteinases.

H. Nagase, 1997, Biological chemistry.

Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1)

K. Shimokawa, H. Nagase, L. Chung, 2002 .

Interleukin 1 acts via c-jun N-terminal kinase-2 signalling pathway to induce aggrecan degradation by human chondrocytes.

L. Rawlinson, J. Saklatvala, T. Vincent, 2015 .

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

O. Fedorov, J. McCafferty, J. Dudhia, 2017, mAbs.

Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

Y. Itoh, J. Dudhia, G. Murphy, 2017, Arthritis & rheumatology.

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.

J. Enghild, V. Dive, I. Thøgersen, 2009, Matrix biology : journal of the International Society for Matrix Biology.

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown

M. Kashiwagi, Y. Itoh, R. Visse, 2005, Arthritis Research & Therapy.

Development of a solid-phase assay for analysis of matrix metalloproteinase activity.

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2004, Journal of biomolecular techniques : JBT.

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.

R. Wynn, R. Copeland, R. Wynn, 1999, Science.

Brief Report: JNK‐2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis

J. Saklatvala, T. Vincent, A. Fosang, 2015, Arthritis & rheumatology.

Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.

H. Nagase, Takashi Sato, K. Ogawa, 2016, Biochemical and biophysical research communications.

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

B. Villoutreix, O. Sperandio, F. Leroux, 2010, Bioorganic & medicinal chemistry letters.

Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium.

C. Vater, E. D. Harris, H. Nagase, 1983, The Journal of biological chemistry.

Human stromelysins 1 and 2.

H. Nagase, 1995, Methods in enzymology.

Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin).

K. Suzuki, P. Bejarano, B. Hudson, 1988, The Biochemical journal.

Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid.

M. de Silva, H. Nagase, T. Cawston, 1982, Biochimica et biophysica acta.

TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.

D. Greenspan, W. Wang, N. Lim, 2006, The Biochemical journal.

Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage.

D. Kaplan, B. An, Yu-Shan Lin, 2018, Journal of structural biology.

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).

U. Wewer, M. Kveiborg, G. Murphy, 2010, The Biochemical journal.

Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage.

C. Brinckerhoff, E. D. Harris, H. Nagase, 1982, Journal of the American Academy of Dermatology.

Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblasts.

H. Nagase, Y. Mori, A. Ito, 1989, Biochimica et biophysica acta.

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain

D. Svergun, W. Bode, D. Franke, 2010, The Journal of Biological Chemistry.

Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.

J. Enghild, H. Nagase, J. Fowlkes, 2004, Endocrinology.

Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond.

Y. Itoh, B. Kudryk, H. Nagase, 1996, Biochemistry.

Matrix Metalloproteinases*

J. Woessner, H. Nagase, 1999, The Journal of Biological Chemistry.

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.

A Yasui, Y Okada, K. Suzuki, 1990, European journal of biochemistry.

Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.

G. Fields, H. Nagase, J. Lauer-Fields, 2000, Journal of chromatography. A.

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

H. Konomi, H. Nagase, K. Kimata, 1989, FEBS letters.

Proactivator-dependent activation of procollagenase induced by treatment with EGTA.

C. Vater, E. D. Harris, H. Nagase, 1986, The Biochemical journal.

Selective hydrolysis of triple-helical peptides by matrix metalloproteinases

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2002 .

Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin).

K. Suzuki, J. Enghild, S. Pizzo, 1991, The Journal of biological chemistry.

Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites.

J. Enghild, K. Brew, G. Salvesen, 1989, The Journal of biological chemistry.

Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase.

C. Brinckerhoff, C. Vater, E. D. Harris, 1983, The Biochemical journal.

Increased level of translatable collagenase messenger ribonucleic acid in rabbit synovial fibroblasts treated with phorbol myristate acetate or crystals of monosodium urate monohydrate.

R. H. Gross, R. Jackson, C. Brinckerhoff, 1982, Biochemistry.

Cell cholesterol modulates metalloproteinase‐dependent shedding of low‐density lipoprotein receptor‐related protein‐1 (LRP‐1) and clearance function

A. Noël, P. Courtoy, G. Perrot, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity*

K. Brew, C. Overall, G. Fields, 2006, Journal of Biological Chemistry.

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.

