J. Flórez

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Participation of pontine structures in the respiratory action of opioids.

M. Hurlé, A. Mediavilla, J. Flórez, 1983, Life sciences.

Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats

M. Hurlé, A. Mediavilla, J. Flórez, 1985, Neuropharmacology.

Potentiation of acute opioid-induced respiratory depression and reversal of tolerance by the calcium antagonist nimodipine in awake rats

M. Dierssen, M. Hurlé, J. Flórez, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome

C. Martínez-Cué, J. Flórez, N. Rueda, 2006, Genes, brain, and behavior.

Mu-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system.

Á. Díaz, Á. Pazos, M. Hurlé, 1995, The Journal of pharmacology and experimental therapeutics.

G-Protein-Associated Signal Transduction Processes Are Restored after Postweaning Environmental Enrichment in Ts65Dn, a Down Syndrome Mouse Model

M. Dierssen, C. Martínez-Cué, J. Flórez, 2011, Developmental Neuroscience.

Vitamin D status in children with Down's syndrome.

J. Riancho, J. González‐Macías, J. Flórez, 2008, Journal of intellectual disability research : JIDR.

A comparative study in rats of the respiratory depression and analgesia induced by μ- and δ-opioid agonists

Á. Pazos, J. Flórez, 1984 .

Interaction of naloxone with μ- and δ-opioid agonists on the respiration of rats

Á. Pazos, J. Flórez, 1983 .

Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report

J. Maestre, M. Hurlé, J. Flórez, 1994, Pain.

Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome

M. Dierssen, J. Flórez, I. Vallina, 1997, Brain Research.

Regulation of μ-opioid receptors, G-protein-coupled receptor kinases and β-arrestin 2 in the rat brain after chronic opioid receptor antagonism

Á. Díaz, Á. Pazos, M. Hurlé, 2002, Neuroscience.

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

E. Valdizán, C. Martínez-Cué, M. Llorens-Martín, 2010, Journal of Alzheimer's disease : JAD.

Autoradiographic mapping of µ-opioid receptors during opiate tolerance and supersensitivity in the rat central nervous system

Á. Díaz, Á. Pazos, M. Hurlé, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Minoxidil in Severe and Moderately Severe Hypertension, in Association with Methyldopa and Chlortalidone

J. Cotorruelo, J. Flórez, C. Llamazares, 1982, Angiology.

A comparative study of the respiratory depressant and analgesic effects of bremazocine, a kappa-agonist.

Á. Pazos, J. Flórez, C. Tristán, 1983, Life sciences.

Annual course of serum 25-OH-D and 1,25-(OH)2-D in children and adults from Northern Spain

J. Riancho, J. González‐Macías, J. Flórez, 1986 .

Respiratory actions induced by cholecystokinin at the brainstem level

M. Dierssen, M. Hurlé, J. Flórez, 1988, Peptides.

The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-XL antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death

C. Martínez-Cué, J. Flórez, N. Rueda, 2011, International Journal of Developmental Neuroscience.

Long-Chain Polyunsaturated Fatty Acids in Rat Maternal Milk, Offspring Brain and Peripheral Tissues in Essential Fatty Acid Deficiency

M. Dierssen, J. Ruiz, J. Flórez, 2002, Clinical chemistry and laboratory medicine.

Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer’s disease

N. Cairns, M. Dierssen, G. Lubec, 2006, Amino Acids.

Tolerance to the respiratory actions of opiates: withdrawal tolerance and asymmetrical cross-tolerance.

J. Flórez, F. Ayesta, 1990, European journal of pharmacology.

Comparative effects of opioid peptides on respiration and analgesia in rats.

Á. Pazos, J. Flórez, 1982, Life sciences.

Apoptosis in Down’s syndrome: lessons from studies of human and mouse models

C. Martínez-Cué, J. Flórez, N. Rueda, 2013, Apoptosis.

Cardiovascular effects of intracerebroventricular injection of dopamine after selective MAO inhibition in rats

Á. Pazos, J. Flórez, A. Villa, 1982, Neuropharmacology.

Opioids in Respiration and Vomiting

M. Hurlé, J. Flórez, 1993 .

Regulation of dihydropyridine-sensitive Ca++ channels during opioid tolerance and supersensitivity in rats.

Á. Díaz, Á. Pazos, M. Hurlé, 1995, The Journal of pharmacology and experimental therapeutics.

