X. Norel

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The muscarinic receptor subtypes in human blood vessels.

L. Walch, C. Brink, X. Norel, 2001, Therapie.

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling.

X. Norel, G. Topal, G. Ozen, 2015, European journal of pharmacology.

Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.

J. Michel, L. Louedec, M. Bäck, 2009, American journal of physiology. Heart and circulatory physiology.

Magnetic wire active microrheology of human respiratory mucus.

X. Norel, J. Berret, M. Radiom, 2021, Soft matter.

Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients.

Y. Castier, A. Silverstein, D. Longrois, 2020, Prostaglandins, leukotrienes, and essential fatty acids.

Interaction between PGI2 and ET-1 pathways in vascular smooth muscle from Group-III pulmonary hypertension patients.

Y. Castier, A. Cazes, A. Silverstein, 2020, Prostaglandins & other lipid mediators.

The quest for new cysteinyl-leukotriene and lipoxin receptors: recent clues.

C. Brink, X. Norel, 2004, Pharmacology & therapeutics.

Prostaglandin E₂ induced contraction of human intercostal arteries is mediated by the EP₃ receptor.

D. Longrois, I. Gomez, X. Norel, 2012, European journal of pharmacology.

Bronchodilation induced by PGE2 is impaired in Group III pulmonary hypertension

Y. Castier, A. Silverstein, H. Mal, 2019, British journal of pharmacology.

Prostacyclin release and receptor activation: differential control of human pulmonary venous and arterial tone

L. Walch, C. Brink, X. Norel, 2004, British journal of pharmacology.

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI 2 : a safer alternative to COX-2 inhibition Correspondence

P. Jakobsson, D. Longrois, I. Gomez, 2017 .

Inodilator versus inotrope: do inodilators have an edge to improve outcome in patients with heart failure or cardiac dysfunction?

D. Longrois, X. Norel, P. Pollesello, 2020 .

Prostaglandin Endoperoxide H Synthase-2 (PGHS-2) Variants and Risk of Obesity and Microvascular Dysfunction Among Tunisians: Relevance of rs5277 (306G/C) and rs5275 (8473T/C) Genetic Markers

Z. Tabka, X. Norel, Sarra Bchir, 2021, Biochemical Genetics.

Neutrophils recruited by leukotriene B4 induce features of plaque destabilization during endotoxaemia

J. Vonesch, J. Michel, M. Bäck, 2018, Cardiovascular research.

Prostanoids in the pathophysiology of human coronary artery.

X. Norel, G. Ozen, Gulsev Ozen, 2017, Prostaglandins & other lipid mediators.

Absence of inflammatory conditions in human varicose saphenous veins

G. Lambeau, D. Longrois, L. Louedec, 2012, Inflammation Research.

A second cysteinyl leukotriene receptor in human lung.

C. Labat, X. Norel, I. Gorenne, 1992, The Journal of pharmacology and experimental therapeutics.

Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype

L. Louedec, G. Leséche, D. Henin, 2008, British journal of pharmacology.

Prostanoid Receptors in the Human Vascular Wall

X. Norel, 2007, TheScientificWorldJournal.

Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

A. Silverstein, R. McAnulty, X. Norel, 2018, International journal of molecular sciences.

Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension.

X. Norel, S. Moledina, Lei Shen, 2019, Biochemical pharmacology.

Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population

Z. Tabka, M. Jacob, X. Norel, 2017, Disease markers.

(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways.

C. Labat, R. Müller-Peddinghaus, C. Brink, 1994, The Journal of pharmacology and experimental therapeutics.

Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma.

C. Labat, V. de Montpréville, C. Brink, 1996, Life sciences.

Functional studies of leukotriene receptors in vascular tissues.

L. Walch, C. Brink, X. Norel, 2000, American journal of respiratory and critical care medicine.

Pharmacological evidence for a novel cysteinyl‐leukotriene receptor subtype in human pulmonary artery smooth muscle

S. Dahlén, L. Walch, M. Bäck, 2002, British journal of pharmacology.

Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins.

L. Walch, M. Bäck, C. Brink, 2002, Acta physiologica Scandinavica.

Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes.