R. Leblanc, G. Sui, G. Fields, 2003, Analytical biochemistry.

Matrix metalloproteinases and their tissue inhibitors at the ovine trophoblast — uterineinterface

D. Woolley, H. Nagase, L. A. Salamonsenl, 2019 .

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

M. Meldal, George Bou-Gharios, N. Lim, 2014, Osteoarthritis and Cartilage.

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion*

J. Sipley, J. Quigley, D. French, 1999, The Journal of Biological Chemistry.

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement

K. Page, A. Dolphin, H. Nagase, 2022, Function.

Tumor necrosis factor alpha (TNFalpha) induces pro-matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha.

T. Sato, H. Nagase, Y. Ogata, 1996, FEBS letters.

Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II.

K. Suzuki, D. Woolley, H. Nagase, 1995, The Biochemical journal.

Effect of matrix glycation on expression of type IV collagen, MMP-2, MMP-9 and TIMP-1 by human mesangial cells.

E. Tsilibary, H. Nagase, Y. Kim, 1996, Cell adhesion and communication.

Tissue inhibitors of metalloproteinases: evolution, structure and function.

K. Brew, D. Dinakarpandian, H. Nagase, 2000, Biochimica et biophysica acta.

Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1).

K. Suzuki, K. Brew, H. Nagase, 1997, The Biochemical journal.

Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases.

H. Nagase, J. Fowlkes, K. Thrailkill, 1997, Endocrine.

Interaction of α2‐Macroglobulin with Matrix Metalloproteinases and Its Use for Identification of Their Active Forms a

Y. Itoh, H. Nagase, S. Binner, 1994 .

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1

J. Iredale, M. Arthur, J. Collins, 2004, Comparative hepatology.

Target-Based Proteolytic Profiling for Characterizing Cancer Progression

Scott A. Busby, M. J. Chalmers, P. Griffin, 2006 .

Altered kidney matrix gene expression in early stages of experimental diabetes.

A. Michael, E. Tsilibary, S. Mauer, 1997, Acta anatomica.

Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates.

G. Fields, H. Nagase, T. Broder, 2001, Biochemistry.

Aggrecanases in Cartilage 九 1 : atrixBreakdown

H. Nagase, The Kennedy lnstitute, 2022 .

X-ray Structure of Human proMMP-1 NEW INSIGHTS INTO PROCOLLAGENASE ACTIVATION AND COLLAGEN BINDING*

W. Bode, G. Bourenkov, R. Visse, 2005 .

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.

K. Suzuki, J. Enghild, G. Salvesen, 1990, Biochemistry.

Human recombinant interleukin‐1α‐mediated stimulation of procollagenase production and suppression of biosynthesis of tissue inhibitor of metalloproteinases in rabbit uterine cervical fibroblasts

H. Nagase, Takashi Sato, K. Yamashita, 1988, FEBS letters.

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin).

K. Suzuki, J. Enghild, G. Salvesen, 1990, Biochemistry.

Collagenase unwinds triple‐helical collagen prior to peptide bond hydrolysis

D. Dinakarpandian, G. Fields, R. Visse, 2004, The EMBO journal.

Proteases involved in cartilage matrix degradation in osteoarthritis.

Linda Troeberg, H. Nagase, L. Troeberg, 2012, Biochimica et biophysica acta.

Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.

Kenta Watanabe, C. Miyaura, G. Murphy, 2018, Archives of oral biology.

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase.

H. Nagase, A. Ito, 1988, Archives of biochemistry and biophysics.

Amino acid sequence of a 32‐residue region around the thiol ester site in duck ovostatin

K. Brew, H. Nagase, 1987, FEBS letters.

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.

E. Novellino, F. Da Settimo, S. Taliani, 2012, European journal of medicinal chemistry.

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.

