Sheng Han

发表

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2020 .

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, Bioorganic chemistry.

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Fen‐er Chen, 2019, European journal of medicinal chemistry.

Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, Journal of medicinal chemistry.

Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.

Youhong Hu, Sheng Han, Jianping Zuo, 2022, European journal of medicinal chemistry.

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

Youhong Hu, Yi Zang, Sheng Han, 2022, Bioorganic & Medicinal Chemistry Letters.

Catalytic asymmetric transfer hydrogenation/dynamic kinetic resolution: an efficient synthesis of florfenicol

Haifeng Wang, Fener Chen, Sheng Han, 2016 .

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles.

E. De Clercq, C. Pannecouque, Fener Chen, 2020, ACS infectious diseases.

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

E. De Clercq, C. Pannecouque, Fener Chen, 2020, Molecules.

Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization.

Fangjun Xiong, Haifeng Wang, Fener Chen, 2016, Organic & biomolecular chemistry.

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.

E. De Clercq, C. Pannecouque, Fener Chen, 2019, European journal of medicinal chemistry.

Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.

Sheng Han, Yiming Lu, 2023, European journal of medicinal chemistry.