S. Dahlén, L. Walch, M. Bäck, 2000, European journal of pharmacology.

Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes.

S. Dahlén, L. Walch, M. Bäck, 2000, European journal of pharmacology.

Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry.

C. Labat, C. Brink, X. Norel, 1998, The Journal of pharmacology and experimental therapeutics.

Cysteinyl leukotriene receptors in the human lung: what's new?

C. Brink, X. Norel, I. Gorenne, 1996, Trends in pharmacological sciences.

EFFECTS OF VARIOUS PHARMACOLOGICAL AGENTS ON ISOLATED HUMAN BRONCHIAL AND PULMONARY ARTERIAL AND VENOUS MUSCLE PREPARATIONS CONTRACTED BY LEUKOTRIENE D4

C. Labat, J. Benveniste, C. Brink, 1987, Fundamental & clinical pharmacology.

Control of human vascular tone by prostanoids derived from perivascular adipose tissue.

D. Longrois, I. Gomez, X. Norel, 2013, Prostaglandins & other lipid mediators.

Prostanoid receptors in GtoPdb v.2021.2

S. Narumiya, Y. Sugimoto, M. Giembycz, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Effect of cold storage on cholinergic responses induced by electrical field stimulation in human bronchi.

M. Bäck, C. Brink, X. Norel, 2006, Pulmonary pharmacology & therapeutics.

Cholinesterase activity in pig airways and epithelial cells

L. Walch, C. Labat, C. Brink, 1997, Fundamental & clinical pharmacology.

Prostaglandin E2 receptor subtypes in human blood and vascular cells.

D. Longrois, I. Gomez, X. Norel, 2012, European journal of pharmacology.

The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release.

S. Dahlén, L. Walch, M. Bäck, 2002, Advances in experimental medicine and biology.

Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.

P. Braquet, M. Chignard, J. Benveniste, 1986, European journal of pharmacology.

A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor.

A. Fabre, A. Silverstein, D. Longrois, 2013, Prostaglandins & other lipid mediators.

Effects of β2‐adrenoceptor agonists on anti‐IgE‐induced contraction and smooth muscle reactivity in human airways

C. Labat, C. Brink, X. Norel, 1995, British journal of pharmacology.

Evidence for a M1 muscarinic receptor on the endothelium of human pulmonary veins

L. Walch, C. Brink, X. Norel, 2000, British journal of pharmacology.

PGE(2) receptor (EP(4)) agonists: potent dilators of human bronchi and future asthma therapy?

D. Longrois, C. Danel, G. Leséche, 2012, Pulmonary pharmacology & therapeutics.

Leukotrienes and the pulmonary vascular bed.

L. Walch, C. Brink, X. Norel, 2002, Advances in experimental medicine and biology.

Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium.

C. Labat, J. Benveniste, C. Brink, 1987, The Journal of pharmacology and experimental therapeutics.

Prostanoid receptors involved in the relaxation of human bronchial preparations

L. Walch, C. Labat, C. Brink, 1999, British journal of pharmacology.

Vasorelaxant effects of atrial peptide II on isolated human pulmonary muscle preparations.

C. Labat, J. Benveniste, C. Brink, 1988, European journal of pharmacology.

Cysteinyl-leukotrienes and the human lung.

C. Labat, C. Brink, X. Norel, 1999, Advances in experimental medicine and biology.

Degradation of acetylcholine in human airways: role of butyrylcholinesterase

C. Labat, C. Brink, X. Norel, 1993, British journal of pharmacology.

M1 and M3 muscarinic receptors in human pulmonary arteries

L. Walch, C. Labat, C. Brink, 1996, British journal of pharmacology.

Differential reactivity of human mammary artery and saphenous vein to prostaglandin E2: Implication for cardiovascular grafts

D. Longrois, L. Louedec, I. Gomez, 2011, British journal of pharmacology.

The role of perivascular adipose tissue on human saphenous vein vascular tone

X. Norel, G. Topal, G. Ozen, 2016 .

Anti-IgE Response in Human Airways: Relative Contribution of Inflammatory Mediators

C. Labat, C. Brink, X. Norel, 1994, Mediators of inflammation.

Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery

D. Longrois, L. Louedec, X. Norel, 2017, European journal of pharmacology.

Comparative study on the effect of aspirin, TP receptor antagonist and TxA2 synthase inhibitor on the vascular tone of human saphenous vein and internal mammary artery.