B. Villoutreix, O. Sperandio, Gaëlle Deglane, 2013, European journal of medicinal chemistry.

Degradation of chromosomal DNA during apoptosis

S. Nagata, H. Fukuyama, Kohki Kawane, 2003, Cell Death and Differentiation.

Metalloproteases

H. Nagase, 2001, Current protocols in protein science.

Gelatin-degrading type IV collagenase isolated from human small cell lung cancer.

L. Liotta, S. Zucker, J. Wieman, 1989, Invasion & metastasis.

Characterization of Rat Uterine Matrilysin and Its cDNA

J. Woessner, G. Conner, H. Nagase, 1995, The Journal of Biological Chemistry.

Collagenase production by immortalized human aortic endothelial cells infected with simian virus 40

Y. Sasaguri, M. Morimatsu, H. Nagase, 1991, Virchows Archiv. B, Cell pathology including molecular pathology.

Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility.

J. Mott, R. Khalifah, B. Hudson, 1997, Kidney international.

Structural properties of matrix metalloproteinases

W. Bode, K. Maskos, H. Tschesche, 1999, Cellular and Molecular Life Sciences CMLS.

Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption.

C. Miyaura, T. Suda, H. Nagase, 1998, Endocrinology.

Alpha-fetoprotein (AFP) levels in normal children.

K. Tsuchida, H. Nagase, S. Horita, 1997, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.

K. Brew, H. Nagase, 2010, Biochimica et biophysica acta.

Matrix metalloproteinases in cancer.

Y. Itoh, H. Nagase, 2002, Essays in biochemistry.

Progress in matrix metalloproteinase research.

H. Nagase, G. Murphy, 2008, Molecular aspects of medicine.

Structural Analysis of the α2 Integrin I Domain/Procollagenase-1 (Matrix Metalloproteinase-1) Interaction*

T. Stricker, S. Santoro, W. Parks, 2001, The Journal of Biological Chemistry.

The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression*

E. Korzus, J. Travis, H. Nagase, 1997, The Journal of Biological Chemistry.

Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.

Noriko Ito, Motoharu Seiki, N. Ito, 2006, Molecular biology of the cell.

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability.

G. Fields, H. Nagase, Janelle L. Lauer-Fields, 2004, Biochemistry.

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis

J. Saklatvala, George Bou-Gharios, M. Gardiner, 2015, Osteoarthritis and cartilage.

UNIT 21.4 Metalloproteases

H. Nagase, 2001 .

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

Gillian Murphy, G. Murphy, H. Nagase, 2008, Nature Clinical Practice Rheumatology.

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases : Structure

R. Visse, H. Nagase, Hideaki Nagase, 2003 .

Production of matrix metalloproteinase 3 (stromelysin) by cultured ovine endometrial cells.

D. Woolley, H. Nagase, L. Salamonsen, 1991, Journal of cell science.

Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases.

D. Abraham, H. Nagase, M. Ponticos, 2005, Current vascular pharmacology.

Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm.

H. Nagase, Y. Ogata, R. Gandhi, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Production of matrix metalloproteinase 1 (interstitial collagenase) and matrix metalloproteinase 2 (gelatinase A: 72 kDa gelatinase) by ovine endometrial cells in vitro: different regulation and preferential expression by stromal fibroblasts.

D. Woolley, H. Nagase, L. Salamonsen, 1993, Journal of reproduction and fertility.

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

Y. Okada, E. D. Harris, H. Nagase, 1986, The Journal of biological chemistry.

Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.

Sejin Han, Dan L Sackett, J. Vera, 2010, Cancer research.

Localizing matrix metalloproteinase activities in the pericellular environment

H. Nagase, G. Murphy, 2011, The FEBS journal.

Continuously recording fluorescent assays optimized for five human matrix metalloproteinases.

H. Birkedal‐Hansen, H. V. Van Wart, H. Nagase, 1991, Analytical biochemistry.

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

J. Enghild, H. Nagase, Y Ogata, 1992, The Journal of biological chemistry.

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

V. Turk, B. Turk, B. Rozman, 2010, Biological chemistry.

The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness.