Respiratory effects of ß-endorphin,d-Ala2-Met-enkephalinamide, and Met-enkephalin injected into the lateral ventricle and the pontomedullary subarachnoid space

Á. Pazos, A. Mediavilla, J. Flórez, 1980, Brain Research.

Respiratory Actions of Cholecystokinin and Its Interaction with Opioids at the Brainstem Level

M. Dierssen, M. Hurlé, J. Flórez, 1988 .

Adrenergic and serotonergic mechanisms in morphine-induced respiratory depression

J. Armijo, J. Flórez, G. Delgado, 2004, Psychopharmacologia.

Long‐term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle‐aged Ts65Dn mice, a model of Down syndrome

C. Martínez-Cué, E. Sánchez-Barceló, J. Flórez, 2013, Journal of pineal research.

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

R. Vidal, C. Martínez-Cué, E. Sánchez-Barceló, 2014, Journal of pineal research.

Brain amines and development of acute tolerance to and dependence on morphine in the respiratory center of decerebrate cats.

J. Armijo, J. Flórez, G. Delgado, 1973, Neuropharmacology.

Postnatal Handling Induces Long-term Modifications in Central β-noradrenergic Signalling in Rats

M. Dierssen, C. Martínez-Cué, J. Flórez, 2002, Stress.

Short-Term Effects of Postnatal Manipulation on Central β-Adrenoceptor Transmission

M. Dierssen, C. Martínez-Cué, J. Flórez, 1999 .

The influence of increased brain 5-hydroxytryptamine upon the respiratory activity of cats.

J. Armijo, J. Flórez, 1974, Neuropharmacology.

The Koolen-de Vries syndrome: a phenotypic comparison of patients with a 17q21.31 microdeletion versus a KANSL1 sequence variant

Bradley P. Coe, Jessie H. Conta, B. Coe, 2015, European Journal of Human Genetics.

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

M. Gratacós, X. Estivill, M. Pujana, 2006, Neurobiology of Disease.

Reducing GABAA α5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome

M. Honer, R. Vidal, Á. Pazos, 2013, The Journal of Neuroscience.

Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

C. Martínez-Cué, J. Flórez, N. Rueda, 2012, Neural plasticity.

Murine models for Down syndrome

X. Estivill, M. Dierssen, M. Arbonés, 2001, Physiology & Behavior.

The stimulatory action of d-amphetamine on the respiratory centre, and its mediation by a central α-adrenergic mechanism

Á. Pazos, A. Mediavilla, J. Flórez, 1979, Neuropharmacology.

Ca2+ channel modulation by dihydropyridines modifies sufentanil-induced respiratory depression in cats.

M. Dierssen, M. Hurlé, J. Flórez, 1991, European journal of pharmacology.

Inhibition of the activity of the respiratory and vasomotor centers by centrally administered 5-hydroxytryptamine in cats.

J. Armijo, A. Mediavilla, J. Flórez, 1979, Revista espanola de fisiologia.

Opioid tolerance and supersensitivity induce regional changes in the autoradiographic density of dihydropyridine-sensitive calcium channels in the rat central nervous system

Á. Díaz, Á. Pazos, M. Hurlé, 2000, Pain.

Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study

J. Armijo, M. Hurlé, J. Flórez, 1998, Pain.

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1

M. Dierssen, C. Martínez-Cué, N. Andreu, 2011, PloS one.

Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome

M. Dierssen, A. Tobeña, R. M. Escorihuela, 1998, Neuroscience Letters.

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model

M. Dierssen, A. Tobeña, R. M. Escorihuela, 1995, Neuroscience Letters.

Effect of central inhibition of the 1-amino acid decarboxylase on the hypotensive action of 5-HT precursors in cats.

J. Armijo, J. Flórez, 1974, European journal of pharmacology.

Mechanism of the respiratory action of pentobarbital at the medullary and pontine levels.

M. Dierssen, M. Hurlé, J. Flórez, 1986, European journal of pharmacology.

Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome

G. Tejeda, C. Martínez-Cué, M. Llorens-Martín, 2010, Neuroscience.

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

C. Martínez-Cué, J. Flórez, N. Rueda, 2008, Behavioural Brain Research.

Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome

M. Davisson, C. Martínez-Cué, J. Flórez, 2005, Behavioural Brain Research.

Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment.

X. Estivill, G. Elston, J. DeFelipe, 2003, Cerebral cortex.

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome

Mara Dierssen, M. Dierssen, M. Davisson, 2002, Behavioural Brain Research.

Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice

D. Davies, M. Dierssen, J. Flórez, 2000, Brain Research.

A murine model for Down syndrome shows reduced responsiveness to pain.

M. Dierssen, C. Martínez-Cué, J. Flórez, 1999, Neuroreport.

Reduced phospholipase C‐β activity and isoform expression in the cerebellum of TS65DN mouse: A model of down syndrome

M. Dierssen, J. Sallés, J. Flórez, 2001, Journal of neuroscience research.

The Ca2+ channel agonist Bay K 8644 induces central respiratory depression in cats, an effect blocked by naloxone.

M. Dierssen, M. Hurlé, J. Flórez, 1993, European journal of pharmacology.

High-affinity choline uptake carrier in Alzheimer's disease: implications for the cholinergic hypothesis of dementia

Á. Pazos, J. Zarranz, J. Berciano, 1991, Brain Research.

Respiratory responses to opiates applied to the medullary ventral surface.

M. Hurlé, A. Mediavilla, J. Flórez, 1982, Life sciences.

Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions

M. Dierssen, M. Hurlé, J. Flórez, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Tolerance to respiratory actions of sufentanil: functional tolerance and route-dependent differential tolerance.

J. Flórez, F. Ayesta, 1989, Journal of Pharmacology and Experimental Therapeutics.

Morphine, pentobarbital and naloxone in the ventral medullary chemosensitive areas: differential respiratory and cardiovascular effects.

M. Hurlé, A. Mediavilla, J. Flórez, 1982, The Journal of pharmacology and experimental therapeutics.

Tolerance to the respiratory effects of opioids: Evidence foran involvement of μ and δ receptors

J. Flórez, F. Ayesta, E. Sánchez, 1994, Regulatory Peptides.

Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome.

M. Dierssen, C. Martínez-Cué, J. Flórez, 2020, Progress in brain research.

A comparative study in rats of the respiratory depression and analgesia induced by mu- and delta-opioid agonists.

Á. Pazos, J. Flórez, 1984, European journal of pharmacology.

Interaction of naloxone with mu- and delta-opioid agonists on the respiration of rats.

Á. Pazos, J. Flórez, 1983, European journal of pharmacology.

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

R. Vidal, C. Martínez-Cué, M. Arbonés, 2014, PloS one.

Autoradiographic studies of neurotransmitter receptors in the brain of newborn infants with Down syndrome.

Á. Pazos, J. Flórez, J. Pascual, 2005, American journal of medical genetics. Supplement.

Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

R. Mostany, Á. Pazos, C. Martínez-Cué, 2005, Neuroscience Letters.

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

C. Martínez-Cué, J. Flórez, N. Rueda, 2008, Neuroscience Letters.

Different mechanisms are involved in the respiratory depression and analgesia induced by neurotensin in rats.

Á. Pazos, J. Flórez, M. López, 1984, European journal of pharmacology.

Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of mice

C. Martínez-Cué, M. Llorens-Martín, J. Flórez, 2007, Neuroscience.

Opiate analgesia and calcium channels modulation by dihydropyridines under acute and tolerant conditions.

M. Dierssen, M. Hurlé, J. Flórez, 1990, Progress in clinical and biological research.

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

X. Estivill, M. Dierssen, E. Martí, 2001, Human molecular genetics.

Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome

A. M. Insausti, L. Cruz-Orive, R. Insausti, 1998, Neuroscience Letters.

Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice

R. Insausti, M. Dierssen, J. Flórez, 1997, Neuroreport.

Characterization of the acute tolerance and dependence to morphine-induced respiratory depression in decerebrate cats.

J. Armijo, J. Flórez, G. Delgado, 1972, Revista espanola de fisiologia.

Subclinical renal toxicity in rheumatic patients receiving longterm treatment with nonsteroidal antiinflammatory drugs.

R. Escallada, J. Calvo-Alén, J. Flórez, 1994, The Journal of rheumatology.

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

R. Vidal, C. Martínez-Cué, E. Sánchez-Barceló, 2014, Journal of pineal research.

The action of diazepam, nitrazepam, and chlonazepam on the respiratory center of decerebrate cats.

J. Flórez, 1971, European journal of pharmacology.

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

C. Martínez-Cué, J. Flórez, N. Rueda, 2008, Behavioural Brain Research.

Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.

M. Dierssen, C. Martínez-Cué, J. Flórez, 1996, Brain research. Developmental brain research.

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1

M. Dierssen, C. Martínez-Cué, N. Andreu, 2011, PloS one.