Shenghua Gao

发表

Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medicinal chemistry.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & medicinal chemistry.

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic & Medicinal Chemistry.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Journal of medicinal chemistry.

Marangoni Flow Manipulated Concentric Assembly of Cellulose Nanocrystals

Yanlin Song, Jun-hua Hu, Gang Chen, 2021, Small methods.

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

P. Zhan, Xinyong Liu, Jian Zhang, 2022, European journal of medicinal chemistry.

A Process for (S)-Ketamine and (S)-Norketamine via Resolution Combined with Racemization.

Shenghua Gao, Fuli Zhang, Zhezhou Yang, 2020, The Journal of organic chemistry.

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Acta Pharmaceutica Sinica B.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Chinese Chemical Letters.

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, Bioorganic chemistry.

Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2020–present)

P. Zhan, Xinyong Liu, E. D. da Silva-Júnior, 2022, Expert opinion on therapeutic patents.

Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Journal of medicinal chemistry.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, International Journal of Molecular Sciences.

Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, Acta pharmaceutica Sinica. B.

Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, European journal of medicinal chemistry.

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Process Research and Impurity Control Strategy of Esketamine

Shenghua Gao, Fuli Zhang, Zhezhou Yang, 2020 .

Lewis Acid-Catalyzed Racemization and Recycling of the Undesired (R)-Ketamine

Shenghua Gao, Anjiang Yang, Fuli Zhang, 2020 .

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2023, Acta pharmaceutica Sinica. B.