F. Saladino, H. Nagase, M. Vittorelli, 1998, Anticancer research.

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

A. Krüger, B. Mari, U. Reuning, 2014, Oncogene.

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

J. McCafferty, M. Dyson, G. Murphy, 2015, The Biochemical journal.

Endoproteinase‐protein inhibitor interactions

W. Bode, K. Maskos, H. Nagase, 1999, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family*

R. Wynn, R. Copeland, Y. Itoh, 1999, The Journal of Biological Chemistry.

YAP is essential for tissue tension to ensure vertebrate 3D body shape

Araxi O. Urrutia, Takashi Sasaki, N. Shimizu, 2015, Nature.

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

John P. Iredale, J. Iredale, M. Arthur, 2002, The Journal of Biological Chemistry.

Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat

K. Shirouzu, Y. Ogata, K. Matono, 2006, International journal of cancer.

Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases*

Wolfgang Losert, Sejin Han, W. Losert, 2010, The Journal of Biological Chemistry.

Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases.

Y. Tominaga, W. Bode, M. Kröger, 2000, Chemistry & biology.

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

G. Fields, C. Fields, G B Fields, 1994, The Journal of biological chemistry.

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage

M. Day, T. Vincent, S. Müller, 2020, Osteoarthritis and cartilage open.

Protein Engineering of the Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) Inhibitory Domain

K. Brew, H. Nagase, Ying Chen, 2003, The Journal of Biological Chemistry.

A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process.

A. Leontovich, J. Zhang, M. Sarras, 2000, Development.

Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice

A. Krüger, T. Reinheckel, M. Heikenwalder, 2015, Hepatology.

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity*

A. Colige, S. Vadon-Le Goff, C. Moali, 2010, The Journal of Biological Chemistry.

A personal journey with matrix metalloproteinases

H. Nagase, 2016, Biological chemistry.

Matrix metalloproteinases and TIMPs

J. Woessner, H. Nagase, 2000 .

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis*

S. Akira, S. Narumiya, S. Uematsu, 2015, The Journal of Biological Chemistry.

Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells.

B. Baxter, H. Nagase, Wanfen Xiong, 2003, Journal of vascular surgery.

Distinct biological events generated by ECM proteolysis by two homologous collagenases

I. Amit, Diego Jaitin, Eyal David, 2016, Proceedings of the National Academy of Sciences.

Ovostatin: a novel proteinase inhibitor from chicken egg white. I. Purification, physicochemical properties, and tissue distribution of ovostatin.

K. Brew, J. Woessner, E. D. Harris, 1983, The Journal of biological chemistry.

Cell surface activation of progelatinase A (proMMP-2) and cell migration

H. Nagase, 1998, Cell Research.

Purification of MMPs and TIMPs.

K. Shimokawa, H. Nagase, 2010, Methods in molecular biology.

Matrix Metalloproteinase 3/Stromelysin 1

H. Nagase, 2013 .

Selective immunosuppressive action of a factor produced by colon cancer cells.

E. Ebert, A. Roberts, H. Nagase, 1990, Cancer research.

LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages

H. Nagase, L. Troeberg, P. Green, 2019, The Journal of Immunology.

Palmitoylation at Cys574 is essential for MT1‐MMP to promote cell migration

J. Couchman, Y. Itoh, M. Seiki, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Matrix Metalloproteinase 1 Interacts with Neuronal Integrins and Stimulates Dephosphorylation of Akt*

K. Conant, A. Nath, D. Gary, 2004, Journal of Biological Chemistry.

Matrix metalloproteinase (stromelysin-1) increases the albumin permeability of isolated rat glomeruli.

K. Suzuki, V. Savin, H. Nagase, 1996, The Journal of laboratory and clinical medicine.

Differential Inhibition of Membrane Type 3 (MT3)-Matrix Metalloproteinase (MMP) and MT1-MMP by Tissue Inhibitor of Metalloproteinase (TIMP)-2 and TIMP-3 Regulates Pro-MMP-2 Activation*

M. Bernardo, R. Fridman, M. Kashiwagi, 2004, Journal of Biological Chemistry.

Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases

A. Baici, H. Nagase, G. Kostoulas, 1999, FEBS letters.

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

A. Krüger, K. Brew, L. Coussens, 2007, Cancer research.

Low Density Lipoprotein Receptor-related Protein Mediates Endocytic Clearance of Pro-MMP-2·TIMP-2 Complex through a Thrombospondin-independent Mechanism*

László Patthy, Etienne Marbaix, Linda Troeberg, 2004, Journal of Biological Chemistry.