X. Norel, G. Topal, Saygin Turkyilmaz, 2021, Life sciences.

Antigen-induced contraction of human isolated lung preparations passively sensitized with monoclonal IgE: effects of indomethacin.

C. Labat, J. Benveniste, C. Brink, 1991, International archives of allergy and applied immunology.

Response to anti-human IgE in human pulmonary arteries. Regulation by endothelium.

C. Labat, C. Brink, X. Norel, 1993, The American review of respiratory disease.

Prostanoid EP1‐ and TP‐receptors involved in the contraction of human pulmonary veins

L. Walch, V. de Montpréville, C. Brink, 2001, British journal of pharmacology.

Inhibitory effects of BAY u3405 on prostanoid‐induced contractions in human isolated bronchial and pulmonary arterial muscle preparations

C. Labat, C. Brink, X. Norel, 1991, British journal of pharmacology.

The Second Leukotriene Receptor in Human Lung

C. Labat, C. Brink, X. Norel, 1993 .

Responsiveness and sensitivity to cholinergic agonists and antagonists in bovine isolated bronchial muscles.

M. Matera, C. Brink, X. Norel, 1990, Pharmacological research.

Prostanoid contractions in human isolated pulmonary muscle preparations: inhibition by BAY u3405.

C. Labat, C. Brink, X. Norel, 1991, Advances in prostaglandin, thromboxane, and leukotriene research.

Omega-3 polyunsaturated fatty acids reduce vascular tone and inflammation in human saphenous vein.

X. Norel, G. Topal, Armond Daci, 2017, Prostaglandins & other lipid mediators.

Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents.

A. Silverstein, D. Longrois, C. Danel, 2015, Prostaglandins & other lipid mediators.

Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels.

L. Walch, C. Brink, X. Norel, 2003, Advances in experimental medicine and biology.

Evaluation of some prostaglandins modulators on rat corpus cavernosum in-vitro: Is relaxation negatively affected by COX-inhibitors?

L. Louedec, X. Norel, T. Daabees, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine

B. Vargaftig, C. Labat, S. Eum, 1999, British journal of pharmacology.

Cholinesterase activity in human pulmonary arteries and veins

L. Walch, C. Brink, X. Norel, 1997, British journal of pharmacology.

Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein.

X. Norel, G. Topal, Saygin Turkyilmaz, 2020, Prostaglandins & other lipid mediators.

Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713.

V. de Montpréville, C. Brink, X. Norel, 2004, Prostaglandins & other lipid mediators.

A new mRNA splice variant coding for the human EP3-I receptor isoform.

A. Couvelard, L. Louedec, X. Norel, 2007, Prostaglandins, leukotrienes, and essential fatty acids.

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP1 receptor antagonist

X. Norel, T. Daabees, A. Senbel, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen P. H. Alexander, Leigh A. Stoddart, Kalyan C. Tirupula, 2021, British journal of pharmacology.

DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE2.

D. Longrois, B. Ho-Tin-Noé, M. Dubourdeau, 2022, Prostaglandins & other lipid mediators.

Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.

C. Labat, C. Brink, X. Norel, 1992, The Journal of pharmacology and experimental therapeutics.

Relaxation of isolated human pulmonary muscle preparations with prostacyclin (PGI2) and its analogs.

C. Labat, J. Benveniste, C. Brink, 1987, Prostaglandins.

Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.

J. Aerts, J. Sallenave, B. Solhonne, 2018, ACS nano.

Sildenafil corrects the increased contractility of rat detrusor muscle induced by alprostadil in vitro

X. Norel, T. Daabees, A. Senbel, 2019, Pharmacological reports : PR.

Prostanoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

S. Narumiya, R. Breyer, Y. Sugimoto, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Magnetic wire active microrheology of human respiratory mucus

X. Norel, J. Berret, M. Radiom, 2021, bioRxiv.

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

I. Amit, J. Casanova, F. Paul, 2017, Cell.

Cysteinyl-leukotriene receptors in pulmonary vessels.

