Fener Chen

发表

Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2021, Journal of medicinal chemistry.

Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.

E. De Clercq, C. Pannecouque, H. Piao, 2021, European journal of medicinal chemistry.

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, Molecules.

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Acta pharmaceutica Sinica. B.

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020 .

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020, European journal of medicinal chemistry.

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Bioorganic chemistry.

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.

C. Pannecouque, Zhi-Qiang Xu, Fener Chen, 2019, European journal of medicinal chemistry.

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

Fangjun Xiong, Fener Chen, Min-jie Liu, 2018, iScience.

Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2012, European journal of medicinal chemistry.

Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.

E. De Clercq, C. Pannecouque, Fener Chen, 2018, European journal of medicinal chemistry.

Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, European journal of medicinal chemistry.

Stereoselective synthesis of 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors

Fangjun Xiong, Fener Chen, Yan Wu, 2015 .

Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.

C. Pannecouque, E. Clercq, Fener Chen, 2022, European journal of medicinal chemistry.

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

C. Pannecouque, J. Balzarini, E. Clercq, 2014 .

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Non‐Nucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 10

C. Pannecouque, J. Balzarini, Yue-ping Wang, 2008, Chemistry & biodiversity.

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic chemistry.

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents

Chunmei Jin, Fener Chen, J. Ai, 2021, Medicinal Chemistry Research.

Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, Journal of medicinal chemistry.

An efficient enantioselective synthesis of florfenicol via a vanadium-catalyzed asymmetric epoxidation

Fangjun Xiong, Fener Chen, Qiu-Qin He, 2011 .

Asymmetric Synthesis of Atorvastatin Calcium through Intramolecular Oxidative Oxygen‐Nucleophilic Bromocyclization

Fangjun Xiong, Hai Huang, Fener Chen, 2017 .

Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: an organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach.

Fangjun Xiong, Fener Chen, Xiaofei Chen, 2014, The Journal of organic chemistry.

Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1

Xiaodong Ma, Fener Chen, Lei Zhao, 2012 .

Synthesis and Evaluation of NF-κB Inhibitory Activity of Mollugin Derivatives

Ming-yue Li, H. Piao, Fener Chen, 2022, Molecules.

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

E. De Clercq, C. Pannecouque, H. Piao, 2022, Acta pharmaceutica Sinica. B.

An efficient enantioselective synthesis of florfenicol via asymmetric aziridination

C. Zheng, Fener Chen, Qiu-Qin He, 2011 .

Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: from S=O to CHOR

E. De Clercq, C. Pannecouque, Fener Chen, 2022, Chinese Chemical Letters.

Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, ChemMedChem.

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, Bioorganic & medicinal chemistry.

Lead Optimization of Diarylpyrimidines as Non‐nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2010, ChemMedChem.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Chloramphenicol base chemistry. Part 101: Asymmetric synthesis of α-hydroxy chiral alcohols via intramolecular Michael additions of γ-hydroxy-α, β-unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts

Haifeng Wang, Fener Chen, Yan Wu, 2017 .

Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities.

C. Pannecouque, Haifeng Wang, Fener Chen, 2023, European journal of medicinal chemistry.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, Medicinal Chemistry Research.

Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Liu-meng Yang, 2012, European journal of medicinal chemistry.

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2011, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Liu-meng Yang, 2011, Bioorganic & medicinal chemistry.

Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Liu-meng Yang, 2011, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Liu-meng Yang, 2011, Bioorganic & medicinal chemistry.

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

Fangjun Xiong, Fener Chen, Yan Wu, 2016 .

Catalytic asymmetric transfer hydrogenation/dynamic kinetic resolution: an efficient synthesis of florfenicol

Haifeng Wang, Fener Chen, Sheng Han, 2016 .

Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Liu-meng Yang, 2011, Bioorganic & medicinal chemistry.

Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity.

Yong-tang Zheng, Liu-meng Yang, Fener Chen, 2011, Bioorganic & medicinal chemistry.

An improved synthesis of (20S)-camptothecin and its analogue via an asymmetric α-hydroxylation with a chiral organocatalyst

Fangjun Xiong, Fener Chen, Yan Wu, 2017 .

Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 13

C. Pannecouque, J. Balzarini, Fener Chen, 2009, Chemistry & biodiversity.

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.

Jan Balzarini, Christophe Pannecouque, E. De Clercq, 2008, European journal of medicinal chemistry.

Chloramphenicol base chemistry. Part 11:1 chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones

Fangjun Xiong, Haifeng Wang, Fener Chen, 2017 .

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & medicinal chemistry.

Substrate stereocontrol in bromine-induced intermolecular cyclization: asymmetric synthesis of pitavastatin calcium

Fangjun Xiong, Fener Chen, Yan Wu, 2015 .

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.

C. Pannecouque, J. Balzarini, E. Clercq, 2010, Bioorganic & medicinal chemistry.

Synthetic studies on (+)-biotin, part 15: A chiral squaramide-mediated enantioselective alcoholysis approach toward the total synthesis of (+)-biotin.

Fener Chen, Fei Xiong, Zhiqiang Liu, 2011, Chemical & pharmaceutical bulletin.

An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide

Fener Chen, Fei Xiong, Xu-Xiang Chen, 2010 .

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2020, ACS infectious diseases.

New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α,β-unsaturated aldehydes with diketene: a short synthesis of atorvastatin calcium

Fangjun Xiong, Haifeng Wang, Fener Chen, 2016 .

Synthetic studies on statins. Part 1: a short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy

Fangjun Xiong, Fener Chen, Xiaofei Chen, 2013 .