Crystal Structure of an Active Form of Human MMP-1

K. Acharya, R. Visse, H. Nagase, 2006, Journal of molecular biology.

Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors*

O. Olsen, M. Overgaard, H. Stennicke, 2015, The Journal of Biological Chemistry.

Nomenclature and glossary of the matrix metalloproteinases.

J. Woessner, H. Nagase, Barrett Aj, 1992, Matrix (Stuttgart, Germany). Supplement.

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity

H. Nagase, L. Troeberg, I. Di Liegro, 2012, Matrix biology : journal of the International Society for Matrix Biology.

Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.

Kenta Watanabe, T. Maruyama, C. Miyaura, 2016, Biochemical and biophysical research communications.

Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3.

C. Brinckerhoff, H. Nagase, G. Murphy, 1988, Collagen and related research.

Signaling Metastasis by Induction of Hepatocyte Growth Factor Tissue Inhibitor of Metalloproteinases-1 Promotes Liver

A. Krüger, K. Brew, L. Coussens, 2007 .

Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms.

B. Baxter, Y. Itoh, A. Ghorpade, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.

P. Roughley, H. Nagase, J. Mort, 2011, European cells & materials.

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)*

M Kashiwagi, K. Brew, M. Kashiwagi, 2001, The Journal of Biological Chemistry.

In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy

M. Herrmann, F. Beau, V. Dive, 2018, Advanced Functional Materials.

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer*

Kenta Watanabe, C. Miyaura, G. Murphy, 2016, The Journal of Biological Chemistry.

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics

K. Brew, H. Nagase, 2002, Arthritis research.

Insights into MMP‐TIMP Interactions

W. Bode, K. Maskos, H. Tschesche, 1999, Annals of the New York Academy of Sciences.

Engineering of Selective TIMPs

K. Brew, W. Bode, K. Maskos, 1999, Annals of the New York Academy of Sciences.

Residue 2 of TIMP-1 Is a Major Determinant of Affinity and Specificity for Matrix Metalloproteinases but Effects of Substitutions Do Not Correlate with Those of the Corresponding P1′ Residue of Substrate*

K. Brew, Yajing Hu, W. Bode, 1999, The Journal of Biological Chemistry.

Individual Timp Deficiencies Differentially Impact Pro-MMP-2 Activation*

R. Khokha, E. Vuorio, Z. Kassiri, 2006, Journal of Biological Chemistry.

Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP‐3

R. Wait, M. Kashiwagi, H. Nagase, 2002, Clinical and experimental immunology.

Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth

H. Aburatani, Y. Homma, K. Takayama, 2016, Oncogene.

Application of hyperspectral fluorescence lifetime imaging to tissue autofluorescence: arthritis

M. J. Lever, C. B. Talbot, R. K. P. Benninger, 2005, European Conference on Biomedical Optics.

Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT 1080 Fibrosarcoma Cells *

V. Dolo, H. Nagase, P. Mignatti, 1997 .

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.

B. Turk, E. Bartnik, N. Lim, 2011, Bioorganic & medicinal chemistry.

Calmodulin antagonists increase the expression of membrane-type-1 matrix metalloproteinase in human uterine cervical fibroblasts.

H. Sato, M. Seiki, T. Sato, 1998, European journal of biochemistry.

Substrate Specificity of MMPs

H. Nagase, 2001 .

Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides.

G. Fields, G B Fields, H. Nagase, 1996, Biopolymers.

Analysis of TIMP expression and activity.

H. Nagase, L. Troeberg, 2007, Methods in molecular medicine.

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

Mingfeng Yu, M. Todd, P. Rutledge, 2013, ChemistryOpen.