L. Walch, C. Brink, X. Norel, 1999, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Decreased PGE2 Content Reduces MMP-1 Activity and Consequently Increases Collagen Density in Human Varicose Vein

D. Longrois, L. Louedec, I. Gomez, 2014, PloS one.

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

D. Longrois, Y. Sugimoto, X. Norel, 2020, Pharmacological Reviews.

Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women

J. Michel, P. Jakobsson, D. Longrois, 2018, International Journal of Obesity.

Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity

D. Longrois, I. Gomez, M. Jacob, 2016, PloS one.

The role of prostaglandin E2 in human vascular inflammation.

D. Longrois, I. Gomez, X. Norel, 2013, Prostaglandins, leukotrienes, and essential fatty acids.

Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation.

L. Louedec, C. Brink, X. Norel, 2008, Cardiovascular research.

Cholinesterase inhibition by vecuronium and pancuronium in human airways.

C. Labat, C. Brink, X. Norel, 1994, Life Science.

60 Cholinesterase (ChE) activity in normotensive rat (WKY) and spontaneous hypertensive rat (SHR)

L. Walch, C. Labat, C. Brink, 1998, Journal of Physiology-Paris.

Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort.

Z. Tabka, D. Longrois, M. Varret, 2021, Prostaglandins, leukotrienes, and essential fatty acids.

Prostanoid receptors involved in the relaxation of human pulmonary vessels

L. Walch, C. Labat, C. Brink, 1999, British journal of pharmacology.

The role of prostaglandin E 2 in human vascular in fl ammation

D. Longrois, I. Gomez, X. Norel, 2013 .

The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.

Pierre Validire, Laurent Boyer, Jorge Boczkowski, 2013, American journal of respiratory and critical care medicine.

Inhibition of microsomal PGE synthase‐1 reduces human vascular tone by increasing PGI2: a safer alternative to COX‐2 inhibition

P. Jakobsson, D. Longrois, I. Gomez, 2017, British journal of pharmacology.

AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery.

Y. Castier, A. Silverstein, D. Longrois, 2023, European journal of pharmacology.

Involvement of prostaglandin F2α in preeclamptic human umbilical vein vasospasm: a role of prostaglandin F and thromboxane A2 receptors

A. Gezer, X. Norel, G. Topal, 2010, Journal of Hypertension.

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP1 receptor antagonist

X. Norel, T. Daabees, A. Senbel, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Potassium channels modulate the action but not the synthesis of hydrogen sulfide in rat corpus cavernosum

L. Louedec, X. Norel, A. Senbel, 2017, Life sciences.

MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity

Z. Tabka, M. Jacob, X. Norel, 2021, Scientific reports.

Endothelin-1 modulates cyclic GMP production and relaxation in human pulmonary vessels.

C. Labat, C. Brink, X. Norel, 1995, The Journal of pharmacology and experimental therapeutics.

Cholinesterase activity in human pulmonary arteries and veins: correlation with mRNA levels.

A. Chatonnet, L. Walch, C. Brink, 2005, Life sciences.

Cholinergic control of human and animal pulmonary vascular tone.

L. Walch, C. Brink, X. Norel, 1999, The´rapie (Paris).

Absence of inflammatory conditions in human varicose saphenous veins

G. Lambeau, D. Longrois, L. Louedec, 2013, Inflammation Research.

Acetylcholine induces a greater production of prostacyclin in human pulmonary arteries than in veins

L. Walch, C. Brink, X. Norel, 1998, Journal of Physiology-Paris.

Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

A. Silverstein, R. McAnulty, X. Norel, 2018, International journal of molecular sciences.

The COX2/PGE2 Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts.

P. Validire, J. Dubois-Randé, D. Longrois, 2013 .

Prostaglandin E2 receptor subtypes in human blood and vascular cells.

D. Longrois, I. Gomez, X. Norel, 2012, European journal of pharmacology.