Efficient Asymmetric Synthesis of (2R,3R)-3-{(1R)-1-(tert-Butyl(dimethyl)- siloxy)ethyl}-4-oxoazetidin-2-yl Acetate

Fener Chen, Shuang‐Xi Gu, Jian Huang, 2011 .

Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.

E. De Clercq, C. Pannecouque, J. Balzarini, 2009, Yao xue xue bao = Acta pharmaceutica Sinica.

Synthetic Studies on (+)‐Biotin, Part 11: Application of Cinchona Alkaloid‐Mediated Asymmetric Alcoholysis of meso‐Cyclic Anhydride in the Total Synthesis of (+)‐Biotin

Chen Wenxue, Fener Chen, Fei Xiong, 2008 .

Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Chemical & pharmaceutical bulletin.

Natural Occurrence, Biological Functions, and Analysis of D-Amino Acids

Haifeng Wang, Fener Chen, Shuang‐Xi Gu, 2020, Pharmaceutical Fronts.

Squaramide‐Linked Chloramphenicol Base Hybrid Catalysts for the Asymmetric Michael Addition of 2,3‐Dihydrobenzofuran‐2‐carboxylates to Nitroolefins

Fangjun Xiong, Haifeng Wang, Fener Chen, 2018 .

Synthesis and Evaluation of Chiral Rhodanine Derivatives Bearing Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors.

Xuejun Jin, L. Piao, Tongyi Dou, 2021, Medicinal chemistry (Shariqah (United Arab Emirates)).

An Efficient EnantioselectiveSynthesis of Florfenicol Based on Sharpless Asymmetric Dihydroxylation

C. Zheng, Fener Chen, Qiu-Qin He, 2012 .

An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem

Chen Wenxue, Fener Chen, Shuang‐Xi Gu, 2010 .

Synthetic studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy

Fangjun Xiong, C. Zheng, Fener Chen, 2014 .

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

E. De Clercq, C. Pannecouque, Fener Chen, 2020, Molecules.

Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy

Fener Chen, Fei Xiong, Jian Huang, 2008 .

Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization.

Fangjun Xiong, Haifeng Wang, Fener Chen, 2016, Organic & biomolecular chemistry.

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction.

Fangjun Xiong, Haifeng Wang, Fener Chen, 2015, Organic & biomolecular chemistry.

An improved process for chiron synthesis of the atorvastatin side chain

Fangjun Xiong, Chen Wenxue, Fener Chen, 2014 .

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK.

E. De Clercq, C. Pannecouque, Li Ding, 2022, Journal of medicinal chemistry.

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Chemical & pharmaceutical bulletin.

Synthesis and evaluation of anticancer activity of quillaic acid derivatives: A cell cycle arrest and apoptosis inducer through NF-κB and MAPK pathways

Jung Joon Lee, Fener Chen, Zhe-Shan Quan, 2022, Frontiers in Chemistry.

Design, Synthesis, and SAR of Naphthyl‐Substituted Diarylpyrimidines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies.

E. De Clercq, C. Pannecouque, J. Balzarini, 2013, Bioorganic & Medicinal Chemistry.

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, European journal of medicinal chemistry.

A novel synthetic route to 7-MAC from 7-ACA

Fener Chen, Fei Xiong, Zhao‐sen Zeng, 2016, Journal of the Iranian Chemical Society.

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs.

E. De Clercq, C. Pannecouque, Li Ding, 2021, Journal of medicinal chemistry.

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1.

C. Pannecouque, E. Clercq, Fener Chen, 2020, Bioorganic chemistry.

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, European journal of medicinal chemistry.

Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket.

Fener Chen, Shuang‐Xi Gu, Yuan-Yuan Zhu, 2019, European journal of medicinal chemistry.

A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin

Fener Chen, Fei Xiong, Zhiqiang Liu, 2010 .

Unexpected Ring Expansion of the (3aS,6aR)-γ-Thiolactone Moiety during the Introduction of the (+)-Biotin Side Chain

Fener Chen, Fei Xiong, Jian Huang, 2009 .

Synthesis and Anti-HIV-1 Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Jan Balzarini, Erik De Clercq, Christophe Pannecouque, 2007 .

Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities.

Fener Chen, Shuang‐Xi Gu, Jingrong Cao, 2023, Bioorganic chemistry.

Anti-aging effect of methylurolithin A and its amide derivatives on nematode Caenorhabditis elegans

X. Chen, Fener Chen, Z. Zhuang, 2023, Tetrahedron Letters.

Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 11. Structural Modulations of Diaryltriazines with Potent anti-HIV Activity.

C. Pannecouque, J. Balzarini, Fener Chen, 2008 .

Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of medicinal chemistry.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

C. Pannecouque, J. Balzarini, E. Clercq, 2014, Medicinal Chemistry Research.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors, Part 6[1]: Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Archiv der Pharmazie.

QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains.

Fener Chen, Yong‐Hong Liang, 2009, European journal of medicinal chemistry.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors. Part 6. Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006 .

Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011).

E. De Clercq, Fener Chen, Shi-qiong Yang, 2012, Current medicinal chemistry.

ONIOM DFT/PM3 calculations on the interaction between dapivirine and HIV-1 reverse transcriptase, a theoretical study.

F. E. Chen, Fener Chen, Y. Liang, 2007, Drug discoveries & therapeutics.

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors.

Christophe Pannecouque, E. De Clercq, C. Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Journal of medicinal chemistry.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, Bioorganic & medicinal chemistry.

Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway.

Fener Chen, Zheng-Fang Liu, Zhe-Shan Quan, 2023, European journal of medicinal chemistry.

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, D. Daelemans, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Christophe Pannecouque, E. De Clercq, C. Pannecouque, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Xiaodong Ma, Yong-tang Zheng, Fener Chen, 2011, Bioorganic & medicinal chemistry.