Purification and characterization of matrix metalioproteinase 9 from U 937 monocytic leukaemia and HT 1080 fibrosarcoma cells

Y. Sasaguri, H. Nagase, Y. Ogata, 2005 .

Selective Hydrolysis of Triple-helical Substrates by Matrix Metalloproteinase-2 and -9*

M. Stack, G. Fields, H. Nagase, 2003, The Journal of Biological Chemistry.

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis

V. Dive, M. Meldal, George Bou-Gharios, 2014, Arthritis & rheumatology.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

K. Ladell, G. Dolton, M. Kashiwagi, 2019, Scientific Reports.

The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface*

N. Ito, Y. Itoh, M. Seiki, 2008, Journal of Biological Chemistry.

Hydrolysis of Triple-helical Collagen Peptide Models by Matrix Metalloproteinases*

G. Fields, K. Shimokawa, H. Nagase, 2000, The Journal of Biological Chemistry.

Human breast carcinoma cells cultured in the presence of serum shed membrane vesicles rich in gelatinolytic activities.

V. Dolo, H. Nagase, G. Ghersi, 1994, Journal of submicroscopic cytology and pathology.

Zinc content and function in human fibroblast collagenase.

H. Birkedal‐Hansen, E. Springman, H. V. Van Wart, 1995, Biochemistry.

Measurement of Protease Activities Using Fluorogenic Substrates.

Salvatore Santamaria, H. Nagase, 2018, Methods in molecular biology.

Triple Helicase Activity and the Structural Basis of Collagenolysis

R. Visse, H. Nagase, 2011 .

Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets

J. Enghild, C. Scavenius, George Bou-Gharios, 2022, bioRxiv.

Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules.

K. Suzuki, J. Calvet, J. Grantham, 1996, Kidney international.

Evidence for a thiol ester in duck ovostatin (ovomacroglobulin).

K. Brew, E. D. Harris, H. Nagase, 1986, Journal of Biological Chemistry.

Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.

A. Miyawaki, Y. Itoh, M. Seiki, 2011, The Biochemical journal.

Distribution of gelatinase B (MMP-9) and type IV collagen in colorectal carcinoma

D. Woolley, H. Nagase, M. Jeziorska, 1994, International Journal of Colorectal Disease.

arthritis . correlation with rheumatoid synovioblasts ( B cells ) : ( stromelysin ) in rheumatoid metalloproteinase 3 Immunolocalization of matrix

K. Tomita, H. Nagase, I. Nakanishi, 2004 .

Proteinases that Digest the Connective Tissue Matrix

A. Sapolsky, J. Woessner, H. Nagase, 1977 .

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

A. Pitsillides, M. Shah, George Bou-Gharios, 2016, PloS one.

Identification of rabbit uterine cervical procollagenase activator as rabbit matrix metalloproteinase 3 (stromelysin).

K. Suzuki, Y. Itoh, T. Sato, 1991, Comparative biochemistry and physiology. B, Comparative biochemistry.

Model peptides of interstitial collagens: hydrolysis by matrix metalloproteinases

G. Fields, K. Shimokawa, H. Nagase, 2002 .

Monitoring Metalloproteinase Activity Using Synthetic Fluorogenic Substrates

H. Nagase, L. Troeberg, 2003, Current Protocols in Protein Science.

TIMP-1 contact sites and perturbations of stromelysin 1 mapped by NMR and a paramagnetic surface probe.

K. Suzuki, S. V. Van Doren, H. Nagase, 1998, Biochemistry.

Simultaneous production of collagenase, matrix metalloproteinase 3 (stromelysin) and tissue inhibitor of metalloproteinases by rheumatoid synovial lining cells.

H. Nagase, I. Nakanishi, Y. Okada, 1992, Matrix (Stuttgart, Germany). Supplement.

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

J. Enghild, K. Brew, M. Kashiwagi, 2010, The Biochemical journal.

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.

T. Spicer, G. Fields, P. Hodder, 2008, Analytical biochemistry.

Shed Membrane Vesicles and Selective Localization of Gelatinases and MMP‐9/TIMP‐1 Complexes

V. Dolo, H. Nagase, G. Ghersi, 1999, Annals of the New York Academy of Sciences.

Bending rigidity of type I collagen homotrimer fibrils

W. Losert, S. Leikin, R. Visse, 2009 .

Identification that ADAM17 mediates proteolytic maturation of calcium channel auxiliary α2δ subunits, and enables calcium current enhancement

K. Page, A. Dolphin, H. Nagase, 2021, bioRxiv.

Catalytic properties of ADAM12 and its domain deletion mutants.

J. Enghild, K. Brew, H. P. Sørensen, 2008, Biochemistry.

Proteases and the regulation of biological processes

G. Salvesen, J. Saklatvala, H. Nagase, 2003 .

Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage.

T. Glant, K. Mikecz, J. Jacobs, 1998, Arthritis and rheumatism.

Comparative sequence specificities of human fibroblast and neutrophil matrix metalloproteinases.

K. Suzuki, H. Birkedal‐Hansen, H. V. Van Wart, 1992, Matrix (Stuttgart, Germany). Supplement.

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

R. Visse, H. Nagase, Hideaki Nagase, 2003, Circulation research.

Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

M. Overgaard, M. Loftager, M. Enoksson, 2018, mAbs.

ADAMDEC1 mAbs for quantification and activity modulation

M. Overgaard, M. Loftager, M. Enoksson, 2018 .

BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice.

Chisato Miyaura, Kenta Watanabe, Masaki Inada, 2016, Biochemical and biophysical research communications.

Generation of a mouse line harboring a bi‐transgene expressing luciferase and tamoxifen‐activatable creERT2 recombinase in cartilage

J. Saklatvala, George Bou-Gharios, N. Lim, 2014, Genesis.

Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3

S. Wren, B. Marsden, H. Nagase, 2017, Molecular Pharmacology.

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

M. Meldal, George Bou-Gharios, N. Lim, 2014, Osteoarthritis and cartilage.

1 Role of the NTR domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity *

A. Colige, C. Moali, B. Font, 2010 .

Characterization of the 46-kDa Intermediates of Matrix Metalloproteinase 3 (Stromelysin 1) Obtained by Site-directed Mutation of Phenylalanine 83 (*)

H. Nagase, M. Kurkinen, G. Buttice, 1996, The Journal of Biological Chemistry.

Insulin-like growth factor binding protein (IGFBP) substrate zymography

H. Nagase, J. Fowlkes, K. Thrailkill, 1997, Endocrine.

Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate.

Y. Itoh, H. Nagase, S. Binner, 1995, The Biochemical journal.

Electron microscopic studies of free and proteinase-bound duck ovostatins (ovomacroglobulins). Model of ovostatin structure and its transformation upon proteolysis.

E. D. Harris, G. Ruben, H. Nagase, 1988, The Journal of biological chemistry.

Progress in matrix metalloproteinase research.

H. Nagase, G. Murphy, 2008, Molecular aspects of medicine.

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

R. Khokha, H. Emonard, H. Nagase, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3

S. Wren, B. Marsden, H. Nagase, 2017, Molecular Pharmacology.

Localizing matrix metalloproteinase activities in the pericellular environment

H. Nagase, G. Murphy, 2011, The FEBS Journal.

Proteolytic activities of human ADAMTS-5. comparative studies with human ADAMTS-4 [Erratum]

J. Enghild, M. Kashiwagi, I. Thøgersen, 2007 .

Elucidating the Function of Non catalytic Domains of Collagenases and Aggrecanases

H. Nagase, K. Fushimi, 2008, Connective tissue research.

Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their active forms.

Y. Itoh, H. Nagase, S. Binner, 1994, Annals of the New York Academy of Sciences.

Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1).

H. Nagase, M. Noelken, L. Chen, 1993, Biochemistry.

Matrix Metalloproteinases*

J. Woessner, H. Nagase, 1999, The Journal of Biological Chemistry.

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1

J. Iredale, J. Collins, D. Mann, 2004, Comparative hepatology.